Claim Missing Document
Check
Articles

Found 31 Documents
Search

Literature review: treatment design to overcome anticancer drug resistance Udin, Baha; Yusransyah, Yusransyah; Stiani, Sofi Nurmay; Rizkiana, Muhammad Dinta
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1573

Abstract

One of the main causes of death in the world today is cancer. Chemotherapy is one treatment that cancer patients may utilize. Anticancer medication resistance, which might forecast a rise in treatment failure rates among cancer patients, poses a challenge to the current use of anticancer treatments. Numerous investigators have studied potential approaches to combat anti-cancer medication resistance. The purpose of this literature review is to provide information on treatment planning that can be applied to counteract anti-cancer medication resistance. Cancer is one of the leading causes of death in the modern world. One therapeutic option available to cancer patients is chemotherapy. The current usage of anticancer medicines is challenged by anticancer medication resistance, which may predict an increase in treatment failure rates among cancer patients. Many researchers have looked into possible strategies to fight drug resistance to anti-cancer medications. This review of the literature aims to give information on treatment planning that can be used to combat drug resistance to anti-cancer medications.
The Effect of Directly Observed Treatment Strategy on Cost Utility of Pulmonary Tuberculosis Patients at Banten Regional Public Hospital Udin, Baha; Yusransyah, Yusransyah; Saepudin, Saepudin
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.8601

Abstract

Pulmonary tuberculosis (TB) is one of the communicable diseases with high prevalence in some provinces in Indonesia, including the Province of Banten. Considering its high prevalence and the high cost of treatment resulting from multiple treatment components, research on the analysis of treatment costs of TB is very important. This study aimed to determine the effect of implementing the directly observed treatment (DOT) strategy on the cost-utility of pulmonary TB patients. The study was conducted at Banten Regional General Hospital using the perspective of the health provider and patients by involving 24 TB patients. Treatment cost was calculated by including direct medical costs, direct non-medical costs, and indirect costs, and then categorized into initial and final cost-utility. The average cost-effectiveness ratio (ACER) was then calculated by setting the patient's quality of life as the clinical outcome in this study. This study found that the average value of the average cost-utility ratio (ACUR) for the initial cost-utility and the final cost-utility were IDR 2,682,343.53 and IDR 2,402,153.15, respectively, and the difference was statistically significant (p=0.006). It indicates that the DOT strategy can potentially improve the utility costs of the treatment of TB patients at Banten Regional Hospital.
EVALUASI IMPLEMENTASI PELAYANAN KEFARMASIAN PADA PUSKESMAS DI KABUPATEN PANDEGLANG TAHUN 2024 Yusransyah, Yusransyah; Stiani, Sofi Nurmay; Nasiti, Febriane Dwi; Kelutur, Faruk Jayanto; Udin, Baha
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2389

Abstract

Pharmaceutical services are considered by some observers to be below standard. Both pharmacists and pharmaceutical technicians as health technicians are required to improve their skills, knowledge and behavior in order to provide quality direct services to patients. The purpose of this study was to determine the implementation of pharmaceutical services at Health Centers in Pandeglang Regency in 2023. This study is an observational study with a case study design. The method used is descriptive using checklist sheets and open statements. Based on the results of this study, there are significant differences in the aspects of facilities and infrastructure and clinical pharmacy services and there are differences but not significant in the aspects of managing pharmaceutical preparations and disposable medical materials. The conclusion of this study is that pharmaceutical services at Health Centers in Pandeglang Regency are in accordance with Permenkes No. 74 of 2016 by obtaining a percentage value of 79%, entering the GOOD category.
ANALISIS EFEKTIVITAS BIAYA PASIEN COVID-19 MENGGUNAKAN TERAPI OKSIGEN DAN REMDESIVIR DI RSUD KABUPATEN TANGERANG Yusransyah, Yusransyah; Udin, Baha; Abdillah , Mursyid; Murdianto, Yudi; Soraya Uli, Elisabeth; Suryana, Nana
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (419.714 KB) | DOI: 10.35617/jfionline.v14i1.75

Abstract

COVID-19 is a contagious disease, so there is a potential for an increase in the number of COVID-19 cases. If there is an increase in incidence or prevalence, it will cause problems related to the costs and outcomes of an intervention. Therefore, a cost-effectiveness analysis is needed. This study aims to determine the cost-effectiveness of COVID-19 patients who use oxygen therapy with and without being given remdesivir. This study uses a cost-effectiveness analysis method that takes into account the ACER (Average Cost-Effectiveness Ratio) and ICER (Incremental Cost-Effectiveness Ratio) values. The data used is retrospective data and sampling is done by purposive sampling, the sample obtained in this study amounted to 34 cases. The results of this study showed that the total average direct medical costs of the remdesivir group were Rp. 32,399,532 with an effectiveness of 47%, while in the non-remdesivir group the total average direct medical costs were Rp. 26,853,729 with an effectiveness of 41%. The ACER value obtained in this study was Rp. 688,490 in the remdesivir group and Rp. 654,969 in the non-remdesivir group. The results of the ICER calculation in this study were Rp. 924,301 per day of hospitalization. In this study, it can be concluded that the therapy group of COVID-19 patients who use oxygen therapy without being given remdesivir is more cost-effective than the therapy group of COVID-19 patients who use oxygen therapy with remdesivir.
Peran Apoteker dalam Kepatuhan Penggunaan Tablet Tambah Darah untuk Pencegahan Stunting pada Siswi Pelita Cibitung Yusransyah, Yusransyah; Alfarizqi, Asep Salman; Sudarto, Teguh; Kholifah, Eva; Stiani, Sofi Nurmay; Udin, Baha
Jurnal IPTEK Bagi Masyarakat Vol 4 No 3 (2025)
Publisher : Ali Institute of Research and Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55537/j-ibm.v4i3.1114

