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All Journal Jurnal Pangan dan Gizi Indonesian Journal of Pharmaceutical Science and Technology EduChemia: Jurnal Kimia dan Pendidikan Jurnal Kimia Riset As-syifaa Jurnal Farmasi Jurnal Kesehatan Bakti Tunas Husada Jurnal Pengabdian Pada Masyarakat Jurnal Agrotek UMMat Journal of Pharmacopolium JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kartika Kimia Jurnal Kreativitas PKM AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Indonesia Natural Research Pharmaceutical Journal (INRPJ) Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Farmagazine Jurnal Health Sains Jurnal Mitra Kesehatan Jurnal Abdimas Kartika Wijayakusuma Medical Sains : Jurnal Ilmiah Kefarmasian Berdikari : Jurnal Pengabdian kepada Masyarakat Sciences of Pharmacy Edukasi Masyarakat Sehat Sejahtera (EMaSS) Karya Kesehatan Siwalima Jurnal Kesehatan Bakti Tunas Husada Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika Sasambo: Jurnal Abdimas (Journal of Community Service) Jurnal Pengabdian kepada Masyarakat (PEMAS) Indonesian Journal of Herbal Science and Innovation
Yuliantini, Anne
Fakultas Farmasi, Universitas Bhakti Kencana
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Ethanol Extract of Grass Jelly Leaves: Bioactive Analysis and In silico Study on Estrogen Receptor Alpha Related to MCF-7 Breast Cancer Irpani, Abdul Mulki; Yuliantini, Anne; Bintang, Muhammad Ilham; Sella, Arinda Tri Pramay; Sodik, Jajang Japar
Sciences of Pharmacy Volume 5 Issue 3 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502619

Abstract

Breast cancer is a major cause of mortality among women and requires the development of alternative therapies derived from natural products. This study aimed to profile bioactive compounds in the ethanol extract of gras jelly leaves (Cyclea barbata Miers) and evaluate their predicted interactions with estrogen receptor alpha (ERα), a key regulator of proliferation in ER-positive MCF-7 breast cancer cells using an in silico approach. LC–HRMS analysis followed by database matching tentatively annotataed 44 major compounds based on peak intensity after data filtering. Molecular docking and simulation results indicated that several compounds exhibited favorable predicted binding affinity toward estrogen receptor targets. Among them, (3β,24R,24′R)-fucosterol epoxide demonstrated the most stable interaction. These findings suggest that the compound showed promising interaction stability toward the estrogen receptor in computational analysis. However, further in vitro and in vivo studies are required to validate its biological activity.
Co-Authors ., Noneng Abdul Mulki Irpani Ade Kurnia Saeful Agus Sulaeman Ahmad Rijalul Arif Aiyi Asnawi Aiyi Asnawi Aiyi Asnawi Aiyi Asnawi Aiyi Asnawi Alfi Fauzia Hakim Aligita, Widhya Andriansyah, Ivan Anggraeni, Vina Juliana Anri M Shaleh Deana, Anri M Shaleh Anti Restiani Antri Ariani Arfan Arfan Asep Mulyana Astri Fitriawati Avita Rischa Yunita Baiq Rimala Purnawija Bintang, Muhammad Ilham Deden Indra Dinata, Deden Indra Desi Wijayanti Eko Dewi Dewi Kurnia Dian Faizal Ellin Febrina Emma Emawati, Emma Emma Emmawati Emma Emmawati Ermilda Ermilda Fauzan Zein Muttaqin Funay, Riska Gaizka Verrel Santosa Gumilar, Hasna Fadhilah Idar Idar Idar Ilyas Nur Fatahillah Jajang Japar Sodik Juanda, Dadang Juliana, Vina Lilis Silviana Lutfiah Sakiba M Ramadhan Saputro Maulana, Mamay Mega Fatimah Rosana Mitsly Fauziyah Jamil Mufti Fauzi Rahman Muhammad Nur Abdillah Mutmainah, Siti Saidah Muttaqin, Fauzan Zein Noneng . Nurfitria, Rizki Siti Oktafiani, Hani Pratiwi, Ellen Rachmatunnisya Purwaniati, Purwaniati - Ranti Fitriyanti Reza Pratama Roni, Asep Saeful, Ade Kurnia Sakiba, Lutfiah Sella, Arinda Tri Pramay Sephia Indah Lutpiah Siti Aisyah Aprilia Siti Nur’aeni SITI SAIDAH Siti Saidah Mutmainah Soni Muhsinin Suhadirman, Aris Vina Juliana Vina Juliana Anggraeni Wendi Andriatna Wendi Andriatna, Wendi Widhya Aligita Widhya Aligita Winasih Rachmawati Winasih Rahmawati Winasih Rahmawati Yuni Kartika Yusiana Yusiana