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All Journal Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Mandala Pharmacon Indonesia Science Midwifery Jurnal Kompilasi Hukum JOURNAL LA MEDIHEALTICO Narra J Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Jurnal Risalah Kenotariatan Jurnal Farmasi Sains dan Praktis Molekul: Jurnal Ilmiah Kimia Media Farmasi Jurnal Pengabdian Masyarakat
Arba, Muhammad
Faculty of Pharmacy, Halu Oleo University, Kendari, 93231
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Pemodelan Farmakofor untuk Identifikasi Inhibitor Heat Shock Proteins-90 (HSP-90): Pharmacophore Modeling to Identify Heat Shock Proteins-9 (HSP-90) Inhibitors Arba, Muhammad; Arfan; Trisnawati, Ayu; Kurniawati, Desi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15036

Abstract

Heat shock proteins-90 (HSP-90) is a protein that plays an important role in the life cycle of normal and cancer cells for their self protection from thermal stress, oxidative damage, and cell hypoxia. Inhibition of HSP90 is one way to suppress the growth of cancer cells. In this study, pharmacophore modeling and molecular docking were conducted to identify hit compounds as inhibitors of HSP-90. The pharmacophore feature consists of three hydrogen bond acceptors, one hydrogen bond donor and one hydrophobic feature with Area Under Curve of Receiver Operating Characteristics (AUCROC) is 0.5 and the Goodness of Hit (GH) value is 0.752. Screening in the ZINC database generated 1,500 hit compounds, were subjected to molecular docking to determine their binding energy and interactions with HSP-90. The range of binding energy (E) of all hit compounds is -5.68 to -12.24 kcal/mol and there are four best hit compounds namely lig_543, lig_527, lig_1337 and lig_337, when compared to native ligands (PU2, E=-8.25 kkal/mol) based on the binding energy and orientation, which indicate their potential as new HSP-90 inhibitors.
PHYSICOCHEMICAL CHARACTERISTICS AND PHARMACOLOGICAL ACTIVITY OF SACHA INCHI SEED OIL (Plukenetia volubilis L.): A LITERATURE REVIEW Saputri, Ulan Mulyani; Irnawati, Irnawati; Sahidin, Sahidin; Arba, Muhammad; Fristiohady, Adryan
Jurnal Farmasi Sains dan Praktis Vol 11 No 3 (September-December 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i3.12719

Abstract

Sacha inchi (Plukenetia volubilis L.) of the family Euphorbiaceae is native to Peruvian in the Amazon forest. SaIn seeds are known to contain a significant fatty acid such as linolenic acid (Omega-3), linoleic acid (Omega-6), and oleic acid (Omega-9). Several studies have shown the benefits of Sacha inchi (SaIn) for various pharmacological activities based on its compound content. The aim of this review article is to provide information about pharmacological activities and describe the physicochemical characteristics of SaIn seed oil. The method used to make this article review is a literature study gathered from national and international journals published in the last ten years through Google Scholar, NCBI-Pubmed, and Crossref with search keys in the form "Plukenetia volubilis L.", "Sacha inchi", "pharmacological activity of Sacha inchi", "physicochemical characteristics of Sacha inchi". Based on the literature review, it was found that the physicochemical characteristics of SaIn seed oil with the observed parameters of peroxide value, iodine number, saponification number and acid number showed different values depending on the extraction method used. SaIn has pharmacological activities as antioxidant, anticancer, antidiabetic, antiobesity, anticonvulsant, anti-aging, antihyperlipidemia, antibacterial and potential for alzheimer therapy.
Evaluation of the Rationality of Antibiotic Use in Pneumonia Patients Using the Gyssens Method Agustiana, Agustiana; Fristiohady, Adryan; Arba, Muhammad; Jabbar, Asriullah; Akib, Nur Illiyyin; Suryani, Suryani
Journal La Medihealtico Vol. 6 No. 6 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i6.2757

