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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Articles 13 Documents
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Search results for , issue "Vol 8 No 2 (2025)" : 13 Documents clear
Biomarker pada Kanker Payudara Indriastuti, Endah; Nur Fitriani, Fatimah; Djunaidi, Anwar
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.218-231

Abstract

Breast cancer is the leading cause of cancer-related death among women worldwide. A biomarker is a molecule in the body that signals an abnormal process or condition, such as cancer. Numerous studies have focused on biomarkers in breast cancer. Widely used biomarkers in clinical settings include estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER2), Ki67, carcinoembryonic antigen (CEA), and cancer antigen (Ca) 15-3. Currently, circulating tumor cells (CTCs) and genome sequencing are being researched and are expected to play significant roles in managing breast cancer patients. These biomarkers can be detected in various sample types, enabling detection tailored to different purposes. They are vital for diagnosis, classification, and selecting effective treatment strategies, including personalized and targeted therapies, as well as predicting treatment response and monitoring for disease recurrence. Understanding of breast cancer biomarkers has improved considerably over time. This knowledge should be applied effectively to enhance diagnosis accuracy and personalize treatment. This narrative review aims to summarize previously used breast cancer biomarkers and provide updates on those currently being developed to improve patient care and outcomes.
Trematoda Darah: Schistosomiasis pada Sistem Saraf Pusat Yuliana, Yuliana; Machrumnizar, Machrumnizar
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Schistosomiasis (bilharzia) is a disease caused by blood trematode worms of the genus Schistosoma, which can be acute or chronic. There are five species of Schistosoma (S. japonicum, S. mansoni, S. intercalatum, S. Mekongi, and S. haematobium) known to infect humans, which are distributed across a wide geographic range. Severe clinical symptoms of schistosomiasis infection on the central nervous system (CNS) are caused by the deposition of eggs when adult worms migrate abnormally to the brain or spinal cord. As a result, radiculopathy, myelopathy, increased intracranial pressure, and clinical sequelae occur. Each species shows different tendencies for atopic infections and clinical symptoms. The most common neurological symptom associated with Schistosoma mansoni or S. haematobium infections is myelopathy, while severe encephalitis is more likely to be caused by S. japonicum infections. The symptoms of encephalopathy can manifest as headache, vision disturbances, delirium, convulsions, motor limitations, and ataxia. Spinal abnormalities may lead to backache, lower limb radiating discomfort, muscular weakness, loss of sensation, and urinary impairment. Histopathological analysis, which shows granulomas and Schistosoma eggs, is necessary for a definitive diagnosis. Current management involves surgical procedures, steroids, and schistosomicide drugs. Corticosteroids are administered in the acute stage, and praziquantel is given after the female worm begins to lay eggs. If medical intervention fails to relieve compression or medullary degeneration, surgery should be postponed in some instances. The earlier a diagnosis is identified and proper therapy begins, the better the patient's outcome.
Efek Anti-Inflamasi Tanaman Avicennia : Kajian Sistematik Dinanti, Fathia Kesuma; Madusari, Benny Diah; Hernanda, Ary Setya
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Avicennia, commonly known as mangrove plants, has been traditionally used to treat various diseases, including cancer, malaria, asthma, rheumatism, and ulcers. This genus possesses a range of unique secondary metabolites, belonging to various classes, which play a crucial role in numerous pharmacological activities, including the regulation of inflammation. Although many research articles have been published on the pharmacological properties of different species within this genus, no systematic review is yet available regarding their ethnomedicinal uses in the inflammatory process. This systematic review critically discusses studies on Avicennia species that exhibit anti-inflammatory effects, providing insights and guidance for future research on the plants as potential sources of new dietary supplements or medicinal agents. A literature search was conducted using internet databases such as PubMed, Scopus, Science Direct, and PubPharm, combining keywords like “Avicennia,” “inflammation,” and other related terms, following the PRISMA 2020 guidelines. Research articles were included if they were experimental (in vitro and in vivo) studies on the anti-inflammatory effects of Avicennia species and published in either Bahasa or English between 2012 and 2024. Ten studies on the anti-inflammatory effects of Avicennia species were selected. The five species of the genus Avicennia examined in these studies are A. alba, A. marina, A. schaueriana, A. officinalis, and A. rumphiana. The anti-inflammatory effects of Avicennia were demonstrated by the inhibition of inflammatory cytokine production, nitric oxide production, and inflammation in animal models. Additionally, the secondary metabolites and antioxidant effects of Avicennia species are reported in the selected articles. The phytochemicals of several Avicennia species have been shown to exhibit strong anti-inflammatory effects. Further preclinical studies, including toxicity and pharmacokinetic assessments, are necessary before they can be considered for clinical trials. The genus Avicennia has great potential to be developed into medicinal agents for diseases related to inflammation.
