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All Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jambura Journal of Chemistry Journal Syifa Sciences and Clinical Research (JSSCR) Kumawula: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmaceutical Education Indonesian Community Journal Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Multidisipliner Kapalamada JIMR : Journal Of International Multidisciplinary Research Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products Jurnal Pengabdian Masyarakat Kesehatan Dan Sains Jurnal Riset dan Pengabdian Interdisipliner Qoumun: Journal of Social and Humanities
Wiwit Zuriati Uno
Universitas Negeri Gorontalo
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Pengaruh Booklet Terhadap Pengetahuan dan Sikap Pasien Asam Urat (Gout Arthritis) Di Puskesmas Biluhu, Kabupaten Gorontalo: Effect of Booklets on Knowledge and Attitudes of Gout Arthritis Patients at Biluhu Community Health Center (Puskesmas), Gorontalo Regency Madania, Madania; Ramadhani, Fika Nuzul; Tuloli, Teti Sutriyati; Uno, Wiwit Zuriati; tuna, nindiyani
Journal of Community and Clinical Pharmacy Vol. 3 No. 1 (2026): Vol. 3, No. 1 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jccp.v3i1.218

Abstract

Asam urat merupakan salah satu masalah kesehatan yang banyak dialami masyarakat, terutama di usia lanjut. Rendahnya tingkat pengetahuan dan sikap terhadap penyakit ini dapat memengaruhi perilaku pengelolaan dan pencegahan asam urat. Oleh karena itu, dibutuhkan media edukasi yang efektif untuk meningkatkan pemahaman pasien. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian booklet terhadap pengetahuan dan sikap pasien asam urat di Puskesmas Biluhu, Kabupaten Gorontalo. Desain penelitian yang digunakan adalah quasi eksperimen dengan rancangan one group pretest-posttest. Sampel penelitian berjumlah 54 orang yang dipilih menggunakan metode sensus dan diolah melalui SPSS. Hasil penelitian menunjukkan bahwa sebelum intervensi, hanya 7,4% responden yang memiliki pengetahuan baik dan 53,7% memiliki sikap positif. Setelah pemberian booklet, terjadi peningkatan dengan 27,8% responden memiliki pengetahuan baik dan 74,1% memiliki sikap positif. Uji statistik menunjukkan bahwa pemberian booklet berpengaruh signifikan terhadap peningkatan pengetahuan (p = 0,000), namun tidak berpengaruh signifikan terhadap sikap (p = 0,105). Dengan demikian, media booklet dapat digunakan sebagai sarana edukasi yang efektif untuk meningkatkan pengetahuan pasien tentang asam urat, namun belum mampu membuat perubahan sikap yang signifikan.
COLLAGEN AND BIOACTIVE PEPTIDES FROM HULU'U FISH SCALES AND GILLS (GIURIS MARGARITICUS) AS POTENTIAL AGENTS FOR DIABETIC WOUND THERAPY Wiwit Zuriati Uno; Siti Naysila; Adelin Salsahbila Usman
Jurnal Multidisipliner Kapalamada Vol. 4 No. 04 (2025): JURNAL MULTIDISIPLINER KAPALAMADA
Publisher : Pusat Studi Ekonomi, Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/kapalamada.v4i04.1938

Abstract

This study aimed to explore collagen content and bioactive peptides derived from scales and gills of endemic upstream fish from Gorontalo, to evaluate their antioxidant activity, fibroblast proliferation stimulation in vitro, and antidiabetic potential through inhibition of ?-glucosidase and ?-amylase enzymes, supporting the development of local diabetic wound therapy agents. Fish scales and gills were dried, ground, and extracted using acetic acid. Collagen was precipitated, dried, and hydrolyzed with pepsin to obtain peptides <10 kDa. Collagen content was determined using a hydroxyproline assay. Antioxidant activity was evaluated using DPPH and ABTS assays. Fibroblast proliferation was assessed by a scratch assay under hyperglycemic conditions (25 mM glucose). Antidiabetic potential was examined through in vitro inhibition of ?-glucosidase and ?-amylase. Results showed that collagen content in scales was higher than in gills. Both extracts exhibited significant antioxidant activity, enhanced fibroblast proliferation, and demonstrated inhibitory effects on ?-glucosidase and ?-amylase. These findings indicate that fish scales and gills are promising sustainable biomaterials for diabetic wound therapy and local pharmaceutical innovation.
ANTIOXIDANT ACTIVITY EVALUATION OF CATFISH (CLARIAS SP.) COLLAGEN EXTRACT USING DPPH AND ABTS METHODS Faramita Hiola; Wiwit Zuriati Uno; Mahdalena Sy. Pakaya; Ariani Hutuba
Jurnal Multidisipliner Kapalamada Vol. 4 No. 04 (2025): JURNAL MULTIDISIPLINER KAPALAMADA
Publisher : Pusat Studi Ekonomi, Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/kapalamada.v4i04.1964

