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Journal : Universa Medicina

Comprehensive analysis of the role of NLRC5 in gastrointestinal cancer: a systematic review Rahadiani, Nur; Ghozali, Mohammad; Dewi, Dyah Laksmi
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.229-239

Abstract

BackgroundGastrointestinal (GI) cancer is affecting millions of people globally, leading to high incidence and mortality rates and a heavy economic burden. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are a family of cytosolic pattern recognition receptors that regulate host defense responses against microorganisms. Among these, NLR family CARD domain-containing 5 (NLRC5) is assumed to function as a regulator of proinflammatory responses to intracellular pathogens. NLRC5 has been known to regulate immune responses, although its association with cancer remains controversial. This systematic review aimed to explore the roles and functions of NLRC5 in GI cancers. MethodsThree electronic databases, PubMed, Scopus, and ProQuest, were used for literature searching on March 18, 2024. From 921 articles found, 157 duplicates were removed, 671 were excluded based on title and abstract screening, and 84 were excluded based on full-text assessment, resulting in 19 articles included in this review. ResultsElevated NLRC5 levels have been observed in tumor tissues compared to normal tissues across esophageal, gastric, colorectal, and liver cancers. NLRC5 is also associated with increased tumor cell proliferation, migration, and invasion. Cancer cell sensitivity to 5-fluorouracil chemotherapy was found to be negatively correlated with NLRC5 expression. NLRC5 expression levels and genetic variations were also associated with cancer susceptibility to chemotherapeutic drugs and cancer survival. ConclusionNLRC5 potentially exhibits diverse functions in GI cancers, acting as a biomarker for diagnosis, disease progression, prognostic assessment, and determining therapeutic implications. Further investigations are warranted to explore these mechanisms and their potentials for the development of effective treatment of GI cancers.
Co-Authors 'Athifa, Rofifa Dhia A.A. Ketut Agung Cahyawan W ABDUL AZIZ, MUHAMMAD Abdul Hafidz Bin Zaid Adhi Sunjaya, Al Farizi Afifah, Amatullah Nur Agnes Rengga Indrati Ahmad Yasin, Ahmad Aini, Yulia Hayatul Akbar, Rohul Amaylia Oehadian Andy Kurniawan, Andy Anggraeni, Neni Annas, Muhamad Arief Boediono Azmi, Muhammad Ulul Bashari, Muhammad H. Candrakusuma, Mushlih Damayanti, Luthfiyah Devid Frastiawan Amir Sup Dewantara, Affrizal Berryl Dwi Wahyudha Wira Dyah Laksmi Dewi Effendi, Ahmat Muzaeni Arif Eko Fuji Ariyanto Fedro, Alfarid Gaga Irawan Nugraha Haerul Akmal Hanifah, Cenia P. Harira, Auna Hasanuddin Yusuf Adan Imam Kamaluddin Iman Nur Hidayat Inayati, Iis Irianto, Gunawan Jamilah, Adinda Muftiviany Nur jayanti, kurnia firmanda Kamri, Norazzah Binti Khafid, M. Ali Zi khoirunnisa, ria khoirunnisa, ria Khristian, Erick Khusniati Rofiah Kusumastuti, Annisa Silvi Laniyati Hamijoyo, Laniyati Lukman Hakim Mafaza, Syofi Aruni Mas Rizky A.A. Syamsunarno Modjaningrat, Ismiana Fatimah Muhammad Irkham Firdaus Mulyono Jamal Nadjwa Zamalek Dalimoenthe Nasyiruddin, Ahmad Zakky Praptama, Suhendra Prastyaningsih, Ika Purnama, Jeri N. Putra, Yoanda Syah putri alyumnah, putri Rachmawati, Andini Rahadiani, Nur Ramdan Panigoro Rangga Setiawan Ratu Safitri Reyhan, Muhammad Rini Widyastuti Rohman, Muchamad Zainur Safitri, Aiza Rahma Sahid, Mualimin Mochammad Sahputra, Jaya Saipul Nasution Sari, Tryas Titi Setiawan Bin Lahuri Siti Nur Fatimah Sonny Zulhuda Sulistiyorini, Ifa Sumirat, Vanessa A. Syamsunarno, Mas Rizky A. A. Syamsunarno, Mas Rizky A.A Syamsuri Syauqoti, Roifatus TAKDIR SAILI Tamliqon, Muhammad Ulfa, Badria Nur Lailina Winangun, Kikin Zahro’, Khurun’in Zatadini, Nabila