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All Journal Jurnal Bios Logos Indonesian Journal of Medicine Jurnal Ilmu Kefarmasian Indonesia Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Jurnal Pengabdian Pada Masyarakat METHABDI Majalah Ilmiah METHODA Jurnal Kedokteran Methodist
Endy Juli Anto
Universitas Methodist Indonesia
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Effect of Ethanol Extract of Suruhan Leaves (Peperomia Pellucida L. Kunth) on Blood Sugar Levels and Macroscopic Wounds in Male White Rats of the Wistar Strain (Rattus norvegicus) Diabetic Ulcer Model Hakim, Enggrek Pelita; Siahaan, Jekson Martiar; Anto, Endy Juli; Eyanoer, Putri Chairani
Indonesian Journal of Medicine Vol. 9 No. 2 (2024)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.2.733

Abstract

Background: High blood sugar levels can cause diabetes mellitus (DM), which currently means more than one in 10 adults live with diabetes, with the biggest risk factor being obesity. Wound healing in DM patients will be hampered and increase the incidence of diabetic ulcers in Indonesia by 12% and the risk of developing diabetic ulcers by 55.4%. Diabetic ulcers and gangrene cases in Indonesia are the most common cases found in hospitals. Mortality due to ulcers and gangrene ranges from 17-23%, while the amputation rate ranges from 15-30%. Therapeutic potential in the treatment of diabetic ulcers is possessed by suruhan leaves which have anti-inflammatory, antipyretic, antimicrobial and anticancer effects, as well as having analgesic effects. Subjects and Method: A total of 30 male white rats of the Wistar strain (Rattus norvegicus) were divided equally into control groups, negative control (STZ induction 40mg/kgBW), positive control (STZ induction 40mg/kgBW with metformin 50mg/kgBW/day), treatment group I (STZ induction 40mg/kgBW with ethanol extract of shrike leaves 40mg/kgBW), and treatment group II (STZ induction 40mg/kgBW). kgBB with ethanol extract of 80 mg/kgBB leaves). Next, blood sugar levels (KGD) and macroscopic examination of diabetic ulcer wounds are carried out. Data were analyzed using the Anova test. Results: The lowest blood sugar levels (183.83 ± 11.39), the lowest wound area (6.89 ± 0.86), and the highest percentage of excision wound healing (89.67 ± 1.37) were found in the positive control group. There was a significant relationship between groups of mean blood sugar levels, between groups of wound area, and between groups of healing percentage of excision area (P<0.05). Conclusion: Administration of ethanol extract of suruhan leaves (Peperomia pellucida L. Kunth) had an effect on reducing blood glucose levels and healing diabetic ulcer wounds in STZ-induced diabetic ulcer model mice.
The Role of Vaccination in Prevention of Foodborne Disease in Children: A Systematic Review Manullang, Frenky Sorimuda; Anto, Endy Juli
Indonesian Journal of Medicine Vol. 10 No. 1 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.1.834

Abstract

Background: Foodborne diseases pose a significant global health challenge, particularly for children in developing countries. Vaccination has emerged as a crucial strategy in controlling these diseases. This review examines the effectiveness and safety of foodborne disease vaccines in children based on recent literature. Subjects and Method: This systematic review was conducted using Google Scholar, PubMed, and WHO websites with the keywords "vaccine" and "foodborne disease". Peer-reviewed articles from the past 10 years were analyzed using a narrative synthesis approach. Results: This review identified significant developments in vaccines for rotavirus, cholera, typhoid, and candidate vaccines for Shigella, ETEC, and norovirus. Rotavirus vaccines demonstrated positive impacts in reducing hospitalization rates and deaths due to diarrhea, although effectiveness varied across populations. Inactivated oral cholera vaccines showed protection rates of 52-62% over the first two years. Typhoid vaccines showed potential in reducing disease burden in endemic areas. Development of Shigella, ETEC, and norovirus vaccines is ongoing with promising initial results. Conclusion: Significant progress has been made in developing foodborne disease vaccines, but efforts are needed to improve global vaccination efficacy and coverage. Further research is required to optimize vaccine formulation, delivery strategies, and long-term evaluation across various target populations.
PENYULUHAN KONTROL HIPERTENSI DAN DIABETES SEJAK DINI KEPADA JEMAAT GEREJA HKBP GEDUNG JOHOR RESORT, KECAMATAN MEDAN JOHOR Anto, Endy Juli; Hutasoit, Eka Samuel P.; Siahaan, Jekson M.; Rimbun, Surjadi; Manullang, Frengky S.; Tiji, Widjaya Taufik; Tambunan, Ronald Tunggul Hotmarojahan; Lim, Hadyanto; Pasaribu, Sumihar Maurist Rantos; Tarigan, Menang Bastanta; Jamnasi, Juli; Sinatra, Jadeny; Silitonga, Hendrika Adriana
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 3 No 2 (2023): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol3No2.pp128-132

