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All Journal Biota Jurnal SOLMA JMM (Jurnal Masyarakat Mandiri) Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Farmasi Indonesia Jurnal Riset Kefarmasian Indonesia Journal SAGO Gizi dan Kesehatan Jurnal Farmasi dan Sains Indonesia (JFSI) Sasambo Journal of Pharmacy Bulletin of Community Engagement Journal of Science and Technology Research for Pharmacy Al-Khidmah Jurnal Pengabdian Masyarakat JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) DEVOTE: Jurnal Pengabdian Masyarakat Global Experimental Student Experiences PCJN Pharmaceutical and Clinical Journal of Nusantara INOVASIA Sinteza Jurnal Ilmiah Kesehatan Jurnal Ilmiah Farmasi Simplisia Journal of Biotropical Research and Nature Technology NAWASENA: Journal of Community Service Nusantara Innovation Journal Jurnal Info Kesehatan Jurnal Biosilampari: Jurnal Biologi
Yahya Febrianto
Department Of Biology, Faculty Of Mathematic And Natural Sciences, Universitas Palangka Raya, Central Kalimantan, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Aktivitas Psikostimulan Tanaman Bajakah (Spatholobus suberectus) : Studi In Silico Terhadap Protein 4M48-Dopamine Transporter Priyadi, Muhammad; Saputra, Rizki Rachmad; Gunawan, Yohanes Edy; Citrariana, Shesanthi; Decenly, Decenly; Febrianto, Yahya
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p149-154

Abstract

Bajakah plants (Spatholobus suberectus) have been widely used by Dayak tribes in Kalimantan with various properties that are believed and have also been studied for various tests of phytochemical compound content and pharmacological tests. Secondary metabolite compounds from bajakah (Spatholobus suberectus) have potential as psychostimulant compounds. The purpose of this study was to investigate the psychostimulant activity of bajakah plants (Spatholobus suberectus) through analysis of the interaction between bajakah secondary metabolite compounds and the 4M48-Dopamine Transporter receptor (PDB: 4M48), which is one of the dopamine transporter proteins. Ligand and receptor interactions were analyzed using molecular docking method with Autodock Vina 4 application with nortriptyline compound as native ligand and 15 secondary metabolite compounds for testing. The results of docking analysis showed that the standard ligand nortriptyline compound has an affinity value of -10.2 kcal/mol. There are 3 compounds from bajakah that have affinity values close to the standard compounds plathymenin, butein and eriodictyol with affinity values of -9.7 kcal/mol, -9.4 kcal/mol and -9.2 kcal/mol respectively. Based on the analysis conducted, it can be concluded that bajakah plants (Spatholobus suberectus) have the potential to be developed as psychostimulant therapy.
Optimasi Ekstraksi Sisik Naga (Drymoglossum Piloselloides) Tumbuhan Epifit Gambut Kalimantan Menggunakan Central Composite Design untuk Aktivitas Antioksidan. Arsana, Muafa Purwa; Monita, Dita; Rahman, Sudarman; Riana, Shesanti Citra; Febrianto, Yahya; Suprayogi, Thatit; Alfanaar, Rokiy; Fatiqin, Awalul
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p112-117

Abstract

Dragon scale (Drymoglossum piloselloides) leaf is a plant that contains secondary metabolites with antioxidant potential. This plant is known for its easy to grow nature and has a wide habitat distribution. The extraction method using acetone solvent has been proven effective in extracting secondary metabolites from this plant. To improve the extraction efficiency, this study used an optimization approach using the Central Composite Design (CCD) method. CCD involves three main factors in extraction experiments, namely solvent concentration, extraction time, and extraction temperature. Experiments were conducted with variations of these factors to find the optimal extraction conditions. The results of CCD method showed that the solvent concentration of 70%, extraction temperature at 52°C, and extraction time of 60 minutes. Statistical analysis showed that the model used was significant, with an F-value of 9.20 and a P-value less than 0.01159, indicating that the factors tested had a significant effect on the extraction results. The results of this study have great potential in maximizing the use of dragon scale leaves as a source of antioxidant secondary metabolites.
Pengaruh Pertumbuhan Pakcoy (Brassica rapa l.) dengan Sistem Tanam Hidroponik Tipe Nutrient Film Technique (NFT) dan Media Kotoran Hewan (KOHE) Elon Jipasca; Muhammad Rifqi Shodri; Ansori Rahman; Putri Wineni; Awalul Fatiqin; Thathit Suprayogi; Yahya Febrianto; Sudarman Rahman; Muafa Purwa Arsana; Rokiy Alfanaar
Jurnal Biosilampari : Jurnal Biologi Vol 7 No 1 (2024): Biosilampari: Jurnal Biologi
Publisher : Universitas PGRI Silampari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62112/biosilampari.v7i1.150

