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OPTIMASI FORMULA HANDSANITIZER MINYAK BUNGA CENGKEH (Syzygium aromaticum): EVALUASI SIFAT FISIK DAN UJI ANTIBAKTERI TERHADAP Staphylococcus aureus : FORMULATION OPTIMIZATION OF CLOVE ESSENTIAL OIL HAND SANITIZER (Syzygium aromaticum) : PHYSICAL PROPPERTY EVALUATION AND ANTIBACTERIAL TESTING AGAINST Staphylococcus aureus Nafisah Isnawati; Pujiastuti, Atikah
Jurnal Ilmiah Pamenang Vol. 6 No. 1 (2024): Jurnal Imiah Pamenang (JIP)
Publisher : Stikes Pamenang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53599/jip.v6i1.210

Abstract

Abstrak   Penyakit infeksi bisa ditularkan melalui perantara tangan maka dari itu, salah satu cara untuk membersihkan tangan secara efisien, efektif dan aman adalah dengan menggunakan hand sanitizer yang mengandung bahan aktif dari alam. Kandungan utama dalam minyak atsiri bunga cengkeh adalah senyawa eugenol sebesar 72-90%. Senyawa eugenol bunga cengkeh merupakan senyawa antibakteri mampu menghambat pertumbuhan bakteri. Penelitian ini bertujuan untuk mengetahui untuk mengetahui mutu fisik yang meliput uji organoleptis, uji pH, uji homogenitas, uji daya sebar, uji daya lekat, uji viskositas dan uji aktivitas antibakteri sediaan terhadap bakteri Staphylococcus aureus. Metode penelitian ini bersifat eksperimental dimana dilakukan formulasi sediaan dengan konsentrasi minyak atsiri bunga cengkeh 4%, 6%, 10%. Evaluasi mutu fisik sediaan emulgel  meliputi uji organoleptis, uji pH, uji homogenitas, uji daya sebar, uji daya lekat, uji viskositas dan uji aktivitas antibakteri terhadap bakteri Staphylococcus aureus dengan metode difusi cakram. Hasil penelitian menunjukkan bahwa ketiga formulasi menghasilkan emulgel yang homogen, lembut, kental, berbau khas cengkeh, berwarna bening, putih tulang, putih kekuningan dan kuning langsat. Mutu fisik homogenitas, daya sebar, daya lekat sediaan emulgel hand sanitizer minyak atsiri bunga cengkeh memenuhi persyaratan mutu fisik sediaan namun untuk uji pH hanya F3 yang memenuhi persyaratan uji mutu pH dan sediaan emulgel F1 dan F1 mempunyai potensi daya hambat sedang, dan F3 memiliki potensi yang paling kuat dalam membunuh bakteri. Abstract   Infectious diseases can be transmitted through hands, therefore one way to clean hands efficiently, effectively and safely is to use an emulgel hand sanitizer which contains active ingredients from nature. The main content of clove flower essential oil is eugenol compound of 72-90%. Clove flower eugenol is an antibacterial compound that can inhibit bacterial growth. This study aims to determine whether clove flower essential oil can be formulated into an emulgel hand sanitizer preparation, to determine the physical quality which includes organoleptic test, pH test, homogeneity test, spreadability test, adhesion test, viscosity test and antibacterial activity test of the preparation against bacteria Staphylococcus aureus. This research method is experimental in nature where formulations are made with clove flower essential oil concentrations of 4% (F1), 6% (F2), 10% (F3) and base control (F0). Evaluation of the physical quality of emulgel preparations included organoleptic tests, pH tests, homogeneity tests, spreadability tests, adhesion tests, viscosity tests and antibacterial activity tests against Staphylococcus aureus bacteria. The results showed that the three formulations produced an emulgel that was homogeneous, soft and viscous, had a distinctive clove odor, was clear in color, white in bone, yellowish white and olive. The physical quality of homogeneity, dispersion, adhesive power of clove essential oil hand-processed clove essential oil met the physical quality requirements of the preparation but for the pH test only F3 met the pH quality test requirements and emulgel preparations F1 and F1 have moderate inhibitory potential, while F3 has the strongest potential in killing bacteria.
Pelatihan Pembuatan Produk Minuman Kesehatan Berbasis Bahan Alam dan Penyuluhan Regulasi Perijinan SPP IRT Nafisah Isnawati; Shinta Mayasari; Khrisna Agung; Endang Lifchatullaillah; Helmalia, Helmalia
ABDIKAN: Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Vol. 2 No. 4 (2023): November 2023
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/abdikan.v2i4.2481