Survei Pola Kuantitas Peresepan Antibiotik di Tiga Rumah Sakit di Indonesia dengan Penatagunaan Antimikroba Digital Natadidjaja, Ronald Irwanto; Lekok, Widyawati; Ariyani, Aziza; Adlani, Hadianti; Adianto, Raymond; Maharani, Ronaningtyas; Sumarsono, Hadi; Yenny, Yenny; Samira, Jihan; Hairunisa, Nany; Amalia, Husnun; Faradila, Meutia Atika; Fadilah, Tubagus Ferdi; Kalumpiu, Joice Viladelvia; Yuliana, Yuliana; Mulyani, Sri; Anggiat, Desi; Marja, Triyoko Septio; Pertiwi, Iin Indra; Dianawati, Dianawati; Legoh, Grace Nerry; Rantung, Alvin Lekonardo
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Background Antimicrobial Stewardship Program (ASP) is very essential. There are three categories of antimicrobial agents as recommended by WHO: Access, Watch and Reserve. e-RASPRO, a digital ASP model, may alter antibiotic prescribing patterns by prioritizing Access category antibiotic prescribing. Methods Our manuscript presented a quantitative survey on antibiotic prescribing patterns within 3 months and 9 months before and after implementing digital electronic-RASPRO (e-RASPRO) in three Indonesian hospitals, utilizing retrospective inpatient data. This analysis included the appropriateness of empirical antibiotic prescribing and the quantity of antibiotic prescribing based on each category. Results In the first 3 months, we found that 90.16%, 83.98%, and 81.15% of patients were included in Type 1 Risk Stratification. The appropriateness of initial empirical antibiotic prescribing with the digital guideline on antimicrobial use of e-RASPRO in three hospitals was 81.59%, 76.09% and 24.48%, respectively. Within 9 months after implementing e-RASPRO in Hospital A and B and within 3 months in Hospital C, there was a trend of reduced quantity of Watch category antibiotic prescribing of 54.93% (-58.86% per inpatient), 21.11% (-9.97% per inpatient), and 8.59% (-4.15% per inpatient), respectively. There was a 12.42% (+2.61 % per inpatient) and 223.17% (+268.83% per inpatient) increase in the quantity of Access category antibiotic prescribing in Hospitals A and B, while in Hospital C, the quantity decreased by 6.81% (-2.29% per inpatient).   Conclusions There are changes in antibiotic prescribing patterns, particularly in the antibiotics included in the Watch and Access categories following the implementation of e-RASPRO. The relationship between digital antimicrobial stewardship use and the results still needs further research.
Laporan Kasus Epidemiologi Infeksi cVDPV2 Tahun 2023 di Jawa Barat, Indonesia: Surveilans dan Respons Wabah Utoro, Sidik; Rachmadi, Dedi; Oktorina, Lenny; Feriandi, Yudi
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Polio eradication remains a global health concern within the World Health Organization (WHO) framework, with Indonesia as a committed member. On February 21, 2023, an acute flaccid paralysis (AFP) case was diagnosed and reported in a 4-year-old girl from a village in Purwakarta District, West Java. The paralysis began on February 16, 2023. The child had no travel history and had never received any polio vaccination. Laboratory analysis of fecal specimens from the case and two nearby children indicated local transmission, confirming the presence of circulating vaccine-derived poliovirus type 2 (cVDPV2). This was Indonesia's first confirmed cVDPV2 outbreak. This article aims to provide a detailed description and analysis of the efforts made by relevant stakeholders in Indonesia to address this outbreak. According to WHO and national guidelines, two rounds of Sub-National Immunization Days (sub-NIDs) were carried out across all districts in West Java, the affected province. These sub-NIDs reached a total population of 3,984,797 with the novel oral poliovirus vaccine type 2 (nOPV2), achieving coverage of 96.2% in the first round and 92.3% in the second. An Outbreak Response Assessment (OBRA) was conducted in July 2023 by a team of ten international, multi-institutional assessors. The assessment concluded that, although the response was appropriate, it was too early to declare the outbreak over, as fewer than six months had passed since the last confirmed cVDPV2 detection. A follow-up review showed no new cases and no additional rounds of response immunization were recommended. This experience highlights the importance of strong surveillance, risk-based immunization planning, and community-focused communication in preventing future outbreaks. Program managers are advised to prioritize localized risk assessments, ensure even vaccine distribution, and remain prepared for rapid response.
