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All Journal HAYATI Journal of Biosciences Journal of Food and Pharmaceutical Science Journal of Mathematical and Fundamental Sciences Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Science and Technology Indonesia Jurnal Pemberdayaan Masyarakat Madani (JPMM) Molecular and Cellular Biomedical Sciences (MCBS) Resona : Jurnal Ilmiah Pengabdian Masyarakat Dinamisia: Jurnal Pengabdian Kepada Masyarakat Journal of Islamic Medicine Jurnal Abdimas Ilmiah Citra Bakti (JAICB) MAHESA : Malahayati Health Student Journal Pharmaceutical Sciences and Research (PSR) Journal Community Service Consortium Jurnal Farmasi Indonesia Journal of Food and Pharmaceutical Sciences
Marisca Evalina Gondokesumo, Marisca Evalina
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Mangosteen Peel Extract (Garcinia mangostana L.) as a Potential Complementary of Leukemia Therapy: In Vitro and In Silico Studies Gondokesumo, Marisca Evalina; Novilla, Arina; Prahastuti, Sijani; Zahiroh, Fadhilah Haifa; Kusuma, Hanna Sari Widya; Widowati, Wahyu; Azis, Rizal; Hadiprasetyo, Dhanar Septyawan; Nurjamil, Aris Muhammad; Surakusumah, Wahyu; Adha, Khoerotul Nur Fadhilah
Journal of Mathematical and Fundamental Sciences Vol. 57 No. 2 (2025)
Publisher : Directorate for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2025.57.2.3

Abstract

Leukemia is caused by abnormal white blood cell proliferation that leads to disruption of conventional blood cell functions. Mangosteen (Garcinia mangostana L.) contains phytochemical compounds with strong anticancer properties, according to various cancer studies. This study investigated the potential of mangosteen peel extract (MPE) as an anti-leukemia agent through molecular docking of LC-MS-identified compounds against FLT-1 and AKT proteins, followed by in vitro evaluation on HL-60 cells, namely cytotoxic (WST-8 assay), ROS levels and senescence (flow cytometry), and then FLT1 and AKT gene expression (qRT-PCR). LC-MS identified α-mangostin, β-mangostin, γ-mangostin, mangostinone, and epicatechin as the main compounds. Molecular docking revealed strong binding affinities from −8.5 to −9.9 kcal/mol against AKT, and from −9.0 to −9.9 kcal/mol against FLT-1. MPE (500 µg/mL) decreased cell viability and increased inhibition of HL-60 cells. Intracellular ROS levels decreased significantly at 0.6, 1.2, and 2.4 µg/mL MPE. MPE induced cell senescence especially at 1.2 and 2.4 µg/mL. Gene expression analysis revealed downregulation of AKT at 1.2 and 2.4 µg/mL and FLT1 at 2.4 µg/mL. These findings suggest that MPE may exert multifactorial anti-leukemic mechanisms, including apoptosis, ROS modulation, senescence induction, and regulation of AKT and FLT1 expression.
Co-Authors Abdul Aziz Adha, Khoerotul Nur Fadhilah Anggraeni, Reta Anita Purnamayanti Ardiansyahmiraja, Bobby Auliyana, Iftitah Putri Azis, Rizal Azminah Azminah Azminah Badriah, Rani Nur Budipramana, Krisyanti Djayapranata, Grace Felicia Elisabeth, Mariska Faisal Akhmal Muslikh Girsang, Ermi Gunanegara, Rimonta Febby Hadiprasetyo, Dhanar Septyawan Hanna Sari Widya Kusuma, Hanna Sari Widya Harjanti, Mathelda Weni Haryanti, Mathelda Weni Hayati, Syafira Nur Herawati, Fauna Ma'arif, Burhan Mariana Wahjudi, Mariana Mars, Nicholas Muthmainnah, Anis Syabani Nindya, Faradhina Salfa Novilla, Arina Nurjamil, Aris Muhammad Pratama, Jainuri Erik Putri, Rizky Ayu Artama RAHMAT, DENI Retno Wilujeng Susilowati, Retno Wilujeng Rizki Rahmadi Pratama Saksono, Astrella Amanda Putri Saufa, Zahra Qisthi Setiadi, Adji Prayitno Setiadi, Antonius Adji Prayitno Sijani Prahastuti Simanjuntak, Inana Ratu Soripada Suryaningsih, Dwie Retna Suryaningsih, Retna Sutejo, Erwin Takasenserang, Oktaviana Teresa Liliana Wargasetia Triharsiwi, Dwi Nur Wahyu Surakusumah WAHYU WIDOWATI Wibowo, Yosi Irawati Widya, Reta Anggraeni Zahiroh, Fadhilah Haifa