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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology JMM (Jurnal Masyarakat Mandiri) Jurnal Kreativitas PKM Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat JURNAL FARMASI GALENIKA JURNAL FARMASIMED (JFM) Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Media Informatika Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Jurnal Ilmu Medis Indonesia Journal Of Human And Education (JAHE) Jurnal Farmasi Klinik dan Sains Indonesian Research Journal on Education Madani: Multidisciplinary Scientific Journal Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Journal of Information System, Technology and Engineering Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Borneo Journal of Pharmacy Journal of Public Health Science (JoPHS) Jurnal Kefarmasian Indonesia Science: Indonesian Journal of Science Journal of Pharmacopoeia Jurnal Ilmiah Ilmu Kesehatan World Health Digital Journal (wolgitj)
Saeful Amin, Saeful
Prodi Farmasi, STIKes Bakti Tunas Husada Tasikmalaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Madani: Multidisciplinary Scientific Journal

 1 
Kimia Medisinal dan Perannya Dalam Pengembangan Terapi Personalisasi M, Maesaroh; Amin, Saeful
Madani: Jurnal Ilmiah Multidisiplin Vol 3, No 3 (2025): April 2025
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.15187886

Abstract

Personalized therapy is a treatment approach that considers genetic, environmental, and lifestyle variations of each individual to optimize the effectiveness and safety of therapy. This study aims to analyze the role of medicinal chemistry in the development of personalized therapy through the perspective of rational design of drug molecules, structural modification, and optimization of pharmacokinetic-pharmacodynamic properties. The method used is a systematic literature review with the PRISMA approach to scientific publications in 2013-2023 that focus on the integration of medicinal chemistry with pharmacogenomics and personalized therapy. The results of the study showed that medicinal chemistry plays an important role in four main areas: (1) drug design based on specific genetic targets with high selectivity (76% of publications); (2) development of prodrugs and drug delivery systems that are responsive to individual biomarkers (63% of publications); (3) optimization of pharmacokinetics based on genetic variations of drug metabolizing enzymes (58% of publications); and (4) development of molecular probes for companion diagnostics (52% of publications). Further analysis identified the development trends of personalized therapy including multi-target drug design based on patient molecular profiles and big data-based medicinal chemistry strategies. The main challenges identified include the complexity of molecular modification to achieve pharmacokinetic profiles that match specific genetic subtypes and the limitations of experimental models that represent individual heterogeneity. In conclusion, medicinal chemistry plays a fundamental role in realizing the concept of personalized therapy through the design and optimization of drug molecules that match individual patient characteristics. Further research is needed for the development of medicinal chemistry methodologies integrated with omics technology and artificial intelligence to accelerate the translation of the concept of personalized therapy into real clinical applications in Indonesia.
Obat-Obatan Laboratorium: Peran Kimia Medisinal Dalam Kesehatan Husen, Desinta Nurohman; Amin, Saeful
Madani: Jurnal Ilmiah Multidisiplin Vol 3, No 3 (2025): April 2025
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.15186482

Abstract

Medicinal chemistry is a branch of science that combines the principles of chemistry and pharmacology to identify, evaluate, and assess drugs that have the potential to become new therapeutic agents. This article discusses the current state of medicinal chemistry and its applications in contemporary health, such as advances in treatment technology, computerization in medicinal chemistry, and innovations in contemporary medicinal chemistry. The methodology used is a systematic literature review related to scientific publications from 2018 to 2024. The research findings show that advances in computer technology, high- throughput screening, and structure-based drug design have accelerated the process of developing new drugs. In addition, there are other types of identification, such as peptide-based medicine, nanomedicine, and the use of intelligence in medicine. The main factors in the development of modern medicine include antimicrobial resistance, the ability to treat long- term diseases, and its bioavailability. The conclusion shows that medicinal chemistry remains an important foundation in the development of new therapies, with suggestions for improving multidisciplinary approaches, investing in computational technology, and focusing on personalized medicine approaches for more effective and safe drug development. 
Peran Kimia Medisinal Dalam Pengembangan Obat Baru Khaerina, Yunisa; Amin, Saeful
Madani: Jurnal Ilmiah Multidisiplin Vol 3, No 3 (2025): April 2025
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.15187685

