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All Journal JURNAL ILMIAH KESEHATAN KEPERAWATAN Pharmaciana: Jurnal Kefarmasian Pharmacon CHEMPUBLISH JOURNAL Pharmascience Acta Pharmaciae Indonesia : Acta Pharm Indo Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Journal of Fundamental and Applied Pharmaceutical Science Prosiding Seminar Nasional Program Pengabdian Masyarakat Jurnal Pijar MIPA Jurnal Farmasi Sains dan Praktis Prosiding University Research Colloquium Jurnal Farmasi Klinik dan Sains Usadha Journal of Pharmacy Jurnal Ilmiah Kesehatan Keperawatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Kiromah, Naelaz Zukhruf Wakhidatul
Program Studi Farmasi Program Sarjana, Sekolah Tinggi Ilmu Kesehatan Muhammadiyah Gombong,
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Journal : Pharmacon

 1 
FORMULASI DAN EVALUASI SEDIAAN TABLET NANOPARTIKEL EKSTRAK DAUN SALAM (SYZYGIUM POLYANTHUM) DENGAN VARIASI KONSENTRASI NA ALGINAT DAN AVICEL PH 102 Setiawan, Agung; Kiromah, Naelaz Zukhruf Wakhidatul; Widiastuti, Tri Cahyani
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10107

Abstract

The use of traditional medicines is an alternative treatment which is considered safer in terms of side effects and toxicity. One of the herbal plants that have properties that can reduce blood pressure is bay leaf (Syzigium polyanthum) because it contains essential oils (citral, eugenol), tannin, and flavonoids. Ethanol extract of bay leaves (Syzigium polyanthum) with antihypertensive potential needs to be made into dosage forms. This study aimed to determine the optimal formula of the preparation of bay leaf (Syzigium polyanthum) nanoparticles tablet with variations in the concentration of Na alginate and Avicel PH 102. Salam leaf extract was made using maceration method using  ethanol 96%, followed by evaporation until thick extract was formed. Colloidal nanoparticles were prepared by mixing bay leaf extract into  technical ethanol 96% and aquadest, chitosan solution in acetic acid and NaTTP solution. Further, it was measured using PSA (Particle Size Analyzer) to determine the particle size. Tablets were prepared using 4 formulas with variations in the concentration of sodium alginate and avicel PH 102 using the direct pressing method. The results of this study indicate that variations in the concentration of Na alginate and Avicel PH 102 affect the physical properties of tablets. The addition of Avicel PH 102 can increase the hardness and disintegration time of the tablet. While the addition of Na alginate can increase the fragility of tablets. Based on the evaluation results, the optimum formulation of tablet formulas is formula 4.
Aktivitas Antibakteri Ekstrak Etanol Daun Sukun (Artocarpus altilis) Terhadap Bakteri Staphylococcus aureus Dan Escherichia coli Fiana, Fuan Maharani; Kiromah, Naelaz Zukhruf Wakhidatul; Purwanti, Ery
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10108

Abstract

Diarrhea is caused by bacterial infections, especially Staphylococcus aureus and Escherichia coli. The breadfruit leaves (Artocarpus altilis) are known contain flavonoid compounds, alkaloids, saponins, and tannins which can be used as antibacterial. This research was conducted to determine the ethanol extract of the breadfruit leaves against Staphylococcus aureus and Escherichia coli bacteria. The manufacture of the breadfruit leaf extract was using a maceration method with 96% ethanol solvent. The result of the tube test and the TLC test was positive, the breadfruit leaf extract containing flavonoids and tannins which have potential as antibacterial. The antibacterial test was carried out using the disc diffusion method (Kirby-Bauer test) against Staphylococcus aureus and Escherichia coli bacteria incubated for 1 x 24 hours. The extract concentrations tested were 10%, 15% and 20%. The positive control was using erythromycin antibiotics and the negative control was using aquades. The identification of the chemical content of plants is done by tube test and the TLC test. The results of incubation of the breadfruit leaf extract with concentrations of 10%, 15% and 20% against Staphylococcus aureus bacteria, the average diameter of inhibitory zones respectively were 3.67, 3.50 and 2.67 mm with the positive control diameter of inhibition zone was 18.5 mm, the negative control diameter of inhibition zone was 0 mm. The results of incubation of the breadfruit leaf extract with concentrations of 10%, 15% and 20% against Escherichia coli bacteria, the average diameter of inhibitory zones respectively were 5.33, 3.17 and 3.33 mm with the positive control inhibition zone diameter of 28.5 mm and the negative control of inhibition zone diameter of 0 mm. The activity of ethanol extract of the breadfruit leaves against the Staphylococcus aureus and Escherichia coli bacteria is included in the weak category.
Aktivitas Antioksidan Ekstrak Etanol Daun Ganitri (Elaeocarpus Ganitrus Roxb.) dengan Metode DPPH (2,2 Difenil-1-Pikrilhidazil) Naelaz Zukhruf Wakhidatul Kiromah; Sadam Husein; Titi Pudji Rahayu
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 1 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i01.12161