Abstract

Anemia in adolescent girls is a significant health issue in Indonesia, with high prevalence and long-term impacts on reproductive health, as well as an increased risk of stunting in their offspring. The Iron Supplementation (TTD) program has been initiated by the government as a stunting prevention effort, yet adherence to TTD consumption among adolescent girls remains low. The role of pharmacists as educators and facilitators in public health programs is crucial in improving TTD consumption adherence. This community service aims to improve adherence to TTD consumption as a stunting prevention measure among female vocational school students through the Anti-Stunting Movement Program at Pelita Cibitung Vocational School in 2024. Activities conducted include interactive education on stunting, anemia, and the importance of TTD consumption, as well as monitoring and evaluating TTD consumption adherence. Evaluation was performed using the Medication Adherence Report Scale (MARS) questionnaire. The evaluation results showed an increase in TTD consumption adherence after education and monitoring through WhatsApp Group. This demonstrates that the active involvement of pharmacists in education and monitoring can improve adherence to TTD consumption in adolescent girls.
Effectiveness of TB-Reminder Application in Improving Medication Adherence and Quality of Life of Lung Tuberculosis Patients in Indonesia Yusransyah, Yusransyah; Stiani, Sofi Nurmay; Chairani, Farahdina; Adini, Syilvi; Subchan, Mohamad; Ferdiyansyah, Ferdiyansyah; Putri, Nabila Septiani; Pratiwi, Rossi; Udin, Baha
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403358

Abstract

Poor adherence to anti-tuberculosis (TB) treatment continues to hinder therapeutic success and patient quality of life. This study aimed to evaluate the effectiveness of the TB-R mobile application in improving medication adherence and quality of life among pulmonary TB patients at Pandeglang Regional Hospital. Eighty-six patients were randomized into intervention (n = 43) and control (n = 43) groups. Adherence and quality of life were measured using the Medication Adherence Rating Scale (MARS) and EQ-5D-5L, respectively. After one month, the intervention group demonstrated significantly higher adherence (97.7% vs. 79.0%, p < 0.001) and improvement in mean MARS scores (24.7 vs. 22.7, p < 0.001). Although quality of life gains were not statistically significant overall, notable improvements were observed in anxiety/depression and self-care domains. Demographic factors influenced outcomes: patients aged 29–39 and those living with others showed better adherence, while patients aged 40–50 experienced greater quality of life gains. Women aged 51–60 living alone had decreased adherence despite quality of life improvements. These results suggest that mHealth tools like TB-R can enhance adherence, especially when supported by favorable social and demographic conditions. Tailored digital interventions may optimize treatment outcomes in TB care. Future mHealth app development should consider these social and demographic factors to maximize effectiveness and user engagement.
Cost-Effectiveness of Oseltamivir and Favipiravir in Covid-19 Patients: a Cost-Effectiveness Analysis Study in a Hospital Yusransyah, Yusransyah; S.farm, Baha Udin
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.29-35.2025

Abstract

The COVID-19 pandemic poses not only a threat to health but also to the global economy, including healthcare costs. Although there is no specific drug for COVID-19 patients, there are antiviral drugs such as oseltamivir and favipiravir that can be used to treat COVID-19. The purpose of this study was to determine the most cost-effective antiviral therapy between oseltamivir and favipiravir for COVID-19 patients in one of the hospitals in Banten province. The pharmacoeconomic method used in this study was cost-effectiveness analysis by calculating the Average Cost-Effectiveness Ratio (ACER) and Incremental Cost-Effectiveness Ratio (ICER). The results of this study showed that the ACER value of the favipiravir group (IDR  364,010 (n = 7)) was lower than the oseltamivir group (IDR 431,744 (n = 7)), with an ICER value of IDR  60,605. Based on the results of the Mann-Whitney test, there was no significant difference between the costs of the favipiravir and oseltamivir groups (p value 0.940). The sensitivity test showed that the cost of medical consumables was the cost that had the greatest impact on cost-effectiveness. Based on the calculation results, it can be concluded that the favipiravir group is more cost-effective than the oseltamivir group.
Pharmacoeconomic Analysis of Drugs Used in Chronic Outpatients at Berkah Pandeglang Regional Hospital Yusransyah, Yusransyah; Nurhikmah, Ihda; Maharani, Zahra Citra; Stiani, Sofi Nurmay; Shobah, Afifah Nur; Udin, Baha
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403343

