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All Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jambura Journal of Chemistry Journal Syifa Sciences and Clinical Research (JSSCR) Kumawula: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmaceutical Education Indonesian Community Journal Jurnal Suara Pengabdian 45 Journal of Noncommunicable Diseases (JOND) Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Multidisipliner Kapalamada JIMR : Journal Of International Multidisciplinary Research Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products Jurnal Pengabdian Masyarakat Kesehatan Dan Sains Jurnal Riset dan Pengabdian Interdisipliner Qoumun: Journal of Social and Humanities
Wiwit Zuriati Uno
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Method Validation and Application of Curcumin UV–Vis Assay for Borax in Nuggets in Gorontalo, Indonesia Ishak Isa; Muhammad Taupik; Paramita Musa; Mahdalena Sy. Pakaya; Wiwit Zuriati Uno
Indonesian Journal of Pharmaceutical Education Vol 6, No 1 (2026): January–April 2026
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v6i1.11855

Abstract

Borax (sodium tetraborate decahydrate; Na₂B₄O₇·10H₂O) is prohibited for use in processed foods in Indonesia, necessitating analytically defensible surveillance methods for routine monitoring. This study aimed to validate a curcumin-based UV–Vis spectrophotometric assay and to apply rapid qualitative screening to nugget products marketed in Gorontalo, Indonesia. Qualitative screening was performed using the flame test and turmeric paper test on six samples (A1–C2) collected in October 2025. For the UV–Vis method, wavelength optimisation using a 500 µg/mL borax standard identified 427 nm as the operational measurement wavelength. Calibration standards (1–9 µg/mL) were analysed in triplicate, and validation was conducted for linearity, LOD, LOQ, repeatability precision, and spike-recovery accuracy (80%, 100%, and 120% levels). The method exhibited excellent linearity (y = 0.1082x + 0.0147; R² = 0.9995), with LOD and LOQ of 0.25849 µg/mL and 0.86165 µg/mL, respectively. Repeatability showed 1.40% RSD, while spike-recovery testing demonstrated high trueness (mean recovery 99.403%) with low dispersion (%RSD 0.201–0.252%). All nugget samples were negative by both qualitative screening assays. However, UV–Vis quantitative values for the nugget extracts were not available in the recorded dataset; therefore, borax-equivalent concentrations in mg/kg could not be reported for the marketed samples. Overall, the validated curcumin UV–Vis procedure demonstrates strong analytical performance and is suitable for confirmatory monitoring, provided that future surveillance applies the method directly to each sample extract to enable defensible classification as ND (LOD), LOQ, or quantified (≥LOQ).
Pengaruh Booklet Terhadap Pengetahuan dan Sikap Pasien Asam Urat (Gout Arthritis) Di Puskesmas Biluhu, Kabupaten Gorontalo: Effect of Booklets on Knowledge and Attitudes of Gout Arthritis Patients at Biluhu Community Health Center (Puskesmas), Gorontalo Regency Madania, Madania; Ramadhani, Fika Nuzul; Tuloli, Teti Sutriyati; Uno, Wiwit Zuriati; tuna, nindiyani
Journal of Community and Clinical Pharmacy Vol. 3 No. 1 (2026): Vol. 3, No. 1 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jccp.v3i1.218

