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All Journal Journal of Biomedicine and Translational Research PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman The Indonesian Biomedical Journal Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry Hearty : Jurnal Kesehatan Masyarakat Jurnal Keperawatan dan Fisioterapi (JKF) JURNAL KEBIDANAN KESTRA (JKK) Jurnal Kesmas dan Gizi (JKG) JURNAL FARMASIMED (JFM) Jurnal Indah Sains dan Klinis FORTE JOURNAL CHEDS: Journal of Chemistry, Education, and Science Jurnal Farmanesia Jurnal Multidisiplin Madani (MUDIMA) Formosa Journal of Sustainable Research (FJSR) JURNAL KIMIA SAINTEK DAN PENDIDIKAN Jurnal Pengmas Kestra (JPK) Jurnal ABDIMAS MUTIARA Jurnal Indah Sains dan Klinis
Aritonang, Barita
Institut Kesehatan Medistra Lubuk Pakam
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Anti-Inflammatory Potential of Combined Turmeric Rhizome Extract (Curcuma longa L.) and Hydroxyapatite in Male White Mice (Mus musculus) Ritonga, Ahmad Hafizullah; Amelia, Fatma; Herlina, Herlina; Aritonang, Barita; Harefa, Karnirius
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/garnbm90

Abstract

Inflammation is a protective response of the body to tissue injury that needs to be controlled to prevent further damage. The use of nonsteroidal anti-inflammatory drugs is effective; however, it has the potential to cause side effects, so safer alternatives are needed. Turmeric rhizome (Curcuma longa L.) is known to have anti-inflammatory activity, while hydroxyapatite (HA) is biocompatible and has the potential to enhance the effectiveness of the combination. This study aims to evaluate the anti-inflammatory potential of the combination of turmeric rhizome ethanolic extract and HA in male white mice (Mus musculus). This research method uses an experimental design with an acute inflammation model induced by intraplanar injection of 1% carrageenan. A total of 25 mice were divided into five groups: negative control (0.5% Na-CMC), positive control (diclofenac sodium), and three treatment groups at 0.5%, 1%, and 1.5%. Edema volume was measured every 1 hour for 6 hours and analyzed using the Kruskal-Wallis test followed by a post hoc test. The results of this study showed that all treatment groups exerted anti-inflammatory effects compared to the negative control, as indicated by decreases in edema volume and the percentage of inflammation and increases in the percentage of inhibition of inflammation, with the 1.5% concentration showing the most optimal effect. These findings indicate that the combination of turmeric rhizome ethanolic extract and HA has potential as an effective anti-inflammatory agent in male white mice.
The Influence of Activated Carbon Produced from Duck Eggshells as an Adsorbent for Free Fatty Acid Content of Used Cooking Oilc Aritonang, Barita; Ritonga, Ahmad Hafizullah; Harefa, Karnirius; Herlina, Herlina; Wiratma, Dicky Yuswardi
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/r6vzyw08

Abstract

The repeated use of cooking oil can lead to a decline in oil quality and an increase in free fatty acid (FFA) levels, which may pose adverse health effects when consumed continuously. Therefore, an effective, safe, and sustainable purification method is required to improve the quality of used cooking oil. This study aims to evaluate the effectiveness of activated carbon derived from duck eggshell waste in reducing FFA levels in used cooking oil. The research employed a laboratory experimental method with a post-test only control group design. Samples of used cooking oil were selected purposively based on a level of degradation representative of real conditions. The preparation of activated carbon began with the carbonisation of duck eggshells, followed by chemical activation using a 3 M phosphoric acid (H₃PO₄) solution to enhance surface area and adsorbent porosity. The resulting activated carbon was then applied in the adsorption process of used cooking oil. FFA levels were analysed using the alkalimetric titration method. The results showed that the activated carbon significantly reduced FFA levels from 1.57% to 0.22%, with a reduction efficiency of 75%. This final value complies with the quality standard for cooking oil according to SNI 3741:2013 (≤0.3%). Furthermore, the produced activated carbon exhibited favourable characteristics, as indicated by a high iodine adsorption capacity and well-developed pore structure. In conclusion, activated carbon derived from duck eggshells is effective as an adsorbent for reducing FFA levels in used cooking oil and shows strong potential as an environmentally friendly and economically valuable solution.
Formulation and Evaluation of Bioactive Gelatin from Tilapia (Oreochromis niloticus) Scales as an Antioxidant-Based Anti-Aging Cream Herlina, Herlina; Wulandari, Suci; Barita Aritonang; Amelia Putri Eflynia; Lasmaryna Sirumapea
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/nnzg2676

