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Journal : Biomedika

IN VITRO EVALUATION OF THE ANTITUBERCULOSIS POTENTIAL OF BASIL LEAF ETHANOL EXTRACT USING THE RESAZURIN MICROTITER ASSAY (REMA) METHOD Setiadi, Nurlina; Lubis, Humairah Medina Liza; Syafina, Ikhfana
Biomedika Vol 18, No 1 (2026): Biomedika February 2026
Publisher : Universitas Muhammadiyah Surakarta

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Abstract

Background: Tuberculosis (TB) remains a global health challenge and is the second leading infectious cause of death. Indonesia ranks among the top three countries with the highest TB burden. Efforts to discover safer and more effective antituberculosis agents include exploring natural products such as basil (Ocimum basilicum), which contains antimicrobial bioactive compounds. Objective: To determine the minimum inhibitory concentration (MIC) of basil leaf ethanol extract against Mycobacterium tuberculosis H37Rv using the Resazurin Microtiter Assay (REMA). Methods: Basil leaves were extracted by maceration using 96% ethanol and tested at concentrations of 2.5%, 1.25%, and 0.625%. Antimycobacterial activity was evaluated using REMA, with rifampicin as the positive control and untreated media as the negative control. Color change from blue to pink indicated bacterial growth. Results: All concentrations of basil extract produced a pink color, indicating continued bacterial growth, whereas rifampicin remained blue, confirming assay validity. The MIC of the extract was >2.5 µg/mL, indicating no inhibitory effect at the tested concentrations. Conclusion: Basil leaf ethanol extract did not inhibit M. tuberculosis H37Rv at the evaluated doses. Further research using higher concentrations, phytochemical profiling (LC–MS/GC–MS), and fractionation of active compounds is recommended to explore its potential antimycobacterial activity.
Co-Authors Afelita, Tia Afif Fadhilah Irsyad Afifah Endah Dwi Purianti Aini, Rahma Ainur Rofiq Ainur Rofiq Aisyah Salsabila Alamsyah, Tegar Alfarisi, Bunail Isna Amanda Farra Assyfah Aminuyati Amira Fazhira Ance Roslina ANNISA . ANNISA FITRI HENDEWI Annisa Rifqa Hestiana Annissa Ambaravista Nasution Anriani, Dwi Arifin, Salsalina Dwi Atika Dwiyanti Atika Rahmi Atmaja, Pramudia Barasa, Neza Farach Addiba Berkah Tania Sawitri Bunail Isna Alfarisi Ceri Permata Ayuni Charisma Yani Roza Cindy, Tiara Safira Cindykia, Assyifa DEA YULIA LUBIS Delyuzar, Delyuzar Des Suryani DEWI AGUSTIN HAKIM HARAHAP Dilma Ayu Khairani DIWA AULIA AHMAD Dwiyanti, Atika Fadillah, Akram Fadlina, Shofiah Dina Farisha Firzana Fayyaza, Nesya Alya Febryandani, Silvy Claresta Filzah, Rahmah Fitri Nur Malini Frina Aeni Putri Galang Ramadhan Hasanah, Nurul HENDRA SUTYSNA Herian, M. Fauzan Alfatin Hervina, Hervina Hestiana, Annisa Rifqa Hidayatullah, Muhammad Rafli HSB, Fatur M Ahmad Hutabarat, Siti Rahmah IBNU AFIF ARMADI Ilham Hariaji Imanda Jasmine Siregar Indra, Kirana Arum Indyra Mahrani Lubis Irsyad, Afif Fadhilah Islami, M. Dian Isnaini Ulfa Jamilah, Qurratu Kasturi KARTIKA HANDAYANI Kesuma, Ilham Jaya KHAIRATUL FITHRIYAH Khairunisa, Zafira Kirana Arum Indra Laden Laden, Laden LITA SEPTINA Lubita, Mardiyah M. Dian Islami Malini, Fitri Nur MEIZLY ANDINA Muhammad Al Anas Muhammad Farouq Hilmi Harahap Muhammad Fathurridha Arabia Salim Muhammad Rafli Hidayatullah Muhammad Zikri Agung Ramadhan Muhammad Zulfikar Karim Chan Nasution, Annissa Ambaravista Nasution, Reyhan Khaira Helmita Nesya Alya Fayyaza Noviardy, Arya Nurcahaya Sinaga Nurfadly, Nurfadly Oche Axena Yulhan Parinduri, Saskya Nabila Prayoga, M. Iqbal Purwiningsih, Emni Purwoningsih, Emni Qatrunnada Medina Salim Qatrunnada Medina Salim Rafa Nabila Haifa Rafa Nabila Haifa Rahma Rifda F.S. Lubis Rahmah Filzah Raihana Zavira Ramadhan, Galang Ramadhan, Reza Mukti Ratih Yulistika Utami Refangga Sudi Wardana Riaulina, Nasha RIFQY IMSYA AL AYYUBI LUBIS Rizkitha Martono Putri Rizky Yusfasari Robitah Asfur Salsabila, Aisyah Salsabila, Asya Salsabila, Salsabila Sari, Indah Permata Sembiring, Khairul Rasyid Septiady, Teuku Baihaqi Setiadi, Nurlina Shaik Hussain, Basrah Bee Binte SITI MIRHALINA Siti Mulyani Sitompul, Asma Dwi Nantika Sri Rezeki Arbaningsih SYAFINA, IKHFANA Tania Mulia Utami Tegar Alamsyah Teuku Baihaqi Septiady USWATUL KHOIROT Utami, Tania Mulia Widya Yustika Yulhan, Oche Axena Yuliansyah, Putri Ridha Yusmawati Yusran Yustika, Widya Zavira, Raihana Zulkarnain, Rizki Chairani