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All Journal PHARMACON Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Jurnal Pengabdian Al-Ikhlas BERNAS: Jurnal Pengabdian Kepada Masyarakat Health Media JUKESHUM: Jurnal Pengabdian Masyarakat Jurnal EduHealth Jurnal Farmasi Tinctura Journal Prima Health Science Multidisiplin Pengabdian Kepada Masyarakat (M-PKM) Jurnal Kesehatan dr. Soebandi Medical Sains : Jurnal Ilmiah Kefarmasian J-CEKI Indonesian Pharmacopeia Journal (IPJ)
Shinta Mayasari
Fakultas Ilmu Kesehatan Universitas Dr Soebandi, Jember, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Exploring the Potential of NIR Spectroscopy and Chemometrics to Verify the Flavonoid Content in Litsea cubeba Cendekiawan, Khrisna Agung; Susanti, Dhina Ayu; Isnawati, Nafisah; Mayasari, Shinta; Riswanto, Florentinus Dika Octa
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.99185

Abstract

The ancient records about herbal medicine show traditional healing practices are deeply rooted in Indonesian culture. The medical use of plants decreased because of inheritance customs combined with the lack of written documentation on medicinal plants but dependent on oral information transmission. Traditional research and preservation activities of local healing plants which belong to specific cultural communities become possible through this phenomenon. Researchers conducted ethnopharmacological research about antidiarrheal medicinal plant uses that included traditional knowledge about flavonoid-containing plants within the Osing ethnic group of West Java Indonesia. The goal of this research was to verify flavonoid compounds in Osing's medicinal plants through Near Infra-Red (NIR) spectroscopy combined with chemometric methods. The evaluation of antidiarrheal potential for these compounds relied on flavonoid standard reference substances because these compounds demonstrate strong antioxidant properties which stabilize intestinal functioning. Chemometric techniques together with Near Infra-Red spectroscopy (NIR) were applied to analyze krangean leaves (Litsea cubeba) in order to establish their flavonoid compound levels. The quality assessment of multivariate calibration models shows that PLS regression produces RMSEC of 2.870 and RMSEP of 0.0124 with R2cal = 0.9931 and R2val = 0.9919. The analysis using linear discriminant analysis (LDA) succeeded in its completion with recognition rates above 90% for each discriminating class.
Profil Pengobatan Pada Pasien Tuberkulosis Di Rumah Sakit Paru Jember Anggie Noviana Putri; SHINTA MAYASARI
Tinctura Vol 7 No 1 (2025): Jurnal Farmasi Tinctura
Publisher : Program Studi S1 Farmasi Fakultas Ilmu Kesehatan Universitas Ibrahimy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35316/tinctura.v7i1.8117

Abstract

Tuberkulosis (TB) identik dengan penyakit yang disebabkan Mycobacterium tuberculosis yang ditularkan melalui droplet udara. Tatalaksana TB dapat diberikan terapi dalam jangka waktu panjang dengan regimentasi yang diberikan sesuai standar. Populasi pasien TB pada periode terakhir 2024 adalah sejumlah 1.582 kunjungan pasien TB. Tujuan penelitian ini adalah untuk mengetahui gambaran tatalaksana pengobatan pada pasien TB di Rumah Sakit Paru Jember. Jenis penelitian ini adalah penelitian deskriptif secara kuantitatif dengan pengumpulan data secara retrospektif. Jumlah sampel sejumlah  94 responden TB dengan menggunakan random sampling. Analisis data berupa analisis univariat, data disajikan dalam bentuk frekuensi dan persentase. Hasil penelitian menunjukkan kategori jenis kelamin laki-laki sejumlah 64,89%, kategori usia 49–59 tahun sejumlah 38,30%. Penggunaan terbanyak yaitu 4 FDC (Fix Doses Combination) dengan dosis 150mg/ 75mg/ 400mg/ 275mg dan frekuensi dari penggunaan yaitu 1x3 sebesar 50%. Profil pengobatan TB di Rumah Sakit Paru Jember menunjukkan bahwa terapi obat TB yang digunakan sesuai dengan panduan formularium di Rumah Sakit Paru Jember.
Evaluasi Ketepatan Obat Antituberkulosis pada Pasien Tuberkulosis Paru di Rumah Sakit Paru Jember Alfira Rosaliana; SHINTA MAYASARI
Tinctura Vol 7 No 1 (2025): Jurnal Farmasi Tinctura
Publisher : Program Studi S1 Farmasi Fakultas Ilmu Kesehatan Universitas Ibrahimy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35316/tinctura.v7i1.8118