Abstract

The empirical utilization of plants as traditional medicine is still limited to making herbal decoctions which are rather long and on average taste bitter. The development of the utilization from medicinal plants in the form of health drinks that are easy to consume and taste acceptable to the public is still very low. Plant materials that are widely used include kencur in the form of herb beras kencur, temu lawak in the form of herb temu lawak. Therefore, this activity is to improve the health status for the community and increase the economic independence of the community by entrepreneurship with health drinks that are made from natural ingredients with innovative processing. The method that used in is counseling and hands-on practice of making, labeling products. The target audience is people whose daily activities are small entrepreneurs. The results obtained from this activity are increasing knowledge about the utilization of natural ingredients as health drinks, knowledge of SPP-IRT licensing regulations, and processing practices for making, packaging and labeling health drink products in the form of instant beras kencur, instant temu lawak and temu lawak syrup that have worth to sell.
EFFECT OF DRYING TEMPERATURE AND TIME ON TABLET FORMULATION OF MORINGA LEAF (Moringa oleifera) EXTRACT WITH WET GRANULATION METHOD USING FLUID BED DRYER Isnawati, Nafisah; Zulfatul Maskuriah, Dian; Wicaksono, Yudi
International Journal of Islamic and Complementary Medicine Vol. 2 No. 2 (2021): International Journal Islamic Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (224.529 KB) | DOI: 10.55116/IJIM.V1I1.27

Abstract

Moringa leave is medicinal plant type that often used by society. Flavonoid and saponin are the content of moringa leave which have benefit as immunomodulator. Moringa leave using can be more practical and easy to used by making as pharmaceutical preparation. Drying temperature and time have a great effect on the physical properties of granule and tablet manufacturing. The objective of this research is to find out the effect of drying temperature and time on the physical-mechanical properties of granule and physical-disintegrant properties of moringa leave extract tablet by wet granulation method. The research method using experimental laboratory methods is correlational (causation). Moringa leave extract tablet was made with 6 formulations by various drying temperature and time. Drying temperature and time which used are FI 40°35', FII 50°35', FIII 60°35', FIV 40°45', FV 50°45', FVI 60°45'. Each formulation was carried out physical properties test of granule and tablet. The data obtained were compared to the pharmacopoeai and other literature and carried out statistical test. In order to know the effect of temperature using Shapiro-Wilk test, then continued ANOVA test, while for the effect of time using independent sample T-test with 95% confidence level, then continued Turkey-HSD test. The result of the test showed that the differences of drying temperature and time have effect on the physical properties of tablet, namely, hardness, brittleness, and disintegration time. The increasing of drying temperature and time are able to reduce the brittleness, increase the hardness, and prolong disintegration time of tablet.  
DESCRIPTION OF CLINICAL POLYPHARMACY PRESCRIPTIONS IN TYPE 2 DIABETES MELLITUS PATIENTS AT HOSPITAL X JEMBER DISTRICT Nurul Fathona; Shinta Mayasari; Nafisah Isnawati
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.29

