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Medika Kartika : Jurnal Kedokteran dan Kesehatan
Published by Universitas Jenderal Achmad Yani
ISSN : 26139332     EISSN : 26556537     DOI : http://dx.doi.org/10.35990/mk
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Veterinary
Medika Kartika : Jurnal Kedokteran dan Kesehatan adalah jurnal yang mempublikasikan artikel hasil penelitian baik ilmu kedokteran dasar maupun terapan, tinjauan pustaka (artikel review), dan laporan kasus. Medika Kartika dipublikasikan dua kali dalam setahun (April dan Oktober) dengan jumlah enam artikel.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 271 Documents
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RASIO VISCERAL FAT TERHADAP BODY FAT PERCENTAGE DAN KORELASI LEMAH DENGAN KADAR HIGH DENSITY LIPOPROTEIN Susanti, Anita Liliana; Pratiwi, Siska Telly; Mardliyah, Emma; Ratwita, Welly; Mutiara, Dinar; Septiadi, Endry; Pradini, Astri; Sa'adah, Hindun
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 7 No 4 (2024): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Pemeriksaan profil lipid dari serum sampai saat ini masih merupakan pemeriksaan yang digunakan untuk menentukan risiko terjadinya penyakit kardiovaskular di kemudian hari. Kadar High Density Lipoprotein (HDL) menggambarkan lipid yang berperan dalam mencegah terjadinya penyakit kardiovaskuler. Adipositas dalam pemeriksaan komposisi tubuh menggambarkan akumulasi lipid dalam jaringan, dan terdiri atas persentase lemak tubuh dan lemak visceral. Penelitian ini mempelajari korelasi antara kadar HDL serum dengan adipositas jaringan. Subyek penelitian merupakan subyek yang sehat, merupakan karyawan dari suatu institusi pendidikan dengan tingkat aktivitas fisik yang serupa. Pemeriksaan komposisi tubuh dilakukan dengan metode Bioimpedanceanalysis (BIA). Pemeriksaan kadar HDL dilakukan dari serum puasa dengan metode enzimatik kolorimetrik. Analisis korelasi dilakukan dengan Spearman correlation test dengan menggunakan program Statistical Package for Social Sciences (SPSS). Hasil penelitian menunjukkan bahwa subyek penelitian memiliki kadar HDL dalam kategori normal. Persentase lemak tubuh dan lemak visceral sebagian besar subyek penelitian berada dalam kategori normal, tinggi, dan sangat tinggi. Median kadar HDL adalah 49,00 mg/dL. Median dari rasio lemak visceral dan lemak tubuh total adalah 0,40. Korelasi antara kadar HDL dan rasio lemak visceral dan lemak tubuh total bermakna (P= 0,027) dengan koefisien korelasi sebesar - 0,4. Penelitian ini menunjukkan bahwa terdapat korelasi lemah antara adipositas jaringan yang ditunjukkan dengan rasio lemak viseral terhadap persentase lemak tubuh, dengan parameter lipid serum yaitu kadar HDL. Kata kunci : adipositas, bioimpedance, body fat, HDL, visceral fat DOI : 10.35990/mk.v7n4.p387-397
INFLUENCE OF BIOPSYCHOSOCIAL FACTORS ON ADAPTIVE COPING STRATEGIES AMONG COVID-19 SURVIVORS IN SURAKARTA Pramulawati, Devi Anggraeni; Fanani, Mohammad; Setyaningrum, Rohmaningtyas Hidayah
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

The COVID-19 pandemic has unleashed a profound psychological crisis, markedly increasing rates of depression, anxiety, loneliness, and PTSD, especially among young adults, women, racialized communities, and individuals with lower education and income. Effective coping strategies like positive reframing, humor, and acceptance have been linked to improved mental health outcomes, while maladaptive coping correlates with worsening psychosocial symptoms. This study explores the biopsychosocial factors that shape adaptive coping mechanisms in COVID-19 survivors. Using a cross-sectional design and quantitative approach, data were analyzed using logistic regression analysis. The study involved 378 COVID-19 survivors from Surakarta, who completed both online (via Telegram and WhatsApp) and offline questionnaires between November 2022 and January 2023. The sample predominantly consisted of women (73%, n=276) aged 18-40 years (89.7%, n=339), with a high prevalence of adaptive coping mechanisms (97.1%, n=367). Results revealed that gender (p=0.029, B=-1.497), history of mental disorders (p=0.039, B=-2.002), and alcohol/substance use (p=0.027, B=-2.572) had a significant influence on adaptive coping. These findings suggest that gender, mental health history, and substance use as crucial factors influencing adaptive coping among COVID-19 survivors. Keywords: adaptive coping, biopsychosocial factors, COVID-19 survivors DOI :10.35990/mk.v8n4.p378-388