Abstract

Tuberculosis (TB) adalah penyakit yang disebabkan oleh Mycobacterium yang menyerang organ paru. Efektiitas pengobatan TB dapat diukur dengan menbandingkan pengobatan dengan pedoman acuan dari Rumah Sakit. Permasalahan ketidaktepatan obat dari penelitian sebelumnya adalah 5% dari total 82 pasien. Tujuan penelitian ini untuk memberikan evaluasi ketepatan obat pada pasien TB. Jenis penelitian ini adalah penelitian deskriptif secara kualitatif dengan menggunakan data rekam medis secara retrospektif. Jumlah sampel yang dibutuhkan adalah 95 sampel dengan menggunakan random sampling. Analisa data menggunakan analisis univariat dengan menampilkan data frekuensi dan persentase. Dari sejumlah 95 sampel terdapat, keseluruhan terapi obat yang diterima pasien adalah tepat. Sejumlah 92,63% menerima terapi dalam bentuk 4FDC, sedangkan 4,21% pasien meneriam 2FDC, dan sejumlah 3,16% pasien menerima sedian lepas yang diberikan secara terpisah.
Profile of Potential Drug Interactions in Chronic Obstructive Pulmonary Disease Patients in One of the Jember District Hospitals Dea Agita Anggraini; Shinta Mayasari
Jurnal EduHealth Vol. 17 No. 01 (2026): Jurnal EduHealt 2026
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Chronic Obstructive Pulmonary Disease or often abbreviated as COPD is a term used for a number of non-communicable diseases that affect the lungs for the long term. COPD is the third leading cause of death in the world. The use of drugs in COPD patients with or without comorbidities is included in the category of drug use with more than two drug items, resulting in one of the DRPs, one of which is drug interaction. The prevalence of patients with potential drug interactions in Ethiopian hospitals was found to be 72.2%. The number of COPD cases is projected to increase by 112 million to a total of 592 million by 2050 (9.5% of the total eligible population), a relative increase of 23.3% from 2020 to 2050. Purpose: The purpose of this study was to determine the study of drug interactions in patients with Chronic Obstructive Pulmonary Disease at the Jember Pulmonary Hospital. Methods: This type of research is qualitative research using the observation method, retrospective data collection taken from medical record data of COPD patients. The number of samples in this study was 96 patients calculated using the Slovin formula. The sampling technique used was random sampling technique. Data were processed using Microsoft Excel and displayed in the form of frequencies and percentages. Conclusion: Potential drug interactions in COPD patients that occurred in one of the Jember Regency hospitals amounted to 97.92% using drug interaction checker with details of minor interaction categories 26,48%, moderate 68,80% and major 4,72%. Monitoring the occurrence of potential drug interactions is carried out in order to minimize the risk of drug side effects. Complaints of potential interactions in patients do not occur which can be seen from clinical manifestations in patients. The limitation of this study is that it does not know the patient's complaints directly because it only uses medical record data.
Processing Papaya Fruit into Snacks as a Food Security Innovation in Mandiku Hamlet, Sidodadi Village Andi Dwi Sandi Hariyono; Aulavia Hidayaturrobbani; Mayasari, Shinta
Multidisiplin Pengabdian Kepada Masyarakat Vol. 5 No. 01 (2026): Multidisiplin Pengabdian Kepada Masyarakat, inpress edition 2026
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dusun Mandiku in the village of Sidodadi is an area with abundant agricultural potential. One of the most commonly found agricultural products in this hamlet is papaya. Papaya plants have high economic value because they have many uses, from the roots, leaves, fruit, stems, to the flowers. The objective of this research is to develop an innovation in papaya processing into a snack, which not only benefits the economic value of papaya but also serves as a concrete step in supporting village food security. The research method employed a descriptive qualitative approach. The research results also show that this papaya processing innovation brings several important benefits. First, from an economic perspective, the community gains additional income from the sale of processed products. Papayas that were previously unsold or discarded can now generate income. Second, from a social perspective, this activity involves housewives, fostering unity, cooperation, and enhancing family self-reliance. Third, from a food safety perspective, papaya snacks can be stored longer than fresh papaya, making them a food reserve when needed.
Potential Hyperglycemia In Type 2 Diabetes Mellitus Patients Due To Drug Interactions At Hospital Avrillana Dewangi Gea Ayunda Diarso; Shinta Mayasari; Khrisna Agung Cendekiawan
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.19

