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Peningkatan fungsional bedak dayak dengan ekstrak daun sirih hutan gambut Kalimantan Tengah (Piper aduncum) sebagai anti dengue Rahman, Sudarman; Febrianto, Yahya; Fatiqin, Awalul; Sulistia, Tiya; Alfanaar, Rokiy; Arsana, Mu'afa Purwa; Suprayogi, Thathit; Desindria, Galang Rizdho; Citrariana, Shesanthi
Jurnal SAGO Gizi dan Kesehatan Vol 6, No 3 (2025): Nopember
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v6i3.2467

Abstract

Background: Dengue Hemorrhagic Fever (DHF) was  disease caused by a virustransmitted the Aedes aegypti. One of the products with local wisdom that prevented DHF was the formulation of dayak powder from sirih hutan leaves. Based on phytochemical, contained terpenoids and flavonoids.Objectives: This study aims to identifythe group of antidengue compounds, determine the formula and evaluate the preparation of topical formulation.Methods: The research design used a pre experimentaldesign with variations and formula development, was conducted at the Biomedical Laboratory FK and PPIIG UPR in August-November 2024. Ethanol extract was obtained using the maceration for 3x24 hours, evaporated using a rotary evaporator and contained 132,5059 g. The extract was analyzed using GC-MS, then formulated with dayak powder and a physical test. Data were analyzed using the One Way Anova statistical test and continued Tukey's post hoc at 95% CI.Results: Sample showed 52 peak areas representing 7 possible identified compounds with a percentage of similarity> 70% (GC-MS). Then the five formulas were physically tested. The results of organoleptic and pH all formulas produced powder aromatic, green, and the criteria of skin pH range (4,5-6,5). The 5th formula showed better results based on the flow time test (5,46 seconds), the settling test produced 3,5-6% (<10%), adhesion test, smoothness, and hedonic. Based on data analysis with One Way Anova, a significant difference was produced in each dayak powder formula (pvalue=0,05).Conclusion: Ethanol extract of sirih hutan leaves has 7 possible compounds with antidengue activity and the 5th formula has better physical test results.
Formulasi Pil Kunyit (Curcuma Longa L.) Kombinasi Sari Jeruk Limau Kuit (Citrus Hystrix Dc.) Sebagai Antioksidan Citrariana, Shesanthi; Muhammad Priyadi; Anograh R, Defilia; Rahmman, Sudarman; Febrianto, Yahya; Irawan, Ahmad; June N, Franz; Elphasa H, Shavira; Adistia P, Allaya
Sinteza Vol. 6 No. 1 (2026): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v6i1.32965

Abstract

Turmeric contains the active compound curcumin, which has been studied for its various biological activities, including antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory properties. Kaffir lime is a plant commonly found on the island of Borneo and is used in traditional medicine and culinary flavors. Kaffir lime fruit and leaves contain various bioactive compounds, such as flavonoids (hesperidin, naringenin), essential oils (citronellal, limonene), and vitamin C. Flavonoids are known to have antioxidant and anti-inflammatory effects that can boost the immune system. Pills are one of the oldest dosage forms in the pharmaceutical world and are still relevant, especially for herbal preparations due to their ease of manufacture and stability. This study aims to formulate pill preparations by combining turmeric and lime juice. The method used is wet granulation to make pills with varying turmeric concentrations, namely F1 0.26% and F2 0.52% using polyvinyl alcohol as a binder. Physical evaluations include water content, weight uniformity, pH, and disintegration time tests. The pills were then tested for antioxidant activity against DPPH. The results showed that the water content of F1 pills was 4.06% and F2 pills 3.75%, pill weight uniformity with RSD value criteria of F1 was 0.21% and F2 pills 3.40%, the average pH of F1 was 6.32 and F2 pills 6.22, and the disintegration time of F1 was 30 minutes and F2 pills 8.26 minutes. The results of the antioxidant activity of the pill preparations showed that the F1 IC50 was 6.36 ppm and the F2 IC50 was 5.53 ppm. From the results obtained, it can be concluded that F2 pill preparations have good physical properties and potential antioxidant activity.
Formulation and Evaluation of Physical Properties of Antioxidant Effervescent Granules and Extract of Karamunting Flower (Melastoma malabathricum L.) Shesanthi Citrariana; Yahya Febrianto; Thathit Suprayogi; Emma Ayudia Noriadita
INOVASIA Vol 2 No 1 (2024): April
Publisher : LPPM Institut Studi Islam Sunan Doe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58330/inovasia.v2i2.359