Abstract

Asam urat merupakan salah satu masalah kesehatan yang banyak dialami masyarakat, terutama di usia lanjut. Rendahnya tingkat pengetahuan dan sikap terhadap penyakit ini dapat memengaruhi perilaku pengelolaan dan pencegahan asam urat. Oleh karena itu, dibutuhkan media edukasi yang efektif untuk meningkatkan pemahaman pasien. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian booklet terhadap pengetahuan dan sikap pasien asam urat di Puskesmas Biluhu, Kabupaten Gorontalo. Desain penelitian yang digunakan adalah quasi eksperimen dengan rancangan one group pretest-posttest. Sampel penelitian berjumlah 54 orang yang dipilih menggunakan metode sensus dan diolah melalui SPSS. Hasil penelitian menunjukkan bahwa sebelum intervensi, hanya 7,4% responden yang memiliki pengetahuan baik dan 53,7% memiliki sikap positif. Setelah pemberian booklet, terjadi peningkatan dengan 27,8% responden memiliki pengetahuan baik dan 74,1% memiliki sikap positif. Uji statistik menunjukkan bahwa pemberian booklet berpengaruh signifikan terhadap peningkatan pengetahuan (p = 0,000), namun tidak berpengaruh signifikan terhadap sikap (p = 0,105). Dengan demikian, media booklet dapat digunakan sebagai sarana edukasi yang efektif untuk meningkatkan pengetahuan pasien tentang asam urat, namun belum mampu membuat perubahan sikap yang signifikan.
COLLAGEN AND BIOACTIVE PEPTIDES FROM HULU'U FISH SCALES AND GILLS (GIURIS MARGARITICUS) AS POTENTIAL AGENTS FOR DIABETIC WOUND THERAPY Wiwit Zuriati Uno; Siti Naysila; Adelin Salsahbila Usman
Jurnal Multidisipliner Kapalamada Vol. 4 No. 04 (2025): JURNAL MULTIDISIPLINER KAPALAMADA
Publisher : Pusat Studi Ekonomi, Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/kapalamada.v4i04.1938

Abstract

This study aimed to explore collagen content and bioactive peptides derived from scales and gills of endemic upstream fish from Gorontalo, to evaluate their antioxidant activity, fibroblast proliferation stimulation in vitro, and antidiabetic potential through inhibition of ?-glucosidase and ?-amylase enzymes, supporting the development of local diabetic wound therapy agents. Fish scales and gills were dried, ground, and extracted using acetic acid. Collagen was precipitated, dried, and hydrolyzed with pepsin to obtain peptides <10 kDa. Collagen content was determined using a hydroxyproline assay. Antioxidant activity was evaluated using DPPH and ABTS assays. Fibroblast proliferation was assessed by a scratch assay under hyperglycemic conditions (25 mM glucose). Antidiabetic potential was examined through in vitro inhibition of ?-glucosidase and ?-amylase. Results showed that collagen content in scales was higher than in gills. Both extracts exhibited significant antioxidant activity, enhanced fibroblast proliferation, and demonstrated inhibitory effects on ?-glucosidase and ?-amylase. These findings indicate that fish scales and gills are promising sustainable biomaterials for diabetic wound therapy and local pharmaceutical innovation.
ANTIOXIDANT ACTIVITY EVALUATION OF CATFISH (CLARIAS SP.) COLLAGEN EXTRACT USING DPPH AND ABTS METHODS Faramita Hiola; Wiwit Zuriati Uno; Mahdalena Sy. Pakaya; Ariani Hutuba
Jurnal Multidisipliner Kapalamada Vol. 4 No. 04 (2025): JURNAL MULTIDISIPLINER KAPALAMADA
Publisher : Pusat Studi Ekonomi, Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/kapalamada.v4i04.1964

Abstract

This study aimed to evaluate the antioxidant activity of collagen extracted from catfish (Clarias sp.) using DPPH and ABTS assays. The research procedures included sample preparation, collagen extraction using an acid-based method, and antioxidant analysis at concentrations ranging from 20–100 ppm. The degree of hydrolysis (DH) was measured to determine the effectiveness of Alkalase in producing bioactive peptides. The results showed that higher enzyme concentrations led to increased DH, with the highest value of 62.42% obtained at 3% Alkalase. Antioxidant activity increased with sample concentration, with maximum inhibition values of 78.57% (DPPH) and 85.00% (ABTS) at 100 ppm. The ABTS assay exhibited higher sensitivity than DPPH. These findings indicate that catfish collagen has strong potential as a safe and natural antioxidant source suitable for further development in food, pharmaceutical, and cosmetic applications.
Pemberdayaan Masyarakat Melalui Inovasi Pemanfaatan Daun Kelor Berbasis Data Empiris Sebagai Permen Pendukung Gizi Anak Wiwit Zuriati Uno; Rifka Anggraini Anggai; Lisa Efriani Puluhulawa; Amelia Regina Arsyad
Jurnal Suara Pengabdian 45 Vol. 5 No. 2 (2026): Juni: Jurnal Suara Pengabdian 45
Publisher : LPPM Universitas 17 Agustus 1945 Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56444/pengabdian45.v5i2.3499