Abstract

This study aimed to evaluate the antioxidant activity of collagen extracted from catfish (Clarias sp.) using DPPH and ABTS assays. The research procedures included sample preparation, collagen extraction using an acid-based method, and antioxidant analysis at concentrations ranging from 20–100 ppm. The degree of hydrolysis (DH) was measured to determine the effectiveness of Alkalase in producing bioactive peptides. The results showed that higher enzyme concentrations led to increased DH, with the highest value of 62.42% obtained at 3% Alkalase. Antioxidant activity increased with sample concentration, with maximum inhibition values of 78.57% (DPPH) and 85.00% (ABTS) at 100 ppm. The ABTS assay exhibited higher sensitivity than DPPH. These findings indicate that catfish collagen has strong potential as a safe and natural antioxidant source suitable for further development in food, pharmaceutical, and cosmetic applications.
ADVANCES IN PROTEIN SYNTHESIS TECHNOLOGY AND THEIR IMPLICATIONS FOR FUTURE PROTEIN AVAILABILITY: A NARRATIVE REVIEW Wiwit Zuriati Uno; Siti Sulistiani Tompe; Salwa Miftahuljannah; Azqia Maharani Pulukadang; Farelia Rizkita Rahmadani J. Hako; Karim Putra Dunggio
JIMR : Journal Of International Multidisciplinary Research Vol 4 No 02 (2025): JIMR : Journal Of International Multidisciplinary Research
Publisher : Pusat Studi Ekonomi Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/jimr.v4i02.1971

Abstract

The availability of conventional protein sources is increasingly limited due to population growth, climate change, and limited land, so innovation is needed in providing more efficient and sustainable protein. This study aims to examine the development of protein synthesis technology and its implications for the availability of future protein sources. The method used is a literature review by examining scientific publications published from 2015-2024 searched through Google Scholar. The results of the study indicate that recombinant technology is able to produce high-quality functional proteins through genetic engineering of microorganisms, while microbial fermentation based on agro-industrial waste offers cheap and environmentally friendly Single Cell Protein production. In addition, increased production of poultry, eggs, and milk is the main support for the national animal protein supply. Overall, the development of protein synthesis technology provides a strategic opportunity to meet global protein needs through a resource-efficient, scalable, and sustainability-oriented approach.
ANTIOXIDANT ACTIVITY OF NIRA SEED WASTE (ARENGA PINNATA) EXTRACTS USING DPPH METHOD Wiwit Zuriati Uno; Rifka Anggraini; Anggi Pratama Solihin; Juliyanti Akuba
JIMR : Journal Of International Multidisciplinary Research Vol 4 No 02 (2025): JIMR : Journal Of International Multidisciplinary Research
Publisher : Pusat Studi Ekonomi Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/jimr.v4i02.1991

Abstract

Agricultural waste from Nira (Arenga pinnata) seeds has attracted increasing attention due to its potential bioactive compounds and value-added applications. Objective: This study aims to evaluate the antioxidant activity of nira seed waste (Arenga pinnata) using solvents with different polarity levels. Method: The research employed an experimental laboratory method with maceration extraction using ethanol, acetone, and n-hexane. Antioxidant activity was analyzed using the DPPH radical scavenging assay measured by UV–Vis spectrophotometry. Results: The results showed that solvent polarity influenced extraction yield, phytochemical composition, and antioxidant potential. The ethanol extract exhibited the strongest antioxidant activity due to its effectiveness in extracting phenolic and flavonoid compounds. These findings indicate that nira seed waste has promising potential as a natural antioxidant source and pharmaceutical raw material supporting the zero waste concept.
STANDARDIZATION OF SPECIFIC AND NON-SPECIFIC PARAMETERS, PHYTOCHEMICAL ANALYSIS, AND KLT PROFILE OF JACKFRUIT SEED EXTRACT (ARTOCARPUS HETEROPHYLLUS LAM) Wiwit Zuriati Uno; Aprilia Hulopi; Fadhilah Nur Rahma Bau; Hariyanto Suronoto; Nazwa Amalia Lantapa; Sasya Ramadhani Usman
JIMR : Journal Of International Multidisciplinary Research Vol 4 No 02 (2025): JIMR : Journal Of International Multidisciplinary Research
Publisher : Pusat Studi Ekonomi Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/jimr.v4i02.2004