Abstract

Background: Diabetes mellitus (DM) is a metabolic disease caused by insulin resistance and pancreatic beta cell dysfunction. Polypharmacy is the use of three or more drugs every day is very common in patients with diabetes mellitus. WHO data shows that the prevalence of Diabetes Mellitus (DM) polypharmacy will reach 7.4% - 43.4% by 2023. Objective: This study aims to determine the clinical picture of polypharmacy prescriptions in patients with type 2 diabetes mellitus at X Hospital, Jember Regency. Method: This study used a descriptive non-experimental method by observation, involving 80 samples. Samples were selected by random sampling and data were analysed and displayed in the form of frequencies and percentages using Microsoft Excel and SPSS. Results: The results of this study are the description of the most polypharmacy prescriptions, namely prescriptions with 3 drug items as many as 3 prescriptions (7.5%), and the description of the least polypharmacy prescriptions, namely prescriptions with 4 drug items, and prescriptions with 10 drug items as many as 1 prescription (1%). In addition, the results of this study also contained drug interactions as many as 72 interacting prescriptions. Conclusion: From the discussion above, it can be concluded that, in the study at Hospital X, Jember Regency, polypharmacy was found from the samples analysed, all of which were polypharmacy prescriptions. This study also found that prescriptions for type 2 diabetes mellitus patients experienced drug interactions with moderate interactions being the most common. These interactions can reduce the effectiveness of treatment and increase risks for patients.
Uji Stabilitas Siklik Hair Growth Tonic Seledri (Apium Graveolens L.) Celery (Apium Graveolens L.) Hair Growth Tonic Cycling Test Ayu Angger Putri M. Soleh; Mery Dian Frissanty; Nafisah Isnawati; Dina Trianggaluh Fauziah
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.6967

Abstract

Kerusakan rambut akibat kebiasaan harian, lingkungan, dan kondisi kesehatan mendorong permintaan tonik penumbuh rambut yang aman, namun bahan sintetis seperti minoxidil berisiko menyebabkan alergi dan sakit kepala. Apigenin dari seledri (Apium graveolens L.) menjadi alternatif alami. Penelitian ini bertujuan menganalisis perbedaan stabilitas siklik hair growth tonic ekstrak daun seledri konsentrasi 4%, 9%, dan 14%. Penelitian eksperimental kuantitatif pra-post test menggunakan tiga formula tonik 100 ml sebagai sampel purposif. Instrumen meliputi pH meter, viskometer, piknometer, dan SPSS 25 untuk uji normalitas Shapiro-Wilk diikuti uji Wilcoxon/T-paired (Sig >0,05). Hasil menunjukkan tidak ada perubahan signifikan parameter fisikokimia (karakteristik fisik, ketersebaran zat aktif, pH 3-7, densitas <1 g/ml) selama 6 siklus pada semua formula, meskipun konsentrasi 14% melebihi batas viskositas (7,7 cPs >5 cPs) siklus ke-3. Konsentrasi lebih tinggi menurunkan pH, meningkatkan densitas dan viskositas. Kesimpulannya, konsentrasi 4% dan 9% menunjukkan stabilitas siklik sangat baik, mendukung pengembangan kosmetik herbal.
Peningkatan Pengetahuan Pemanfaatan Tanaman Obat Daun Sirih (Piper Betle) Pada Masyarakat Suku Osing Kabupaten Banyuwangi Khrisna Agung Cendekiawan; Nafisah Isnawati; Shinta Mayasari; Neny Poerwahyuningrum; Firdha Aprillia Wardhani; Dea Maulidi Saputri
Jurnal Pengabdian Masyarakat Madani Vol 6 No 1 (2026): Jurnal Pengabdian Masyarakat Madani (JPMM)
Publisher : Sekolah Tinggi Ekonomi Bisnis Syariah Bina Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51805/jpmm.v6i1.218

