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All Journal Health Science Journal of Indonesia Jurnal Kebijakan Kesehatan Indonesia Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kesehatan Andalas Berkala Kedokteran MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Penelitian Kesehatan Suara Forikes Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Pengabdian Pada Masyarakat Jurnal Kesehatan Komunitas BIOEDUSCIENCE Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Window of Health : Jurnal Kesehatan Media Keperawatan Indonesia IKRA-ITH ABDIMAS Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education INTEGRITAS : Jurnal Pengabdian Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Journal of Applied Data Sciences SEGARA : Jurnal Pengabdian Kepada Masyarakat Journal of Research in Pharmacy and Pharmaceutical Sciences Jurnal Kedokteran Meditek The Health Researchers Journal Journal of Religion and Public Health Medicosphere
Makkiyah, Feda Anisah
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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OPTIMIZATION OF EXTRACTION WITH SOLVENT VARIATION BASED ON TOTAL FLAVONOID CONTENT IN WUNGU LEAVES (Graptophyllum pictum (L.) Griff): A LITERATURE REVIEW Subeno, Setia; Makkiyah, Feda
The Health Researcher's Journal Vol. 1 No. 03 (2024): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/2zdv1d13

Abstract

There are many studies analyzing the flavonoid content based on the total flavonoid content (TFC) of wungu leaves through the extraction process with different extraction solvents. So, this review using literature review methodology is aimed to find out the type of extraction solvent that has the most optimum condition based on the highest TFC. The databases for collecting data involved PubMed, Scopus, and Google Scholar. Temporary, the results based on some previous studies vary greatly. Two of four selected articles showed that the highest TFC was found in semi-polar solvents; ethyl acetate and acetone. It is suspected that the samples contain more aglycones (a subtype of flavonoids) that can be soluble in semi-polar solvents. Whereas, the two others showed that the nonpolar solvent (hexane) had the highest TFC. It is suspected that the samples contain more subtypes of flavonoids called isoflavones, flavanones, flavones, and flavonols that can be soluble in nonpolar solvents. To get the appropriate and best standardized extract of wungu leaves, re-examination of this optimization based on the highest TFC in further research is necessary by using different extraction solvents that are equally polar like water, methanol, and ethanol; because the flavonoids as secondary metabolites in plants are basically polar.
Analysis of Mortality Risk Factors in Children with Epidural Hematoma (EDH) Nafira, Amodya Dahayu; Makkiyah, Feda Anisah
The Health Researcher's Journal Vol. 1 No. 03 (2024): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/zjdx6d05

Abstract

Head injuries hold the third position among all injury categories in Indonesia, with the highest number of cases occurring in children. Approximately 2% of all head injury cases are epidural hematomas (EDH). The majority of these epidural hematoma cases are caused by head trauma such as accidents, falls, collisions, or other physical assaults leading to traumatic mechanisms. Additionally, EDH can also be caused by non-traumatic processes such as infection/abscess, vascular malformations, tumors, and coagulopathy disorders. Epidural hematoma has a relatively favorable prognosis, yet there are several factors that contribute to a worsened prognosis. This study aims to examine of several research articles outlining the factors contributing to mortality in pediatric EDH cases. The method used is a literature review technique utilizing scholarly databases meeting specific inclusion criteria. The study found that the preoperative GCS, preoperative treatment time interval, operative treatment, and pupillary abnormalities are some of the factors that can impact patient outcomes, including mortality rates, in pediatric EDH cases. Subsequent research is expected to delve deeper on the outcomes of patients undergoing surgical and conservative interventions to address mortality incidents in pediatric EDH.
Developing Adaptive Bra Design For Woman With Hemiplegia: A Literature Review Juliana, Dian; Feda Anisah Makkiyah
The Health Researcher's Journal Vol. 1 No. 03 (2024): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/yxvkwg56

