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All Journal HAYATI Journal of Biosciences Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Science and Technology Indonesia Jurnal Pemberdayaan Masyarakat Madani (JPMM) Molecular and Cellular Biomedical Sciences (MCBS) Resona : Jurnal Ilmiah Pengabdian Masyarakat Dinamisia: Jurnal Pengabdian Kepada Masyarakat Journal of Islamic Medicine Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Abdimas Ilmiah Citra Bakti (JAICB) MAHESA : Malahayati Health Student Journal Pharmaceutical Sciences and Research (PSR) Journal Community Service Consortium Jurnal Farmasi Indonesia Journal of Food and Pharmaceutical Sciences
Marisca Evalina Gondokesumo, Marisca Evalina
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Anti‐inflammatory properties of conditioned medium from human Wharton’s jelly mesenchymal stem cells Azis, Rizal; Widowati, Wahyu; Gunanegara, Rimonta Febby; Kusuma, Hanna Sari Widya; Triharsiwi, Dwi Nur; Hadiprasetyo, Dhanar Septyawan; Gondokesumo, Marisca Evalina; Mars, Nicholas
Indonesian Journal of Biotechnology Vol 30, No 4 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.107035

Abstract

Acute respiratory distress syndrome (ARDS) is a critical respiratory dysfunction triggered by intense in‐ flammation, microvascular damage, and increased epithelial and pulmonary vascular permeability. Human Wharton’s jelly mesenchymal stem cells (hWJMSCs) possess regenerative and anti‐inflammatory activities through the cytokines, chemokines, and growth factor secretion. The development of anti‐inflammatory agents derived from hWJMSCs has become one of the therapeutic solutions. Instead of direct cell use of hWJMSCs, their conditioned medium (CM) provides a cell‐free approach that delivers bioactive factors while minimizing the risks associated with stem cell transplantation. This study aims to measure the levels of vascular endothelial growth factor‐α (VEGF‐α), epidermal growth factor‐β (EGF‐β), interleukin‐10 (IL‐10), and hepatocyte growth factor (HGF) in CM‐hWJMSCs under non‐starvation and starvation conditions (24, 48 and 72 hours) using ELISA. The anti‐inflammatory potential of these factors was then analyzed through molecular docking with pro‐inflammatory cytokines. VEGF‐α, EGF‐β, IL‐10 and HGF levels were measured across all conditions. VEGF‐α ranged from 2590.37 to 3613.92 ng/mg protein; EGF‐β 347.01–504.43 ng/mg; IL‐10 302.59–729.28 pg/mg; and HGF 1747.20–2903.52 ng/mg. The molecular docking revealed strong binding between VEGF‐α, EGF‐β, IL‐10 and HGF with pro‐inflammatory cytokines, namely IL‐1β, IL‐6 and TNF‐α. VEGF‐α had the strongest bond with TNF‐α (–1162.3 kJ/mol), while EGF‐β formed the most hydrophobic and hydrogen interactions. The findings suggest that CM‐hWJMSCs, enriched with anti‐inflammatory and regenerative cytokines, may serve as a promising candidate for modulating the inflammatory pathways involved in ARDS pathogenesis. Longer starvation increased the secretion of VEGF‐α, EGF‐β, IL‐10 and HGF. These factors are known to promote angiogenesis, regulate immune responses, and protect against epithelial injury, thereby supporting the anti‐inflammatory and regenerative potential of hWJMSCs‐CM for ARDS therapy.
IMPLEMENTASI METODE ENFLEURASI DALAM PRODUKSI MINYAK ATSIRI MELATI DI DESA JATIJEJER Gondokesumo, Marisca Evalina; Azminah, Azminah; Suryaningsih, Dwie Retna; Djayapranata, Grace Felicia
RESONA : Jurnal Ilmiah Pengabdian Masyarakat Vol 9, No 2 (2025)
Publisher : Lembaga Penerbitan dan Publikasi Ilmiah (LPPI) Universitas Muhammadiyah Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35906/resona.v9i2.2670

