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All Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat IDJP (Indonesian Journal of Pharmaceutics) Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) Majalah Farmasetika Jurnal Kesehatan Community Empowerment Jurnal Pengabdian kepada Masyarakat Desa (JPMD) Medical Sains : Jurnal Ilmiah Kefarmasian Gemakes: Jurnal Pengabdian Kepada Masyarakat Sci-Tech Journal Sciences of Pharmacy Jurnal Pengabdian Pada Masyarakat Consilium Sanitatis: Journal of Health Science and Policy Warta LPM Medimuh : Jurnal Kesehatan Muhammadiyah Medical Sains : Jurnal Ilmiah Kefarmasian Medimuh : Jurnal Kesehatan Muhammadiyah Jurnal Kesehatan
Suharyani, Ine
Sekolah Tinggi Farmasi Muhammadiyah Cirebon
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Liposomal Gel of Centella asiatica: Antioxidant Activity and Release Profile Indriaty, Sulistiorini; Firmansyah, Deni; Utami, Mima Eliestya; Karlina, Nina; Suharyani, Ine; Haidar, Hilal; Safitri, Amanda; Setiawati, Elis
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404437

Abstract

Centella asiatica (L.) Urban contains flavonoids and triterpenoids with strong antioxidant activity; however, its topical bioavailability is limited by poor solubility. This study aimed to formulate and evaluate liposomal gel systems containing a 70% ethanol extract of C. asiatica to enhance dermal penetration while preserving antioxidant activity. The extract was incorporated into liposomes using a lecithin–cholesterol ratio of 9:1 and formulated into gels at concentrations of 0.3% (FG1) and 0.5% (FG2). Physicochemical characterization showed mean particle sizes of 119.8 ± 7.21 nm (FG1) and 101.3 ± 6.55 nm (FG2), with polydispersity index values of 0.410 and 0.306, respectively, indicating acceptable vesicle homogeneity across three independent replicates (n = 3). The formulations were physically stable for two weeks at 4 °C but exhibited instability at elevated temperatures. Antioxidant activity evaluated using the DPPH assay yielded IC₅₀ values of 13.87 ± 0.02 µg/mL for FG1 and 13.97 ± 0.06 µg/mL for FG2, which were not significantly different (p > 0.05) from vitamin C (9.16 ± 0.06 µg/mL), indicating preservation of radical-scavenging capacity. In vitro permeation studies using Franz diffusion cells demonstrated cumulative quercetin penetration of 280.86 ± 1.12 µg/cm² for FG1 and 314.40 ± 0.93 µg/cm² for FG2 over 4 h, with FG2 showing significantly higher flux (p < 0.05). Release kinetics followed a zero-order model (R² = 0.9881–0.9914), suggesting controlled release behavior. Overall, liposomal gel formulations show potential for improving topical delivery of C. asiatica without overstating long-term stability or therapeutic superiority.
Co-Authors Aan Kunaedi Adiibah, Siti Adilla Edi Arief Ahadi, Ghany Aida Maftuhah Alifia, Fathia Putri Alifia, Fathiya Putri Andriana Angela, Elva Ani Fatonah Ani Fatonah apriliyanti mugianto putri, ira dwi Arief, Adilla Edi Atiqoh Hakim Ayu Mulyani Ayu Mulyani ayunda Azzahra, Siti Berliani, Fadiyah Romadhona Cep Martono Defina Fajira Deni Firmansyah Desy Wulan Dari Dhia Salsabila Dolih Gozali Dwi Indra Purnomo Eka Nur Septya Elis Setiawati, Elis Elva Angela Encu Asep Setiadi Euis Setiawati Falya, Yuniarti Farhan Zulfa Madani Farhan Zulfa Madani Farhat Fadhilah, Muhammad Fatikhatussa'adah, Intan Fitriah, Aulia Fitriani, Vina Nurul Grantika Putri, Adelia Hafidah, Nurul Haidar, Hilal Hamidan, Azmi Hapsari, Dinda Alifia Herliningsih, Herliningsih Hidayat, Salsabila Aulia Ibnu Mas'ud IIN INDAWATI Intan Intan Lela Sulastri, Lela Lestari, Trisna Liu, Lili Diana Maisya Mauliana Insani Maryam, Diana Dwi Maryanto, Naida Ajeng Mas'ud, Ibnu Meilani Melina Mulyani, Ayu Munira, Nura Amanda mutmainah, iin Nasrul Wathoni Nina Karlina Nina Karlina Nisa Nurmaya Nisya Chairunisya Noviani, Lusy Nur Annisa Sadira NUR RAHAYU, NUR Nur Rahmi Hidayati, Nur Rahmi Nurcholisah Nurcholisah Nurdianti, Lusy Nurhidayah, Sri Opi Nurholipah Putri, Maisya Mauliana Insani Alifa Rahmawati, Firda Renny Amelia Renny Amelia Renny Amelia Rima Yulia Senja, Rima Yulia Rindiyani Rindiyani, Rindiyani RR. Ella Evrita Hestiandari Safitri, Amanda Setiadi, Encu Asep Setyaningsih, Indah Shadrina, Ghesani Nur Sindy Putri Pratama, Sindy Putri Sri Astuti Suharyani, Arikhatuzzahro Sulistiorini Indriaty Supartini, Entin Susilo, Rinto Syafiq, Muhammad Firas Teguh Prasetyo TIANA MILANDA Tresna Lestari, Tresna Tri Septiyati Tussadiyah, Halimah Ussya'adah, Nida Utami, Mima Eliestya Wahyuni, Popi Sri Widia Ningsih, Widia Yadi Supriyadi Yasmin Yasmin Yayan Rizikiyan Yohana Yulia Afidah Yuni Rahmasari Zamzam, Muhammad Yani