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All Journal Biota Jurnal Florea JPSE (Journal of Physical Science and Engineering) Jurnal SOLMA JMM (Jurnal Masyarakat Mandiri) Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Farmasi Indonesia Jurnal Riset Kefarmasian Indonesia Journal SAGO Gizi dan Kesehatan Jurnal Farmasi dan Sains Indonesia (JFSI) Sasambo Journal of Pharmacy Bulletin of Community Engagement Journal of Science and Technology Research for Pharmacy Al-Khidmah Jurnal Pengabdian Masyarakat JUMANTIK (Scientific Journal of Health research) DEVOTE: Jurnal Pengabdian Masyarakat Global Experimental Student Experiences PCJN Pharmaceutical and Clinical Journal of Nusantara INOVASIA Sinteza Jurnal Ilmiah Kesehatan Jurnal Ilmiah Farmasi Simplisia NAWASENA: Journal of Community Service Jurnal Biosilampari: Jurnal Biologi
Yahya Febrianto
Department Of Biology, Faculty Of Mathematic And Natural Sciences, Universitas Palangka Raya, Central Kalimantan, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Peningkatan fungsional bedak dayak dengan ekstrak daun sirih hutan gambut Kalimantan Tengah (Piper aduncum) sebagai anti dengue Rahman, Sudarman; Febrianto, Yahya; Fatiqin, Awalul; Sulistia, Tiya; Alfanaar, Rokiy; Arsana, Mu'afa Purwa; Suprayogi, Thathit; Desindria, Galang Rizdho; Citrariana, Shesanthi
Jurnal SAGO Gizi dan Kesehatan Vol 6, No 3 (2025): Nopember
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v6i3.2467

Abstract

Background: Dengue Hemorrhagic Fever (DHF) was  disease caused by a virustransmitted the Aedes aegypti. One of the products with local wisdom that prevented DHF was the formulation of dayak powder from sirih hutan leaves. Based on phytochemical, contained terpenoids and flavonoids.Objectives: This study aims to identifythe group of antidengue compounds, determine the formula and evaluate the preparation of topical formulation.Methods: The research design used a pre experimentaldesign with variations and formula development, was conducted at the Biomedical Laboratory FK and PPIIG UPR in August-November 2024. Ethanol extract was obtained using the maceration for 3x24 hours, evaporated using a rotary evaporator and contained 132,5059 g. The extract was analyzed using GC-MS, then formulated with dayak powder and a physical test. Data were analyzed using the One Way Anova statistical test and continued Tukey's post hoc at 95% CI.Results: Sample showed 52 peak areas representing 7 possible identified compounds with a percentage of similarity> 70% (GC-MS). Then the five formulas were physically tested. The results of organoleptic and pH all formulas produced powder aromatic, green, and the criteria of skin pH range (4,5-6,5). The 5th formula showed better results based on the flow time test (5,46 seconds), the settling test produced 3,5-6% (<10%), adhesion test, smoothness, and hedonic. Based on data analysis with One Way Anova, a significant difference was produced in each dayak powder formula (pvalue=0,05).Conclusion: Ethanol extract of sirih hutan leaves has 7 possible compounds with antidengue activity and the 5th formula has better physical test results.
Formulation and Evaluation of Physical Properties of Antioxidant Effervescent Granules and Extract of Karamunting Flower (Melastoma malabathricum L.) Shesanthi Citrariana; Yahya Febrianto; Thathit Suprayogi; Emma Ayudia Noriadita
INOVASIA Vol 2 No 1 (2024): April
Publisher : LPPM Institut Studi Islam Sunan Doe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58330/inovasia.v2i2.359

Abstract

Karamunting (Melastoma malabathricum L.) contains several compounds with pharmacological activities including antioxidant, analgesic, anti-inflammatory, antipyretic and diuretic. Karamunting flowers contain flavonoid compounds, saponins and tannins. Tannin compounds can stabilize free radicals by complementing the electron deficiency of free radicals. To increase the utilization of karamunting flowers, it is formulated in the form of effervescent granules. This study aims to determine the ethanol extract of karamunting flower (Melastoma malabathricum L.) with concentrations of 1%, 2%, and 3% can be formulated in the form of effervescent granules. The physical properties of the granules were tested which included organoleptic test, flow rate test, granule compressibility test, dissolving time test and pH of effervescent granules. The results showed that formula 3 with a concentration ratio of 3% ethanol extract was a formula that met the requirements for the physical properties of the granules, namely with a sweet and sour taste, a characteristic odor of karamunting, and a dark purple-brown color. With an average flow rate of 2.853 g/sec, average compressibility of 21.12%, an average dissolving time of 7.52 seconds and a pH measurement of 5.
Physicochemical Characterization and Phytochemical Screening of Citrus aurantifolia Lime Peel Ethanolic Extract from Kediri as Antibacterial Agent Putri, Luluk Aniqoh Meliana; Febrianto, Yahya
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 03 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v2i02.13