Abstract

Female stroke patients with hemiplegia will experience difficulties to not be able to use bras independently are due to weakness in the upper extremities. Meanwhile, the use of bras is very important for women because bras have a major function in maintaining breast shape by lifting the breasts. Therefore, this study aims to review developing adaptive bra design for woman with hemiplegia. The method of this study was a literature review. After screening stages, two studies are included in this review. Adaptive bra design for woman with hemiplegia is the development of a bra with modifications of material, design, and additional features, especially in the fasteners section by paying attention to good and comfortable materials for users. Some additional features can also be used either to monitor the physiological body of the user or in order to assist the use of the bra. A good adaptive bra design is a design that can help wear and remove the bra with one hand while still paying attention to comfort and aesthetic value.
The Relationship between Visceral Fat and Cognitive Function in Medical Students Budiman, Anisa Novita; Bustamam, Nurfitri; Safira, Lisa; Makkiyah, Feda Anisah
Window of Health : Jurnal Kesehatan Vol 7 No 2 (April 2024)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.v7i2.728

Abstract

During COVID-19, there was a change in student lifestyle, which triggered visceral fat accumulation. The accumulation of visceral fat is one of the causes of systemic inflammation, which is dangerous for the integrity of the brain and can potentially reduce cognitive function. This study aimed to determine the relationship between visceral fat and cognitive function among medical students. This study used a cross-sectional design towards 73 Faculty of Medicine Universitas Pembangunan Nasional “Veteran” Jakarta students who met the criteria and were selected using a simple random sampling technique. The measurement of visceral fat was done using the Tanita Body Composition Analyzer, while the measurement of cognitive function was done using the Digit Symbol Substitution Test questionnaire. The study showed differences in sex and body mass index between normal and high visceral fat groups. There were no differences in age, consumption of junk food, and physical activity between the visceral fat groups. The Spearman test results showed a relationship between visceral fat and cognitive function (p-value equal 0.000; r equal -0.561). The higher the visceral fat, the lower the cognitive function.
Antibacterial Activity of Graptophyllum pictum (L.) Griff Extract using Variations of Ultrasonic Frequency against Escherichia coli Oktavia, Sabina; Bahar , Meiskha; Wahyuningsih, Sri; Zulfa , Fajriati; Makkiyah, Feda Anisah
BIOEDUSCIENCE Vol 8 No 2 (2024): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/14168

Abstract

Background: Escherichia coli is a Gram-negative bacteria and is the main suspect for urinary tract infections and gastroenteritis. The cases of antibiotic resistance against E. coli continue to increase due to public non-compliance with taking antibiotics. Purple leaf (Graptophyllum pictum (L.) Griff) is a plant that grows widely in Indonesia and is generally used as a herbal medicine. This plant contains alkaloids, flavonoids, tannins, and steroids, which can inhibit bacterial growth. This content is obtained through an extraction process. This study aimed to determine the difference in effectiveness of purple leaves extracted using the Ultrasound-Assisted Extraction method at a frequency of 30 kHz, 40 kHz, and 50 kHz against the growth of E. coli. Methods: This research is purely experimental and was carried out in vitro. The antibacterial activity test used the suitable diffusion method, and then the diameter of the inhibition zone was measured. This research was analyzed using the Kruskal-Wallis and Mann-Whitney tests, which resulted in significant differences between treatment groups. Results: The average diameter of the inhibition zone produced at frequencies of 30 kHz, 40 kHz, and 50 kHz is 3,40 mm, 6,22mm, and 4,37mm. Conclusions: The results of this research show that the most optimal frequency is 40 kHz; this frequency can form cavitation in purple leaf cells, thereby producing phytochemical substances that can damage the cell structure of E. coli.
Studi Pendahuluan: Pengaruh Cognitive Transcendence Strategy terhadap Stres dan Adiksi Internet pada Mahasiswa Kedokteran Aisyah, Ammara; Pasiak, Taufiq Fredrik; Harfiani, Erna; Makkiyah, Feda Anisah
Andalas Journal of Health Vol. 12 No. 3 (2023): Online November 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i3.2263