Abstract

Hypertension and type 2 diabetes mellitus (T2DM) are chronic conditions requiring long-term pharmacotherapy, placing significant financial pressure on patients and healthcare systems. Drug selection should prioritize both clinical efficacy and cost-efficiency, particularly in resource-limited settings. This study conducted a pharmacoeconomic evaluation of commonly used therapies at RSUD Berkah Pandeglang using a retrospective, non-experimental design. Data were collected from 2023 outpatient records and analyzed from the hospital’s perspective. Cost-effectiveness was assessed using the Average Cost-Effectiveness Ratio (ACER). For hypertension, amlodipine (n=20) had a lower ACER (Rp 283,913) than candesartan (n=15; Rp 883,000), indicating higher cost-effectiveness. In T2DM patients, metformin (n=25) was more cost-effective (ACER: Rp 317,746.75) than glimepiride (n=25; ACER: Rp 607,148.84). These findings support prioritizing amlodipine and metformin as first-line treatments in similar public healthcare settings to improve therapeutic outcomes while managing costs.
Analisis biaya penggunaan analgetik sebagai terapi antinyeri pada pasien pasca bedah apendisitis di RSUD Aulia Pandeglang Yusransyah, Yusransyah; Stiani, Sofi Nurmay; Cahya, Wulan; Udin, Baha
Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Vol. 9 No. 1 (2025): Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan)
Publisher : Sekolah Tinggi Ilmu Kesehatan Holistik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51873/jhhs.v9i1.349

Abstract

Latar belakang: Penggunaan analgetik sebagai terapi antinyeri pada pasien pasca bedah apendisitis di rumah sakit memiliki peran yang signifikan dalam mendukung proses pemulihan pasien. Namun, seiring meningkatnya biaya perawatan kesehatan, penting bagi fasilitas kesehatan untuk mengoptimalkan penggunaan analgetik agar tetap efektif namun juga ekonomis. Minimisasi biaya penggunaan analgetik tanpa mengorbankan efektivitas terapi menjadi tantangan utama dalam memastikan pasien mendapatkan perawatan yang optimal. Tujuan penelitian: Penelitian ini bertujuan untuk menentukan penggunaan obat analgesik dengan biaya paling rendah pada pasien pasca operasi apendisitis di RSUD Aulia Pandeglang. Metode penelitian: Metode penelitian yang digunakan adalah pengambilan data secara retrospektif dengan menggunakan data sekunder berupa rekam medis dan rincian biaya pengobatan pasien pasca operasi apendisitis yang tersedia di rumah sakit. Hasil: Hasil penelitian menunjukkan bahwa rata-rata biaya total untuk analgetik Tramadol injeksi dengan lama pengobatan 3 hari adalah Rp. 2.893.400,00/pasien, Dexketoprofen oral dengan lama pengobatan 3 hari adalah Rp. 11.051.400,00/pasien, Ketorolac injeksi dengan lama pengobatan 9 hari adalah Rp. 27.067.531,00/pasien, Paracetamol oral dengan lama pengobatan 7 hari adalah Rp. 13.212.000,00/pasien, Asam Mefenamat oral dengan lama pengobatan 10 hari adalah Rp. 2.929.000,00/pasien, Natrium Diklofenak oral dengan lama pengobatan 3 hari adalah Rp. 10.929.052,00/pasien, Ibuprofen oral dengan lama pengobatan 5 hari adalah Rp. 3.957.000,00/pasien, dan Ketoprofen injeksi dengan lama pengobatan 6 hari adalah Rp. 13.239.000,00/pasien. Simpulan: Berdasarkan data tersebut, analgetik injeksi Tramadol memiliki biaya total rata-rata paling rendah dibandingkan dengan analgetik lainnya
Edukasi Efek Samping Obat dan Resiko Penggunaan Obat yang Salah di Pantiasuhan Hasanudin Pandeglang Stiani, Sofi Nurmay; Yusransyah, Yusransyah; Ernawati, Eneng Elda; Udin, Baha; US, Sumarlin; Fahlevy, Muhamad Ichsan; Junaedi, Candra; Noviyanto, Fajrin
Jurnal IPTEK Bagi Masyarakat Vol 5 No 1 (2025)
Publisher : Ali Institute of Research and Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55537/j-ibm.v5i1.1117

Abstract

Improper use of drugs can cause adverse side effects, especially among people with limited access to information such as people living in orphanages. This community service activity aims to increase the knowledge of residents of the Hasanudin Pandeglang Orphanage regarding the side effects of drugs and the risks of incorrect drug use through educational activities. The method used is health education accompanied by a question and answer discussion and pretest and posttest evaluation using a knowledge questionnaire. The questionnaire was designed to measure participants' understanding of the material presented before and after education. The number of participants in this activity was 57 participants. The evaluation results showed a significant increase in participants' knowledge scores after the education. This proves that this educational activity is effective in increasing awareness and understanding of the safe use of drugs. This activity is expected to be a model for similar health education in other orphanages to prevent irrational drug use.