Abstract

Karamunting (Melastoma malabathricum L.) contains several compounds with pharmacological activities including antioxidant, analgesic, anti-inflammatory, antipyretic and diuretic. Karamunting flowers contain flavonoid compounds, saponins and tannins. Tannin compounds can stabilize free radicals by complementing the electron deficiency of free radicals. To increase the utilization of karamunting flowers, it is formulated in the form of effervescent granules. This study aims to determine the ethanol extract of karamunting flower (Melastoma malabathricum L.) with concentrations of 1%, 2%, and 3% can be formulated in the form of effervescent granules. The physical properties of the granules were tested which included organoleptic test, flow rate test, granule compressibility test, dissolving time test and pH of effervescent granules. The results showed that formula 3 with a concentration ratio of 3% ethanol extract was a formula that met the requirements for the physical properties of the granules, namely with a sweet and sour taste, a characteristic odor of karamunting, and a dark purple-brown color. With an average flow rate of 2.853 g/sec, average compressibility of 21.12%, an average dissolving time of 7.52 seconds and a pH measurement of 5.
Improving Drug Literacy Among Students Through the DAGUSIBU Educational Program Riani, Defilia Anogra; Irawan, Ahmad; Citrariana, Shesanthi; Hakim, Shavira Alpasa; Pritaningtyas, Nazifa Wulan; Desindria, Galang Rizdho; Kaharati, Jonathan
Bubungan Tinggi: Jurnal Pengabdian Masyarakat Vol 8, No 1 (2026): FEBRUARY 2026
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/btjpm.v8i1.17047

Abstract

Low public literacy regarding the correct application of the DAGUSIBU (Obtain, Use, Store, and Dispose) principles of drugs contributes to the persistently high prevalence of irrational drug use in Indonesia. This situation has the potential to lead to drug abuse, antibiotic resistance, and negative impacts on public health. This community service activity aims to improve the knowledge and rational drug use behavior of 10th-grade students at SMA Negeri 2 Palangka Raya regarding safe and responsible drug management. The methods used include interactive outreach through educational media, practical simulations, and evaluation using pre- and post-tests. The target group was 35 10th-grade students at SMA Negeri 2 Palangka Raya. The results showed an increase in student understanding with an average pre-test score of 6.9 to 7.6 on the post-test (maximum score of 8) regarding the DAGUSIBU principles, which were delivered directly through practice and active discussion. The conclusion of this activity is that the interactive DAGUSIBU outreach is effective in improving understanding of drug literacy and fostering more responsible drug management behaviors in students, which have a positive impact on reducing the risk of drug abuse and supporting individual and environmental health.
Co-Authors Adi, Mika Adistia P, Allaya Ahmad Irawan, Ahmad Akhmad Kharis Nugroho Alfanaar, Rokiy Anograh R, Defilia Ardi Akbar Tanjung Ari Wibowo Arsana, Mu afa Arsana, Mu’afa Purwa Arsana, Mu’afa Purwa Awalul Fatiqin Awumistiko Awumistiko Ayu, Regina Wahyudyah Sonata Ayuchecaria, Noverda Baiq Maylinda Gemantari Bambang Hernawan Nugroho Chuchita Dea Betriksia Decenly Decenly Decenly, Decenly Defilia Anogra Riani Defilia Anograh Riani Desindria, Galang Rizdho Efriyana Oksal Efriyana Oksal Elphasa H, Shavira Emma Ayudia Noriadita Endang Lukitaningsih Erni Dwi Puji Setyowati, Erni Dwi Puji Fatiqin, Awalul Fauziah, Anisa Rahma Gerung, Jenny Blessia Gintoro, Atilla Dian Dewanti Gunawan, Yohanes E Gunawan, Yohanes Edy Guntur Satrio Pratomo Hakim, Shavira Alpasa Halida Suryadini Haq, Muhammad Hasanul Ita Nurma Sari Ita Nurma Sari Jipasca, Elon June N, Franz Kaharati, Jonathan Kalalinggi, Septaria Yolan Krissilvio, Eka Jonathan Kurniawan, Yehezkiel Steven M Munawwarah Ma'rifah, Siti Mariasa, Joice Cleriska Melliani Melliani Muhammad Dawam Muhammad Priyadi Mu’afa Purwa Arsana Mu’afa Purwa Arsana Ngazizah, Febri Nur Nur Hidayat Oktavia Indrati, Oktavia Parametta, Vidya Pritaningtyas, Nazifa Wulan Puspa Dwi Pratiwi Puspa Dwi Pratiwi Rahman, Ansori Rahman, Sudarman Rahmman, Sudarman Reny Nadya Oktari Riani, Defilia Risqika Yulia Tantri Paramawidhita Rizki Rachmad Saputra Rokiy Alfanaar Shodri, Muhammad Rifqi Simajuntak, Ruth Riama Siti Sunariyati Sulistia, Tiya Thathit Suprayogi Thathit Suprayogi Tri Megawati Wahyu Nugroho Wilda, Robiatul Witari Yahya Febrianto Yahya Febrianto Yohanes Edy Gunawan Yosaeunike, Vitatani Yulita, Elia Zimon Pereiz