Abstract

Free radicals are one of the cause of various diseases. The use of synthetic antioxidant compounds could prevent the effect of the free radicals, however may cause adverse effects on the human body such as impaired liver, lung, intestinal and poisoning. Therefore antioxidant from natural resources needs to be developed. The purpose of this research was to determine the antioxidant activity and IC50 value of the ethanol extract of ganitri (Elaeocarpus ganitrus Roxbs.) leaves. Ganitri leaf ethanol extract activity test was carried out using DPPH method with vitamin C as a standard. Antioxidant activity was determined as a decreas in the absorbance of DPPH at 517 nm wavelength after an addition of the extract with the concentrations of 20, 40, 80, and 100 ppm. The antioxidant acitivity measurement of the ganitri leaf extract showed that the linier regression equation obtained was y = 0.3669x + 29.546, r = 0.4573 while the IC50 value was 54,12 ppm. Based on the result, it is concluded that the ethanol extract of ganitri (Elaeocarpus ganitrus Roxb.) leaf showed was categorized as strong antioxidant.
Formulasi dan Evaluasi Sediaan Tablet Nanopartikel Ekstrak Daun Salam (Syzygium Polyanthum) dengan Variasi Konsentrasi Na Alginat dan Avicel PH 102 Agung Setiawan; Naelaz Zukhruf Wakhidatul Kiromah; Tri Cahyani Widiastuti
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10107

Abstract

The use of traditional medicines is an alternative treatment which is considered safer in terms of side effects and toxicity. One of the herbal plants that have properties that can reduce blood pressure is bay leaf (Syzigium polyanthum) because it contains essential oils (citral, eugenol), tannin, and flavonoids. Ethanol extract of bay leaves (Syzigium polyanthum) with antihypertensive potential needs to be made into dosage forms. This study aimed to determine the optimal formula of the preparation of bay leaf (Syzigium polyanthum) nanoparticles tablet with variations in the concentration of Na alginate and Avicel PH 102. Salam leaf extract was made using maceration method using  ethanol 96%, followed by evaporation until thick extract was formed. Colloidal nanoparticles were prepared by mixing bay leaf extract into  technical ethanol 96% and aquadest, chitosan solution in acetic acid and NaTTP solution. Further, it was measured using PSA (Particle Size Analyzer) to determine the particle size. Tablets were prepared using 4 formulas with variations in the concentration of sodium alginate and avicel PH 102 using the direct pressing method. The results of this study indicate that variations in the concentration of Na alginate and Avicel PH 102 affect the physical properties of tablets. The addition of Avicel PH 102 can increase the hardness and disintegration time of the tablet. While the addition of Na alginate can increase the fragility of tablets. Based on the evaluation results, the optimum formulation of tablet formulas is formula 4.
Aktivitas Antibakteri Ekstrak Etanol Daun Sukun (Artocarpus altilis) Terhadap Bakteri Staphylococcus aureus Dan Escherichia coli Fuan Maharani Fiana; Naelaz Zukhruf Wakhidatul Kiromah; Ery Purwanti
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10108

