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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Udayana Dinamisia: Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia Pharmacoscript Jurnal Farmamedika (Pharmamedica Journal) Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Journal of Experimental and Clinical Pharmacy (JECP) Jurnal IPTEK Bagi Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Ilmiah Bakti Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Sciences of Pharmacy Jurnal Pengabdian Pada Masyarakat Jurnal Farmasi Indonesia Jurnal Ilmiah Kesehatan Delima Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika
Baha Udin
Program Studi S1 Farmasi, Sekolah Tinggi Ilmu Kesehatan Salsabila Serang
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Effectiveness of Apigenin–Banana Stem (Musa paradisiaca) Combination Gel on Incised Wound Healing Stiani, Sofi Nurmay; Selviani, Astri; Chairani, Farahdina; Yusransyah, Yusransyah; Udin, Baha
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

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Abstract

Wound healing is a complex biological process involving inflammation, proliferation, and tissue remodeling. Delayed healing increases the risk of infection and other complications. Ambon banana stem (Musa acuminata) contains flavonoids, polyphenols, and tannins that support tissue regeneration, while apigenin exhibits anti-inflammatory and pro-regenerative activities. The combination of these two agents is expected to enhance wound repair. This study aimed to evaluate the effectiveness of a gel containing Ambon banana stem powder and apigenin in promoting wound healing in Sprague Dawley rats. A linear incision wound (1.5 cm × 2 mm) was created on the dorsal skin of anesthetized rats. Twenty-four male Sprague Dawley rats were divided into six groups (n = 4): untreated control (F0), negative control (gel base), positive control (Bioplacenton®), and three test formulations (F1: 5% banana stem + 10% apigenin; F2: 7.5% + 7.5%; F3: 10% + 5%). Wound length was measured daily for eight days using a digital caliper, and the percentage of wound closure was calculated. All combination gels significantly accelerated wound contraction compared with the negative control (p < 0.001). Formula F3 demonstrated the fastest healing, achieving complete closure on day 5 (1.50 ± 0.00 cm to 0.00 ± 0.00 cm), whereas the positive control reached 87.8 ± 0.15% closure by day 8. No significant differences were observed among the three test formulations. The accelerated healing is attributed to the synergistic effects of banana stem phytochemicals and apigenin. Overall, the combination gel effectively promotes wound healing and shows potential as a natural-based topical therapeutic.
Co-Authors Abdillah , Mursyid Abdillah Mursyid Ade Anwar Adini, Syilvi Ai Yeni Herlinawati Alfarizqi, Asep Salman Anita Nugraheni, Diesty Ashari, Elva Febri Aulia, Ayu Cahya, Wulan Chairani, Farahdina Deya Adiby Nabillah Diesty Anita Nugraheni Endah Endah endah, endah Endang Safitri Ernawati, Eneng Elda Eva Kholifah Fahlevy, Muhamad Ichsan Fajrin Noviyanto, Fajrin Farahdina Chairani Farahdina, Chairani Fauzi, Andrian Maulana Ferdiyansyah, Ferdiyansyah Fifih Lutfiyah Fifih Lutfiyah Harpan, Andri Hasanah, Indah Ayu Nur Herawati, Fera Ismiyati, Renditya Junaedi, Candra Kelutur, Faruk Jayanto Kholifah, Eva Kurnia, Nia Marlina Latifah Nur, Rizki Leni Halimatusyadiah Maharani, Sylvianti Maharani, Zahra Citra Murdianto, Yudi Nana Suryana Nasiti, Febriane Dwi Nurani, Agnes Wieanita Nurhikmah, Ihda Nurul Fitri, Nabila Ofsah, Olin Najilah Oktaviana Hadi, Agriyaningsih Perdi, Perdi Pratiwi, Linda Rani Pratiwi, Rossi Putri, Nabila Septiani Renditya Ismiyati Ristiani, Yuanisa Rizkiana, Muhammad Dinta Rozwaliza Annintan Rustiyani, Risa Saepudin Saepudin Salsabillah, Audy Nursifa'atun Selviani, Astri Septina Sumantri, Aulia Shobah, Afifah Nur Siti Rhopi’ah Soraya Uli, Elisabeth Stiani, Sofi Nurmay Subchan, Mohamad Sudarto, Teguh US, Sumarlin Wibirezkina, Aufalya Yulistina, Isti Yuni Rahmawati Yusransyah, Yusransyah