Abstract

Daun kelor (Moringa oleifera) merupakan tanaman lokal yang kaya protein, vitamin, dan mineral, serta berpotensi mendukung pemenuhan gizi anak apabila diolah dalam bentuk yang lebih diterima. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberdayakan masyarakat melalui inovasi pemanfaatan daun kelor (Moringa oleifera) berbasis data empiris masyarakat sebagai permen pendukung gizi anak. Kegiatan dilaksanakan di Desa Tinelo, Kabupaten Bone Bolango, Provinsi Gorontalo, dengan sasaran ibu yang memiliki anak usia 5–12 tahun. Tahap awal dilakukan pengumpulan data empiris melalui wawancara semi-terstruktur untuk mengidentifikasi pola pemanfaatan daun kelor dan tingkat penerimaan anak. Selanjutnya dilakukan kegiatan edukasi mengenai manfaat gizi daun kelor serta pendampingan pembuatan permen herbal kelor sebagai inovasi pengolahan pangan berbasis kearifan lokal. Evaluasi kegiatan dilakukan secara deskriptif dengan membandingkan kondisi pra dan pasca kegiatan terhadap perubahan pengetahuan, sikap, dan penerimaan masyarakat. Hasil kegiatan menunjukkan adanya peningkatan pemahaman ibu terhadap manfaat gizi daun kelor, dukungan terhadap inovasi pengolahan, penerimaan anak terhadap konsumsi kelor, partisipasi aktif masyarakat, serta minat untuk mengolah daun kelor secara mandiri. Kegiatan ini menunjukkan bahwa pendekatan pemberdayaan berbasis data empiris dan inovasi pangan lokal efektif dalam meningkatkan pemanfaatan daun kelor sebagai pendukung gizi anak.
ADVANCES IN PROTEIN SYNTHESIS TECHNOLOGY AND THEIR IMPLICATIONS FOR FUTURE PROTEIN AVAILABILITY: A NARRATIVE REVIEW Wiwit Zuriati Uno; Siti Sulistiani Tompe; Salwa Miftahuljannah; Azqia Maharani Pulukadang; Farelia Rizkita Rahmadani J. Hako; Karim Putra Dunggio
JIMR : Journal Of International Multidisciplinary Research Vol 4 No 02 (2025): JIMR : Journal Of International Multidisciplinary Research
Publisher : Pusat Studi Ekonomi Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/jimr.v4i02.1971

Abstract

The availability of conventional protein sources is increasingly limited due to population growth, climate change, and limited land, so innovation is needed in providing more efficient and sustainable protein. This study aims to examine the development of protein synthesis technology and its implications for the availability of future protein sources. The method used is a literature review by examining scientific publications published from 2015-2024 searched through Google Scholar. The results of the study indicate that recombinant technology is able to produce high-quality functional proteins through genetic engineering of microorganisms, while microbial fermentation based on agro-industrial waste offers cheap and environmentally friendly Single Cell Protein production. In addition, increased production of poultry, eggs, and milk is the main support for the national animal protein supply. Overall, the development of protein synthesis technology provides a strategic opportunity to meet global protein needs through a resource-efficient, scalable, and sustainability-oriented approach.
ANTIOXIDANT ACTIVITY OF NIRA SEED WASTE (ARENGA PINNATA) EXTRACTS USING DPPH METHOD Wiwit Zuriati Uno; Rifka Anggraini; Anggi Pratama Solihin; Juliyanti Akuba
JIMR : Journal Of International Multidisciplinary Research Vol 4 No 02 (2025): JIMR : Journal Of International Multidisciplinary Research
Publisher : Pusat Studi Ekonomi Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/jimr.v4i02.1991