Abstract

Diarrhea is caused by bacterial infections, especially Staphylococcus aureus and Escherichia coli. The breadfruit leaves (Artocarpus altilis) are known contain flavonoid compounds, alkaloids, saponins, and tannins which can be used as antibacterial. This research was conducted to determine the ethanol extract of the breadfruit leaves against Staphylococcus aureus and Escherichia coli bacteria. The manufacture of the breadfruit leaf extract was using a maceration method with 96% ethanol solvent. The result of the tube test and the TLC test was positive, the breadfruit leaf extract containing flavonoids and tannins which have potential as antibacterial. The antibacterial test was carried out using the disc diffusion method (Kirby-Bauer test) against Staphylococcus aureus and Escherichia coli bacteria incubated for 1 x 24 hours. The extract concentrations tested were 10%, 15% and 20%. The positive control was using erythromycin antibiotics and the negative control was using aquades. The identification of the chemical content of plants is done by tube test and the TLC test. The results of incubation of the breadfruit leaf extract with concentrations of 10%, 15% and 20% against Staphylococcus aureus bacteria, the average diameter of inhibitory zones respectively were 3.67, 3.50 and 2.67 mm with the positive control diameter of inhibition zone was 18.5 mm, the negative control diameter of inhibition zone was 0 mm. The results of incubation of the breadfruit leaf extract with concentrations of 10%, 15% and 20% against Escherichia coli bacteria, the average diameter of inhibitory zones respectively were 5.33, 3.17 and 3.33 mm with the positive control inhibition zone diameter of 28.5 mm and the negative control of inhibition zone diameter of 0 mm. The activity of ethanol extract of the breadfruit leaves against the Staphylococcus aureus and Escherichia coli bacteria is included in the weak category.
Co-Authors Afif Hussein Kholid Bahrisy Agung Setiawan agung setiawan Ainni, Ayu Nissa Arnika Dwi Asti Asriani Tagawuningsih Astri Ayu Febri Yuliani Awalia, Luluk Azhari, Tasya Khairunisa Azizah, Rizki Nur Bahrisy, Afif Hussein Kholid Billa, Zalsa Chondrosuro Miyarso Chondrosuro Miyarso Churrohmah, Syifa Condro Suro Miyarso Dwiki Fitri EkaWuri Handayani Eko Prasetyo Ery Purwanti Ery purwanti Evi Marlina Farda, Zais Fatimah, Ayu Febrialfiyan, Sukma Edhie Fiana, Fuan Maharani Fitriyati, Laeli Fuan Maharani Fiana Hamzah, Hasyrul Hasanah, Saniati Herniyatun Herniyatun, H Inayah, Siti Khobiratul Majidah Khuluk, Khusnul Khuluq, Muh Husnul Khusnul Khuluk Krisdiyanti, Yayu Kumalasari, Siska Kurniasih Kurniasih Kurniasih Kurniasih L Ledianasari L Ledianasari Laeli Fitriyati Laeli Fitriyati Laeli Fitriyati Ledianasari, L Majidah, Khobiratul Melisa, Leni Miyarso, Chondrosuro Miyarso, Condro Suro Muchromin Muchromin Muhammad Luthfi Mulyana, Satria Eta Nafarina, Eka Rezki Tri Ningsih, Eka Ratna Pamungkas, Anindya Arya Pratama, Dimas Aji pratiwi, lia nur Pratiwi, Noviani Pravitasari, Rokhania Eka Rachman Aziz, Dwinuari Rachmawati, Indah Raharjo, Rahmat Budhi Rahayu, Titi Pudji Rahayu, Venny Septiana Rahmat Ismail Rahmawati Rahmawati Sadam Husein Sadam Husein Sadam Husein Saputra, Aditya Mahe Septiani, Sinta Wahyu Sholihah, Rizka Hidayatus Sinta Wahyu Septiani Sinta Wahyu Septiani Sugeng Supriyanto Supriyanto, Sugeng Tagawuningsih, Asriani Tangawuningsih, Asriani Titi Pudji Rahayu Titi Pudji Rahayu TITI PUDJI RAHAYU Tri Cahyani Widiastuti Tri Cahyani Widiastuti Tri Cahyani Widiastuti Tri Cahyani Widiastuti Uswatun Hasanah Utomo, Hijan Dzulfadhli Wahyu Rahmatulloh Wahyuni, Septi Widiastuti, Tri Cahyani Yayu Krisdiyanti Yayu Krisdiyanti Yusuf Kurniawan Yusuf Kurniawan Zubaidah, Siti Nur