Abstract

The increasing demand for sustainable, bioactive cosmetic ingredients has driven the use of marine by-products as alternative raw materials. Tilapia (Oreochromis niloticus) scales, an abundant aquaculture waste, are rich in collagen that can be converted into gelatin with potential dermatological applications. This study aimed to develop and evaluate bioactive gelatin derived from tilapia scales as an antioxidant-based anti-aging cream. Gelatin was extracted with 15% acetic acid and characterized by physicochemical parameters, including yield (4.6%), moisture content (12%), and ash content (2.2%), all of which met SNI standards. Antioxidant activity was determined using the DPPH method, yielding an IC₅₀ value of 139.46 ppm, indicating moderate to weak antioxidant activity. The gelatin was formulated into cream preparations at concentrations of 1%, 1.5%, and 2%, and the formulations were evaluated for stability, homogeneity, pH, spreadability, and irritation. Anti-aging efficacy was assessed using a skin analyzer, showing improvements in skin moisture and sebum balance, with the 1% formulation demonstrating optimal performance. Although the antioxidant activity was relatively low, topical application of gelatin contributed to measurable anti-aging effects. These findings highlight the potential of tilapia scale-derived gelatin as a sustainable bioactive ingredient for cosmeceutical applications.
Efektivitas Antimikroba Kombinasi Ekstrak Etanol Rimpang Kunyit (Curcuma longa L.) dan Hidroksiapatit dalam Menghambat Pertumbuhan Streptococcus sobrinus Ritonga, Ahmad Hafizullah; Purba, Kristin Eliana; Aritonang, Barita; Herlina, Herlina; Harefa, Karnirius
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.01

Abstract

Latar Belakang: Karies gigi merupakan salah satu masalah kesehatan mulut dengan prevalensi tertinggi di seluruh dunia, yang memengaruhi baik anak-anak maupun orang dewasa. Streptococcus sobrinus berperan penting dalam perkembangan karies dengan memfermentasi karbohidrat dan menghasilkan asam yang menyebabkan demineralisasi enamel. Penggunaan antimikroba kimiawi konvensional dapat menimbulkan efek samping, termasuk gangguan mikroflora oral dan berkembangnya resistensi bakteri. Oleh karena itu, diperlukan alternatif antimikroba alami. Tujuan: Penelitian ini bertujuan untuk mengevaluasi efektivitas antimikroba dari kombinasi ekstrak etanol rimpang kunyit (Curcuma longa L.) dan hidroksiapatit terhadap Streptococcus sobrinus. Metode: Penelitian eksperimental ini menilai berbagai rasio ekstrak etanol kunyit dan hidroksiapatit terhadap pertumbuhan Streptococcus sobrinus menggunakan metode zona hambat. Skrining fitokimia juga dilakukan untuk mengidentifikasi senyawa bioaktif dalam ekstrak kunyit. Hasil: Analisis fitokimia menunjukkan adanya alkaloid, flavonoid, tanin, dan saponin. Pengujian antibakteri menunjukkan zona hambat sebesar 10,6 mm untuk ekstrak kunyit, 7,7 mm untuk hidroksiapatit, dan 10,7 mm untuk kombinasi dengan rasio 3:1. Kesimpulan: Ekstrak etanol rimpang kunyit yang dikombinasikan dengan hidroksiapatit menunjukkan aktivitas penghambatan terhadap Streptococcus sobrinus, sehingga berpotensi sebagai antimikroba alami untuk pencegahan karies gigi.
Co-Authors Abdi Lestari Sitepu Ahmad Hafizullah Ritonga Amelia Putri Eflynia Amelia, Fatma Asvia Rahayu Badriani, Nurainun Chatarina Umbul Wahyuni Cut Masyitah Thaib Cut masyithah Debi Meilani Desideria Yosepha Ginting Dicky Yuswardi Wiratma Eka Margareta Sinaga Eka Margareth Erawati, Suci Erdiana Gultom Erdiana Gultom Erdiana Gultom Gultom, Erdiana Harahap, Hasni Yaturramadhan Hasni Yaturramadhan Harahap Hendri Faisal Herlina Herlina , Herlina Herlina . Herlina H Herlina Herlina Hermansyah Aziz Hestina . Hestina Hestina Hestina, Hestina Imel Santika Irmayani Irmayani Karnirius Harefa Karo-Karo, Julyenni Khairiah, Khairiah Lasmaryna Sirumapea Lenny Novita Liver Iman Putra Zai manullang, Selda Melda Astrika Sianipar Munthe, Novita Br Ginting Ningrum, Dian Hastari Nova Florentina Nova Florentina Nova Florentina Ambarwati Novesar Jamarun Novita Br Ginting Nur Mala Sari Panjaitan, Delita Pitriani, Pitriani Pranata, Chandra Purba, Kristin Eliana Putri, Gusliani Eka Rahmad Gurusinga Rahmad Gurusinga RAMAWATI, NURVITA rianta, Rianta Rima Anggeraini Riri Safitri Rotua Sumihar Sitorus Salomo Sijabat Saragih, Eriani Senaya Siagian, Ernita Siahaan, Enzo W.B Sijabat, Salomo Simanjuntak, Putri Nuraimun Sinaga, Eka M Sinaga, Evi Yuni Sintia Sinaga, Sri Lestari Siregar, Sa'adah Sitepu, Rahmadani Sitorus, Elly Sri Melda Bangun Sri Ulina Sri Wulan, Sri Suarnikan Hulu Suci Wulandari Supartiningsih - - Syarifuddin, Shofian Syukri Arief Tamrin Tamrin Virta Filantropi Zebua Widyaningsih, Fadlilah Yanti, Rahma Yaturramadhan Harahap, Hasni Yosi Darmirani Yossy Silalahi Yulidar Laila Safitri Yunita Sari