Faktor Risiko Kelelahan Kerja pada Operator Internal Transfer Vehicle (ITV) di PT. Belawan New Container Terminal Lubis, Fatma Sri Ramadhan; Arrazy, Syafran; Eliska, Eliska; Batubara, Abdul Karim
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Background Occupational fatigue is an important issue in the field of occupational health and safety that is often experienced by workers in the industrial sector, especially workers who are involved in activities that are monotonous, repetitive, and last for a long duration of time. This condition can have an impact on reducing work productivity, increasing the risk of work accidents, and affecting the physical and mental health of workers. This study aims to analyze the risk factors associated with job fatigue in ITV (Internal Transfer Vehicle) Operators at PT Belawan New Container Terminal. Methods The research method uses a quantitative approach with a cross-sectional study design. The number of samples in this study were 39 respondents selected by total sampling technique. Data analysis was carried out through univariate analysis to describe the characteristics of respondents and bivariate analysis using the chi-square test to determine the relationship between independent variables, namely length of work, Body Mass Index (BMI), age, medical history, and work shifts with fatigue. Results The results showed a significant relationship between length of work (p = 0.005), BMI (p = 0.001), and work shift (p = 0.000) with job fatigue. However, the variables of age (p = 0.318) and medical history (p = 0.816) did not have a significant relationship. Therefore, the management is expected to formulate appropriate policies related to the setting of working hours. Conclusions The conclusion in this study is that there is a relationship between length of work, BMI, and work shifts with job fatigue, but there is no relationship between age and medical history. Therefore, management is expected to formulate appropriate policies related to setting working hours, structuring the shift system, and monitoring the nutritional status of workers in order to reduce the rate of fatigue.
Perbandingan Respons Antibodi setelah Vaksinasi COVID-19 antara Individu dengan dan tanpa Komorbiditas Bella, Isa; Khariri, Khariri; Hartanti, Monica Dwi; Sisca, Sisca; Thabit, Jihan Samira; Effendi, Ida; Devita, Arleen; Robertus, Thomas
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Background Vaccination is a Crucial public health strategy for reducing the transmission of viral infections and protecting populations from severe illness. COVID-19 vaccines have played a significant role in decreasing the incidence and mortality rates linked to the virus. However, immune responses to vaccination may differ among individuals, especially those with comorbidies that could alter immune function. This study aimed to compare antibody responses in adults with and without comorbidities, 18 months after receiving the COVID-19 vaccine. Methods This was a cohort study with two sampling time points: before vaccination and 18 months after vaccination. The study was conducted in Yogyakarta, Indonesia. Data were collected through self-administered questionnaires and venous blood sampling. Antibody titers were measured to evaluate the humoral immune response in participants with and without comorbidities. Results Before vaccination, the highest proportion of positive antibody titers was found among females (40.2%), individuals aged 18–44 years (44.7%), those with a senior high school education (48.1%), and individuals with normal body weight (44.3%). A Comparison of antibody levels at baseline and 18 months after vaccination between groups with and without comorbidities showed no statistically significant difference, with a p-value of 0.992.   Conclusions Although no significant difference was found in antibody responses between individuals with and without comorbidities, comorbid conditions may still influence immune response depending on their type and severity. These findings suggest the need for further research to examine the specific effects of various comorbidities on long-term vaccine-induced immunity.