Abstract

Agricultural waste from Nira (Arenga pinnata) seeds has attracted increasing attention due to its potential bioactive compounds and value-added applications. Objective: This study aims to evaluate the antioxidant activity of nira seed waste (Arenga pinnata) using solvents with different polarity levels. Method: The research employed an experimental laboratory method with maceration extraction using ethanol, acetone, and n-hexane. Antioxidant activity was analyzed using the DPPH radical scavenging assay measured by UV–Vis spectrophotometry. Results: The results showed that solvent polarity influenced extraction yield, phytochemical composition, and antioxidant potential. The ethanol extract exhibited the strongest antioxidant activity due to its effectiveness in extracting phenolic and flavonoid compounds. These findings indicate that nira seed waste has promising potential as a natural antioxidant source and pharmaceutical raw material supporting the zero waste concept.
STANDARDIZATION OF SPECIFIC AND NON-SPECIFIC PARAMETERS, PHYTOCHEMICAL ANALYSIS, AND KLT PROFILE OF JACKFRUIT SEED EXTRACT (ARTOCARPUS HETEROPHYLLUS LAM) Wiwit Zuriati Uno; Aprilia Hulopi; Fadhilah Nur Rahma Bau; Hariyanto Suronoto; Nazwa Amalia Lantapa; Sasya Ramadhani Usman
JIMR : Journal Of International Multidisciplinary Research Vol 4 No 02 (2025): JIMR : Journal Of International Multidisciplinary Research
Publisher : Pusat Studi Ekonomi Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/jimr.v4i02.2004

Abstract

This study aimed to determine the specific parameters, non-specific parameters, phytochemical screening results, and TLC profile of jackfruit seed extract. The evaluations included organoleptic assessment, moisture content, total ash content, microbial contaminat ion, phytochemical identification, and TLC analysis using n-hexane: ethyl acetate eluents. The results showed that the extract was viscous, yellow-brown, and had a characteristic aroma; the moisture content was 6% and the total ash content was 2.85%, both meeting the quality requirements. Microbial contamination indicated acceptable values with total plate count at dilutions 10?²–10?³ and yeast-mold count at dilutions 10?¹–10?², remaining below the maximum limits. Phytochemic al screening identified the presence of alkaloids and steroids/terpen oids, while flavonoids, tannins, and saponins were not detected. TLC profiling produced several Rf values indicating the dominance of non-polar to semi-polar compounds. These findings demonstrate that jack fruit seed extract meets physical, chemical, and microbiological qua lity standards and presents a consistent chemical profile, supporting its potential for use as a raw material in herbal product development.
ANALYSIS OF SPECIFIC AND NON SPECIFIC PARAMETERS OF GOROHO BANANAS (Musa acuminata L.) Wiwit Zuriati Uno; Rionaldo Arginggang; Lya Yulyani Sulasdi; Makhfudia A. Masulili; Sri Safitri Nasib; Hudan Wijaya
JIMR : Journal Of International Multidisciplinary Research Vol 4 No 02 (2025): JIMR : Journal Of International Multidisciplinary Research
Publisher : Pusat Studi Ekonomi Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/jimr.v4i02.2007

Abstract

Goroho banana (Musa acuminata subsp. goroho) is a local Indonesian plant with potential as a traditional medicine due to its secondary metabolite content. This study aimed to standardize goroho banana extract through testing specific and nonspecific parameters to ensure the quality, safety, and quality of the extract. The method used was maceration extraction with 96% ethanol. Specific parameters tested included organoleptic testing, water-soluble extract content, ethanol- soluble extract content, and phytochemical screening. Nonspecific parameters included water content and microbial contamination testing. The results showed that goroho banana extract was thick, light yellow, and had a distinctive banana odor. The water-soluble extract and ethanol content were each 16.6%, meeting quality requirements. Phytochemical screening revealed the presence of flavonoids and saponins, while alkaloids yielded negative results in the Mayer test. Nonspecific testing indicated that the water content and microbial contamination were within safe limits according to standards. Based on these results, goroho banana extract meets the quality criteria for herbal extracts and has the potential to be developed as a raw material for traditional medicine
STANDARDIZATION OF SPECIFIC AND NON-SPECIFIC PARAMETERS OF DAYAK ONION BULB (ELEUTHERINE PALMIFOLIA L. MERR.) Wiwit Zuriati Uno; Nazwa Salfadila Hasan; Serlin N. Tilola; Salwa Rumampuk; Mohammad Qarlan Pratama; Meira Kumala Arista
JIMR : Journal Of International Multidisciplinary Research Vol 4 No 02 (2025): JIMR : Journal Of International Multidisciplinary Research
Publisher : Pusat Studi Ekonomi Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/jimr.v4i02.2008