Abstract

Pulau Jawa merupakan “pulau yang kaya keanekaragaman hayati. Obat tradisional pada etnis Suku Osing umumnya masih dalam bentuk yang sederhana. Bahan baku yang diambil dari alam setelah dibersihkan biasanya langsung digunakan dalam bentuk segar dengan cara direndam atau direbus, kemudian diminum, diolah dengan cara dihaluskan dan ditumbuk/dipanaskan dalam bungkusan daun. Pengetahuan dan pemanfaatan tanaman obat masih minim, terutama dalam pengolahannya menjadi sediaan yang efektif dan efisien agar mudah digunakan. Sirih hijau (Piper betle) merupakan tumbuhan yang dapat dimanfaatkan sebagai obat tradisional terutama pada bagian daunnya. Tujuan dari kegiatan ini adalah untuk meningkatkan pengetahuan warga tentang khasiat tanaman sirih hijau sekaligus mendorong warga memanfaatkan lahan pekarangan rumah untuk menanam tanaman tersebut sebagai tanaman obat keluarga serta dapat mengolah simplisia sirih hijau sebagai teh herbal untuk digunakan sebagai minuman berkhasiat obat. Metode yang digunakan adalah sosialisasi, edukasi materi tentang daun sirih hijau, dan pelatihan pembuatan teh herbal. Edukasi dilakukan dengan mengukur tingkat pengetahuan menggunakan kuesioner yang dibagikan sebelum (pretest) dan sesudah (post-test) pemberian materi. Hasil pretest menunjukkan bahwa pengetahuan dan minat warga untuk membudidayakan tanaman sirih hijau masih kurang. Namun, hasil post-test menunjukkan bahwa pengetahuan mereka menjadi meningkat. Kesimpulan dari kegiatan ini adalah terdapat peningkatan pengetahuan warga tentang tanaman berkhasiat obat daun sirih hijau (Piper betle).”
The Examination activity of salam leaf ethanolic ekstract (Syzygium polyanthum)[Wight] in mice: The examination activity of salam leaf ethanolic ekstract (Syzygium polyanthum)[Wight] in mice Shinta Mayasari; Wima Anggitasari; Nafisah Isnawati
Health Media Vol. 1 No. 2 (2020)
Publisher : UrbanGreen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55756/hm.v1i2.35

Abstract

The examination effect of salam leaf ethanolic extract where the purposed of this study was to determine the effect and concentration of salam leaves as antidiarrheals. Ethanol extract dosages of salam leaf given orally (mg/kgbw) was 15;20;25;30;and 35, carried out abservations on mice starting diarrhea, weight of faeces, frequency diarrhea, and the duration of diarrhea for 5 hours. Loperamide HCl given dose of 1 mg/kg is used comparison with negative control CMC-Na, and comparison of Loperamide HCl was the 56th minute, 57,3; 57,9; 59; 58; 64,3 ; 54,3. Stool weight obtained an average of 0,34; 0,35; 0,32; 0,25; 0,27; 0,53; 0,21. The frequency of diarrhea was 8,8; 8,6; 8,9; 9,3; 8,6; 11,2; 8,5. Onset of diarrheal was average of minutes was 206,8; 207,6 ; 209,2; 209; 206,2; 230 and 88. From the research results obtained ethanol extract salam leaves given antidiarrheal effects with an optimum dose of 35mg/kgbw.
Formulation and Effectiveness Test of Eschericia coli Bacteria Organic Liquid Soap Preparations Aloe Vera Leaf (Aloe Vera Linn) Nafisah Isnawati
Health Media Vol. 1 No. 2 (2020)
Publisher : UrbanGreen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55756/hm.v1i2.39

