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Putu Oky Ari Tania
Bagian Biomedik Penelitian Biomolekuler Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
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Journal : INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY

 1 
Liver Histopathological Change and Malondialdehyde Level of Rattus Norvegicus on Administration of Curcuma Zedoaria and Paracetamol Toxic Dose Putu Oky Ari Tania; Puja Ayu Misuari; Satya Yudhayana; Ketut Ayesha Edelwise Prayoga
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 3 No 1 (2021): Laboratory innovation : The challenge for medical laboratory
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v3i1.1927

Abstract

High doses of paracetamol create necrosis in the liver and produce free radicals. When liver function decreased in a long time, it will lead to severe liver damage and it will be irreversible. Rhizome of Curcuma zedoaria has the potential effect as an antioxidant, it is assumed that  its properties inhibit the formation of free radicals which formed from toxic doses of paracetamol. The aim of this study was to examine the histological structure of the liver and to determine MDA levels in the administration of C. zedoaria toxic dose and paracetamol on the Rattus norvegicus. The study was used twenty-four rats divided into four groups (positive control: CMC 0.5%; negative control: paracetamol 1.35g/kg body weight; treatment group 1 (T1): C. zedoaria 105 mg/200g and paracetamol 1.35g/kg Body weight 2 hours later, and treatment group 2 (T2): paracetamol 1.35g/ kg Body weight and C. zedoaria 105 mg/200g 2 hours later).  The Kruskall-Wallis test results showed MDA level did not significantly different between groups (p = 0.087). Hepatocellular changes were observed descriptively with Hematoxylin-eosin staining. Positive control showed greater hepatocellular changes rather than other groups, hepatocyte cells were enlarged with cytoplasm showing eosinophilic granules infiltrates, enlarged irregular nuclei, nucleolus prominent, there are many necrosis cells.
Co-Authors AFAF BAKTIR Agusniar Furkani Listyani Agusniar Furkani Setiyawati Ahista Saskirana Putri Ahnaf Farel Al Raihaan akhmad sudibya, akhmad Amirotul Khifana Andiani Andiani Andra Agnez Al Aska Athaya Azalia Yasirah Ayling Sanjaya Ayly Soekanto Azka, Andra Agnes Al Cahyadi, I Kadek Angga Dwi Candra Rini Hasanah Putri Candra Rini Hasanah Putri Colin, Muhammad Deddy Hartanto Dorta Simamora Emanuel, Endrayana Putut Laksminto Emilia Devi D. Rianti Emilia Devi Dwi Rianti Emilia Devi Dwi Rianti Emilia Devi Dwi Rianti Emillia Devi Dwi Rianti, Emillia Devi Dwi Enny Willianti, Enny Erlix R Purnama Erny Erny Erny Erny Fadilla Lutvi Aryanti Febtarini Rahmawati Febtarini Rahmawati Fuad Ama Furkani, Agusniar Hardiyono Hardiyono Hardiyono Hardiyono Hardiyono Hardiyono HARMAN AGUSAPUTRA Harsono Wiradinata Haru Setiawan I Kadek Putra Dwipayana I Made Subhawa Harsa Ibrahim Njoto, Ibrahim Inawati Inawati, Inawati Indra Firismanda Dermawan Kadek Adi Sudarmika Ketut Ayesha Edelwise Prayoga Listyawati, Agusniar Furkani Loo Hariyanto Raharjo, Loo Hariyanto Lusiani Tjandra Marcela Anindita Masfufatun Masfufatun Masfufatun Maverick Nathanael Adirangga Meivy Isnoviana Muhammad Collin Nadila, Sucia Ni Kadek Evita Vara Rosieana Ni Made Ayu Gea Niquita Noer Kumala Indahsari, Noer Kumala Nugraha, Wima Handika Nur Sri Wahyuni Olivia Rahayu Ramadhani Pramita Laksitarahmi Isrianto Puja Ayu Misuari Puja Ayu Misuari Putra, Wisnu Pratama Putut Laksminto Emanuel Rini Purbowati Sakri, Brian Manggala Satya Yudhayana Satya Yudhayana Sianny Suryawati, Sianny Sudarmika, Kadek Adi Sukma Sahadewa, Sukma Syeira Rigita Noptavia Theodora Theodora Titiek Sunaryati Titiek Sunaryati Titiek Sunaryati, Titiek Wahyuni Dyah Parmasari, Wahyuni Dyah