Abstract

This study aimed to determine the specific and non-specific parameters of Dayak onion bulb extract as a basis for herbal standardization. The research methods included organoleptic identification, phytochemical screening, Thin Layer Chromatography (TLC) analysis, and determination of non-specific parameters, namely moisture content, total ash content, Total Plate Count (TPC), and Yeast and Mold Count (YMC). Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, and saponins, while steroids and terpenoids were not detected. The TLC profile showed several spots with varying Rf values, indicating the presence of compounds with different polarity levels. The moisture content (5.07%) and total ash content (4.31%) met the standards of the Indonesian Herbal Pharmacopoeia. TPC (5.4 × 10² CFU/mL) and YMC (3.2 × 10² CFU/mL) were below the permissible limits. These results indicate that Dayak onion bulb extract meets the required specific and non-specific parameters and is suitable for use as a standardized herbal raw material.
Co-Authors A. Mu’thi Andy Suryadi Abdul Rahman A. Djakaria Adelin Salsahbila Usman Aditya Kuengo Alvionita B. Anwar Amelia Regina Arsyad Andy Suryadi, A. Mu'thi Anggai, Rifka Anggraini Anggi Pratama Solihin Aprilia Hulopi Aqymnastiar R. Djakaria Ariani H. Hutuba Arona Salama Azqia Maharani Pulukadang Beby Triana A.Z. Muis Cahniar Djamil Cahniar Djamil Detasya Detasya Dewi Rahmawaty Moo Dian Pratiwi Iman Dizky Ramadhani Putri Papeo Djuwarno, Endah Nurrowinta Dr. Apt. Hamsidar Hasan S.Si.,M.Si Fadhilah Nur Rahma Bau Faizha Putri Delia Faradila Ratu Cindana Farelia Rizkita Rahmadani J. Hako Fika Nuzul Ramadhan Fika Nuzul Ramadhani Flora Ninta Tarigan Gubali, Derina Dwifrila Ridhani Hariyanto Suronoto Hiola, Faramita Hudan Wijaya Hunawa, Rachmawaty Dirham Hutuba, Ariani Iman, Dian Pratiwi Intan Abdul Razak Ishak Isa Jafar La Kilo Jihan Astuti Kai Juliyanti Akuba Karim Putra Dunggio kopman, aldafarista La Ode Aman Lamatenggo, Nina Lisa Efriani Puluhulawa Lisa Efriani Puluhulawa Lya Yulyani Sulasdi Madania, Madania Magfirah Nur Cahyani Mahdalena Sy Pakaya Mahdalena Sy Pakaya Mahdalena Sy. Pakaya Makhfudia A. Masulili Makkulawu, Andi Maku, Diva Julyar Cahyani Malopo, Ekaria Revalya Mamat Abas Manno, Mohamad Reski Meira Kumala Arista Moh. Rivai Nakoe Mohamad Adam Mustapa Mohamad Aprianto Paneo Mohammad Qarlan Pratama Molou, Muh Dwi Septian Muhammad Taupik Nazwa Amalia Lantapa Nazwa Salfadila Hasan Novriani Amran Nur Ain Thomas Nur Rasdianah Olii, Zihan Maura Putri Papeo, Dizky Ramadani Putri Papeo, Dizky Ramadhani Putri Paramita Musa Puluhulawa, Lisa Efriani Putri Fauzia Datunsolang Rahmatia Baharuddin Rahmawati Hunawa Rifka Anggraini Rifka Anggraini Anggai Rifka Anggraini Anggai Rionaldo Arginggang Salwa Miftahuljannah Salwa Rumampuk Samsul Bahri Badjeber Sasya Ramadhani Usman Serlin N. Tilola Siti Naysila Siti Sulistiani Tompe Sri Manovita Pateda Sri Safitri Nasib Suryadi, A. Muthi Andi Teti Supriyati Tuloli Teti Sutriyati Tuloli Tolulu, Sri Noviani tuna, nindiyani Umi Yuminarti Widy Susanti Abdulkadir Widy Susanti Abdulkadir Yanti Menu