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All Journal Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Mandala Pharmacon Indonesia Science Midwifery Jurnal Kompilasi Hukum Narra J Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Jurnal Risalah Kenotariatan Jurnal Farmasi Sains dan Praktis Molekul: Jurnal Ilmiah Kimia Media Farmasi
Arba, Muhammad
Faculty of Pharmacy, Halu Oleo University, Kendari, 93231
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Pemodelan Farmakofor untuk Identifikasi Inhibitor Heat Shock Proteins-90 (HSP-90): Pharmacophore Modeling to Identify Heat Shock Proteins-9 (HSP-90) Inhibitors Arba, Muhammad; Arfan; Trisnawati, Ayu; Kurniawati, Desi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15036

Abstract

Heat shock proteins-90 (HSP-90) is a protein that plays an important role in the life cycle of normal and cancer cells for their self protection from thermal stress, oxidative damage, and cell hypoxia. Inhibition of HSP90 is one way to suppress the growth of cancer cells. In this study, pharmacophore modeling and molecular docking were conducted to identify hit compounds as inhibitors of HSP-90. The pharmacophore feature consists of three hydrogen bond acceptors, one hydrogen bond donor and one hydrophobic feature with Area Under Curve of Receiver Operating Characteristics (AUCROC) is 0.5 and the Goodness of Hit (GH) value is 0.752. Screening in the ZINC database generated 1,500 hit compounds, were subjected to molecular docking to determine their binding energy and interactions with HSP-90. The range of binding energy (E) of all hit compounds is -5.68 to -12.24 kcal/mol and there are four best hit compounds namely lig_543, lig_527, lig_1337 and lig_337, when compared to native ligands (PU2, E=-8.25 kkal/mol) based on the binding energy and orientation, which indicate their potential as new HSP-90 inhibitors.
PHYSICOCHEMICAL CHARACTERISTICS AND PHARMACOLOGICAL ACTIVITY OF SACHA INCHI SEED OIL (Plukenetia volubilis L.): A LITERATURE REVIEW Saputri, Ulan Mulyani; Irnawati, Irnawati; Sahidin, Sahidin; Arba, Muhammad; Fristiohady, Adryan
Jurnal Farmasi Sains dan Praktis Vol 11 No 3 (September-December 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i3.12719

Abstract

Sacha inchi (Plukenetia volubilis L.) of the family Euphorbiaceae is native to Peruvian in the Amazon forest. SaIn seeds are known to contain a significant fatty acid such as linolenic acid (Omega-3), linoleic acid (Omega-6), and oleic acid (Omega-9). Several studies have shown the benefits of Sacha inchi (SaIn) for various pharmacological activities based on its compound content. The aim of this review article is to provide information about pharmacological activities and describe the physicochemical characteristics of SaIn seed oil. The method used to make this article review is a literature study gathered from national and international journals published in the last ten years through Google Scholar, NCBI-Pubmed, and Crossref with search keys in the form "Plukenetia volubilis L.", "Sacha inchi", "pharmacological activity of Sacha inchi", "physicochemical characteristics of Sacha inchi". Based on the literature review, it was found that the physicochemical characteristics of SaIn seed oil with the observed parameters of peroxide value, iodine number, saponification number and acid number showed different values depending on the extraction method used. SaIn has pharmacological activities as antioxidant, anticancer, antidiabetic, antiobesity, anticonvulsant, anti-aging, antihyperlipidemia, antibacterial and potential for alzheimer therapy.
Co-Authors Agustiana, Agustiana Ahmad Najib Arfan Arfan Arfan Ari Sartinah, Ari Asbah, Asbah Ayu Wulandari Bahar, Muhammad A. Candrayanti, Gusti Ayu Made Darmin, Wa Ode Yentri Putia Ningtiyas Desi Kurniawati Djumardin, Djumardin Filmaharani, Filmaharani Firzan Nainu Fitrawan, La Ode Muhammad Fristiohady, Adryan Habibie Habibie Hamzah, Any Suryani Irnawati Irnawati Jabbar, Asriullah Kuncoro, Shienny L, Adryan Fristiohady. La Aba Latada, Nadila P. Mallarangeng, Andi Nafisah Tendri Adjeng Mudjahid, Mukarram Muhammad Jefriyanto B Nur Illiyyin Akib nuralifa, nuralifa Nuralifah Nuralifah, Nuralifah Nurcahyani, Fitria Nurhasana, N Nurrokhmadhani, Wa Ode Sitti Pascayantri, Asniar Priarti, Linda Putri, Annisa A. Putri, Natalia Christiani Putri, Suci Rahmawati Ridwan, Harnina Rudiah Rudiah Ruslin, R Ruslin, Ruslin Ruslin, Ruslin Sabarudin Sabarudin Sahidin . Saputra, L. Yusril Wira Saputri, Ulan Mulyani Setyanto Tri Wahyudi Solo, Dian Munasari Sudiarto Sunandar Ihsan, Sunandar Suryani Suryani Sutrisna, Rahmad Trisnawati, Ayu wahyuni wahyuni Widodo Dwi Putro Wu, Chun Yamin, Y Yamin, Yamin Yodha, Agung Wibawa Mahatva Yuniansari, Rizki Zubair, Muhammad S.