Abstract

Community Service (PKM) in the form of health education conducted by lecturers at the Faculty of Medicine, Indonesian Methodist University provides outreach about the benefits of controlling hypertension and diabetes mellitus from an early age. PKM was held on August 5 2023 at the HKBP church, Medan Johor District, North Sumatra. Lectures, question and answer discussions and motivation are used as orientation methods. A question and answer discussion was held with the aim of gaining insight and understanding to avoid complications from hypertension and DM. The results of PKM's socialization and work are very effective considering that there are still many people who have not received information about the benefits of vaccination through the basic immunization program. This education makes people more aware of the importance of routine control of health services. The HKBP church community must be aware and know the importance of early control in avoiding complications.
Penyuluhan Otitis Media Akut kepada Anak Panti Asuhan Advent Peduli Sembiring, Budi Darmanta; Anto, Endy Juli; Fauzi, Tengku Muhammad; Siahaan, Jekson Martiar; Tarigan, Menang Bastanta; Sijabat, Kesia; Sihaloho, Kerin Repaskatri; Manik, Widya Dayanti Feronika; Simanjuntak, Jeremia; Wijaya, Mega; Sihaloho, Lovian Nauli; Sembiring, Mikael; Panjaitan, Bintang Andika; Sitompul, Michael Sabatino; Momot, Estela Salomina
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 4 No 1 (2024): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol4No1.pp6-10

Abstract

In accordance with the application of the Tri Darma of Higher Education in the doctor's professional study program, one of which is community service. The purpose of community service activities is to provide explanations and education that can influence community behavior. This community service was carried out at an advent orphanage caring for children and adolescents with 25 participants. This community service activity was carried out on December 6, 2023, with the material of acute otitis media. This topic is very much needed in order to provide information and knowledge about acute Otitis media. Behavior to maintain ear hygiene and health to prevent this disease. Lack of knowledge many are subjected to unfavorable issues. Through this health counseling, it is expected that children and adolescents at Advent Peduli Orphanage, Gg. Kasih no 8, Sudirejo II, Kec. Medan Kota are always motivated to stay alert when playing with friends and keep their ears healthy.
Antidiabetic and Anti-inflammatory Effects of Peperomia pellucida Leaf Extract: Modulation of Blood Glucose, IL-1β, and Pancreatic Histopathology in STZ-Induced Diabetic Rats Oktavia, Ria; Anto, Endy Juli; Siahaan, Jekson Martiar
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.870