Abstract

Background: Hyperglycemia is a medical condition in the form of an increase in blood glucose levels beyond normal limits with a blood sugar concentration of ≥200 mg/dl. Hyperglycemia that is not well controlled can cause serious disorders of the body's systems, especially the nerves and blood vessels. Based on WHO data, the prevalence of type 2 DM with the potential for hyperglycemia in the world in 2019 was 5.3%. This figure is expected to increase to 6.3% in 2030. Objective: This research was conducted to determine the potential for hyperglycemia in type 2 diabetes mellitus patients due to drug interactions at one of hospital in Jember. Method: This research uses a quantitative design with retrospective data collection, namely research obtained based on information from patient medical records. The population in this study was 539 patients suffering from type 2 diabetes mellitus for the period January-December 2022. The sample from this study was type 2 diabetes mellitus patients who met the inclusion criteria. Sampling was calculated using the Slovin formula using random sampling techniques and the results obtained were 84 medical record samples. Analysis using univariate. Data is displayed in frequency and percentage form. Data processing uses Microsoft Excel and SPSS. Results: Most of the drugs received by type 2 diabetes mellitus patients experienced interactions that had the potential to cause hyperglycemia with blood sugar levels ≥200 mg/dl (96.43%) and a moderate clinical significance level of 70.24%. Conclusion: There is a potential for hyperglycemia caused by diabetes drug interactions. Monitoring drug interactions and effective treatment in patients with type 2 diabetes mellitus needs to be carried out to achieve optimal therapy targets and increase awareness of healthy lifestyles in diabetes management.
Potential Hypoglycemia in Patients With Type 2 Diabetes Mellitus Due to Drug Interactions in Citra Husada Hospital Elisa wardatul awaliya; shinta mayasari; khrisna agung cendekiawan
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.24

Abstract

Diabetes mellitus (DM) is a metabolic disorder disease characterized by an increase in blood glucose due to decreased insulin secretion by pancreatic beta cells, insulin disorders or resistance. The main risks that are commonly found in every patient diagnosed with DM disease include hypoglycemia. In a study conducted at a public hospital in Jakarta, 186 incidents of interaction of antidiabetic drugs with other drugs that have hypoglycemia potential with a moderate clinical significance level of 83.8% were found. The potential for drug interactions in DM patients is still very frequent. This can be caused by the number of drugs that are often used (Polipharmacy or multiple drug therapy). The purpose of this study is to identify the potential for hypoglycemia in type 2 DM patients due to drug interactions at Citra Husada Jember hospital. This type of research is qualitative research with retrospective data collection. The design of this study uses a cross-sectional design. The population of this study is 662 medical record data of outpatients with type 2 diabetes for the period of January – December 2022. Data analysis uses univariate analysis. In this study, most patients have the potential to experience hypoglycemia.
DESCRIPTION OF CLINICAL POLYPHARMACY PRESCRIPTIONS IN TYPE 2 DIABETES MELLITUS PATIENTS AT HOSPITAL X JEMBER DISTRICT Nurul Fathona; Shinta Mayasari; Nafisah Isnawati
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.29

