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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 16 Documents
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Search results for , issue "Vol 13, No 1 (2026)" : 16 Documents clear
Efek Imunostimulan Ekstrak dan Fraksi dari Buah Limpasu (Baccaurea lanceolata) pada Mencit Jantan Miranti, Rizka Mulya; Mulyani, Tuty; Nashihah, Siti
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.52721

Abstract

Limpasu merupakan tanaman khas Kalimantan yang ditemukan di pegunungan Meratus dan secara empiris digunakan untuk membantu mengobati COVID-19. Buah limpasu mengandung senyawa fenol dan flavonoid yang telah terbukti memiliki aktivitas antioksidan dan antibakteri, namun uji coba sebagai imunomodulator belum pernah dilaporkan. Penelitian ini bertujuan mengevaluasi aktivitas imunomodulator ekstrak etanol buah limpasu (EEBL) serta fraksi etil asetat (FEA) dan fraksi air (FA) pada dosis 250 dan 500 mg/kgBB pada hewan. Buah limpasu diekstraksi menggunakan pelarut etanol 70% dengan metode maserasi dan difraksinasi dengan pelarut n-heksana, etil asetat, dan air. Pengujian imunomodulator dilakukan menggunakan metode uji bersihan karbon untuk menggambarkan aktivitas respon imun non spesifik, uji titer antibodi untuk menggambarkan aktivitas respon imun spesifik dan uji hipersensitivitas tipe lambat untuk menggambarkan respon imun seluler. Hasil uji bersihan karbon pada kelompok EEBL dan FEA menunjukkan aktivitas imunostimulan kuat, sedangkan kelompok FA menunjukkan hasil imunostimulan ringan. Hasil uji titer antibodi primer menunjukkan kelompok yang diberi zat uji memiliki angka titer antibodi lebih tinggi dibandingkan kontrol, namun hanya kelompok EEBL yang mengalami peningkatan angka titer antibodi sekunder. Selanjutnya, EEBL, FEA dan FA menyebabkan peningkatan tebal kaki mencit. Secara keseluruhan, hanya EEBLyang menunjukkan aktivitas imunostimulan berdasarkan respon imun non spesifik, spesifik dan seluler.
Hypoxic MSCs Reduce UV-B Collagen Loss by Modulating CD68 and TNF-α Expression Ati, Sri Umi; Putra, Agung; Sumarawati, Titiek; Setiawan, Eko; Ibrahim, Sugeng; Taskworo, Dodik
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.63650

Abstract

Ultraviolet-B (UV-B) radiation-induced skin photoaging is marked by collagen degradation and chronic inflammation, with limited effective treatments currently available. Hypoxic-preconditioned mesenchymal stem cells (H-MSCs) offer a novel therapeutic approach due to their immunomodulatory capabilities. This study evaluated the effects of H-MSCs at two doses (2.5×105 and 5×105 cells) on UVB-induced collagen loss, focusing on CD68 expression and TNF-α levels in a rat model. Male Wistar rats were divided into five groups: healthy controls, UV-B-exposed negative controls (saline), positive controls (hyaluronic acid), and two H-MSC-treated groups. After UV-B exposure (160 mJ/cm², five times per week for two weeks), validated H-MSCs were administered subcutaneously. Collagen content was assessed histologically, while CD68 gene expression and TNF-α levels were measured by qRT-PCR and ELISA, respectively. UVB exposure led to significant reductions in collagen and increased levels of inflammatory markers. H-MSC treatment showed dose-dependent anti-inflammatory effects, with the higher dose (5×105 cells) optimally reducing CD68 expression and TNF-α levels, nearly matching healthy controls. These results suggest that H-MSCs, particularly at higher doses, may be a promising therapy for UVB-induced skin damage and collagen loss.
Geographical Characterization of West Java Clove by FTIR and Chemometrics PCA Analysis Rachmawati, Winasih; Khoirunnisa, Intan; Asnawi, Aiyi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.61029