Abstract

Citrus aurantifolia (Christm.) Swingle lime peel, widely discarded as agricultural waste in Kediri, East Java, Indonesia, is a promising source of bioactive compounds for antibacterial applications. Quality standardization of herbal materials is prerequisite for reproducible pharmacological activity, yet comprehensive physicochemical and microbiological characterization of lime peel simplicia from this region has not been reported. This study aimed to characterize the dried powder of C. aurantifolia lime peel collected from Kediri according to Indonesian Herbal Pharmacopoeia (IHP) standards, including microbial quality parameters (Total Aerobic Plate Count/ALT and Mold-Yeast Count/AKK), and to conduct phytochemical profiling of both simplicia and the ethanolic extract. Lime peels were cleaned, dried at 40–50°C, powdered, and characterized for water content (8.64%), water-soluble extract (26.67%), ethanol-soluble extract (18.14%), total ash (5.62%), acid-insoluble ash (0.35%), ALT (3.5 × 10³ CFU/g), and AKK (1.2 × 10² CFU/g)—all within IHP requirements. Phytochemical screening detected alkaloids, flavonoids, glycosides, saponins, tannins, and steroids/triterpenoids in both simplicia and extract. These findings establish a standardized pharmacognostic profile supporting the use of Kediri-sourced lime peel extract in evidence-based antibacterial research.
FORMULASI DAN EVALUASI KRIM VITAMIN E DENGAN VARIASI EMOLIEN Pritaningtyas, Nazifa Wulan; Putri, Alayya Adistia; Manik, Adelia Margareta; Gintoro, Atilla Dian Dewanti; Elsandi, Elsa; Febrianto, Yahya
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i2.702

Abstract

Skin health and aesthetics are becoming a major focus in modern society’s lifestyle, with issues such as dehydration, premature aging, and hyperpigmentation due to UV exposure and pollution. The skin, as the largest organ, requires protection from the harmful effects of sunlight, and the use of sunscreen and skincare products containing vitamin E is becoming increasingly important. This study aims to explore the formulation of vitamin E cream with various emollients to improve product quality and effectiveness. The methodology used includes the creation of cream formulas and evaluation through organoleptic, homogeneity, pH, spreadability, viscosity, and preference tests. The results showed that all three cream formulas met the established standards, with appropriate pH and good homogeneity. The preference test showed varying preferences, providing insight into the development of innovative skincare products. This study is expected to provide solutions for consumers who want effective and environmentally friendly skincare products
Dillapiole-Rich Piper aduncum L.: Phytochemistry, Bioactivity, and Pharmaceutical Applications – A Systematic Review Yahya Febrianto; Erindyah Retno Wikantyasning; Ratna Yuliana
Florea : Jurnal Biologi dan Pembelajarannya Vol. 13 No. 2 (2026)
Publisher : UNIVERSITAS PGRI MADIUN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/florea.v13i2.24389

