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Journal : Narra J

Intravenous administration of iron dextran as a potential inducer for hemochromatosis: Development of an iron overload animal model Khristian, Erick; Ghozali, Mohammad; Bashari, Muhammad H.; Purnama, Jeri N.; Irianto, Gunawan; Panigoro, Ramdan; Safitri, Ratu
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1003

Abstract

Iron overload in transfusion-dependent thalassemia patients represents a significant public health challenge due to its high mortality rate and risks of severe complications. Therefore, developing safe and effective therapeutic modalities for managing iron overload is critical, as current animal models inadequately replicate human conditions. The aim of this study was to investigate the effects of intravenous iron dextran on hepatocyte morphology, liver iron concentration, and serum iron profile changes as a model for hemochromatosis. An experimental design with a post-test-only control group method was conducted using animal models. Fifty rats were used and divided into ten groups, nine received different intravenous doses of iron dextran: 10, 20, 30, 40, 50, 60, 80, 100, and 120 mg/kg body weight (BW) and a control group received no treatment. The results showed that intravenous iron dextran starting at a dose of 10 mg/kg BW caused significant changes in liver iron concentration while starting at 20 mg/kg BW significantly affected hepatocyte morphology, transferrin levels, unsaturated iron binding capacity, serum iron levels, and transferrin saturation. Intravenous iron dextran starting at 40 mg/kg BW resulted significant changes in the level of total iron binding capacity compared to control group. In conclusion, intravenous iron dextran significantly altered hepatocyte morphology, increased liver iron concentration, and modified the serum iron profile, reflecting changes that might be observed in patients with transfusion-dependent thalassemia.
Co-Authors 'Athifa, Rofifa Dhia A.A. Ketut Agung Cahyawan W ABDUL AZIZ, MUHAMMAD Abdul Hafidz Bin Zaid Adhi Sunjaya, Al Farizi Afifah, Amatullah Nur Agnes Rengga Indrati Ahmad Yasin, Ahmad Aini, Yulia Hayatul Akbar, Rohul Amaylia Oehadian Andy Kurniawan, Andy Anggraeni, Neni Annas, Muhamad Arief Boediono Azmi, Muhammad Ulul Bashari, Muhammad H. Candrakusuma, Mushlih Damayanti, Luthfiyah Devid Frastiawan Amir Sup Dewantara, Affrizal Berryl Dwi Wahyudha Wira Dyah Laksmi Dewi Effendi, Ahmat Muzaeni Arif Eko Fuji Ariyanto Fedro, Alfarid Gaga Irawan Nugraha Haerul Akmal Hanifah, Cenia P. Harira, Auna Hasanuddin Yusuf Adan Imam Kamaluddin Iman Nur Hidayat Inayati, Iis Irianto, Gunawan Jamilah, Adinda Muftiviany Nur jayanti, kurnia firmanda Kamri, Norazzah Binti Khafid, M. Ali Zi khoirunnisa, ria khoirunnisa, ria Khristian, Erick Khusniati Rofiah Kusumastuti, Annisa Silvi Laniyati Hamijoyo, Laniyati Lukman Hakim Mafaza, Syofi Aruni Mas Rizky A.A. Syamsunarno Modjaningrat, Ismiana Fatimah Muhammad Irkham Firdaus Mulyono Jamal Nadjwa Zamalek Dalimoenthe Nasyiruddin, Ahmad Zakky Praptama, Suhendra Prastyaningsih, Ika Purnama, Jeri N. Putra, Yoanda Syah putri alyumnah, putri Rachmawati, Andini Rahadiani, Nur Ramdan Panigoro Rangga Setiawan Ratu Safitri Reyhan, Muhammad Rini Widyastuti Rohman, Muchamad Zainur Safitri, Aiza Rahma Sahid, Mualimin Mochammad Sahputra, Jaya Saipul Nasution Sari, Tryas Titi Setiawan Bin Lahuri Siti Nur Fatimah Sonny Zulhuda Sulistiyorini, Ifa Sumirat, Vanessa A. Syamsunarno, Mas Rizky A. A. Syamsunarno, Mas Rizky A.A Syamsuri Syauqoti, Roifatus TAKDIR SAILI Tamliqon, Muhammad Ulfa, Badria Nur Lailina Winangun, Kikin Zahro’, Khurun’in Zatadini, Nabila