Abstract

Clove is a plant native to West Java, Indonesia, and its composition has been scientifically proven to have antioxidant, antibacterial, antinociceptive, and cytotoxic effects. The quality of a plant is influenced by its growth location, harvest time, and genetic attributes. This study was designed to determine the characteristics of the cloves from West Java. This study aimed to develop a clove fingerprint profile using Fourier transform infrared (FTIR) spectroscopy and principal component analysis (PCA) chemometrics across five regions of West Java. Clove flowers were collected from Bandung, Bogor, Purwakarta, Cianjur, and Tasikmalaya, Indonesia. The cloves were then extracted by maceration with 96% ethanol for three 24-hour periods. The extract was analyzed by FTIR over 4000-650 cm-1 and then subjected to preprocessing steps, including smoothing, differentiation, and Standard Normal Variate. A cumulative PC value of 91% formed three clusters with similar qualities in the score plot: Group 1 (Purwakarta), Group 2 (Bandung, Cianjur, and Tasikmalaya), and Group 3 (Bogor). Chemometric analysis can be used to authenticate and classify cloves based on geographical distribution.
Formulasi dan Karakterisasi Liposom Koenzim Q10 dengan Variasi Kolesterol dan Lesitin sebagai Fosfolipid Rochman, M Fatchur; Yumni, Gharsina Ghaisani; Ramaesa, Anjani; Octafia, Putri Yolanda; Nuladani, Anggriya Syahvirga Masidqi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.56987

Abstract

Koenzim Q10 mengandung antioksidan yang bersifat tidak stabil terhadap cahaya. Untuk mengatasi ketidakstabilan tersebut, diperlukan sistem penghantaran berupa liposom yang dapat meningkatkan stabilitas zat aktif. Penelitian ini bertujuan untuk mengetahui karakteristik liposom koenzim Q10 yang dihasilkan dengan variasi konsentrasi kolesterol. Koenzim Q10 dienkapsulasi dalam sistem penghantaran liposom dengan berbagai konsentrasi kolesterol, yaitu FI (300 mg), FII (600 mg), dan FIII (900 mg), menggunakan metode hidrasi lapis tipis dan sonikasi. Liposom dibuat dengan komponen penyusun berupa lesitin kedelai, kolesterol, dan kloroform, serta dikarakterisasi melalui uji organoleptik, pH, efisiensi penjeratan, ukuran partikel, indeks polidispersitas, dan morfologi. Hasil penelitian menunjukkan bahwa liposom koenzim Q10 dengan variasi konsentrasi kolesterol memiliki karakteristik organoleptik berupa tekstur cair, warna kuning, dan aroma khas kedelai. Nilai pH berkisar antara 5,75 hingga 5,86. Efisiensi penjeratan masing-masing formula adalah FI sebesar 95,56%, FII sebesar 96,95%, dan FIII sebesar 97,88%. Ukuran partikel berkisar antara 154,8 hingga 187,5 nm, dengan indeks polidispersitas antara 0,230 hingga 0,450. Hasil uji morfologi menunjukkan globul berbentuk bulat. Berdasarkan hasil tersebut, liposom koenzim Q10 menunjukkan karakteristik fisikokimia yang baik.
Rimpang Etlingera rubroloba A.D. Poulsen sebagai Kandidat Imunostimulator terhadap Fagositosis Makrofag dan Sel CD8 Ilyas Y., Muhammad; Reymon, Reymon; Rasak, Adriatman; Rubak, Bonni; Pascayantri, Asniar; Malik, Fadhliyah; Jabbar, Asriullah; Wahyuni, Wahyuni; Setiawan, La Ode Roni; Halik, Halik; Sahidin, Idin
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.52621

Abstract

Etlingera rubroloba A.D. Poulsen merupakan tumbuhan yang digunakan secara tradisional oleh masyarakat Sulawesi Tenggara untuk menjaga kebugaran tubuh dan telah terbukti secara ilmiah mampu meningkatkan sistem imun bawaan melalui peningkatan ekspresi reseptor sel makrofag (CD14). Namun, pengaruhnya terhadap aktivitas fagositosis makrofag dan kadar sel limfosit T sitotoksik (CD8+) belum pernah dilaporkan. Penelitian ini bermaksud mengevaluasi ekstrak etanol rimpang E. rubroloba terhadap efek peningkatan fagositosis makrofag dan kadar CD8+ pada tikus putih (Rattus norvegicus) galur Wistar. Sebanyak 24 ekor tikus dibagi enam kelompok, yaitu kontrol normal, kontrol negatif, kontrol positif, serta kelompok ekstrak dosis 200, 300, dan 400 mg/kg BB. Ekstrak diberikan secara oral selama tujuh hari, kemudian pada hari kedelapan hewan uji diinfeksi Staphylococcus aureus secara intraperitoneal. Aktivitas fagositosis diamati secara mikroskopik, sedangkan kadar CD8+ diukur menggunakan metode ELISA. Dosis 300 mg/kg BB menghasilkan peningkatan aktivitas fagositosis tertinggi sebesar 77,25% dan kadar CD8+ tertinggi sebesar 650,71 ng/mL, dengan perbedaan bermakna dibandingkan kontrol negatif (p<0,05). Temuan ini mengindikasikan bahwa rimpang E. rubroloba berpotensi dikembangkan sebagai kandidat imunostimulator alami.
Mapping the Anticancer Mechanism of Asiatic Acid : A systematic review of preclinical evidence Sari, Rina Kartika; Dalimunthe, Rahmi Syaflida; Amir, Lisa Rinanda; Wimardhani, Yuniardini Septorini; Musfiroh, Ida; Sastradipura, Dewi Fatma Suniarti
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.62028