Abstract

Research on organic liquid soap formulations and the effectiveness test of Echericia coli bacteria from Aloe vera (Aloe vera linn) have been conducted. This research aims to formulate and test the effectiveness of liquid soap preparations using natural ingredients. The formulation is made by aloe vera leaves, sodium chloride, suji leaf coloring, and the lime scent with concentrations of 10%, 25%, and 50%. The results of the research organoleptic test process were the results of soap preparations with liquid texture, the lime scent and the typical green color of suji leaves. The pH of the observations was 6 for various concentrations. High liquid soap foam with 10% concentration obtained an average of 89.27 mm, a concentration of 25%, 69.46 mm, and a concentration of 50% with an average of 52.05 mm. the result of liquid test specific soap obtained from 10% concentration is 1.037g / ml, 25% concentration is 1.048 g / ml and 50% concentration is 1.059 g / ml. the resultsof research obstacles zone on Echericia coli bacteria obtained an average of 16.7 mm for a concentration of 10%, 18.7 mm for a concentration of 25%, and a obstacles zone of 22.7 mm for a concentration of 50% and for irritation test 100% found no irritation.
PENGETAHUAN IBU TENTANG SWAMEDIKASI DAN HUBUNGAN DENGAN KEBERHASILAN PENGELOLAAN DIARE   PADA ANAK BALITA Shela Nur Amita; Jenie Palupi; Nafisah Isnawati
The Health Researcher's Journal Vol. 3 No. 1 (2026): The Health Researchers Journal
Publisher : The SDGS Forum Communication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.00000/f2693g40

Abstract

Diare merupakan salah satu masalah kesehatan yang masih menjadi penyebab utama morbiditas dan mortalitas pada anak balita di negara berkembang, termasuk Indonesia. Kondisi ini dapat menyebabkan dehidrasi yang berpotensi fatal apabila tidak ditangani secara cepat dan tepat. Penanganan yang efektif di tingkat rumah tangga menjadi aspek penting dalam pencegahan komplikasi. Salah satu pendekatan yang umum dilakukan masyarakat adalah swamedikasi, yaitu upaya pengobatan sendiri tanpa resep dokter, yang dilakukan berdasarkan pengetahuan dan pengalaman sebelumnya. Pengetahuan ibu sebagai pengasuh utama balita memegang peranan penting dalam menentukan keberhasilan swamedikasi, karena ketepatan pemilihan obat, dosis, frekuensi pemberian, serta pengenalan tanda bahaya sangat bergantung pada pemahaman mereka. Penelitian ini bertujuan untuk mengidentifikasi tingkat pengetahuan ibu tentang swamedikasi diare pada balita, menilai keberhasilan penanganan diare, serta menganalisis hubungan antara keduanya. Penelitian menggunakan desain deskriptif analitik dengan pendekatan cross sectional pada 47 ibu yang memiliki anak balita pernah mengalami diare, yang dipilih menggunakan teknik purposive sampling. Instrumen berupa kuesioner tertutup telah teruji validitas (0,926) dan reliabilitas (0,813), dengan analisis data univariat dan bivariat menggunakan uji Chi-Square pada tingkat signifikansi 0,05. Hasil penelitian menunjukkan sebagian besar ibu memiliki pengetahuan cukup (85,6%) dan keberhasilan penanganan diare tergolong tinggi (31,9%). Uji Chi-Square menghasilkan p-value 0,000 yang menunjukkan adanya hubungan signifikan antara pengetahuan ibu tentang swamedikasi dan keberhasilan penanganan diare pada balita. Oleh karena itu, diperlukan edukasi lanjutan agar ibu dapat melakukan penanganan awal diare secara tepat.
Analisis Break Even Point pada Manajemen Budidaya Pemeliharaan Domba di Kabupaten Jember Endang Lifchatullaillah; Stivaniyanti Atmanegara; Nafisah Isnawati; Adi Rama
AKUA: Jurnal Akuntansi dan Keuangan Vol. 4 No. 3 (2025): Juli 2025
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/akua.v4i3.4307