Abstract

The growing interest in the development of phytopharmaceuticals derived from traditional medicinal plants has driven in-depth exploration of Piper aduncum L., a species with diverse therapeutic potential that has not yet been systematically consolidated. This systematic review aims to identify, analyze, and synthesize recent scientific evidence regarding the phytochemical constituents, pharmacological activities, and pharmaceutical development prospects of P. aduncum based on publications from 2021 to 2025. The study adopted the PRISMA 2020 framework, conducting a comprehensive search across five electronic databases using a combination of keywords related to the phytochemistry and pharmacology of P. aduncum. Literature selection was performed through three stages, resulting in six articles that met the inclusion criteria, consisting of two in vivo studies, three laboratory experimental studies, and one systematic review. Methodological quality assessment was conducted using the Modified Downs and Black Checklist and the SYRCLE’s Risk of Bias Tool, followed by systematic data extraction and qualitative narrative synthesis. The findings indicate that dillapiole is the predominant component of the essential oil, with concentrations ranging from 77.6–85.5%, exhibiting antiparasitic, acaricidal, antimycobacterial, immunomodulatory, and anti-inflammatory activities through mechanisms involving modulation of detoxification enzymes and intestinal microbiota. The development of nanocarrier systems has produced stable nanometric formulations with an excellent safety profile for topical applications. This review confirms the significant potential of P. aduncum as a candidate for the development of biopesticides, alternative antimicrobial agents, and phytogenic feed additives. However, further translational research is required, including extraction standardization, investigation of molecular mechanisms, pharmacokinetic–pharmacodynamic studies, long-term toxicological evaluation, and clinical trials to validate efficacy and safety prior to therapeutic application in humans.
Formulasi Pil Kunyit (Curcuma Longa L.) Kombinasi Sari Jeruk Limau Kuit (Citrus Hystrix Dc.) Sebagai Antioksidan Shesanthi Citrariana; Muhammad Priyadi; Defilia Anograh R; Sudarman Rahmman; Yahya Febrianto; Ahmad Irawan; Franz June N; Shavira Elphasa H; Allaya Adistia P
Sinteza Vol. 6 No. 1 (2026): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v6i1.32965

Abstract

Turmeric contains the active compound curcumin, which has been studied for its various biological activities, including antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory properties. Kaffir lime is a plant commonly found on the island of Borneo and is used in traditional medicine and culinary flavors. Kaffir lime fruit and leaves contain various bioactive compounds, such as flavonoids (hesperidin, naringenin), essential oils (citronellal, limonene), and vitamin C. Flavonoids are known to have antioxidant and anti-inflammatory effects that can boost the immune system. Pills are one of the oldest dosage forms in the pharmaceutical world and are still relevant, especially for herbal preparations due to their ease of manufacture and stability. This study aims to formulate pill preparations by combining turmeric and lime juice. The method used is wet granulation to make pills with varying turmeric concentrations, namely F1 0.26% and F2 0.52% using polyvinyl alcohol as a binder. Physical evaluations include water content, weight uniformity, pH, and disintegration time tests. The pills were then tested for antioxidant activity against DPPH. The results showed that the water content of F1 pills was 4.06% and F2 pills 3.75%, pill weight uniformity with RSD value criteria of F1 was 0.21% and F2 pills 3.40%, the average pH of F1 was 6.32 and F2 pills 6.22, and the disintegration time of F1 was 30 minutes and F2 pills 8.26 minutes. The results of the antioxidant activity of the pill preparations showed that the F1 IC50 was 6.36 ppm and the F2 IC50 was 5.53 ppm. From the results obtained, it can be concluded that F2 pill preparations have good physical properties and potential antioxidant activity.
Flow-Rate-Regulated Co-Precipitation via Peristaltic Pump for Controlled Nucleation and Morphology of ZnO Nanorods Thathit Suprayogi; Samsul Arifin; Sudarman Rahman; Mu&#039;afa Purwa Arsana; Rokiy Alfanaar; Awalul Fatiqin; Yahya Febrianto
JPSE (Journal of Physical Science and Engineering) Vol 9, No 2 (2024): JPSE (Journal of Physical Science and Engineering)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study presents a flow-rate-regulated co-precipitation method for synthesizing ZnO nanoparticles using a peristaltic pump to enhance control over nucleation and growth processes. The primary objective was to investigate the effect of controlled reactant delivery on the structural and morphological properties of ZnO nanoparticles. A peristaltic pump system was calibrated to provide a stable and continuous flow of the precipitating agent, achieving an average flow rate of 93.39 ± 1.39 µL/s with high linearity (R² = 0.99946). ZnO nanoparticles were synthesized under controlled conditions and characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The XRD results confirmed the formation of a single-phase hexagonal ZnO structure with high crystallinity and an average crystallite size of 55.98 ± 8.35 nm. SEM analysis revealed the formation of nanorod structures with relatively uniform morphology. The improved uniformity is attributed to stable supersaturation conditions enabled by precise flow-rate control. These findings demonstrate that flow-rate regulation is a critical parameter in co-precipitation synthesis and offers a simple, cost-effective strategy for improving reproducibility and structural control in nanoparticle fabrication.
ANALISIS KADAR ALKOHOL PADA OBAT BATUK SIRUP ANAK: VALIDASI METODE HALAL PRODUK Shesanthi Citrariana; Puspa Dwi Pratiwi; Yahya Febrianto
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 1 (2024): Volume 7, No 1, Tahun 2024
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i1.52860

