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Denny Satria, Denny
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Journal : International Journal Of Science, Technology

 1 
Immunomodulator Activity Test of Curucuminoid Extract Derived from Turmeric Rhizome (Curcuma domestica Val.) In VCO On Rats Injected with Staphylococcus aureus Against an Increase in The Concentration of Leucocyte and Its Components. Pratiwi, Indah; Yuandani; Putra, Effendy De Lux; Satria, Denny
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.905

Abstract

One of the medicinal Zingiberaceae plants which is regularly used by the society as a traditional remedy is turmeric rhizome. The pharmacological properties of turmeric rhizome include anti-inflammatory, anti-immunodeficiency, anti-viral. Anti-bacterial, anti-fungal, anti-oxidant, anti-carcinogenic, and anti-infectious. This study aimed to identify the immunomodulator activity of curcuminoid extract of turmeric rhizome against the increase of leucocyte and its components, lymphocyte and neutrophil in white Galur Wistar rats that had been injected with Staphylococcus aureus. These test animals were given curcuminoid extract in VCO 100 mg/ml on a dosage of 1 ml, 0,5 ml, 0,25 ml curcuminoid powder 200 mg/kg body weight. Curcuminoid was suspended in Na CMC0,5%, Levamisole 25 mg/kg of body weight suspended in Na CMC 0,5%, VCO 1 ml. For the negative control, merely Na CMC 0,5% was given. The extract was orally given daily for 14 days. On the 4th day, Staphylococcus aureus was injected intra-peritoneally. The rats’ blood was then drawn from the heart and was observed to calculate the volume of the leucocytes, lymphocyte, and neutrophil which was conducted using flow cytometry.The findings suggested that there was a significant difference between the immunomodulatory activity of the curcuminoid extract in VCO at the doses of 1 ml, 0,5 ml, 0,25 ml on the increase in leucocyte, lymphocyte, and neutrophil compared to that of the negative control.Therefore, the findings of this study indicated that the extracts of curcuminoid in VCO could increase the number of leucocytes, lymphocytes, and neutrophils. Thus, the curcuminoid extract of turmeric rhizome in VCO potentially possessed immunomodulatory activity.
Toxic Effect Of The Compound {1,3 Bis (P-Hydroxyphenyl) Urea} On Triiodothyronine (T3) Hormone Levels In Pregnant White Rats (Rattus Norvegicus L.) Putri Aisyia Fauzi, Ziza; Harahap, Urip; Yuandani, Yuandani; Berkat Waruwu, Syukur; Purnomo, Hari; Satria, Denny
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.719

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs for pregnant women to treat fever, pain and inflammation. Specific NSAIDs can displace thyroid hormone from its protein binding sites, causing thyroid hormone measurement problems. {1,3 bis (p-Hydroxyphenyl)urea} is a modified p-aminophenol compound with potent analgesic and anti-inflammatory activity and less toxicity. This study is a follow-up to previous research to observe the toxic effect on triiodothyronine hormone levels after administration of {1,3 bis(p-Hydroxyphenyl)urea} compound in pregnant white rats. The toxic effect test was carried out by giving the test preparation to pregnant rats, which had been divided into five groups, namely the normal control group (CMC-Na 0.5%), the positive control (Gabapentin 50 mg/kg BW), Compound {1.3 bis (p- Hydroxyphenyl)urea} at a dose of 50 mg/kg BW, 500 mg/kg BW and 1000 mg/kg BW. Mice were given the test preparation every day from the 6th to the 15th day of pregnancy. Blood was taken on the 16th day, and T3 hormone levels were measured using the ELISA method. The results showed that the T3 hormone levels in the {1,3 bis(p-Hydroxyphenyl)urea group had no significant difference from the normal control group, so it was concluded that {1,3 bis(p-Hydroxyphenyl)urea) did not have a significant effect on the hormone T3.
Immunostimulant Effect Test Of Curcuminoid Extract From Turmeric Rhizome (Curcuma Domestica Val.) In VCO On Rats Induced Cyclophosphamide Againts An Increasing Total Leukocytes And Leukocyte Differential Damayanti, Damayanti; Yuandani, Yuandani; Satria, Denny
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.852

Abstract

Turmeric (Curcuma domestica Val.) is a traditional Indonesian plant that has many benefits. Curcuminoids are turmeric compounds known to have effects as immunomodulators and have been proven in several in vivo tests. Immunosuppressive drugs such as cyclophosphamide are widely given to improve clinical symptoms in autoimmune patients and cancer treatment which can cause susceptibility to infection.Therefore,this study aimed to determine the immunostimulating effect of curcuminoid extract from turmeric rhizome on cyclophosphamide-induced white rats. Proof of the immunostimulating effect of curcuminoid extracts was by testing the total leukocytes and leukocytesdifferential. The test results showed that curcuminoid extracts of 1 mL, 0.5 mL, and 0.25 mL increased total leukocytes and leukocyte differential (lymphocytes, neutrophils, monocytes, basophils, eosinophils) with a significant difference (p<0.05) to the Na group CMC 0.5% as a negative control. Therefore, curcuminoid extract had the potential to have an effect as an immunostimulant. The test results showed that curcuminoid extracts of 1 mL, 0.5 mL, and 0.25 mL increased total leukocytes and leukocyte differential (lymphocytes, neutrophils, monocytes, basophils, eosinophils) with a significant difference (p<0.05) to the Na group CMC 0.5% as a negative control. Therefore, curcuminoid extract had the potential to have an effect as an immunostimulant.
Co-Authors Amalia, Martina Aminah Dalimunthe Aminah Dalimunthe Berkat Waruwu, Syukur Brahmana, Nettietalia Br Budi Budi Damayanti Damayanti Diana Sofia Hanafiah Dohude, Gostry Aldica Effendy De Lux Putra, Effendy De Lux Eka Nugraha, Sony Estefania, Kaban Vera Hafid Syahputra Harahap, Nurul Izzatunna Jhirah HARI PURNOMO Hari Purnomo4 Haro, Ginda Hasibuan, Poppy Anjelisa Zaitun Indah Pratiwi Jansen Silalahi Lisda Rimayanti Nasution Lubis, Arga Lubis, Meiva Amelia lubis, muhammad fauzan Manuppak Irianto, Manuppak Irianto Manurung, Kesaktian Melasari, Wulan Panduwi Muhammad Wahyu, Muhammad Munthe, Alfian Rejekinta Nasri Nasri, Nasri Octora, Debi Dinha Olivia Avriyanti Hanafiah Pitu Wulandari Putri, Maharani Syahnia Rifda Amaliya Ma’ruf Rosidah Rosidah Rosidah Rosidah, R Ruth Christiani N Daely Said Aldi Palevi Simanjuntak, Rio Siregar, Nina Ashariani Siti Bahirrah Siti Morin Sinaga Sitorus, Binsar Sitorus, Panal Sumaiyah, Sumaiyah Syukur Berkat Waruwu Tarigan, Yenni Gustiani Taruli Rohana Sinaga Urip Harahap Vadhila, Mumtaz Waruwu, Syukur Berkat Widjaja, Sri Suryani Yanti Yemima Yuandani Yuandani, Y Yuwanda, Cindy Ziza Putri Aisyia Fauzi Zuhairiah Nasution, Zuhairiah