Abstract

This study aims to assess the effect of planting media on pakchoi (Brassica rapa L.) growth. The research was conducted at Pak Slamet's Cipta Rasa Fruit Farm in October 2024. Each treatment used different planting media, with hydroponics supplemented with AB mix nutrients and KOHE without additional nutrients. The results showed that variations in growing media and nutrient supplementation had a significant impact on plant growth. The NFT hydroponic system gave the best results, with pakcoy reaching an average plant height (6.5 cm), number of leaves (8 leaves), and leaf width (5.8 cm) at 3-4 weeks after transplanting (HST) The results of plant height, number, and width of leaves from KOHE are listed. The provision of nutrients shows that the right amount and concentration can increase the overall growth of pakcoy.
Formulation and Evaluation of Physical Properties of Antioxidant Effervescent Granules and Extract of Karamunting Flower (Melastoma malabathricum L.) Shesanthi Citrariana; Yahya Febrianto; Thathit Suprayogi; Emma Ayudia Noriadita
INOVASIA Vol 2 No 2 (2024): April
Publisher : LPPM Institut Studi Islam Sunan Doe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58330/inovasia.v2i2.359

Abstract

Karamunting (Melastoma malabathricum L.) contains several compounds with pharmacological activities including antioxidant, analgesic, anti-inflammatory, antipyretic and diuretic. Karamunting flowers contain flavonoid compounds, saponins and tannins. Tannin compounds can stabilize free radicals by complementing the electron deficiency of free radicals. To increase the utilization of karamunting flowers, it is formulated in the form of effervescent granules. This study aims to determine the ethanol extract of karamunting flower (Melastoma malabathricum L.) with concentrations of 1%, 2%, and 3% can be formulated in the form of effervescent granules. The physical properties of the granules were tested which included organoleptic test, flow rate test, granule compressibility test, dissolving time test and pH of effervescent granules. The results showed that formula 3 with a concentration ratio of 3% ethanol extract was a formula that met the requirements for the physical properties of the granules, namely with a sweet and sour taste, a characteristic odor of karamunting, and a dark purple-brown color. With an average flow rate of 2.853 g/sec, average compressibility of 21.12%, an average dissolving time of 7.52 seconds and a pH measurement of 5.
Improving the Quality of Students of SD Negeri 2 Rantau Pulut Lifestyle Characterized by Clean Water and Renewable Energy: Peningkatan Kualitas Gaya Hidup Siswa SD Negeri 2 Rantau Pulut Bercirikan Air Bersih dan Energi Terbarukan Fatiqin, Awalul; Alfanaar, Rokiy; Rahman, Sudarman; Febrianto, Yahya; Riana, Shesanti Citra; Karyadi, Karyadi; Sahari, Yudhi Ekakristian; Gunawan, Yohanes Edy; Arsana, Mu'afa Purwa; Suprayogi, Thathit
NAWASENA : JOURNAL OF COMMUNITY SERVICE Vol. 1 No. 02 (2023): Vol. 01 No.02 2023
Publisher : NAWASENA : JOURNAL OF COMMUNITY SERVICE

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Clean water is a vital requirement for children at the primary school level as it supports their learning process. The availability of clean water not only facilitates learning activities but is also an important aspect in supporting a lifestyle that is responsible for natural resources, especially in the context of using renewable energy. The emphasis on an appropriate lifestyle in the utilisation of clean water became the focus of the community service conducted at SD Negeri 2 Rantau Pulut. Through this socialisation activity, students were given an understanding of the importance of a clean lifestyle that utilises clean water sources wisely, while integrating the use of renewable energy. The results of this service showed positive progress. Students' understanding of the importance of a clean lifestyle and the utilisation of clean water with renewable energy has increased significantly, reaching an understanding level of 91.67%. From this, it can be concluded that this socialisation successfully achieved its goal of raising students' awareness of the importance of clean water and a sustainable lifestyle.
Profil fitokimia dan aktivitas antibakteri fraksi etil asetat daun jarak pagar (Jatropha curcas) Sudarman Rahman; Alfanaar, Rockiy; Fatiqin, Awalul; Febrianto, Yahya; Suprayogi, Thathit; Arsana, Mu’afa Purwa
Journal of Biotropical Research and Nature Technology Vol. 1 No. 1 (2022): Borneo
Publisher : Prodi Biologi FMIPA Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52850/borneo.v1i1.8332