Abstract

Background: Diabetes mellitus (DM) is a significant global health challenge with a rapidly increasing prevalence. Although synthetic antidiabetic drugs remain the standard treatment, long-term use often leads to adverse side effects, prompting exploration of natural alternatives. This study investigated the therapeutic potential of ethanol extract of Peperomia pellucida (L.) Kunth leaves in diabetes management through comprehensive assessment of glycemic control, inflammatory marker (IL-1β), and pancreatic tissue histopathology. Subjects and Method: Thirty male Wistar rats were randomized into five groups (n=6): normal control, negative control (STZ-induced), positive control (STZ+metformin 50 mg/kg BW), and two treatment groups receiving Peperomia pellucida extract at doses of 40 mg/kg BW and 80 mg/kg BW, respectively. After 7 days of treatment, blood glucose levels, serum IL-1β concentrations, and pancreatic histopathology were evaluated. Phytochemical screening was conducted to identify bioactive compounds in the extract. Results: Phytochemical analysis confirmed the presence of alkaloids, flavonoids, tannins, saponins, and phenolics. Blood glucose measurements showed significant intergroup differences on day 0 (p<0.001) and day 7 (p<0.001). The 80 mg/kg BW extract group showed a reduction in blood glucose from day 0 (Mean=312.83; SD=40.92) to day 7 (Mean=281.00; SD=34.86). IL-1β serum analysis revealed significant differences among groups (p<0.001), with lower IL-1β levels observed in extract-treated groups compared to the negative control. Histopathological examination demonstrated improved pancreatic tissue structure in extract-treated groups, especially at higher doses. Conclusion: Ethanol extract of Peperomia pellucida (L.) Kunth leaves exhibits promising antidiabetic and anti-inflammatory properties in STZ-induced diabetic rats, as evidenced by reduced blood glucose, decreased IL-1β levels, and improved pancreatic histology. These findings suggest that Peperomia pellucida (L.) Kunth is a potential candidate for the development of natural therapies for diabetes management.  
Anti-inflammatory and Anti-infertility Effects of Ethanol Extract of Turmeric (Curcuma longa) in Male Wistar Rats with Type 2 Diabetes Mellitus Induced by Streptozotocin-Nicotinamide-High Fat Diet Vivian, Vivian; Lim, Hadyanto; Siahaan, Jekson Martiar; Anto, Endy Juli; Ilyas, Syaffrudin; Ardinata, Dedi
Indonesian Journal of Medicine Vol. 10 No. 4 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.4.891

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder associated with chronic inflammation and male reproductive dysfunction. The ethanol extract of turmeric (Curcuma longa) has demonstrated potential as an alternative therapeutic agent due to its anti-inflammatory and reproductive restorative properties. This study aims to analyze the anti-inflammatory and anti-infertility effects of the ethanol extract of Curcuma longa in male Wistar rats with T2DM induced by a streptozotocin-nicotinamide-high fat diet (STZ-NA-HFD). Subjects and Method: Thirty male Wistar rats were randomized into six groups (n=5): normal control (K1), diabetic control (K2), positive control (T2DM + metformin 45 mg/kgBW, K3), and three treatment groups receiving Curcuma longa extract at doses of 50 mg/kgBW (K4), 100 mg/kgBW (K5), and 150 mg/kgBW (K6). Diabetes was induced with STZ (55 mg/kgBW) and nicotinamide (120 mg/kgBW). Blood glucose, IL-6, testosterone levels, sperm count, and sperm motility were evaluated after 21 days of treatment. Results: The turmeric extract significantly reduced blood glucose levels (p<0.001) and IL-6 concentrations from 574.06±68.99 to 214.06±78.71 ng/mL at a dose of 150 mg/kgBW (p<0.001). Normal sperm motility increased significantly at 150 mg/kgBW (20.0±2.55%) compared to the diabetic control (8.40±2.07%) (p=0.008). Conclusion: The ethanol extract of Curcuma longa demonstrated significant anti-inflammatory activity by reducing IL-6 levels and improving glycemic control. Its anti-infertility effect was reflected by enhanced sperm motility, particularly at the 150 mg/kgBW dose. These findings indicate that Curcuma longa possesses potential as an adjuvant therapy for the management of T2DM and its associated complications.
PENYULUHAN MANFAAT IMUNISASI DASAR KEPADA MASYARAKAT DESA AJIJULU, KABUPATEN KARO Anto, Endy Juli; Hutasoit, Eka Samuel P.; Rimbun, Surjadi; Sinaga, Inda M.; Manullang, Frengky S.; Situmorang, Novrina; Tiji, Widjaya Taufik; Situmeang, Ivonne Ruth Vitamaya Oishi; Tambunan, Ronald T. H.; Simanjuntak, Evirosa J.; Anjany, Larasaty; Kembaren, Alfri Yoganta S.
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 3 No 1 (2023): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol3No1.pp1-5

