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Journal : Jurnal Farmasi Sains dan Praktis

PREPARATION OF PHYTOSOME OF KERSEN LEAVES (Muntingia calabura L.) ETHANOL EXRTACT AS ANTIOXIDANT Nur Illiyyin Akib; Nabila Saraswati Hendra; Andi Eka Purnama Putri; Indradewi Armadhani; Andi Nafisah Tendri Adjeng; Rifa’atul Mahmudah
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6206

Abstract

Kersen (Muntingia calabura L.) contains flavonoids that have the potential as antioxidants. However, its hydrophilic characteristics cause poor penetration so that its bioavailability is low. Research had been carried out on the preparation of ethanol extract of cherry leaves in ethosomal vesicle carriers. This study aimed to obtain the optimal phytosome suspension formula. Methods: Sample extraction was carried out by maceration method using ethanol as a solvent and was delipidated was by liquid-liquid method with n-hexane. The characterization of the extract included organoleptic, water-soluble extract content, ethanol soluble extract content, water content, ash content, acid insoluble ash content, and residual solvent. flavonoid contents were carried out by the TLC method and antioxidant activity was determined using DPPH method. Phytosome preparation was prepared by solvent evaporation and thin film hidration with ratio of extract and phosphatidylcholine 1:1 with concentration of 0.5% (A); 1% (B); and 1.5% (C). The characterization included observing morphology of vesicles using optical microscope, determining the size distribution of vesicles using PSA, and calculating the sorption efficiency using a spectrophotometer at max 281 nm. Results: The characteristics of extract were dark green; thick; distinctive aroma; ethanol soluble content were 70.91%; water soluble content were 32.5%; water content were 1.19%; ash content were 1.25%; acid insoluble ash content were 0.49%; and the remaining solvent was 0. The identification of flavonoids showed positive results. The extract has flavonoids and strong antioxidant activity with 62.71 g/mL for IC50. The shape is single layer large vesicle (LUV), diameter was 445.7 nm (A); 420.7 nm (B); and 419.6 nm (C). Vesicle entrapment efficiency was 5.83% (A); 47.575% (B); and 68.81% (C). It can be concluded that the optimal phytosome suspension formula is C with 1.5% phosphatidylcholine and 1.5% of extract.
Co-Authors Adrifianie, Femmy Afna Nur Afni Palogan Ali, Nur Fitriana Muhammad Andi Eka Purnama Putri Andrifianie, Femmy Arba, Muhammad Ari Sartinah, Ari Armadany, Fery Indradewi Armadany, Fery Indradewi Asep Sukohar Asep Sukohar Asniar Pascayantri Athallah, Muhammad Muzhafar Athallah, Muhammad Muzhaffar Ciptaningrum, Sekar Rahmasari Ratna Citra Yuliyanda Pardilawati Dzulhijjah Dzulhijjah Ety Apriliana Febriyanti, Triana Femmy Andrifianie Fifi Nirmala Fitrawan, La Ode Muhammad Fitrawan, La Ode Muhammad Fitriani, Rezky Dwi Fiyana, Ayu Sasta Hairah, Sania Herman, Syahlan Humaira, Nayarani Husnaeni, Husnaeni Indradewi Armadhani Juswita, Endeng Kasmawati, Henny Kurniawaty, Evi Lakasa, Rahiswari Pramudita Linda Septiani Lyansaputri Salsabila Madjid, Waode Istiqamah Mardikasari, Sandra Aulia Mutiara Nauli Br. Sitinjak Nabila Saraswati Hendra Novi Novi NUR AFRIYANI Nur Illiyin Akib, Nur Illiyin Nur Illiyyin Akib Nur Illiyyin Akib Nurhasana, N Nurmasuri Nurmasuri Nurul Islamy Oktafany, Oktafany Oktoba, Zulpakor Pardilawati, Citra Yuliyanda Pascayantri, Asniar Purba, Gemi Sabrina Rahmasari, Sekar Ramadhani, Untia Kartika Sari Ramdini, Dwi Aulia Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Rifal, Aofan Rifa’atul Mahmudah Ringgi Tantra Setiawan Rini Hamsidi Risti Graharti Ritonga, Halimahtussaddiyah Romulya, Ari Irawan Ruslin Ruslin Ruslin, R Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin, S Salsabila, Lyansaputri Sayoeti, Muhammad Fitra Wardana Silalahi, Pius Ave Rafael Situmorang, Ephraim Matthew Sebastian Sulthan Alam Yasyfa Sunandar Ihsan Suri, Nurma Suryani Agustina Daulay Suryani Suryani Susianti Susianti Sutarto Sutarto Syafiz, Kamadie Sumanda Syazili Mustofa Taalami, La Ode Terza Aflika Happy Tri Umiana Soleha Triyandi, Ramadhan Widodo, Alya Rahmah Yamin, Y Yuliana Muslimin Zubaydah, Wa Ode Sitti Zunando, Mirza