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Journal : Pharmacology and Clinical Pharmacy Research

FABP4 and Metabolite Profile in Lipopolysaccharide-Induced Mice Model Treated with Moringa oleifera Ethanol Leaf Extract Hanifah, Cenia P.; Sulistiyorini, Ifa; Sumirat, Vanessa A.; Anggraeni, Neni; Putri, Mirasari; Ghozali, Mohammad; Syamsunarno, Mas Rizky A.A
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.50860

Abstract

Sepsis, a life-threatening organ dysfunction resulting from a dysregulated host response to infection, induces changes in blood cells and metabolic alterations. Fatty acid binding protein 4 (FABP4), a lipid chaperone predominantly expressed in adipose tissue, is modulated in sepsis and may contribute to metabolic and immunologic changes. Moringa oleifera (M. oleifera) leaf extract (MOLE) is known to modulate immune system activity, but its potential for treating acute inflammatory conditions like sepsis remains unclear. This study investigates the ability of MOLE to modulate metabolite and hematological profiles in lipopolysaccharide (LPS)-induced sepsis in mice. Thirty-five male Swiss Webster mice (Mus musculus) were divided into five groups, including healthy control pre-treated with 0.5% carboxymethyl cellulose (CMC), an LPS-induced negative control, an LPS-induced positive control treated with dexamethasone (DMX) 7mg/KgBW/day and two MOLE treatment groups with doses of 5.6 and 11.2 mg/20 gBW. Mice received MOLE pre-treatment for three days before LPS induction. Three hours post-LPS injection, the LPS-induced group exhibited leukopenia (1.4 [0.9-2.5] x109 cells/L) and a 68.3% increase in triglyceride levels. However, the MOLE-treated group showed improved erythrocyte levels compared to the positive control group; [(9.9(9.3-10.0) x1012 cell/L) vs (7.7(7.0-9.0) x1012 cells/L), p<0.05]. The study suggests that MOLE administration may positively impact sepsis conditions, particularly by enhancing RBC levels. Further research with an extended observation period is recommended to address limitations in metabolite level assessment.  
Co-Authors 'Athifa, Rofifa Dhia A.A. Ketut Agung Cahyawan W ABDUL AZIZ, MUHAMMAD Abdul Hafidz Bin Zaid Adhi Sunjaya, Al Farizi Afifah, Amatullah Nur Agnes Rengga Indrati Ahmad Yasin, Ahmad Aini, Yulia Hayatul Akbar, Rohul Amaylia Oehadian Andy Kurniawan, Andy Anggraeni, Neni Annas, Muhamad Arief Boediono Azmi, Muhammad Ulul Bashari, Muhammad H. Candrakusuma, Mushlih Damayanti, Luthfiyah Devid Frastiawan Amir Sup Dewantara, Affrizal Berryl Dwi Wahyudha Wira Dyah Laksmi Dewi Effendi, Ahmat Muzaeni Arif Eko Fuji Ariyanto Fedro, Alfarid Gaga Irawan Nugraha Haerul Akmal Hanifah, Cenia P. Harira, Auna Hasanuddin Yusuf Adan Imam Kamaluddin Iman Nur Hidayat Inayati, Iis Irianto, Gunawan Jamilah, Adinda Muftiviany Nur jayanti, kurnia firmanda Kamri, Norazzah Binti Khafid, M. Ali Zi khoirunnisa, ria khoirunnisa, ria Khristian, Erick Khusniati Rofiah Kusumastuti, Annisa Silvi Laniyati Hamijoyo, Laniyati Lukman Hakim Mafaza, Syofi Aruni Mas Rizky A.A. Syamsunarno Modjaningrat, Ismiana Fatimah Muhammad Irkham Firdaus Mulyono Jamal Nadjwa Zamalek Dalimoenthe Nasyiruddin, Ahmad Zakky Praptama, Suhendra Prastyaningsih, Ika Purnama, Jeri N. Putra, Yoanda Syah putri alyumnah, putri Rachmawati, Andini Rahadiani, Nur Ramdan Panigoro Rangga Setiawan Ratu Safitri Reyhan, Muhammad Rini Widyastuti Rohman, Muchamad Zainur Safitri, Aiza Rahma Sahid, Mualimin Mochammad Sahputra, Jaya Saipul Nasution Sari, Tryas Titi Setiawan Bin Lahuri Siti Nur Fatimah Sonny Zulhuda Sulistiyorini, Ifa Sumirat, Vanessa A. Syamsunarno, Mas Rizky A. A. Syamsunarno, Mas Rizky A.A Syamsuri Syauqoti, Roifatus TAKDIR SAILI Tamliqon, Muhammad Ulfa, Badria Nur Lailina Winangun, Kikin Zahro’, Khurun’in Zatadini, Nabila