Abstract

Community Service carried out by the Faculty of Medicine at the Universitas Methodist Indonesia by providing counseling about the benefits of basic immunization. Community Service was held 14-16 April 2023 in Ajijulu Timur Village, Tigapanah District, Karo Regency, North Sumatra. The counseling method used is by giving lectures, discussions and providing motivation. Question and answer discussions were carried out with the aim of gaining understanding, understanding and solutions as a form of solving problems and constraints faced by the local community. The results of this community service counseling and outreach are very effective considering that there are still many people who do not receive information about the benefits of immunization. With this counseling, the community becomes more aware of the importance of basic immunization. It is hoped that the people of Ajijulu will become more responsive and know how important this basic immunization is for infants, children and adolescents.
PENYULUHAN KONTROL HIPERTENSI DAN DIABETES SEJAK DINI KEPADA JEMAAT GEREJA HKBP GEDUNG JOHOR RESORT, KECAMATAN MEDAN JOHOR Anto, Endy Juli; Hutasoit, Eka Samuel P.; Siahaan, Jekson M.; Rimbun, Surjadi; Manullang, Frengky S.; Tiji, Widjaya Taufik; Tambunan, Ronald Tunggul Hotmarojahan; Lim, Hadyanto; Pasaribu, Sumihar Maurist Rantos; Tarigan, Menang Bastanta; Jamnasi, Juli; Sinatra, Jadeny; Silitonga, Hendrika Adriana
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 3 No 2 (2023): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol3No2.pp128-132

Abstract

Community Service (PKM) in the form of health education conducted by lecturers at the Faculty of Medicine, Indonesian Methodist University provides outreach about the benefits of controlling hypertension and diabetes mellitus from an early age. PKM was held on August 5 2023 at the HKBP church, Medan Johor District, North Sumatra. Lectures, question and answer discussions and motivation are used as orientation methods. A question and answer discussion was held with the aim of gaining insight and understanding to avoid complications from hypertension and DM. The results of PKM's socialization and work are very effective considering that there are still many people who have not received information about the benefits of vaccination through the basic immunization program. This education makes people more aware of the importance of routine control of health services. The HKBP church community must be aware and know the importance of early control in avoiding complications.
Penyuluhan Otitis Media Akut kepada Anak Panti Asuhan Advent Peduli Sembiring, Budi Darmanta; Anto, Endy Juli; Fauzi, Tengku Muhammad; Siahaan, Jekson Martiar; Tarigan, Menang Bastanta; Sijabat, Kesia; Sihaloho, Kerin Repaskatri; Manik, Widya Dayanti Feronika; Simanjuntak, Jeremia; Wijaya, Mega; Sihaloho, Lovian Nauli; Sembiring, Mikael; Panjaitan, Bintang Andika; Sitompul, Michael Sabatino; Momot, Estela Salomina
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 4 No 1 (2024): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol4No1.pp6-10

Abstract

In accordance with the application of the Tri Darma of Higher Education in the doctor's professional study program, one of which is community service. The purpose of community service activities is to provide explanations and education that can influence community behavior. This community service was carried out at an advent orphanage caring for children and adolescents with 25 participants. This community service activity was carried out on December 6, 2023, with the material of acute otitis media. This topic is very much needed in order to provide information and knowledge about acute Otitis media. Behavior to maintain ear hygiene and health to prevent this disease. Lack of knowledge many are subjected to unfavorable issues. Through this health counseling, it is expected that children and adolescents at Advent Peduli Orphanage, Gg. Kasih no 8, Sudirejo II, Kec. Medan Kota are always motivated to stay alert when playing with friends and keep their ears healthy.
Edukasi Kesehatan Prostat untuk Meningkatkan Kesadaran Deteksi Dini pada Jemaat GMI Manna Helvetia Medan Anto, Endy Juli; Siahaan, Jekson Martiar; Fauzi, Tengku M.; Normi, Siti; Panjaitan, Maludin; Hutapea, Kenal P.; Panataria, Lince Romauli; Simanjuntak, Pantas; Sihombing, Parsaoran; Saragih, Meylin Kristina; Manurung, Agnes Imelda; Sitorus, Efbertias; Sitorus, Ragnar Oktavianus; Simatupang, Jones T.; Nababan, Manaor Bismar Posman; Simatupang, Aditia Erick Cantona; Sirait, Kilian; Silalahi, Veraci
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 4 No 2 (2024): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol4No2.pp215-218