Abstract

Medicinal chemistry plays a crucial role in the discovery and development of new, effective and safe drugs. This study aims to analyze the contribution of medicinal chemistry in the stages of drug development, from identification of target compounds to optimization of pharmacokinetic characteristics. The method used is a systematic literature review of the latest research and developments in the field of medicinal chemistry over the past ten years. The results of the study indicate that structure-based and computer-aided (in silico) approaches have significantly increased the efficiency of drug discovery, while molecular modification techniques contribute to the development of drugs with higher efficacy and minimal side effects. The analysis also identifies trends in nanotechnology-based drug development, the use of artificial intelligence, and green chemistry approaches in the synthesis of medicinal compounds. In conclusion, medicinal chemistry continues to develop as a vital discipline in facing the complex challenges of developing new drugs to overcome diseases that do not yet have adequate treatment. Further research is recommended to optimize the integration of various medicinal chemistry approaches with other interdisciplinary fields to accelerate the discovery of innovative new drugs.
Literature Review: Potensi Senyawa Alkaloid Dalam Inhibisi Enzim Asetilkolinerase Melalui Pendekatan In Silico Untuk Terapi Alzheimer Annisa, Hilma Tri; Amin, Saeful
Madani: Jurnal Ilmiah Multidisiplin Vol 3, No 8 (2025): September
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.17283347

Abstract

Alzheimer’s disease is a major neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and behavioral impairment. A therapeutic approach widely employed is the inhibition of acetylcholinesterase (AChE) to sustain acetylcholine levels in the synaptic cleft. Alkaloids, abundantly found in medicinal plants, have demonstrated promising activity as AChE inhibitors. With advances in computational techniques, in silico methods including molecular docking, molecular dynamics (MD), density functional theory (DFT), and ADMET prediction are increasingly used to evaluate molecular interactions efficiently prior to in vitro or in vivo validation. This study aims to review the potential of alkaloids in inhibiting AChE through in silico approaches for Alzheimer’s therapy. A systematic literature review was conducted using PubMed, ScienceDirect, ResearchGate, and Google Scholar with structured keywords, covering publications from 2015 to 2025. Out of 15 identified studies, 10 were screened, and 5 met eligibility criteria. The findings indicate that key alkaloids such as berberine, palmatine, huperzine A, and biflavanone exhibited binding affinities comparable to or greater than standard ligands, with stable hydrogen bonding and hydrophobic interactions at the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. Studies by Qi et al. (2022) and Rawat et al. (2024) confirmed these results through in vitro validation, while Guo et al. (2020) and Negru et al. (2025) reported favorable ADMET profiles supporting their pharmacokinetic feasibility. In conclusion, alkaloids represent strong candidates for Alzheimer’s therapy via AChE inhibition, and in silico strategies play a pivotal role in accelerating active compound screening and drug development efficiency.
Literature Review: Potensi Senyawa Bahan Alam Sebagai Inhibitor A-Glukosidase Untuk Terapi Diabetes Melitus Melalui Pendekatan Molecular Docking Weguna, Asti Awaliyah; Amin, Saeful
Madani: Jurnal Ilmiah Multidisiplin Vol 3, No 8 (2025): September
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.17281128