Abstract

Pneumonia is one of the leading causes of morbidity and mortality worldwide. The irrational use of antibiotics in pneumonia management can reduce therapeutic effectiveness and increase the risk of antimicrobial resistance. This study aimed to evaluate the rationality of antibiotic use in pneumonia patients at Hospital X using the Gyssens method. This research employed a descriptive observational design with a retrospective approach, utilizing medical record data of adult inpatients diagnosed with pneumonia during the period of January–December 2024. A total of 86 patient records meeting the inclusion criteria were analyzed. Evaluation was conducted using the Gyssens method by comparing the appropriateness of therapy with the Guidelines for the Management of Adult Pneumonia issued by the Indonesian Ministry of Health (Regulation No. 28 of 2021) and the Infectious Diseases Society of America/American Thoracic Society (IDSA/ATS, 2023) guidelines. The results showed that the most frequently used antibiotics were Ceftriaxone (34.88%), Azithromycin (32.56%), and Levofloxacin (32.56%). The most common duration of therapy was five days (53.9%). Based on the Gyssens categories, rational antibiotic use (category 0) was found in 57 cases (66.28%), while the remaining cases were categorized as I (6.98%), IIa (11.63%), IIIa (9.30%), and IIIb (5.81%). These findings indicate that most antibiotic use at Hospital X was rational; however, continuous monitoring and periodic evaluation through the Antimicrobial Resistance Control Program (PPRA) are still necessary to optimize therapeutic effectiveness and prevent antibiotic resistance.
Predicting the Anti-Tuberculosis Mechanism of Vitex cofassus Methanolic Extracts through Network Pharmacology Analysis: Prediksi Mekanisme Antituberkulosis Ekstrak Metanol Vitex cofassus melalui Analisis Farmakologi Jejaring Omir, Sri Wahyuli Astian; Ruslin, Ruslin; Arba, Muhammad
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 12 No. 1 (2026): (March 2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2026.v12.i1.17780

Abstract

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EDUKASI KESEHATAN REMAJA MELALUI KAMPANYE PENCEGAHAN MEROKOK, VAPE, MINUMAN KERAS, DAN PERGAULAN BERESIKO PADA SISWA SMA NEGERI 1 SAWA Hasnawati, Hasnawati; Arba, Muhammad; Fitrawan, La Ode Muhammad; Indalifiany, Astrid; Idrus, Loly Subhiaty; Pascayantri, Asniar; Sida, Nurramadhani A.; Solo, Dian Munasari; Malik, Fadhliah; Irvan, Irvan; Sartinah, Ari; Olyvia, Ocha; Aksan, Aisah Fitriani
BESIRU : Jurnal Pengabdian Masyarakat Vol. 3 No. 4 (2026): BESIRU : Jurnal Pengabdian Masyarakat, April 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v3i4.2514

Abstract

Adolescence is a vulnerable period for risky behaviors such as smoking, vaping, alcohol consumption, and unsafe social relationships. Limited health literacy often causes adolescents to perceive these behaviors as normal. This community service program aimed to improve the knowledge and awareness of students at SMA Negeri 1 Sawa regarding the dangers of smoking, vaping, alcohol consumption, and the risks of unsafe social behavior and HIV/AIDS. The activity was conducted on January 2026, at SMA Negeri 1 Sawa, Konawe Utara Regency, involving 40 twelfth-grade students. The methods used included interactive counseling, discussion, question-and-answer sessions, educational games, and simple demonstrations. The results showed an increase in students’ understanding of the dangers of smoking and vaping, the negative effects of alcohol consumption, and the risks associated with unsafe social behavior. Students began to understand that vaping is not a safe alternative to smoking and that risky behaviors may affect their reproductive health and future. The high level of student participation during the discussion indicated that an interactive approach is effective for adolescent health education.
Lantana Camara Linnaeus : Profil Fitokimia dan Potensi Aktivitas Farmakologi Putri, Intan Permata; Irnawati, Irnawati; Fristiohady, Adryan; Sahidin; Arba, Muhammad
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.2022

Abstract

Lantana camara L. is a tropical plant from the Verbenaceae family that is widely known for its invasive nature, but also has high ethnomedicinal value. This study aims to examine the phytochemical profile and potential pharmacological activities of L. camara plants based on the latest scientific data. The study method uses a literature study approach to scientific literature from the Scopus database in the period 2015–2025 with keywords related to the phytochemistry and pharmacology of L. camara. The collected data were analyzed descriptively to identify the main bioactive compounds and their biological activities. The results of the study indicate that L. camara contains triterpenoids, flavonoids, phenolics, and iridoid glycosides that play an important role in various pharmacological activities, including antidiabetic, anticancer, antimicrobial, antioxidant, anti-inflammatory, and neuroprotective. Compounds such as ursolic acid, lantadene A and B, and quercetin-3-O-glucoside are reported to have significant biological effects through different molecular mechanisms. Furthermore, the potential use of L. camara in nanoparticle synthesis shows broad application prospects in the pharmaceutical and industrial fields. In conclusion, L. camara is a promising natural bioactive source for modern drug development and sustainable therapeutic applications.
Tanaman Obat Sebagai Inhibitor Xanthine Oxidase Dengan Mekanisme Multitarget Pada Hiperurisemia Dan Gout Srimuliana; Nasrudin; Sahidin; Arba, Muhammad; Fristiohady, Adryan; Irnawati; Ilyas Y, Muhammad; Jabbar, Asriullah
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.2024