ANALYSIS OF THE EFFECTIVENESS OF DUAL PI3K/mTOR INHIBITORS IN INHIBITION OF PI3K/AKT/mTOR SIGNALING PATHWAY IN BREAST CANCER Susanto, Andi; Subardin, Dian Aryanti; Gunadi, Julia Windi; Sanjaya, Ardo
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Breast cancer is a malignancy originating from breast cells, ducts, and tissues that can occur due to genetic mutations due to DNA damage in normal cells. The PI3K/Akt/mTOR pathway is an intracellular pathway that plays an important role in regulating basic cell functions such as cell growth, movement, survival, metabolism, and angiogenesis. Some examples of PI3K/mTOR pathway inhibitor drugs on the market and often used are dactolisib, samotolisib, voxtalisib, and so on. These drugs are more effective than single-pathway inhibitors. This article was prepared using the literature review method. The data used in this article were obtained from the PubMed and Google Scholar using the keywords breast cancer, PI3K/Akt/mTOR inhibitor, and PI3K/AKT/mTOR signaling pathway. Several studies suggest that the PI3K-AKT-mTOR pathway is critical in mediating the proliferation and migration of breast cancer cells. Because of the importance of the PI3K-AKT-mTOR pathway in the pathogenesis of breast cancer, it is often used as a target for breast cancer therapy. PI3K/mTOR dual ATP competitive inhibitors can directly act on the main target proteins of PI3K and mTOR, thereby more efficiently inhibiting the PI3K/AKT/mTOR signaling pathway and effectively preventing other factors that can activate the PI3K pathway, and reducing the resistance and side effects produced by single inhibitors. Keywords: breast cancer, dual inhibitor, PI3K-AKT-mTOR DOI : 10.35990/mk.v8n4.p434-445
FACTORS RELATED TO ANXIETY LEVEL AMONG PROFESSIONAL PROGRAM STUDENTS AT THE FACULTY OF MEDICINE, HASANUDDIN UNIVERSITY DURING THE COVID-19 PANDEMIC Ismail, Muhammad Wirasto; Syamsuddin, Saidah; Arman, Arman
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

COVID-19 has caused health problems, including stress or anxiety among the general public, health workers and students. Anxiety disorders related to COVID-19 have been reported with a high prevalence. Professional Program Medical Students (PPMS), as part of the groups in direct contact with patients in hospitals during the pandemic, are also affected. This research used a descriptive correlational design with a quantitative approach. Generally, this study aims to identify the factors that influence anxiety level among PPMS, or medical students, of Faculty of Medicine at Hasanuddin University during the COVID-19 pandemic. Specifically, it examines demographic and clinical factors associated with anxiety. The results showed that 53.1% of students did not experience anxiety, while 46.9% reported mild to severe anxiety. Significant factors influencing anxiety included gender, number of friends, and psychiatric history. In contrast, age, marital status, COVID-19 history, academic level, and Personal Protective Equipment (PPE) availability did not significantly affect anxiety levels. Keywords: anxiety, COVID-19, GAD, Medical students DOI : 10.35990/mk.v8n4.p389-399
ANTIBACTERIAL POTENTIAL OF DAYAK ONION BULB EXTRACT (Eleutherine sp) AS A TREATMENT FOR ACNE VULGARIS: A LITERATURE REVIEW Pradhea, Tifani Antonia; Clarissa, Maria; Ridho, Muhammad; Aqsa, Sadilla; Sumarna, Dimas Aldianakhi; Assegaf, Syarifah Nurul Yanti Syahab; Zakiah, Mistika
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Acne vulgaris is a common skin disorder that can significantly affect quality of life. Although conventional antibiotic treatments are commonly used, herbal alternatives such as Eleutherine sp. (Dayak onion) bulb extract may offer therapeutic options for acne vulgaris. This study is a literature review that evaluates the antibacterial activity of Dayak onion bulb extract against bacteria that cause acne vulgaris. The search was conducted in the ScienceDirect, PubMed, Google Scholar, and Garuda databases, focusing on in vitro studies published in the last 10 years. Of the 8 articles analyzed, Dayak onion bulb extract was effective against Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes. The