Abstract

Break Even Point (BEP) in sheep farming management can be used to provide information about breaking even point search (Break Even Point) as the basis for profit planning for the business being run. Information regarding production costs, management strategies, and break-even challenges was collected through semi-structured interviews. The results of the study show that most farmers have not systematically applied BEP analysis in their business planning. The main factors that affect the break-even are fluctuations in feed prices, livestock mortality rates, and access to markets. Farmers' experience in managing finances and marketing strategies also plays a role in the success of the livestock business. This research framework refers to a descriptive quantitative approach with a direct interview method with sheep farmers as the research subject. Implications for Farmers, providing a deeper understanding of the importance of Break-Even Point (BEP) analysis in business financial management, for Policymakers as a basis for designing training and mentoring programs for farmers, Academics and Researchers opens up opportunities for further research on the role of social, technological, and innovative factors in achieving BEP in sheep farming, for Financial Institutions, To assess the feasibility of a sheep farming business in providing business credit, for investors to identify investment risks and opportunities in the sheep farming industry.
Co-Authors Abdullah Azzam Mubarok Achmadan Rizki Trisnawan Adek Intan Suryaning Rahayu Adi Rama Agustin, Nanda Nelly Alfajri, Irza Aliyah Purwanti Ana Karunia Angga Dwi Rofiqil Anggraeni, Lutvi Anisa Agustina April Nuraini April Nuraini Aril Alifia Salsabila Athallah, Naufal Atmanita Khairomatul L Ayu Angger Putri M. Sholeh Ayu Angger Putri M. Soleh Danipratiwi, Sidta Putrirachman Darotin, Rida Dea Maulidi Saputri Dewi Lufitasari Dhina Ayu Susanti Diah Yuli Pangesti Dina Tria Dina Tria Dina Trianggaluh Dina Trianggaluh Fauziah Dina Trianggaluh Fauziah Dwi, Jacinta Dyan Wigati Dzikri, Fachrizal Endang Lifchatullaillah Endang Lifchatullaillah Fachrizal Dzikri Fathmasari, Tiara Fatika, Diva Aulia Nur Fitria Meliana Putri Florentinus Dika Octa Riswanto Friskila Nenobesi Galuh Maulidatun Nufus H, Prasetyo HELMALIA HELMALIA, HELMALIA Helmalia Shintawati Hidayatul Wahdah Hilda Khoirunnisa Rohma Illa Faizah Nur’Ain Irza Alfajri Iski Weni Pebriarti Jenie Palupi Kenny Raul Supaat Khafifah Indar Purwaningsih Khamim, Nur Khofifah Amini Khoirun N., Hilda Khrisna Agung Cendekiawan Kustin Kustin, Kustin Lina Winarti Lina Winarti lindawati setyaningrum Lufitasari, Dewi M. Rofik Usman Mega Fitriya Purnama Dewi Mery Dian Frissanty Miatuz Zaqia Mubarok, Abdullah Azzam Nanda Yulita Sari Natasya, Leanasta Ina Naufal Athallah Neny Poerwahyuningrum Noval Kurniawan Nufus, Galuh Maulidatun Nur Azizah Perdani Puteri Syahuri Syahuri Nuraini, April Nurul Fathona Nurul Izmi Agustina Pangesti, Yuli Perdana, Rastra Airlangga Poppy, Leony Rayvina Pujiastuti, Atikah Purwaningsih, Khafifah Indar Rahayu, Adek Intan Suryaning Rastra Airlangga Perdana Ratri Rokhani Ratri Rokhani Rayyan Sabil Prayoga Regeena Juia Yasmine Rike Septianingrum Rindiani Safitri Rokhani, Ratri Rosita Bahadun Safitri, Rindiani Shela Nur Amita Shinta Mayasari Shinta Mayasari Sholihatil Hidayati Sidta Putrirachman Danipratiwi Silvia Yunani Trisnani Siti Rosyida Sivi Richa Marini Stivaniyanti Atmanegara Supaat, Kenny Raul Susanti, Dhina Ayu Thomas Adhi Tamsyah Tiara Fathmasari Trisnani, Silvia Yunani Trisnawan, Achmadan Rizki Tsamarotu Qobi Imamah Utomo, I,R1, Utomo, I,R1 Violyn Candra Hadizahar Halim Wahdah, Hidayatul Wardhani, Firdha Aprillia Yudi Wicaksono Yunitasari, Risky Zakiyah Tur Rohmah Zidni Nuris Yuhbaba Zulfatul Maskuriah, Dian Zulkarnain Permana