Abstract

Prostate disease is a significant health concern affecting men, particularly those over 35 years old. This community service activity aimed to increase knowledge and awareness about prostate disease among the congregation of GMI Manna Helvetia Medan through health education. The methods included educational presentations, motivational sessions, and question-and-answer discussions. The activity was attended by 45 participants aged 35-70 years. Results showed improved participant understanding of prostate disease symptoms, risk factors, and the importance of early detection. About 70% of participants committed to undergo prostate examination within the next 6 months. The educational approach through church community proved effective in delivering sensitive health information and raising awareness about the importance of regular check-ups.
Co-Authors Agnes Imelda Manurung Alex M. Lumbanraja Alexander P. Marpaung Anjany, Larasaty Ardinata, Dedi - B. Hutagalung , Sanggam Caroline Koswara Chalil, M. Jalaluddin A. Dearni Damanik Depari, A. A. Diani Nazma Dina Keumala Sari Dwi L. D. S. Siahaan Efbertias Sitorus Elizabeth Septianur Girsang Evirosa J. Simanjuntak Fadinie, Wulan Faskanita M. Nadapdap Fauzi, Tengku M. Fauzi, Tengku Muhammad Frengky S. Manullang Frengky S. Manullang Gani, Endang Haryanti Girsang, Elizabeth Girsang, Elizabeth Septianur Hadyanto L Hadyanto Lim Hakim, Enggrek Pelita Hamdi, Tasrif Helmida Gultom Hutapea, Kenal P. Hutasoit, Eka Samuel P Hutasoit, Eka Samuel P Hutasoit, Eka Samuel P. Ilyas, Syaffrudin Inda M. Sinaga Irfan Hamdani, Irfan Irina, Sinta Ivonne R. V. O Situmeang Ivonne Ruth Vitamaya Oishi Situmeang Jadeny Sinatra Jadeny Sinatra Jeffrey Jekson M. Siahaan Jerry Tobing Jimmy Jimmy Jones Simatupang Juli Jamnasi Juli Jamnasi Juliyanti Juliyanti Kembaren, Alfri Yoganta S. Laura P. S. Tambunan Lubis, Andriamuri P. Maludin Panjaitan Manik, Widya Dayanti Feronika Manullang, Frengky S. Manullang, Frenky Sorimuda Meilinda, Selvia Momot, Estela Salomina Nababan, Manaor Bismar Posman Natalie S., Karen Novianti, Wulan Noviyanti, Berliana Noviyanti, Berliana Novrina Situmorang Panataria, Lince Romauli Panjaitan, Bintang Andika Pasaribu, Sumihar Pratiwi, Ade Dwi Putri Chairani Eyanoer, Putri Chairani Ria Oktavia Rimbun, Surjadi Ronald T. H. Tambunan SARAGIH, MEYLIN KRISTINA Sari, Dina Keumala Sembiring, Budi Darmanta Sembiring, Mikael Siahaan, Dwi Lunarta D. S. Siahaan, Jekson M Siahaan, Jekson Martiar Sihaloho, Kerin Repaskatri Sihaloho, Lovian Nauli Sihombing, Parsaoran Sijabat, Kesia Silaen, Ester L. R. Silalahi, Veraci Silangit, Thomas Silitonga, Hendrika A Silitonga, Hendrika A Silitonga, Hendrika Adriana Silitonga, Hendrika Andriana Simanjuntak, Evirosa J. Simanjuntak, Harry C Simanjuntak, Harry C Simanjuntak, Jeremia Simanjuntak, Pantas Simatupang, Aditia Erick Cantona Simbolon, Boyke M. Sinaga, Inda M. Sinatra, Jadeny Sirait, Kilian Sitepu, John Frans Siti Normi, Siti Sitompul, Michael Sabatino Sitorus, Ragnar Oktavianus Situmeang, Ivonne Ruth Vitamaya Oishi Situmorang, Novrina Stephanie S., Kezia Sucipto Sucipto Syafruddin Ilyas Tambunan, Ronald T. H. Tambunan, Ronald Tunggul Hotmarojahan Tampubolon, Benny Tanjung, Qodri F. Tarigan, Juliyanti Tarigan, Menang B Tarigan, Menang Bastanta Tengku M. Fauzi Thomas Silangit Tiji, Widjaya Taufik Tiji, Wijaya Taufik Tim Lions Club Medan Angkasa Tobing, Paul S. M. L. Vivian Vivian Widjaya Taufik Tiji Widjaya Taufik Tiji Wijaya, Mega YUNAFRI, ANDRI Zainumi, Cut M.