Abstract

The global halal market, including halal food and beverage products, is expected to continue to grow widely. Halal food and drinks according to Islamic law have the criteria of being free from alcoholic, intoxicating and dangerous drinks as well as food additives containing derivatives of these drinks. There are many medicinal preparations circulating on the market that contain alcohol, one of which is cough medicine. This study aims to validate the method and measure alcohol levels in children's cough medicine taken randomly on the market. The method used is GC (Gas Chromatography) with validation determination in the form of linearity tests, system suitability tests, accuracy, LOD and LOQ calculations. The results of this study show that the linearity is R = 0.998. In the system suitability test, the chromatographic N value was >1000, HETP <0.3, and R >1.5. The accuracy obtained is in the range 81.13% - 123.57%. The LOD value is 0.1106% and LOQ is 0.3352%. As well as alcohol residue found in cough medicine samples of 0.075%. From these results it can be concluded that the GC (Gas Chromatography) method used has good validity and the residual alcohol content in children's cough medicine preparations meets the BPOM and MUI halal requirements. Keywords: Gas Cromatography, validation, halal, medicine
Co-Authors Abdul Chakim Adi, Mika Agustina Putri Pitarisa Agustina Putri Pitarisa Sudarsono Ahmad Irawan Ahmad Muammar Kadafi Akhmad Kharis Nugroho Alfanaar, Rockiy Alfanaar, Rokiy Allaya Adistia P Ana Indrayati Anna Dwiningsih Ansori Rahman Arsana, Mu afa Ayu, Regina Wahyudyah Sonata Ayuningtyas, Nurista Dida Buanasari Buanasari, Buanasari Cholifah Citrariana, Shesanthi Citrariana, Shesanti Decenly Decenly Decenly, Decenly Defilia Anogra Riani Defilia Anograh R Defilia Anograh Riani Desindria, Galang Rizdho Desy Suweni Nugrahaningtyas Dewi, Apriana Dida, Nurista Dita Monita Elfahmi . Elon Jipasca Elsandi, Elsa Emma Ayudia Noriadita Erindyah Retno Wikantyasning Fatiqin, Awalul Fauzan Fikri Fauziah, Anisa Rahma Febri Nur Ngazizah Febri Nur Ngazizah Fifi Nur Apriliani Franz June N Gintoro, Atilla Dian Dewanti Gunawan, Yohanes E Gunawan, Yohanes Edy I Nyoman, Sudyana, Jipasca, Elon Kamison Karyadi Karyadi Karyadi Karyadi Kiki Septiyani Manik, Adelia Margareta Mariasa, Joice Cleriska Masithoh Nur Mega Eka Yuniyasanti Monita, Dita Mu&#039;afa Purwa Arsana Muhamad Taufik Hidayat Muhammad Priyadi Muhammad Rifqi Shodri Muhammad Sadam Rahmansyah Mu’afa Purwa Arsana Ngazizah, Febri Nur Norhusna, Norhusna Novia Putri Santari Nur Hidayat Nurista Dida Parametta, Vidya Pitarisa, Agustina Putri Prasetyo, Alno Pritaningtyas, Nazifa Wulan Puspa Dwi Pratiwi Putri Wineni Putri, Alayya Adistia Putri, Luluk Aniqoh Meliana Ra Hoetari Tirta Amelia Rahman, Sudarman Ratna Yuliana Riana, Shesanti Citra Riani, Defilia Riri Novita Sunarti Rizki Rachmad Saputra Sahari, Yudhi Ekakristian Samsul Arifin Sandi Mahesa Yudhantara Sawal, Rizky Ardian Hartanto Setiyaningsih, Wahyu Shavira Elphasa H Shesanthi Citrariana Shesanti Citra Riana Shesanti Citra Riana Shodri, Muhammad Rifqi Simajuntak, Ruth Riama Siti Sunariyati Sudarman Rahmman Sulistia, Tiya Syarifah Syarifah Thathit Suprayogi Wahyu Setiyaningsih Wahyu Setiyaningsih Wilda, Robiatul Witari Yithro Serang Yithro Serang Yithro Serang Yohanes Edi Gunawan Yosaeunike, Vitatani Yudhi Ekakristian Sahari Yulita, Elia