Abstract

Bacterial infection is a major cause of chronic infection and death that continues to threath public health worldwide. Improper use of antibiotics can cause pathogenic bacteria to become resistant to antibiotics and have side effects, so alternative sources of antibiotics from natural ingredients are needed. One type of plant that is efficacious as an antibacterial is jarak pagar leaves (Jatropha curcas). This study aims to examine the phytochemical content qualitatively using the tube method and the antibacterial activity of the ethyl acetate fraction of jarak pagar leaves using the disc diffusion method. Extraction of jarak pagar leaves by maceration method with 96% ethanol then fractionated with ethyl acetate. Data on the diameter of the inhibition zone in the antibacterial test were analyzed using the non-parametric test, namely the Kruskal Wallis test. The analysis was continued with Mann Whitney's post hoc with a confidence level (pvalue<0.05). Based on the results of the phytochemical test obtained alkaloids, saponins, flavonoids, polyphenols and tannins. The antibacterial activity of the ethyl acetate fraction of jarak pagar leaves at a concentration of 8 mg/mL showed an inhibition zone of 19.73±0.25 mm which was included in the very moderate category and weakly inhibited at a concentration of 0.5 mg/mL which was 4.87±0.31 mm and the results of statistical tests showed that the ethyl acetate fraction of jarak pagar leaves had antibacterial activity and each concentration had a significant effect on inhibiting the growth of S. aureus.
Kajian aktivitas antioksidan dan sitotoksik ekstrak etil asetat daun jarak pagar (Jatropha curcas) Rahman, Sudarman; Febrianto, Yahya; Citrariana, Shesanthi; Sulistia, Tiya; Alfanaar, Rokiy; Suprayogi, Thathit; Arsana, Mu’afa Purwa; Fatiqin, Awalul
Sasambo Journal of Pharmacy Vol. 6 No. 1 (2025): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i1.409

Abstract

Antioxidants are chemical substances that have the ability to protect body cells from damage caused by excessive oxidation reactions. One of the uses of antioxidants from natural materials is jarak pagar leaves (J. curcas). This study aims to determine the antioxidant and cytotoxic activity against shrimp larvae from ethyl acetate extract of J. curcas leaves. Ethyl acetate extract from J. curcas leaves was extracted using the soxhletation method. Phytochemical testing was carried out using the tube method, antioxidant testing using the DPPH method and cytotoxic using the BSLT method. The results of the research showed that J. curcas contained secondary metabolite compounds in the form of flavonoids and polyphenols, the antioxidant activity test of Ethyl acetate extract from J. curcas leaves and the comparison control (vitamin C) produced an IC50 of 71,79±0.35 ppm and 8.78±0.21 ppm, respectively. The cytotoxic test of the ethyl acetate extract of J. curcas leaves contains active compounds that are toxic to the shrimp larvae with an LC50 of 72.13 ppm (LC50≤1000 ppm). The most effective concentration in free radicals scavenging is 160 ppm. Based on the results obtained, the ethyl acetate extract of J. curcas showed strong antioxidant activity and potential as an anticancer agent.
Evaluation of Antioxidant Activity in Solanum Ferox (Through DPPH and FRAP Assays) Leki, Karol Giovani Battista; Febrianto, Yahya; Serang, Yithro
JURNAL INFO KESEHATAN Vol 23 No 2 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss2.1743