Abstract

Background: Diabetes mellitus (DM) is a metabolic disease caused by insulin resistance and pancreatic beta cell dysfunction. Polypharmacy is the use of three or more drugs every day is very common in patients with diabetes mellitus. WHO data shows that the prevalence of Diabetes Mellitus (DM) polypharmacy will reach 7.4% - 43.4% by 2023. Objective: This study aims to determine the clinical picture of polypharmacy prescriptions in patients with type 2 diabetes mellitus at X Hospital, Jember Regency. Method: This study used a descriptive non-experimental method by observation, involving 80 samples. Samples were selected by random sampling and data were analysed and displayed in the form of frequencies and percentages using Microsoft Excel and SPSS. Results: The results of this study are the description of the most polypharmacy prescriptions, namely prescriptions with 3 drug items as many as 3 prescriptions (7.5%), and the description of the least polypharmacy prescriptions, namely prescriptions with 4 drug items, and prescriptions with 10 drug items as many as 1 prescription (1%). In addition, the results of this study also contained drug interactions as many as 72 interacting prescriptions. Conclusion: From the discussion above, it can be concluded that, in the study at Hospital X, Jember Regency, polypharmacy was found from the samples analysed, all of which were polypharmacy prescriptions. This study also found that prescriptions for type 2 diabetes mellitus patients experienced drug interactions with moderate interactions being the most common. These interactions can reduce the effectiveness of treatment and increase risks for patients.
ADMINISTRATIVE AND PHARMACEUTICAL SCREENING OF DIABETES MELLITUS PRESCRIPTIONS IN TYPE 2 DIABETES MELLITUS PATIENTS IN THE HOSPITAL X JEMBER. Michael Nicoin DC Michael Nicoin DC; Shinta Mayasari
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.32

Abstract

AbstractBackground: Pharmaceutical services are drug and clinical pharmacy services that enhance therapeutic effects and minimize the risk of medication errors. A form of pharmaceutical service is prescription screening. Prescription screening is a prescription review which is an activity of pharmacists in reviewing prescriptions which includes administration before the prescription is compounded. Another study conducted by Aryzki entitled "Administrative completeness of prescriptions carried out at Pharmacy X Banjarmasin in January, completeness of 0.26%, incompleteness with a percentage of 99.74% has not met according to PERMENKES number 73 of 2016 concerning pharmaceutical service standards. Objective: To identify the administrative and pharmaceutical screening of DM prescriptions for type 2 DM patients at X Jember Hospital. Methods: Descriptive research using observation method with a total of 125 samples by Random Sampling using the slovin formula. Results: overall administrative completeness is 100% complete written indicators, while most of the pharmaceutical completeness (60%) is incomplete of the five indicators identified as not written, namely the dosage form is still 56.8%, the dosage of the drug is still 91.2%, and overall 100%, the rules of use have not been written. Conclusion: From the total sample taken 125 prescriptions in the administrative aspect were all written completely for the pharmaceutical aspect most of them were not written completely, namely the indicators of drug dosage forms, drug dosages, and rules of use. Keyword : Skrining; Administrative; Phasmaceutical; Indicato
Effectiveness of Ethanol Extract of Mangosteen Leaves (Garcinia mangostana L.) as Anti-diarrhea in Mice Induced by Oleum Ricini Ahmad Khoirul Azwar; Shinta Mayasari; Mohammad Rofiq Usman
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.34