Abstract

The incidence of Internet addiction in the world continues to increase in various circles of society. One of the causes is stress. Mindfulness methods such as the Cognitive Transcendence Strategy (CTS) are strategies for changing behavior through cognitive functions and spiritual values. Objective: To determined the effect of CTS on stress in medical students who suffer from internet addiction. Methods: This research is a quantitative experimental study with the Quasi Eksperimental Nonequivalent Control Group Design. The sample of 16 people was collected through a purposive sampling technique based on inclusion and exclusion criteria. Data were analyzed using the Wilcoxon test. Results: Univariate shows that 60.1% of medical students experience internet addiction, of which 38.4% is in the mild category, 21.4% were moderate, and 0.4% were severe. The stress level of selected respondents based on the HRV analyzer stress index obtained was 62.5% normal, 12.5% good, 18.75% excellent, and 6.25% poor. The results of the Wilcoxon statistical test between CTS and stress were found to be p = 0.261 (p>0.05), which shows that there is no effect of CTS administration on stress statistically. The results of the Wilcoxon test between CTS and internet addiction showed a p = 0.012 (p<0.05). Conclusion: There is the influence of CTS on internet addiction.Keywords: cognitive transcendence strategy, stress, internet addiction, medical student
ANTI-INFLAMMATORY EFFECTS OF Graptophyllum pictum (L.) GRIFF EXTRACT IN PRECLINICAL RATS HIND-PAW EDEMA MODELS: A LITERATURE REVIEW Shofiy, Alifya Rayyani; Makiyyah, Feda Anisah
The Health Researcher's Journal Vol. 2 No. 01 (2025): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/37a33t66

Abstract

Graptophyllum pictum (L.) Griff or daun ungu is a common medical plant in Indonesia that possesses many promising medical properties, including anti-inflammation. This review aims to discuss the anti-inflammatory effects of Graptophyllum pictum (L.) Griff extract in preclinical hind-paw edema animal models. Through literature search and analyze based on keywords, PICO, inclusion, and exclusion criteria, a total of four studies were included in this review. As a result, ethanol extract of Graptophyllum pictum (L.) Griff shows anti-inflammatory effects significantly reducing the volume of edema and having high anti-inflammatory power by inhibition of the arachidonic inflammatory pathway. Therefore, these preclinical test studies confirmed the anti-inflammatory effects of Graptophyllum pictum (L.) Griff. However, further studies and human trials are required to confirm the efficacy and develop a  standardized formula for Graptophyllum pictum (L.) Griff.
COMPARATIVE ANALYSIS OF INFARCT VOLUMES IN PERMANENT AND TRANSIENT MCAO MODELS USING TTC STAINING: A REVIEW OF CURRENT RESEARCH AND FUTURE DIRECTIONS Buana, Gherriandi Raja; Makkiyah, Feda Anisah; Wahyudi, Dhyani Paramita
The Health Researcher's Journal Vol. 2 No. 01 (2025): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/js818616

Abstract

Ischemic stroke research often relies on animal models to understand the pathological processes underlying brain injury. Among the most widely used models are permanent middle cerebral artery occlusion (pMCAO) and transient middle cerebral artery occlusion (tMCAO), both of which simulate ischemic events in the brain. However, while existing studies have compared the effects of pMCAO and tMCAO on infarct volumes, many have been limited by short observation periods (e.g., 4 hours) or have focused only on non-occlusion models. This literature review aims to evaluate the comparative effectiveness of these two models in generating infarct sizes, specifically utilizing triphenyltetrazolium chloride (TTC) staining to measure infarct volumes. Our analysis highlights the variability in infarct volumes between the two models and emphasizes further research incorporating longer observation intervals (e.g., 6, 18, and 24 hours). This gap in research is crucial for refining experimental stroke models and improving the clinical relevance of findings, particularly regarding therapeutic strategies for ischemic stroke. The review also suggests potential research pathways to enhance model standardization and consistency in future studies, aiming for more accurate and reproducible results that will inform the development of effective stroke treatments.
PURPLE LEAVES (Graptophyllum pictum L. Griff) AND PINEAPPLE (Ananas comosus L. Merr.) FOR THE PRODUCTION OF HERBAL TEA TO SUPPORT NERVOUS SYSTEM HEALTH Aritonang, Hosianna Stephany; Makkiyah, Feda Anisah
The Health Researcher's Journal Vol. 2 No. 01 (2025): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/fadfe331

