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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Brawijaya Althea Medical Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Biota Jurnal Florea Berkala Kedokteran BIOMA International Journal of Applied Biology Jurnal Ilmiah Kedokteran Wijaya Kusuma Briliant: Jurnal Riset dan Konseptual The Indonesian Journal of Infectious Diseases Care : Jurnal Ilmiah Ilmu Kesehatan Majalah Kedokteran Andalas INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Abdidas Eureka Herba Indonesia Journal of Community Development Jurnal Pengabdian Masyarakat Kedokteran Sinnun Maxillofacial Journal Stigma : Jurnal Matematika dan Ilmu Pengetahuan Alam Unipa JAPI: Jurnal Akses Pengabdian Indonesia Journal of Community Services Jurnal Pengabdian Masyarakat Prosiding Seminar Nasional Kusuma Prosiding Seminar Nasional COSMIC Kedokteran
Putu Oky Ari Tania
Bagian Biomedik Penelitian Biomolekuler Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
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Journal : Althea Medical Journal

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Expression Levels of Intestinal Toll-Like Receptors 2 and 4 in Acute Inflammation Caused by Intestinal Candidiasis: An Experimental Study in Wistar Rats Tania, Putu Oky Ari; Masfufatun, Masfufatun; Baktir, Afaf
Althea Medical Journal Vol 11, No 3 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n3.3345

Abstract

Background: Candida albicans grows in the gastrointestinal tract as a normal microflora that may cause intestinal candidiasis, characterized by formation of biofilm and inflammation. Candida is recognized by toll-like receptors (TLRs). This study aimed to explore the relationship between intestinal TLR 2 and TLR 4 expression levels in candidiasis at each phase of inflammation.Methods: An experimental study was performed using a simple randomized sampling on 30 male Wistar rats divided into a control and a treatment group. Each group was inoculated with Candida albicans. Dysbiosis conditions were designed in the treatment group using multiple antibiotics and on day 5 the rats were injected with subcutaneous cortisone acetate. The groups were terminated in five different times (days 7, 14, 21, 28 and 35). On the termination day, intestinal tissue was isolated and the TLR 2 and TLR 4 expression were analyzed by immunohistochemistry. The data were analyzed by parametric test with SPSS (p<0.05) and completed by post-hoc test Least Significance Difference (LSD) to compare pairs of groups.Results: The expression of TLR 2 and TLR 4 between control and treatment groups showed significant differences (p=0.005). In the treatment group, there was a gradual increase in the TLR2 and TLR 4 expressions.  Positive expression of TLR appeared more in the submucosal or basal area than apical surface. The treatment group showed the highest expression of both TLR2 (82.37%) and TLR4 (87.40%) on termination day 35.Conclusions: Inflammation caused by intestinal candidiasis can result in increased expression of intestinal TLR2 and 4 contributing to an increased risk of biofilm formation.
Co-Authors AFAF BAKTIR Agusniar Furkani Listyani Agusniar Furkani Setiyawati Ahista Saskirana Putri Ahnaf Farel Al Raihaan akhmad sudibya, akhmad Amirotul Khifana Andiani Andiani Andra Agnez Al Aska Athaya Azalia Yasirah Ayling Sanjaya Ayly Soekanto Azka, Andra Agnes Al Cahyadi, I Kadek Angga Dwi Candra Rini Hasanah Putri Candra Rini Hasanah Putri Colin, Muhammad Deddy Hartanto Dorta Simamora Emanuel, Endrayana Putut Laksminto Emilia Devi D. Rianti Emilia Devi Dwi Rianti Emilia Devi Dwi Rianti Emilia Devi Dwi Rianti Emillia Devi D.Rianti, Emillia Devi Enny Willianti, Enny Erlix R Purnama Erny Erny Erny Erny Fadilla Lutvi Aryanti Febtarini Rahmawati Febtarini Rahmawati Fuad Ama Furkani, Agusniar Hardiyono Hardiyono Hardiyono Hardiyono Hardiyono Hardiyono HARMAN AGUSAPUTRA Harsono Wiradinata Haru Setiawan I Kadek Putra Dwipayana I Made Subhawa Harsa Ibrahim Njoto, Ibrahim Inawati Inawati, Inawati Indra Firismanda Dermawan Kadek Adi Sudarmika Ketut Ayesha Edelwise Prayoga Listyawati, Agusniar Furkani Loo Hariyanto Raharjo, Loo Hariyanto Lusiani Tjandra Marcela Anindita Masfufatun Masfufatun Masfufatun Maverick Nathanael Adirangga Meivy Isnoviana Muhammad Collin Nadila, Sucia Ni Kadek Evita Vara Rosieana Ni Made Ayu Gea Niquita Noer Kumala Indahsari, Noer Kumala Nugraha, Wima Handika Nur Sri Wahyuni Olivia Rahayu Ramadhani Pramita Laksitarahmi Isrianto Puja Ayu Misuari Puja Ayu Misuari Putra, Wisnu Pratama Putut Laksminto Emanuel Rini Purbowati Sakri, Brian Manggala Satya Yudhayana Satya Yudhayana Sianny Suryawati, Sianny Sudarmika, Kadek Adi Sukma Sahadewa, Sukma Syeira Rigita Noptavia Theodora Theodora Titiek Sunaryati Titiek Sunaryati Titiek Sunaryati, Titiek Wahyuni Dyah Parmasari, Wahyuni Dyah Widjaja, Jimmy Hadi