Abstract

Diarrhea is a condition where a person experiences defecation with a soft or liquid consistency, with more frequent frequency (generally three or more times) a day One of the plants used as treatment for diarrhea is mangosteen leaves (Garcinia mangostana L). The leaves of the mangosteen plant (Garcinia mangostan L.) contain tannin compounds which can be useful as an antidiarrheal. Tannin is a substance that is effective as an adstringents, so it is thought to be able to provide an anti-dare effect. To determine the effectiveness of ethanol extract of mangosteen leaves (Garcinia mangostana L) as antidiarrhea in male white mice (Mus musculus) induced by oleum ricini. This research uses a type of laboratory experimental study using male mice (Muss musculus L) that have been induced with oIeum ricini. There were 15 mice used and divided into 5 groups, namely: negative control group (CMC Na 0.5%), positive control group (loperamide HCl) and treatment groups with dose concentrations of 250 mg/kgBW, 450 mg/kgBW and 650 mg/ kg BW. The research results showed that mangosteen leaves contain flavonoids and tannin compounds. This study shows the antidiarrheal activity value of 3 extract dose groups. There were 4 test parameters with the greatest antidiarrheal activity results at a dose of 650 mg/kgBB. The average result of the onset of diarrhea was 62.3 minutes, then the average result of the frequency of diarrhea was 5 times, while the duration of diarrhea was 85 minutes with an average feces weight of 0.99 grams. The ethanol extract of mangosteen leaves at a dose of 650 mg/kgBW had the most effective antidiarrheal activity in male (mus musculus) mice induced by oleum ricini. Key words: anti-diarrhoea, mangosteen leaves, loperamide; oleum ricini, garcinia mangostana
Co-Authors Afnan Septi Mulyani Afnan Septy Mulyani Afrizal Maulidan Rachmawan Agustin, Ayu Tri Ahmad Khoirul Azwar Alfarisi, Hilmi Pratama Alfi Nur Ramadhani Alfira Rosaliana Aliyah Purwanti Alvia Putri Priyono, Rosyidatul Amalia Wardatul Firdaus Ambari, Yani Anas, Mohammad Nizar Andi Dwi Sandi Hariyono Anggie Noviana Putri Anggitasari, Wima Anggraeni, Linda Suci Anggraeni, Lutvi Arista Wahyu Ningsih Arista Wahyuningsih Atmanegara, Stivani Yanti Aulavia Hidayaturrobbani Aulia, Andira Aura Denaneer Mulya Aura Denaneer Mulya Avrillana Dewangi Gea Ayunda Diarso Ayu Angger Putri M. Soleh Ayu Dwi Wardani Ayu Tri Agustin Bekti Kusuma Primadani Damayanti, Mita Eka Damayanti, Selvi Danny Dwi F Danny Dwi Firmansyah Darrojah, Urfi Narva’u Dea Agita Anggraini DEWI RAHMAWATI Dewi, Novi Rosita Dina Trianggaluh Fauziah Dinayah, Syafinatud Dinda Febri Puspitasari Dinda Febri Puspitasari Dwi Koko Pratoko Dyan Wigati Elisa wardatul awaliya Fadli Muhammad F Fadli Muhammad Fathoni Fadli Muhammad Fathony Fahrur Rozi Shodiqi Fendy Prasetyawan Fitria, Ayu Florentinus Dika Octa Riswanto Hafiz Achmad Hafiz Auni Iswanto Haris Agung Hartalina Mufidah Hasanah, Adinda Shofiatul Hasiseh Hasiseh Heri Setyo Budi Hidayati, Sholihatil IGA Karnasih Indah Suciati Iski Weni Pebriarti Iski Weni Pebriarti Ismanti, Septie Putri Kanaya Dewayanti Khrisna Agung C Khrisna Agung Cendekiawan lindawati setyaningrum Maheswari, Anindya Dinarya Martina, Ina Michael Nicoin DC Michael Nicoin DC Mohammad Rofik Usman Mohammad Rofiq Usman Muhammad Alvin Yovansya Mu’affan, Achmad Adha Nabila, Talitha Vanian Nadia Khairun Nisa nafisah isnawati Nanda Pradwitha Fariansiska Novyananda Salmasfattah Nur Hasanah Nurul Fathona Pangesti, Yuli Pebriarti, Iski Weni Permatasari, Shafira Restu Pramesti, Lita Aulia Puteri Shinta Putra, Zulkarnain Permana Putri Ramadani Putri Ramadhani Putri, Masitah Nurwidiya Qurrotul Aini Rahmadania Affelia Dianto Ramadhan Bagus Cahyono Ramadhan, Muhammad Ridho Ratna Amelia Ratna Amelia Ressi, Monica Risqi Wahyudi rofiqoh rofiqoh savitri, Lisa Sepbrilla Ananda Kusriadi Sholihatil Hidayati Siti Aisyah Siti Hotima Siti Hotimah Siti Nur Maulita Siti Saidah Soleh, Ayu angger Putri M. Stevi R izky Anandha Susanti, Dhina Ayu Swastika, Melur Tri Taniya Tri Oktavia Ningrum Tuhfatul Hilmits T Tuhfatul Hilmits Tsania Ulum, Miftahol Wanda Tri Agustin Wardani, Ali Ridho Wardhani, Firdha Aprillia Wima Anggitasari Yola Kristina Cendani Yuneka Saristiana Zulkarnain Permana