Abstract

Studies have demonstrated that Asiatic acid (AA) from Centella asiatica has anticancer properties in cancer cell lines, but translating these findings into clinical research remains challenging. This review aims to provide a robust scientific foundation for enhancing the translational potential of AA-based anticancer therapy. The PubMed, Scopus, and ScienceDirect databases were searched electronically using specific keywords and screened in accordance with the PRISMA 2020 guidelines.  Fourteen studies meet the criteria. All research was conducted in vitro; four studies were conducted both in vitro and in vivo, and three were conducted in silico.Asiatic acid (AA) demonstrates potent anticancer activity by modulating key signaling pathways, including PI3K/Akt and NF-κB, thereby inhibiting proliferation, promoting apoptosis, and reducing metastasis. Its cytotoxic effects are time- and dose-dependent (1–50 µM) and minimal in normal cells. While AA and its derivatives consistently outperform controls, limitations such as missing control dose data warrant further investigation. Future studies should focus on in vivo validation, clinical translation, and advanced strategies such as targeted delivery and AI-assisted drug development to fully realize AA’s therapeutic potential.
Formulation and Anti-Hypertensive Activity of Ambon Banana Peel Foam Mat Drying Granules as a Nutraceutical Arifin, Ibrahim; Anwar, Khoirul; Shabrina, Ayu; Wibowo, Danang Novianto; Amirudin, Muhammad Subhan; Kumalasari, Wahyu; Angelita, Anastasya; Mastuti, Sri; Inayati, Dian
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.63013

Abstract

Ambon banana peel (ABP) is rich in phenolic compounds yet unstable to light and heat. Foam-mat drying (FMD) protects bioactive components and facilitates the development of nutraceutical products. This study aimed to formulate and evaluate FMD granules containing ABP for their antioxidant and antihypertensive activities. Granules were prepared with ABP at 1% (F1), 2.5% (F2), and 5% (F3) w/w, combined with 6% Tween-80 and 15% maltodextrin, dried at 40 °C for 60 min, and blended with excipients. Physical characteristics, pH, flowability, and antioxidant activity (ABTS assay) were assessed. Antihypertensive effects were tested in Wistar rats induced with 2% NaCl and treated orally for 14 days; captopril (5 mg/kg BW) served as a positive control. Data were analyzed by one-way ANOVA. All formulations produced free-flowing granules with a moisture content <2% and a dissolution time <5 min. Antioxidant inhibition increased with ABP content, with F3 showing the highest activity (71.3 ± 1.4%). F3 also achieved the greatest reductions in systolic (≈31%) and diastolic (≈39%) blood pressure, approaching the effect of captopril. Moreover, F3 exhibits strong antioxidant activity and significant antihypertensive effects, indicating potential as a sustainable nutraceutical for the management of hypertension. Further studies on product stability and clinical efficacy are warranted.
Pengembangan Dispersi Padat Glukosamin-PEG 6000/PVP untuk Meningkatkan Disolusi Celecoxib sebagai Agen Antiinflamasi Wibowo, Danang Novianto; Prihantini, Malinda; Nazilah, Nur Milatin; Novitaningrum, Pramesti Ayu; Fina, Ya’ti Nur
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.51711