Abstract

The antioxidant properties of natural compounds have garnered significant attention for their potential therapeutic applications. Solanum ferox, a plant traditionally used in several countries for medicinal purposes, has been identified as possessing potential antioxidant properties. However, the extent and efficacy of its antioxidant capacity have not been thoroughly examined, creating a gap in understanding its effectiveness compared to established antioxidants like ascorbic acid. This study aims to evaluate the antioxidant capacity of Solanum ferox using DPPH and FRAP assays across concentrations ranging from 20 to 100 µg/µl, with ascorbic acid serving as a standard reference. The DPPH assay measured the scavenging activity of both samples to assess their radical-quenching properties, while the FRAP assay evaluated their reducing power. Findings indicate that ascorbic acid exhibits significantly higher scavenging activity than Solanum ferox across all concentrations, with consistent activity ranging between 88.4% and 90.88% in the DPPH assay and from 45.16% to 83.89% in the FRAP assay. In contrast, Solanum ferox shows a gradual but much lower increase in activity, from 6.8% to 35.5% in the DPPH assay and from 10.59% to 33.82% in the FRAP assay, suggesting limited antioxidant potential. The study contributes to the understanding of the antioxidant properties of Solanum ferox, highlighting its limited efficacy compared to ascorbic acid and suggesting that further research is needed to explore its potential at higher concentrations or through alternative methods. These insights provide a foundational basis for future studies investigating Solanum ferox as a potential natural antioxidant source.   
INITIATING NANOBUBBLE TECHNOLOGY FOR IMPROVING FRESHWATER FISH FARMING QUALITY Rahman, Sudarman; Suprayogi, Thathit; Ngazizah, Febri Nur; Citrariana, Shesanthi; Haq, Muhammad Hasanul; Gerung, Jenny Blessia; Rahman, Ansori; Fatiqin, Awalul; Alfanaar, Rokiy; Febrianto, Yahya; Arsana, Mu'afa Purwa
JMM (Jurnal Masyarakat Mandiri) Vol 8, No 5 (2024): Oktober
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v8i5.25685

Abstract

Abstrak: Komunitas KKSS Palangka Raya menghadapi tantangan dalam budidaya ikan air tawar, termasuk kualitas air yang buruk dan pertumbuhan ikan yang tidak optimal, yang menghambat produktivitas perikanan. Program pengabdian ini bertujuan untuk meningkatkan keterampilan 18 anggota komunitas dalam menerapkan teknologi nano bubble sebagai solusi inovatif. Metode yang digunakan meliputi sosialisasi, penyuluhan, diskusi kelompok terarah (FGD), dan praktik langsung penerapan teknologi di kolam ikan mitra. Evaluasi dilakukan dengan wawancara dan observasi untuk mengukur perubahan keterampilan dan hasil budidaya pasca penerapan teknologi. Hasilnya menunjukkan bahwa teknologi nano bubble secara signifikan meningkatkan kualitas air dan mempercepat pertumbuhan ikan, serta meningkatkan keterampilan peserta dalam pengoperasian dan pemeliharaan sistem sebesar 80%. Peningkatan keterampilan ini berkontribusi pada peningkatan produktivitas perikanan di kawasan tersebut, sekaligus menjadi model untuk pengelolaan perikanan air tawar di wilayah Palangka Raya.Abstract: The KKSS Palangka Raya Community faces challenges in freshwater fish farming, including poor water quality and suboptimal fish growth, which hinder aquaculture productivity. This community service program aimed to enhance the skills of 18 community members in applying nanobubble technology as an innovative solution. The methods employed included socialization, counseling, focus group discussions (FGD), and hands-on practice in applying the technology in the community's fishponds. Evaluation was conducted through interviews and observations to measure changes in skills and farming outcomes after the technology's implementation. The results indicated that nanobubble technology significantly improved water quality and accelerated fish growth, while also enhancing participants' skills in operating and maintaining the system by 80%. This skill enhancement contributed to increased aquaculture productivity in the area and serves as a model for freshwater fishery management in the Palangka Raya region.
Optimasi Tablet Levofloksasin Immediate Release Menggunakan Disintegran Sodium Starch Glycolate (SSG) dan Pengisi Laktosa dengan Metode Simplex Lattice Design (SLD) Shesanthi Citrariana; Akhmad Kharis Nugroho; Yahya Febrianto; Defilia Anograh Riani
JURNAL ILMIAH FARMASI SIMPLISIA Vol. 3 No. 2 (2023): Desember 2023
Publisher : Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/jifs.v3i2.459

