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Journal : Medula

REVIEW ARTIKEL : UJI EFEK ANTI AGING DARI BERBAGAI EKSTRAK TUMBUHAN SECARA IN VIVO DAN IN VITRO Febriyanti, Triana; Sukohar, Asep; Pardilawati, Citra Yuliyanda; Adjeng, Andi Nafisah Tendri
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1041

Abstract

The outermost and largest organ in our body is the skin. Skin can experience aging when exposed to sunlight. Sunlight contains ultraviolet. Exposure to ultraviolet (UV) radiation causes damage to the skin and can lead to photoaging. Photoaging can be prevented with antioxidant compounds. Many plant extracts or synthetic compounds act as anti-aging agents. These plant extracts become active ingredients that can be formulated into pharmaceutical preparations. Plant extracts that have anti-aging potential include red cabbage, kepok banana peel, red pomegranate, moringa leaves, butterfly pea flower, black cumin seeds and libo fruit. To prove this, a test was carried out. The testing carried out can be in the form of in vivo and in vitro testing methods. This research was carried out using the article review method and obtained several journals from online literature, local journals and international journals, namely electronic searches with the keywords anti-aging, in vitro, in vivo on the website, namely Google Scholar. The number of journals used in this review was 11 journals spanning the last eight years. The results of the article review study showed that several methods used were UV-VIS spectrophotometer, DPPH method, anti-elastase, as well as tests on rats, mice and guinea pigs. From the results of the review of articles on plant extracts, most of them use in vivo tests on experimental animals.
POTENSI INTERAKSI OBAT PADA PASIEN SKIZOFRENIA Suri, Nurma; Salsabila, Lyansaputri; Adjeng, Andi Nafisah Tendri; Oktafany, Oktafany
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1165

Abstract

In the treatment of schizophrenia, antipsychotics as the main therapy are generally combined with additional therapy. Combination therapy has a risk of drug interactions. The aim of the study was to describe the potential factors that influence drug interactions. The study was conducted using observational quantitative analytic methods with a retrospective cross-sectional approach. The sample was selected by total sampling method in the medical records of inpatients at the Lampung Mental Hospital from January-December 2022. The Lexicomp software was used to identify potential drug interactions. In the 265 samples, 344 treatment profiles were obtained with a total of 1349 drugs used. Then, 1786 potential drug interactions were classified as level of risk A (0%), B (0.8%), C (80.2%), D (19%), and X (0%). There was a significant relationship between gender, length of stay, and number of drugs (p<0.05) on potential drug interaction level D (major). Multivariate analysis showed the number of drugs had the strongest relationship (p=0.000 OR=8.233) to potential drug interactions. There was a significant relationship between gender, length of stay, and number of drugs with potential drug interactions level D. The number of drugs had the strongest with potential drug interactions.
Co-Authors Adrifianie, Femmy Afna Nur Afni Palogan Ali, Nur Fitriana Muhammad Andi Eka Purnama Putri Andrifianie, Femmy Arba, Muhammad Ari Sartinah, Ari Armadany, Fery Indradewi Armadany, Fery Indradewi Asep Sukohar Asep Sukohar Asniar Pascayantri Athallah, Muhammad Muzhafar Athallah, Muhammad Muzhaffar Ciptaningrum, Sekar Rahmasari Ratna Citra Yuliyanda Pardilawati Dzulhijjah Dzulhijjah Ety Apriliana Febriyanti, Triana Femmy Andrifianie Fifi Nirmala Fitrawan, La Ode Muhammad Fitrawan, La Ode Muhammad Fitriani, Rezky Dwi Fiyana, Ayu Sasta Hairah, Sania Herman, Syahlan Humaira, Nayarani Husnaeni, Husnaeni Indradewi Armadhani Juswita, Endeng Kasmawati, Henny Kurniawaty, Evi Lakasa, Rahiswari Pramudita Linda Septiani Lyansaputri Salsabila Madjid, Waode Istiqamah Mardikasari, Sandra Aulia Mutiara Nauli Br. Sitinjak Nabila Saraswati Hendra Novi Novi NUR AFRIYANI Nur Illiyin Akib, Nur Illiyin Nur Illiyyin Akib Nur Illiyyin Akib Nurhasana, N Nurmasuri Nurmasuri Nurul Islamy Oktafany, Oktafany Oktoba, Zulpakor Pardilawati, Citra Yuliyanda Pascayantri, Asniar Purba, Gemi Sabrina Rahmasari, Sekar Ramadhani, Untia Kartika Sari Ramdini, Dwi Aulia Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Rifal, Aofan Rifa’atul Mahmudah Ringgi Tantra Setiawan Rini Hamsidi Risti Graharti Ritonga, Halimahtussaddiyah Romulya, Ari Irawan Ruslin Ruslin Ruslin, R Sabarudin Sabarudin Sabarudin Sabarudin Sabarudin, S Salsabila, Lyansaputri Sayoeti, Muhammad Fitra Wardana Silalahi, Pius Ave Rafael Situmorang, Ephraim Matthew Sebastian Sulthan Alam Yasyfa Sunandar Ihsan Suri, Nurma Suryani Agustina Daulay Suryani Suryani Susianti Susianti Sutarto Sutarto Syafiz, Kamadie Sumanda Syazili Mustofa Taalami, La Ode Terza Aflika Happy Tri Umiana Soleha Triyandi, Ramadhan Widodo, Alya Rahmah Yamin, Y Yuliana Muslimin Zubaydah, Wa Ode Sitti Zunando, Mirza