Abstract

Celecoxib memiliki disolusi yang rendah sehingga memengaruhi bioavailabilitas obat. Sistem dispersi padat dapat digunakan sebagai salah satu pendekatan untuk meningkatkan disolusi obat. Glukosamin HCl, PEG 6000, dan PVP merupakan bahan yang dapat digunakan sebagai pembawa dalam sistem dispersi padat. Penelitian ini bertujuan untuk meningkatkan disolusi celecoxib melalui pembentukan dispersi padat, dan mengevaluasi perubahan kristalinitas yang terbentuk. Dispersi padat dan campuran fisik celecoxib dibuat menggunakan pembawa glukosamin HCl dengan rasio (F1) 1:1, (F2) 1:2, dan (F3) 2:1; glukosamin HCl–PEG 6000 dengan rasio (F4) 1:1:1, (F5) 1:2:1, dan (F6) 1:1:2; serta glukosamin HCl–PVP dengan rasio (F7) 1:1:1, (F8) 1:2:1, dan (F9) 1:1:2. Dispersi padat dipreparasi menggunakan metode pelarutan. Celecoxib murni, campuran fisik, dan dispersi padat diuji disolusinya serta dikarakterisasi sifat kristalnya menggunakan x-ray diffraction (XRD). Hasil penelitian menunjukkan bahwa disolusi celecoxib meningkat pada sistem dispersi padat. Nilai Q45 dispersi padat celecoxib memenuhi kriteria karena memiliki nilai lebih dari 45%. Nilai DE60 tertinggi diperoleh pada sistem dispersi padat celecoxib dengan pembawa glukosamin HCl pada rasio 1:2, yaitu 80,28% ± 0,58. Hasil difraktogram menunjukkan bahwa dispersi padat dapat mengubah sifat kristalin celecoxib. Secara keseluruhan, sistem dispersi padat meningkatkan disolusi celecoxib dengan pembawa glukosamin, baik tunggal maupun dikombinasikan dengan PEG 6000 atau PVP.
Pea Seed (Pisum sativum L.) Extract Exhibits Cytotoxic Activity against T47D Cancer Cells Chasani, Failasufia Maulida; Hidayati, Devi Nisa; Hartati, Indah
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.62205

Abstract

Pea (Pisum sativum L.) contain flavonoids with potential anticancer activity against breast cancer cells. Yet, the influence of extraction methods and solvent choice on flavonoid yield and bioactivity remains insufficiently studied. This study evaluated the effect of solvent type and extraction method on the flavonoid content and cytotoxic activity of Pisum sativum L. seed extract on T47D breast cancer cells. Extraction was performed using reflux and infusion methods with 96% ethanol, 70% ethanol, and water solvents. Flavonoid content was determined using the AlCl₃ colorimetric test, while cytotoxic activity was tested using the MTT method. The results showed that the 96% ethanol extract had the highest flavonoid content (9.88 ± 0.05 mg QE/g), followed by 70% ethanol (5.91 ± 0.26 mg QE/g) and water extract (2.63 ± 0.06 mg QE/g). Cytotoxic activity was demonstrated by 96% and 70% ethanol extracts with IC₅₀ values of 147.12 ± 8.81 µg/mL and 90.59 ± 5.75 µg/mL, respectively, while the water extract was inactive. These findings confirm that solvent polarity plays an important role in optimizing flavonoid content and cytotoxic potential. However, high flavonoid content does not always correlate with cytotoxic effects, so a comprehensive approach is needed in the development of natural-based anticancer agents.
Rapid and Non-Destructive Analysis of Plant Material Using FTIR and Chemometric Methods Salsabilla, Bunga Indra; Muchtaridi, Muchtaridi; Megantara, Sandra; Novitasari, Dhania; Musfiroh, Ida
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.63950

Abstract

Plant material analysis requires efficient, reliable, and sustainable methods for characterization, authentication, and quality control. Fourier Transform Infrared Spectroscopy (FTIR), combined with chemometrics, has emerged as a non-destructive approach that requires minimal sample preparation. This review summarizes developments and applications of FTIR chemometrics in plant analysis from 2015 to 2025, based on more than 32 published studies. The evolution of data analysis is described from classical techniques, including Principal Component Analysis and Partial Least Squares, to machine learning methods such as Support Vector Machines and Random Forests. Various FTIR modes, namely ATR FTIR, DRIFTS, and FTIR PAS, are discussed for analyses of leaves, roots, rhizomes, flowers, fruits, and fossilized plant materials. Reported applications include species identification with accuracies approaching 100%, geographic origin authentication with 77-94% accuracy, detection of adulteration in high-value commodities such as saffron, quantification of bioactive constituents with determination coefficients of 0.96-0.99, and assessment of environmental or agronomic influences on plant composition. Although challenges remain, particularly matrix complexity and calibration transfer, FTIR chemometrics represents a sustainable, rapid, and cost-effective tool for research and industrial quality control. Future directions emphasize the global integration of artificial intelligence and instrument miniaturization.

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