Abstract

Desa Jatijejer di Mojokerto, Jawa Timur, memiliki potensi sumber daya alam yang besar, khususnya di sektor pertanian. Salah satu komoditas unggulan yang dibudidayakan adalah bunga melati (Jasminum sambac), yang memiliki aroma khas dan berpotensi diolah menjadi minyak atsiri dengan manfaat aromaterapi. Produksi minyak atsiri melati dilakukan menggunakan metode khusus, yaitu enfleurasi. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk mengenalkan metode enfleurasi kepada warga Desa Jatijejer. Kegiatan diawali dengan edukasi mengenai konsep dan tahapan enfleurasi, kemudian dilanjutkan dengan praktik langsung pembuatan minyak atsiri melati. Program ini diikuti oleh 30 peserta yang terdiri dari perangkat desa, perwakilan kelompok tani, PKK, BUMDes, serta tim pengabdi dari Universitas Surabaya (UBAYA) dan Universitas Wijaya Kusuma Surabaya (UWKS). Evaluasi dilakukan melalui pre-test, post-test, dan observasi langsung. Hasil kegiatan menunjukkan peningkatan pemahaman, keterampilan, serta antusiasme peserta, disertai komitmen untuk mengembangkan produksi minyak atsiri melati secara berkelanjutan. Abstract. Jatijejer Village, located in Mojokerto, East Java, has abundant natural resources, particularly in the agricultural sector. One of the cultivated plants is jasmine (Jasminum sambac), which is known for its distinctive fragrance and aromatherapeutic benefits when processed into essential oil. The production of jasmine essential oil requires a specific technique called enfleurage. This community service program aimed to introduce the enfleurage method for producing jasmine essential oil to the residents of Jatijejer Village. The activities began with an educational session explaining the enfleurage process, followed by hands-on practice in producing jasmine essential oil using this method. The program involved 30 participants, including village officials, representatives of farmer groups, the Family Welfare Empowerment group (PKK), the Village-Owned Enterprise (BUMDes), and service teams from the University of Surabaya (UBAYA) and Wijaya Kusuma University Surabaya (UWKS). Pre-tests and post-tests were administered to assess participants’ understanding, along with direct observation of practical skills. The results showed improved participant knowledge and skills, high enthusiasm, and a strong commitment to implementing the enfleurage method on a larger and more sustainable scale.
Co-Authors Abdul Aziz Anggraeni, Reta Anita Purnamayanti Ardiansyahmiraja, Bobby Auliyana, Iftitah Putri Azis, Rizal Azminah Azminah Azminah Badriah, Rani Nur Budipramana, Krisyanti Djayapranata, Grace Felicia Elisabeth, Mariska Faisal Akhmal Muslikh Girsang, Ermi Gunanegara, Rimonta Febby Hadiprasetyo, Dhanar Septyawan Hanna Sari Widya Kusuma, Hanna Sari Widya Harjanti, Mathelda Weni Haryanti, Mathelda Weni Hayati, Syafira Nur Herawati, Fauna Ma'arif, Burhan Mariana Wahjudi, Mariana Mars, Nicholas Muthmainnah, Anis Syabani Nindya, Faradhina Salfa Novilla, Arina Pratama, Jainuri Erik Putri, Rizky Ayu Artama RAHMAT, DENI Retno Wilujeng Susilowati, Retno Wilujeng Saksono, Astrella Amanda Putri Saufa, Zahra Qisthi Setiadi, Adji Prayitno Setiadi, Antonius Adji Prayitno Sijani Prahastuti Simanjuntak, Inana Ratu Soripada Suryaningsih, Dwie Retna Suryaningsih, Retna Sutejo, Erwin Takasenserang, Oktaviana Teresa Liliana Wargasetia Triharsiwi, Dwi Nur Wahyu Surakusumah WAHYU WIDOWATI Wibowo, Yosi Irawati Widya, Reta Anggraeni Zahiroh, Fadhilah Haifa