Abstract

Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels due to insulin resistance. One effective therapeutic strategy is the inhibition of the ?-glucosidase enzyme, which plays a crucial role in carbohydrate breakdown into glucose. This study aims to review the potential of natural compounds as ?-glucosidase inhibitors for diabetes therapy through a molecular docking approach. Literature searches were conducted through PubMed, ScienceDirect, and Google Scholar databases (2020–2025), and eight eligible articles were analyzed. The results revealed that orientin, vitexin, and reserpine from Sonneratia alba, pimaric acid from Michelia champaca, mimopudine from Mimosa pudica, apigenin from Psidium guajava, and spirost-8-en-11-one from Momordica charantia exhibited stronger binding affinities than acarbose. Their interactions with key catalytic residues (Asp215, Glu277, His351, and Asp542) indicate a strong inhibitory potential against ?-glucosidase. These findings suggest that flavonoids, alkaloids, and triterpenoids from medicinal plants possess significant potential as natural ?-glucosidase inhibitors that are safer and more effective. Further in vitro and in vivo studies are recommended to validate their pharmacological activity and safety prior to clinical application.
Co-Authors Abdurrahman, Muhammad Iqmal Afifah, Fitri Nur Aisyah, Rohmah Ala Anistia Widya Alfarizi, Andris Allita, Nur Alya, Elsa Amelya, Isti Nisa Amelya, Risna Anggi Setiawan, Rio Anisa, Anis Anna Yuliana, Anna Annisa, Hilma Tri Ansyirohanisa Ansyirohanisa, Ansyirohanisa Apriliani, Cici Aprillia, Ade Yeni Ardian, Mohamad Idwar Arman, Siti Alisa Assafa, Zifa Athaya, Rahil Auliya, Shafa Awalia, Najla Nisa Az Zahra, Siti Zulfa Azijah, Rachma Nur Azzahra, Shafa Meyliana Beni Maulana Habib Cahya, Nabilla Amelia Claudya, Stefanie Darmawan, Muhammad Rahmat De Hiban Fauzan Mabruro Destian, Lufi Dian Eka Pratama, Dian Eka Esti Mumpuni, Esti Fadli Fadli Fajarini, Syifa Rizkia Fajrin, Ari Muhammad Fatihatul Makia, Fina Fauzi, Rifqi Ahmad Febriana Nur Anggraeni Fernanda, Refa Fitri, Nabila Ainul Fitria, Annisya Ahya Friana, Derina Agus Fuadah, Iga Syamratul GUNAWAN, ADRI Gunawan, Febrianti Rizki Guspiana, Rudi Harahap, Fithriyah Salsabila Hasanah, Muna Shintya Heppi Syofya, Heppi Herawati, Tantri Herdianti, Nita Heryanto, Popih Huda, Dian Fitri Kulyatul Huda, Muhammad Ismail Sabilul Hurry, Zulfan Alfairuz Zabbady Husen, Desinta Nurohman Ibadurrahman, Rifki Ilham Alifiar, Ilham Imani, Anneu Deanti Ira Rahmiyani Jannah, Isma Aenul Judijanto, Loso Justicia, Adhisty Kharisma Jutti Levita Khaerina, Yunisa Kurniawan, Yoga Sugama Kushariyadi Kusumadewi, Fitria Balqis Lansini, Sinka M, Maesaroh Maharani, Cici Maharani, Komang Dewi Maria, Hana Diana Meilani, Yeni Meithasari, Fauziah METI MEGAWATI, METI Muhammad Rahmat Darmawan Muhtar, Nenden Laila Nurafifah Mulhimah, Ai Mustafidah, Syifa Nabila, Liza Salsa Nabila, Nazelia Saila Nabila, Tiana Zulfa Nabila, Yesita Yumna Nadhira Alika Putri Neng Widy Widiyawati Nurahman, Rima Putri Nurassyifa, Reva Puspa Rizkia Nurcahya, Eulis Nurhadiska, Muchamad Nizam Nurliawati, Fadhillathul Paridah, Dea Nur Pebiansyah, Anisa Pitara, Devi Prasetyo, Andri Prasetyo Pujiyani, Delya Putri, Listya Nurina Putri, Puspa Virgiantika Adzkia Rachmat, Shinta Widia Rahmadhani, Sekar Harsti Rahmawati, Desti Rais, Rinovian Ramadani, Adinda Laisya Ramdhiani, Nova Dwi Rangga Pratama, Andi Riedho Prima Cahya Riesna Apramilda Riska Prasetiawati, Riska Rizky Pratama Putra Rusdaita, Febia Citraeni Rusiyana, Nisrina Putri Salimah, Suci Intan Salsabila Adlina Saputra, Erwin Yuliana Satria, Deagi Taufik Shaleha, Resha Resmawati Sheryl, Vanessa Angelica Slamet Ibrahim - Soegeng Wahyoedi Sophi Damayanti Sri Adi Sumiwi Sudrajat, Nisya Aulia Rahmatillah Sulaeman, Muhammad Ilham Sumantri, Tri Adi Sumardiawan, Dhiyaa Kaamilah Supriatna, Galuh Taruna Syamsudin, Atasya Taufik Hidayat Tia Setiawati Wardiah, Shelya Nurul Weguna, Asti Awaliyah Wibisono, Mohammad Alfin Wihdatunnisa, Imelda Yuliani, Renny Yulianingsih, Tipani Sri Yulianingsih Yustianti, Fitria Zahra, Hanum Nurannisa Zahra, Naila Maulida Zain, Dichy Nuryadin Ziani, Ziani