Abstract

Hiperurisemia merupakan faktor utama penyebab gout yang berkaitan dengan peningkatan kadar asam urat akibat produksi berlebih maupun gangguan ekskresi. Enzim xanthine oxidase (XO) berperan penting dalam pembentukan asam urat sehingga menjadi target utama dalam terapi gout. Review ini bertujuan untuk mengidentifikasi dan menganalisis tanaman obat yang memiliki aktivitas penghambatan enzim xanthine oxidase (XO) serta potensi terapinya dalam penanganan hiperurisemia dan gout. Pencarian literatur dilakukan menggunakan metode literature review dengan menelusuri artikel yang dipublikasikan pada periode 2020- 2025. Database yang digunakan meliputi Scopus, PubMed, ScienceDirect, dan Google Scholar. Artikel yang diseleksi membahas aktivitas penghambatan XO oleh tanaman obat berdasarkan uji in vitro dan in vivo. Sebanyak 23 tanaman obat teridentifikasi memiliki aktivitas penghambatan XO yang signifikan. Senyawa aktif seperti chrysin (Piper sarmentosum), limonene (Pistacia chinensis), andrographolide (Andrographis paniculata), dan morin (Maclura cochinchinensis) menunjukkan potensi tinggi, bahkan pada beberapa studi melebihi allopurinol. Mekanisme kerja tanaman obat tidak hanya melalui inhibisi XO langsung, tetapi juga melibatkan modulasi transporter asam urat ginjal seperti URAT1, GLUT9, OAT1, dan ABCG2. Selain itu, aktivitas antioksidan dan anti-inflamasi melalui penekanan jalur NF-κB dan NLRP3 turut berkontribusi, yang sering disertai dengan efek perlindungan ginjal dan hati. Dengan mekanisme kerja yang bersifat multi-target dan profil keamanan yang lebih baik, tanaman obat berpotensi menjadi alternatif terapi gout, meskipun uji klinis lanjutan masih diperlukan.
Co-Authors Agustiana, Agustiana Ahmad Najib Aksan, Aisah Fitriani Arfan Ari Sartinah, Ari Asbah, Asbah Ayu Wulandari Bahar, Muhammad A. Candrayanti, Gusti Ayu Made Darmin, Wa Ode Yentri Putia Ningtiyas Djumardin, Djumardin Filmaharani, Filmaharani Firzan Nainu Fitrawan, La Ode Muhammad Fitrawan, La Ode Muhammad Fristiohady, Adryan Habibie Habibie Hamzah, Any Suryani Hasnawati Hasnawati Idrus, Loly Subhiaty Ilyas Y, Muhammad Indalifiany, Astrid Intan Permata Putri Irnawati Irnawati Irnawati Irvan Irvan Jabbar, Asriullah Kuncoro, Shienny L, Adryan Fristiohady. La Aba Latada, Nadila P. Malik, Fadhliah Mallarangeng, Andi Nafisah Tendri Adjeng Mega Fatimah Rosana Mudjahid, Mukarram Muhammad Jefriyanto B NASRUDIN Nur Illiyyin Akib nuralifa, nuralifa Nuralifah Nuralifah, Nuralifah Nurcahyani, Fitria Nurhasana, N Nurramadhani A. Sida Nurrokhmadhani, Wa Ode Sitti Olyvia, Ocha Omir, Sri Wahyuli Astian Pascayantri, Asniar Priarti, Linda Putri, Annisa A. Putri, Natalia Christiani Putri, Suci Rahmawati Ridwan, Harnina Rudiah Rudiah Ruslin, R Ruslin, Ruslin Ruslin, Ruslin Sabarudin Sabarudin Sahidin Sahidin . Saputra, L. Yusril Wira Saputri, Ulan Mulyani Setyanto Tri Wahyudi Siswahyudianto Solo, Dian Munasari Srimuliana Sudiarto Sunandar Ihsan, Sunandar Suryani Suryani Sutrisna, Rahmad Trisnawati, Ayu wahyuni wahyuni Widodo Dwi Putro Wu, Chun Yamin, Y Yamin, Yamin Yodha, Agung Wibawa Mahatva Yuniansari, Rizki Zubair, Muhammad S.