best antibacterial activity was obtained from extracts at high concentrations with several methods. Temperature and incubation duration also affected the results. Active compounds such as flavonoids, alkaloids, triterpenoids, steroids, and tannins contributed to the antibacterial effectiveness of this extract. Dayak onion bulb extract showed strong antibacterial effectiveness, making it a potential alternative for treating acne vulgaris. This extract as an additional therapy offers a safe option as a natural acne vulgaris treatment solution. Keywords: acne vulgaris, antibacterial, Eleutherine DOI : 10.35990/mk.v8n4.p446-457
THE EFFECT OF GUIDED IMAGERY THERAPY ON THE LEVEL OF DEPRESSION IN PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE Ningrum, Ika Agitra; Seno, Budhi Hami; Muljanto, Rahaju Budhi
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Chronic obstructive pulmonary disease (COPD) is a disease that can lead to morbidity and mortality worldwide. This experimental study aimed to evaluate the effectiveness of guided imagery interventions in COPD patients treated in the Pulmonology Unit of Sebelas Maret University Teaching Hospital, Surakarta. An analytical experimental design with a randomized controlled trial (pre and post test) approach was used. Paired T-test results showed that the intervention group had a p-value < 0.001, indicating a significant change in the Hamilton Depression Rating Scale (HRDS) scores, while the control group had a p-value of 0.578, showing no significant change. It can be concluded that guided imagery effectively decreased HRDS scores in the intervention group compared to the control group; in other words, guided imagery decreased depression levels among COPD patients. Keywords: COPD, guided imagery, HRDS DOI : 10.35990/mk.v8n4.p344-354
RATIONALITY OF ANTIBIOTIC PRESCRIPTIONS AMONG OUTPATIENTS IN THE INTERNAL MEDICINE CLINIC AT PERSAHABATAN GENERAL HOSPITAL JULY–SEPTEMBER 2023 Artanti, Astrid Nada; Maria, Ima; Rahmi, Eldiza Puji; Citra Pradana, Dhigna Luthfiyani; Diliana, Diliana
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Antibiotic use has increased in both developing countries, such as Indonesia, and developed countries, such as Japan and Australia. This trend may lead to a rise in antibiotic resistance if antibiotics are used irrationally. This study aimed to evaluate antibiotic prescribing patterns using the Gyssens method among adult outpatients in the Internal Medicine Clinic at Persahabatan General Hospital during the period of July–September 2023. This was a descriptive study with a cross-sectional design. Data were collected retrospectively from the medical records of adult outpatients attending the Internal Medicine Clinic during the study period. Of the 30 patient records that met the inclusion and exclusion criteria, the age group 51–60 years represented the largest proportion of antibiotic prescriptions (46.67%). Levofloxacin was the most frequently prescribed antibiotic (30.3%). Based on the Gyssens method, 88.8% of prescriptions were classified as rational, while 11.1% were irrational. In conclusion, 88.8% of antibiotics prescribed for adult outpatients in the Internal Medicine Clinic at Persahabatan General Hospital during July–September 2023 were deemed rational according to the Gyssens method. Keywords : antibiotics, gyssens method, outpatient DOI : 10.35990/mk.v8n4.p400-411
THE CORRELATION BETWEEN BURNOUT SYNDROME AND TENSION-TYPE HEADACHE IN NURSES AT THE ROEMANI MUHAMMADIYAH HOSPITAL SEMARANG Zafirah, Adela; Prihatin, Murwani Yekti; Setiawan, Muhammad Riza
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Tension-type headache (TTH) is the most common form of primary headache in the general population, with a one-year prevalence ranging from 38 to 78%. The most common triggers for TTH are stress and emotional conflict. Nurses are among the workers exposed to high work stressors, placing them at risk of developing TTH, which is often triggered by chronic occupational stress known as burnout syndrome. This study aims to determine the correlation between burnout syndrome and tension-type headaches in nurses. This research employed an observational cross-sectional design conducted on 87 nurses at Roemani Muhammadiyah Hospital in Semarang, using proportional random sampling. The