Abstract

This study explores the potential of purple leaves and pineapple as raw materials for producing herbal tea. It examines the availability of these plants in Indonesia, analyzes their bioactive compounds, investigates the tea production process, and evaluates food safety through toxicity and microbiological testing. The research employs an experimental approach, integrating literature reviews, phytochemical analysis, and laboratory testing. The study involves identifying key bioactive compounds in purple leaves and pineapple, formulating an optimal tea blend, and conducting toxicity and microbial safety evaluations.The study finds that purple leaves contains flavonoids, alkaloids, and tannins, which possess neuroprotective and anti-inflammatory. Pineapple contains bromelain and vitamin C, which are known for their antioxidative and anti-inflammatory. This research provides a novel contribution by introducing a herbal tea formulation combining purple leaves and pineapple. It offers valuable insights into the potential of Indonesian herbal resources for functional food development and phytopharmacology.
A COMPARATIVE ANALYSIS OF TRANSCARDIAL PERFUSION TECHNIQUES FOR BRAIN FIXATION IN RODENTS: A CALL FOR STANDARDIZATION OF TRANSCARDIAL PERFUSION Wahyudi, Dhyani Paramita; Makkiyah, Feda Anisah; Buana, Gherriandi Raja
The Health Researcher's Journal Vol. 2 No. 01 (2025): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/6nrjth51

Abstract

Transcardial perfusion is a crucial technique in rodent research for tissue fixation and preservation. The process typically involves flushing the vascular system with saline to remove blood, followed by fixation with 4% paraformaldehyde (PFA) or formalin. However, differences in species, procedural techniques, and fluid volumes can influence perfusion efficiency and tissue quality. This literature review compares six transcardial perfusion protocols used in mice and rats, focusing on procedural variations and fluid volume requirements. Data were collected from published protocols detailing perfusion techniques, obtaining evidence that substantial variability is observed in the protocols, including differences in anesthesia regimens, surgical approaches, perfusion techniques, fluid compositions, and fixation outcomes. Future research should focus on standardizing perfusion protocols to improve consistency in fixation quality, minimize tissue degradation, and preserve structural and molecular integrity.
Co-Authors Abd. Rasyid Syamsuri Ahmad Aulia Jusuf Ahmad Taufik Aisyah, Ammara Alifah Safira Amperatmoko Alya Roza Lisanti Anisah Anisah Antoni, Darius Apriningsih, Apriningsih Apriningsih Arfiyanti Arfiyanti Aritonang, Hosianna Stephany Ayu Devania Dipta Gayatri, Gusti Ayu Magdalena Natalia Situmeang Basuki Supartono Bintang Bayu Aryandi Buana, Gherriandi Raja Budiman, Anisa Novita Dian Pertiwi Dian Pertiwi Digna, Audrey Alvura Erna Harfiani Fitriana Fitriana Gracella Faustine Heni Pujiastuti Heristyorini, Ayodya Herkan, Muhamad Thariq Imam Prabowo, Imam Juliana, Dian Kamaludin, Fahmi Marlina Dewiastuti Marlina Dewiastuti, Marlina Masiran, Ruziana` Meiskha Bahar Melly Kristanti Muhammad Ferrel Privansyah Cader Cader Muhammad Reihan Arianda Nabila Aulia Ainaya Nafira, Amodya Dahayu Napitupulu, Partogi Natanel, Handro Steve Nugrahana, Raisa Yunika Nurfitri Bustamam Nurhadi Ibrahim Nurrahmah, Rahma Nida Oktafiani, Devi Oktavia, Sabina Pasiak, Taufiq Fredrik Prita Maya Savitri Rachmawati, Alfira Rahma Hida Nurrizka Rahmah Hida Nurrizka Rahmah Huda Nurrizka Rifqi Sabita Rizkyta, Bunga Mentari Roman Goenarjo Rosadi, Andrea Salsabila Safira, Lisa Salim Harris Sembiring, Rinawati Setyaningsih, Yuni Shelly Nobel Shofiy, Alifya Rayyani Sihotang, Theodora Caroline Sri Yani Subeno, Setia Syahrin, Rosita Alfi Taufik Jamaan Taufiq Fredrik Pasiak Tiwuk Susantiningsih Wahyudi, Dhyani Paramita Widayani Wahyuningtyas Yuni Setyaningsih Yuri Nurdiantami Zulfa , Fajriati