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Journal : JURNAL ILMIAH SIMANTEK

ANTIINFLAMASI NANOPARTIKEL BUAH ANDALIMAN (ZANTHOXYLUM ACANTHOPODIUM DC.) PADA ATEROSKLEROSIS : INTERAKSI ENDOTELIAL HSP70 DIWA AULIA AHMAD; IBNU AFIF ARMADI; KHAIRATUL FITHRIYAH; HUMAIRAH MEDINA LIZA LUBIS
JURNAL ILMIAH SIMANTEK Vol 5 No 2 (2021): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

This study aims to determine the effect and potential mechanism with the treatment of nanoparticles from andaliman fruit(Zanthoxylum acanthopodium DC.) As an anti-inflammatory in atherosclerosis through the HSP70 route. Method, andalimanfruit dried in an oven at a temperature of 40ºC and powdered with nano technology using a High Energy Ballmill. This studyused 27 rat samples which were divided into 3 groups. The examination was carried out by routine histopathologicalexamination procedures for the assessment of atherosclerosis and immunohistochemistry HSP70. Assessment of HSP70immunoreactive cells is indicated by the expression of cells that appear reddish brown in the intima and endothelial media ofblood vessels. The result, of the total 27 samples found 8 atherosclerosis (29.7%) and 19 did not experience atherosclerosis(70.3%). The difference in HSP70 expression in the positive control group and the treatment group was statistically testedwith Chi Square and the result was p = 0.007 (p <0.05). Conclusion, the administration of Andaliman fruit nanoparticles hasan effect on the repair of blood vessel endothelium in atherosclerosis which is assessed by an increase in HSP70expression.
FAKTOR RISIKO TUBERKULOSIS PARU KASUS KAMBUH DI RSUD DR. PIRNGADI KOTA MEDAN DEWI AGUSTIN HAKIM HARAHAP; ANNISA .; SRI REZEKI ARBANINGSIH; HUMAIRAH MEDINA LIZA LUBIS
JURNAL ILMIAH SIMANTEK Vol 5 No 4 (2021): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Pulmonary tuberculosis is an infectious infectious disease caused by the bacterium Mycobacterium tuberculosis. Pulmonarytuberculosis is one of the ten diseases that cause the largest mortality rate in the world. In addition to the increasing numberof new tuberculosis cases, the high number of cases is also due to pulmonary tuberculosis cases which tend to recur. Todetermine the risk factors for relapse in pulmonary tuberculosis in RSUD Dr. Pirngadi Medan City. This type of research isdescriptive observational with the research design used is a cross sectional study. The research method used is logisticregression. Medical record data as a research instrument that has been validated is 94 research samples. Age ofrespondents in relapse cases where the most age was >45 years, based on gender the most were men as many as 37people (78.7%), based on smoking habits, based on a history of disease Most of them did not have a history of diabetesmellitus, based on adherence to taking medication, where the most patients were non-adherent to taking medication, basedon work where. Data analysis obtained p<0.05 on factors of age, gender, diabetes mellitus, smoking habits, medicationadherence and work status with a value of p=0.113 (p≥0.05) Factors that have an influence on the incidence of relapsepulmonary tuberculosis are diabetes mellitus, smoking habits and adherence to medication.
Co-Authors Afelita, Tia Afif Fadhilah Irsyad Afifah Endah Dwi Purianti Aini, Rahma Ainur Rofiq Ainur Rofiq Aisyah Salsabila Alamsyah, Tegar Alfarisi, Bunail Isna Amanda Farra Assyfah Aminuyati Amira Fazhira Ance Roslina ANNISA . ANNISA FITRI HENDEWI Annisa Rifqa Hestiana Annissa Ambaravista Nasution Anriani, Dwi Arifin, Salsalina Dwi Atika Dwiyanti Atika Rahmi Atmaja, Pramudia Barasa, Neza Farach Addiba Berkah Tania Sawitri Bunail Isna Alfarisi Ceri Permata Ayuni Charisma Yani Roza Cindy, Tiara Safira Cindykia, Assyifa DEA YULIA LUBIS Delyuzar, Delyuzar Des Suryani Des Suryani DEWI AGUSTIN HAKIM HARAHAP Dilma Ayu Khairani DIWA AULIA AHMAD Dwiyanti, Atika Fadillah, Akram Fadlina, Shofiah Dina Fayyaza, Nesya Alya Febryandani, Silvy Claresta Filzah, Rahmah Fitri Nur Malini Frina Aeni Putri Galang Ramadhan Hasanah, Nurul HENDRA SUTYSNA Herian, M. Fauzan Alfatin Hervina, Hervina Hestiana, Annisa Rifqa Hidayatullah, Muhammad Rafli HSB, Fatur M Ahmad Hutabarat, Siti Rahmah IBNU AFIF ARMADI Ilham Hariaji Indyra Mahrani Lubis Irsyad, Afif Fadhilah Islami, M. Dian Isnaini Ulfa Jamilah, Qurratu Kasturi KARTIKA HANDAYANI Kesuma, Ilham Jaya KHAIRATUL FITHRIYAH Khairunisa, Zafira Kirana Arum Indra Laden Laden, Laden LITA SEPTINA Lubita, Mardiyah M. Dian Islami Malini, Fitri Nur MEIZLY ANDINA Muhammad Al Anas Muhammad Farouq Hilmi Harahap Muhammad Fathurridha Arabia Salim Muhammad Rafli Hidayatullah Muhammad Zikri Agung Ramadhan Muhammad Zulfikar Karim Chan Nasution, Annissa Ambaravista Nasution, Reyhan Khaira Helmita Nesya Alya Fayyaza Noviardy, Arya Nurcahaya Sinaga Nurfadly, Nurfadly Oche Axena Yulhan Parinduri, Saskya Nabila Prayoga, M. Iqbal Purwoningsih, Emni Qatrunnada Medina Salim Qatrunnada Medina Salim Rafa Nabila Haifa Rafa Nabila Haifa Rahma Rifda F.S. Lubis Rahmah Filzah Raihana Zavira Ramadhan, Galang Ramadhan, Reza Mukti Ratih Yulistika Utami Riaulina, Nasha RIFQY IMSYA AL AYYUBI LUBIS Rizkitha Martono Putri Rizky Yusfasari Robitah Asfur Salsabila, Aisyah Salsabila, Asya Salsabila, Salsabila Sari, Indah Permata Sembiring, Khairul Rasyid Septiady, Teuku Baihaqi Shaik Hussain, Basrah Bee Binte SITI MIRHALINA Siti Mulyani Sitompul, Asma Dwi Nantika Sri Rezeki Arbaningsih Tania Mulia Utami Tegar Alamsyah Teuku Baihaqi Septiady USWATUL KHOIROT Utami, Tania Mulia Widya Yustika Yulhan, Oche Axena Yusmawati Yusran Yustika, Widya Zavira, Raihana Zulkarnain, Rizki Chairani