Efektivitas Program PKPR terhadap Kesehatan Reproduksi Remaja di Puskesmas Sigambal Wijaya, Arini Aisyahfira; Agustina, Dewi; Utami, Tri Niswati
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Background the Adolescent Care Health Service Program (PKPR) plays a crucial role in improving adolescent reproductive health. Adolescents experience various physical, psychological, and social changes that influence their knowledge and behavior regarding reproductive health. In Indonesia, adolescent reproductive health needs serious attention because 18.55% of adolescents marry at a young age (16-18 years), with 2.39% marrying before age 16. Additionally, 43.55% of young women give birth before age 21. However, the implementation of the PKPR program still faces multiple challenges that hinder its optimal impact. Methods This study used a descriptive qualitative approach, collecting data through direct observation and in-depth interviews with program implementers and adolescent beneficiaries in the working area of Sigambal Public Health Center. Results The PKPR program at Sigambal Health Center faces several obstacles, including low adolescent participation (17.52%), infrequent and ineffective counseling sessions, and limited outreach and socialization. Out-of-school adolescents are not reached effectively, and the role of peer counselors has not been strengthened. Moreover, adolescents' low awareness of the importance of reproductive health services limits the program’s effectiveness. Conclusions While the PKPR program has shown a positive impact on some adolescents, its overall effectiveness remains limited. Expanding coverage, increasing activity frequency, strengthening peer counselor involvement, and developing more innovative outreach strategies are essential to ensure broader and more sustainable adolescent engagement.
Hubungan Posisi Kerja Dengan Keluhan Musculoskletal Disorder (MSDs) Pada Pemanen Sawit di PTPN IV Tanah Itam Ulu Ananda, Zahra; Astuty, Delfriana Ayu; Indriani, Fatma
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Background Musculoskeletal disorders (MSDs) are a common occupational health issue among plantation workers due to unergonomic working postures. Oil palm harvesters are especially vulnerable because of repetitive physical activities and awkward body positions. Work processes involving strenuous physical effort, such as lifting tools, cutting bunches, bending, and reaching for fronds for extended periods, along with unergonomic postures, increase the risk of MSDs. This study aims to determine the relationship between work posture and MSDs complaints among oil palm harvesting workers at PTPN IV Tanah Itam Ulu. Methods A cross-sectional quantitative study was performed with a sample of 50 Fresh Fruit Bunch (FFB) harvesters. Data were collected through observations and interviews using the Rapid Entire Body Assessment (REBA) to evaluate work posture and the Nordic Body Map (NBM) to assess MSDs symptoms. Data analysis was conducted using the Chi-Square test with a significance level of α = 0.05 in SPSS. Results The study revealed that 52% of workers experienced high-risk MSDs, while 48% faced very high-risk MSDs. A statistically significant relationship was identified between work posture and MSDs complaints (p = 0.000).   Conclusions Poor ergonomic posture significantly increases the risk of MSDs among palm oil harvesters. Ergonomic interventions, including training on proper posture and the use of assistive tools, are strongly recommended to reduce risk and improve occupational health well-being.
Memahami Perbedaan antara Apheresis, Plasmapharesis, dan Pertukaran Plasma: Urgensi Memahami Terminologi dalam Praktek Klinis Sehari-hari Mashabi, Yasmine; Rorong, Agnes Tineke Waney; Abdillah, Fauzan; Widowati, Henie
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Apheresis is a modern technique that is relatively safe and more efficient compared to conventional methods in blood component collection. In this procedure, only specific components of the blood such as platelets, plasma, or red blood cells are collected, while the other blood components are returned to the donor's body. This approach allows for more focused donations and minimizes overall blood volume loss. Transfusions from apheresis results from a single donor have also been shown to reduce the risk of immunological reactions as well as decrease the likelihood of bacterial contamination. Now, in addition to being used as a blood collection method for donation purposes, apheresis is also increasingly widely applied as therapy for various medical conditions. The accuracy in medical terminology is a crucial element for clinical practice, directly contributes to the effectiveness of therapeutic interventions, patient safety, and the efficiency of communication among health professionals. Three terms that are often misinterpreted as synonyms but have substantial clinical differences are apheresis, plasmapheresis, and plasma exchange. Although all three are based on the principle of extracorporeal separation of blood components, each procedure has different indications, methods of execution, and therapeutic goals. This article aims to elaborate on the fundamental differences among these three terms while emphasizing the urgency of education and standardization of terminology in everyday health service practice.

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