Abstract

This study aimed to determine the specific parameters, non-specific parameters, phytochemical screening results, and TLC profile of jackfruit seed extract. The evaluations included organoleptic assessment, moisture content, total ash content, microbial contaminat ion, phytochemical identification, and TLC analysis using n-hexane: ethyl acetate eluents. The results showed that the extract was viscous, yellow-brown, and had a characteristic aroma; the moisture content was 6% and the total ash content was 2.85%, both meeting the quality requirements. Microbial contamination indicated acceptable values with total plate count at dilutions 10?²–10?³ and yeast-mold count at dilutions 10?¹–10?², remaining below the maximum limits. Phytochemic al screening identified the presence of alkaloids and steroids/terpen oids, while flavonoids, tannins, and saponins were not detected. TLC profiling produced several Rf values indicating the dominance of non-polar to semi-polar compounds. These findings demonstrate that jack fruit seed extract meets physical, chemical, and microbiological qua lity standards and presents a consistent chemical profile, supporting its potential for use as a raw material in herbal product development.
ANALYSIS OF SPECIFIC AND NON SPECIFIC PARAMETERS OF GOROHO BANANAS (Musa acuminata L.) Wiwit Zuriati Uno; Rionaldo Arginggang; Lya Yulyani Sulasdi; Makhfudia A. Masulili; Sri Safitri Nasib; Hudan Wijaya
JIMR : Journal Of International Multidisciplinary Research Vol 4 No 02 (2025): JIMR : Journal Of International Multidisciplinary Research
Publisher : Pusat Studi Ekonomi Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/jimr.v4i02.2007

Abstract

Goroho banana (Musa acuminata subsp. goroho) is a local Indonesian plant with potential as a traditional medicine due to its secondary metabolite content. This study aimed to standardize goroho banana extract through testing specific and nonspecific parameters to ensure the quality, safety, and quality of the extract. The method used was maceration extraction with 96% ethanol. Specific parameters tested included organoleptic testing, water-soluble extract content, ethanol- soluble extract content, and phytochemical screening. Nonspecific parameters included water content and microbial contamination testing. The results showed that goroho banana extract was thick, light yellow, and had a distinctive banana odor. The water-soluble extract and ethanol content were each 16.6%, meeting quality requirements. Phytochemical screening revealed the presence of flavonoids and saponins, while alkaloids yielded negative results in the Mayer test. Nonspecific testing indicated that the water content and microbial contamination were within safe limits according to standards. Based on these results, goroho banana extract meets the quality criteria for herbal extracts and has the potential to be developed as a raw material for traditional medicine
STANDARDIZATION OF SPECIFIC AND NON-SPECIFIC PARAMETERS OF DAYAK ONION BULB (ELEUTHERINE PALMIFOLIA L. MERR.) Wiwit Zuriati Uno; Nazwa Salfadila Hasan; Serlin N. Tilola; Salwa Rumampuk; Mohammad Qarlan Pratama; Meira Kumala Arista
JIMR : Journal Of International Multidisciplinary Research Vol 4 No 02 (2025): JIMR : Journal Of International Multidisciplinary Research
Publisher : Pusat Studi Ekonomi Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/jimr.v4i02.2008

Abstract

This study aimed to determine the specific and non-specific parameters of Dayak onion bulb extract as a basis for herbal standardization. The research methods included organoleptic identification, phytochemical screening, Thin Layer Chromatography (TLC) analysis, and determination of non-specific parameters, namely moisture content, total ash content, Total Plate Count (TPC), and Yeast and Mold Count (YMC). Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, and saponins, while steroids and terpenoids were not detected. The TLC profile showed several spots with varying Rf values, indicating the presence of compounds with different polarity levels. The moisture content (5.07%) and total ash content (4.31%) met the standards of the Indonesian Herbal Pharmacopoeia. TPC (5.4 × 10² CFU/mL) and YMC (3.2 × 10² CFU/mL) were below the permissible limits. These results indicate that Dayak onion bulb extract meets the required specific and non-specific parameters and is suitable for use as a standardized herbal raw material.
ETHNOMEDICIAL STUDY OF TRADITIONAL INDONESIAN MEDICINAL PLANT Wiwit Zuriati Uno; Aditya Kuengo; Alvionita B. Anwar; Faizha Putri Delia
JIMR : Journal Of International Multidisciplinary Research Vol 4 No 02 (2025): JIMR : Journal Of International Multidisciplinary Research
Publisher : Pusat Studi Ekonomi Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/jimr.v4i02.2100