Abstract

Levofloksasin adalah antibiotik yang digunakan dalam terapi utama infeksi paru, juga merupakan sediaan farmasi yang memiliki penerimaan yang baik oleh pasien. Tablet immediate release memerlukan super disintegran yang merupakan eksipien dalam formulasi, perbedaan eksipien yang digunakan dapat memengaruhi bioperformance dari tablet. Optimasi formula digunakan sebagai metode untuk menentukan komposisi eksipien dalam formula. Penelitian ini bertujuan untuk melakukan optimasi formula tablet levofloksasin dengan metode simplex lattice design menggunakan sodium starch glycolate sebagai superdisintegran. Pembuatan tablet dilakukan dengan proses granulasi basah dan dikempa kemudian dilakukan pengujian sifat fisik berupa kekerasan, kerapuhan, waktu hancur dan disolusi efisiensi pada waktu ke 60 menit. Optimasi nilai prediksi dilakukan dengan cara observasi dan dibandingkan nilai responnya menggunakan one sample t-test. Hasil penelitian menunjukan bahwa perbedaan nilai SSG terlihat signifikan pada waktu hancur dengan nilai p<0,05 (0,0056). Hasil formula optimal dengan nilai desirability 0,811 berada pada komposisi SSG sebanyak 8mg/tablet. Pengujian konfirmasi memberikan hasil bahwa antara nilai prediksi vs observasi memberikan nilai yang tidak berbeda p>0,05. Dapat disimpulkan bahwa tablet levofloksasin yang diformulasikan memberikan nilai yang memnuhi kriteria baik sifat fisik dan efisiensi disolusi.
Co-Authors Abdul Chakim Adi, Mika Adistia P, Allaya Adventus Panda Agung Samudra Agustina Putri Pitarisa Agustina Putri Pitarisa Sudarsono Ahmad Irawan, Ahmad Ahmad Muammar Kadafi Akhmad Kharis Nugroho Al-Hadi, Risfa Aliya Alfanaar, Rockiy Alfanaar, Rokiy Ana Indrayati Anna Dwiningsih Anograh R, Defilia Ansori Rahman Arsana, Mu afa Ayu, Regina Wahyudyah Sonata Ayuningtyas, Nurista Dida Buanasari Buanasari, Buanasari Cholifah Citrariana, Shesanthi Citrariana, Shesanti Decenly Decenly Decenly, Decenly Defilia Anogra Riani Defilia Anograh Riani Desindria, Galang Rizdho Desy Suweni Nugrahaningtyas Dewi, Apriana Dida, Nurista Dita Monita Elfahmi . Elon Jipasca Elphasa H, Shavira Elsandi, Elsa Emma Ayudia Noriadita Fatiqin, Awalul Fauzan Fikri Fauziah, Anisa Rahma Febri Nur Ngazizah Febri Nur Ngazizah Fifi Nur Apriliani Gerung, Jenny Blessia Gintoro, Atilla Dian Dewanti Gunawan, Yohanes E Gunawan, Yohanes Edy Haq, Muhammad Hasanul I Nyoman, Sudyana, Ike Apriani, Ike Jipasca, Elon June N, Franz Kamison Karyadi Karyadi Karyadi Karyadi Kiki Septiyani Leki, Karol Giovani Battista Manik, Adelia Margareta Mariasa, Joice Cleriska Masithoh Nur Mega Eka Yuniyasanti Monita, Dita Muhamad Taufik Hidayat Muhammad Priyadi Muhammad Rifqi Shodri Muhammad Sadam Rahmansyah Mu’afa Purwa Arsana Ngazizah, Febri Nur Norhusna, Norhusna Novia Putri Santari Nur Hidayat Nurista Dida Parametta, Vidya Pitarisa, Agustina Putri Prasetyo, Alno Pritaningtyas, Nazifa Wulan Puspa Dwi Pratiwi Putri Wineni Putri, Alayya Adistia Putri, Luluk Aniqoh Meliana Ra Hoetari Tirta Amelia Rahman, Ansori Rahman, Sudarman Rahmman, Sudarman Riana, Shesanti Citra Riani, Defilia Riri Novita Sunarti Rizki Rachmad Saputra Sahari, Yudhi Ekakristian Sandi Mahesa Yudhantara Saputra, Mika Adi Sawal, Rizky Ardian Hartanto Serang, Yithro Setiyaningsih, Wahyu Shesanti Citra Riana Shesanti Citra Riana Shodri, Muhammad Rifqi Simajuntak, Ruth Riama Siti Sunariyati Sulistia, Tiya Syarifah Syarifah Thathit Suprayogi Wahyu Setiyaningsih Wahyu Setiyaningsih Wilda, Robiatul Witari Yithro Serang Yithro Serang Yithro Serang Yohanes Edi Gunawan Yosaeunike, Vitatani Yudhi Ekakristian Sahari Yulita, Elia