research instruments included a tension-type headache questionnaire and the Maslach Burnout Inventory (MBI). The statistical test used is the chi-square test. Among the 87 respondents, mild burnout syndrome was present in 64.4%, moderate burnout syndrome in 24.1%, and severe burnout syndrome in 11.5%. Respondents reporting tension-type headache constituted 26.4%, compared to 73.6% without this condition. The majority of respondents with severe burnout syndrome also experienced tension-type headaches (70%). There was a significant correlation between burnout syndrome and tension-type headaches among nurses at Roemani Muhammadiyah Hospital, Semarang, with a p-value of less than 0.005. Keywords: burnout syndrome, headache, tension-type headache DOI : 10.35990/mk.v8n4.p355-365
ANALYSIS OF KIDNEY FUNCTION PARAMETERS ON THE RENOPROTECTIVE EFFECTS OF ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH CHRONIC KIDNEY FAILURE Mourisa, Cut; Sukatendel, Firya Nadine Chalishny
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

The renoprotective effect in chronic kidney disease (CKD) patients can be induced by antihypertensive therapy, which provides a vasodilatory effect on the blood vessels leading to the kidneys. This resulting renoprotective function is considered to slow the decrease in kidney function in CKD patients. The purpose of this study was to examine the effectiveness of antihypertensive therapy as renoprotective agents through the analysis of kidney function parameters in CKD patients. A descriptive design with a cross-sectional method was used, and the study sample used data from patient medical records, specifically focusing on kidney function parameters of CKD patients during the January-June 2023 treatment period at RSUD Sultan Abdul Aziz Syah Peureulak. Of the 134 respondents, there were two groups of patients receiving antihypertensive therapy: ACE-Inhibitors (ACEIs) and (angiotensin receptor blockers) ARBs. After conducting the Wilcoxon test, there were significant changes in kidney function parameters (Urea, creatinine, and eGFR) between before and after antihypertensive therapy, with a p value <0.05. In the ACEI group, the mean urea level was 72.4 ± 48.3 mg/dL, creatinine 4.8 ± 4.3 mg/dL, and eGFR 30.6 ± 30.8 mL/min. In the ARB group, mean urea was were 85.2 ± 48.7 mg/dL, creatinine 6.1 ± 4.2 mg/dL, and eGFR 21.6 ± 26.7 mL/min. These findings indicate that ACEI and ARB antihypertensive therapies are effective as renoprotective agents in CKD patients. Keywords: ACE-Inhibitor, antihypertensive, ARB, reno-protective effect DOI : 10.35990/mk.v8n4.p412-422
EVALUATION OF ANTIOXIDANT CAPACITY AND TOXICITY OF CHRYSANTHEMUM FLOWER (Chrysanthemum morifolium) EXTRACT Malano, Zahra Khoirunissa; Hendrawan, Siufui; Ferdinal, Frans
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

The increasing trend of air pollution has worsened the air quality and deteriorated human health. This situation subsequently causes the accumulation of free radicals, leading to oxidative stress, and eventually the emergence of various diseasessuch as. respiratory and degenerative disorders. Indonesia is home to a wide variety of plantsthat may posses medicinal beneficial and efficacy. Chrysanthemum (Chrysanthemum morifolium) is one of the most commonly found flowers and is known to containphytochemicals. Therefore, this research aimed to determine the antioxidant activity and toxicity level of Chrysanthemum morifolium flower extract. In brief, chrysanthemum flowers were dried and extracted, screened for phytochemical content, and tested for antioxidant activity using the Ferric Reducing Antioxidant Power (FRAP) methods. Toxicity assay was determined using the Brine Shrimp Lethality Test. The results showed that the chrysanthemum ectract contained several phytochemicals, including alkaloids, flavonoids, terpenoids, betacyanins, and phenolics.The antioxidant activity test yielded an IC50 value of 11.13 μg/mL, inidicating a very strong antioxidant activity. Meanwhile the toxicity test showed an LC50 value of 15.49 μg/mL. In conclusion, chrysanthemum flowers exhibit very strong antioxidant activity and have potential as an antimitotic agent. Keywords: antioxidant, chrysanthemum flower, phytochemicals, toxicity assay DOI : 10.35990/mk.v8n4.p366-377

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