Abstract

The title of study is Ethnomedicial Study Of Traditional Indonesian Medicinal Plant. This study aimed to review the ethnomedicinal use of moringa leaves (Moringa oleifera Lam.) among Indonesian communities and to analyze its relevance to scientific evidence related to phytochemical composition, pharmacological activities, and safety aspects. The research employed a literature review method with a descriptive-analytical approach by examining scientific articles, ethnomedicinal books, and research reports obtained from Google Scholar, PubMed, and ScienceDirect databases. The results indicate that moringa leaves are traditionally used to maintain health, enhance immune function, promote lactation, reduce inflammation, and assist in blood glucose management. Scientific findings support these traditional uses through the identification of bioactive compounds and relevant pharmacological activities, while also indicating that moringa leaves are generally safe when consumed at traditional doses. This study highlights the importance of ethnomedicine as a scientific foundation for the rational development of evidence-based traditional medicine.
PENAPISAN FITOKIMIA DAN UJI TOKSISITASFRAKSI DAUN KAYU PUTIH (Malaleuca leucadendraL.) DENGAN METODEBrine Shrimp Lethality Test (BSLT) Abdul Rahman A. Djakaria; Hamsidar Hasan; Muhammad Taupik; Dizky Ramadani Putri Papeo; Wiwit Zuriati Uno; Rifka Anggraini Anggai
Journal of Pharmacology and Natural Products Vol. 3 No. 1 (2026): Volume 3, Nomor 1, Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Melaleuca leucadendramerupakan salah satu tanaman yang memiliki potensi sebagai obat tradisional.Tujuan penelitian ini adalah untuk mengidentifikasi komponen kimia dan menguji efek toksisitasdengan metode Brine Shrimp Lethality Test (BSLT) pada fraksi daunkayu putih (Malaleuca Leucadendra).Metode ekstraksi yang digunakan adalah maserasi bertingkat dengan pelarut berdasarkan tingkat kepolaran yang berbeda yaitu n-heksan, klorofrom, etil asetat dan metanol.Identifikasi komponen kimia dengan menggunakan uji tabung dan uji KLT, pengujian toksisitas menggunakan metode Brine Shrimp Lethality Test (BSLT).Hasil skrining fitokimia semua fraksi yaitu n-heksan, klorofrom, etil asetat dan methanol positif mengandung senyawa alkaloid, flavonoid, tanin, terpenoid. Hasil pengujian toksisitas menggunakan larva udang dengan fraksi n-heksan, kloroform, etil asetat dan metanol didapatkan diperoleh nilai LC50masing-masing sebesar 218,43µg/mL; 81.20 µg/mL; 111,85 µg/mL; dan 58,52 µg/mL. Semua nilai LC50 termasuk kedalam kategori toksik.
Co-Authors A. Mu’thi Andy Suryadi Abdul Rahman A. Djakaria Adelin Salsahbila Usman Aditya Kuengo Alvionita B. Anwar Andy Suryadi, A. Mu'thi Anggai, Rifka Anggraini Anggi Pratama Solihin Aprianto Paneo, Mohamad Aprilia Hulopi Ariani H. Hutuba Arona Salama Azqia Maharani Pulukadang Cahniar Djamil Dewi Rahmawaty Moo Dian Pratiwi Iman Djuwarno, Endah Nurrowinta Fadhilah Nur Rahma Bau Faizha Putri Delia Faradila Ratu Cindana Faramita Hiola Farelia Rizkita Rahmadani J. Hako Fika Nuzul Ramadhan Fika Nuzul Ramadhani Flora Ninta Tarigan Gubali, Derina Dwifrila Ridhani Hamsidar Hasan Hariyanto Suronoto Hiola, Faramita Hudan Wijaya Hunawa, Rachmawaty Dirham Hutuba, Ariani Iman, Dian Pratiwi Intan Abdul Razak Ishak Isa Jafar La Kilo Jihan Astuti Kai Juliyanti Akuba Karim Putra Dunggio kopman, aldafarista La Ode Aman Lamatenggo, Nina Lya Yulyani Sulasdi Madania Madania, Madania Magfirah Nur Cahyani Mahdalena Sy Pakaya Mahdalena Sy Pakaya Makhfudia A. Masulili Makkulawu, Andi Maku, Diva Julyar Cahyani Malopo, Ekaria Revalya Mamat Abas Manno, Mohamad Reski Meira Kumala Arista Moh. Rivai Nakoe Mohamad Adam Mustapa Mohammad Qarlan Pratama Molou, Muh Dwi Septian Muhammad Taupik Muhammad Taupik Nazwa Amalia Lantapa Nazwa Salfadila Hasan Nur Ain Thomas Nur Rasdianah Olii, Zihan Maura Putri Papeo, Dizky Ramadani Putri Papeo, Dizky Ramadhani Putri Puluhulawa, Lisa Efriani Rahmatia Baharuddin Rahmawati Hunawa Rifka Anggraini Rifka Anggraini Anggai Rifka Anggraini Anggai Rifka Anggraini Anggai Rionaldo Arginggang Salwa Miftahuljannah Salwa Rumampuk Samsul Bahri Badjeber Sasya Ramadhani Usman Serlin N. Tilola Siti Naysila Siti Sulistiani Tompe Sri Manovita Pateda Sri Safitri Nasib Suryadi, A. Muthi Andi Teti Sutriyati Tuloli Tolulu, Sri Noviani tuna, nindiyani Umi Yuminarti Widy Susanti Abdulkadir Widy Susanti Abdulkadir