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All Journal Medika Tadulako Pharmascience E-Dimas: Jurnal Pengabdian kepada Masyarakat Panrita Abdi - Jurnal Pengabdian pada Masyarakat Journal of Public Health for Tropical and Coastal Region Journal of Epidemiology and Public Health Oto Rhino Laryngologica Indonesiana Unnes Journal of Public Health Medica Hospitalia Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Responsive: Jurnal Pemikiran dan Penelitian Administrasi, Sosial, Humaniora dan Kebijakan Publik Jurnal Pengabdian pada Masyarakat Kepulauan Lahan Kering Jurnal Kedokteran Universitas Palangka Raya Pancasakti Journal Of Public Health Science And Research Jurnal Pengabdian Kesehatan Masyarakat Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Pengabdian Kepada Masyarakat (JPKM) Jurnal Penelitian Multidisiplin Bangsa Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Christin Rony Nayoan
Departemen Farmakologi, Fakultas Kedokteran, Universitas Tadulako, Palu – Bagian THT-KL RSUD Undata, Palu
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Pharmascience

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Komparasi Efek Analgesia yang Ditimbulkan Oleh Ibuprofen Arginin dan Natrium Diklofenak Zaid Akbar Al Muharram; Christin Rony Nayoan
Jurnal Pharmascience Vol 10, No 2 (2023): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i2.14664

Abstract

Nyeri merupakan masalah global yang telah dirasakan oleh seluruh generasi umat manusia. Banyak cara telah dilakukan oleh umat manusia dalam mencoba menangani nyeri dan pemakaian OAINS merupakan salah satu cara yang telah terbukti efektif. Penggunaan OAINS non-spesifik seperti ibuprofen dan diklofenak merupakan suatu fenomena yang umum diamati, lebih dari 30 juta orang di dunia mengkonsumsi OAINS setiap harinya. Menurut Oxford league of analgesics table kedua obat tersebut memiliki potensi analgesia yang serupa dengan NNT ibuprofen 400 mg/600 mg (2,4) dan NNT diklofenak (2,3). Sediaan baru ibuprofen yang disalifikasi dengan asam amino l-arginin memunculkan pertanyaan tentang perbandingan potensi analgesianya terhadap diklofenak. Penelitian dilakukan secara quasi experimental dan double blind dengan perlakuan pre-test dan post-test. Sampel penelitian terdiri atas 30 probandus sehat yang dibagi menjadi 3 kelompok perlakuan (n = 10). Kelompok perlakuan mendapatkan ibuprofen arginin 600 mg, gula 500 mg (plasebo), atau natrium diklofenak 50 mg. Efek analgesia diamati dengan pengukuran pain latency sebelum perlakuan (0’) dan sesudah perlakuan (30’, 60’, 90’, 120’, 150’, 180’). Perbandingan langsung antara ibuprofen arginin 600 mg dan natrium diklofenak 50 mg tidak memunculkan hasil yang signifikan, natrium diklofenak 50 mg hanya unggul 1,2 detik dibandingkan dengan ibuprofen arginin 600 mg (p > 0,9999). Kata Kunci: OAINS, Ibuprofen Arginin, Natrium Diklofenak, Nyeri, Nyeri Latensi Pain is a global problem that has been felt by all generations of mankind. The humankind has employed many methods in handling pain and the use of NSAIDs is a proven effective method. The use of non-specific NSAIDs such as ibuprofen and diclofenac is a commonly observed phenomenon as >30 million people around the world take NSAIDs every day. According to the Oxford league of analgesics table, both drugs have similar analgesic potency, ibuprofen 400 mg/600 mg (NNT: 2,4) and diclofenac (NNT: 2,3). A new preparation of ibuprofen salinized with the amino acid l-arginine raises questions about the comparison of its analgesic potency to diclofenac. This research was conducted in a quasi-experimental and double-blind setting with pre- and post-tests treatments. The research sample consisted of 30 healthy subjects who were divided into 3 groups (n= 10). The groups received 600 mg ibuprofen arginine, 500 mg sugar (placebo), or 50 mg diclofenac sodium. Analgesia effect was observed by measuring pain latency before treatment (0') and after treatment (30', 60', 90', 120', 150', 180'). A direct comparison of the two drugs does not produce significant results, 50 mg diclofenac sodium is only 1.2 seconds superior to 600 mg ibuprofen arginine (p >0.9999).
Co-Authors Adu, Petronela Adelfin Amany, Anisha Inas Amelya Betsalonia Sir Anderias Umbu Roga Andi Alfia Muthmainnah Tanra Andi Alfia Muthmainnah Tanra Andreastra, Agustinus Putu Anna Mailasari kusuma Dewi Asrawati Sofyan Azizah Azizah David Pakaya Devi Oktafiani Dida, Grace Youngest Dimu, Rivaldo Deljunior Dwi Antono Eryc Z. Haba Bunga Faathir ‘Ilmi Haditsah Fistra Janrio Tandirerung Fitriani, Junjun Fransiskus G. Mado Geghi, Cathrin Wea Djogo Gilbert Yesaya Haninuna Gita Yasmin Safitri Haerani harun Haninuna, Gilbert Yesaya Helga Jilvera Nathalia Ndun Imtihanah Amri Indra Yohanes Kiling Intje Picauly Ipfi White Ishak Limbong Jehanu, Fidryanto Jeida, Serena Gussatdy Jhonario Talaen Junjun Fitriani Kana, Indah M.P Klau, Marlin Adriana Kornelia Limbu, Ribka Limbu, Ribka Litelnoni, Aletha Anasthasya Lopo, Christian Lopo, Wigia Hanalia M. Sabir Mado , Fransiskus Geroda Maharani , Arum Manurung, Imelda Februati Ester Marni Marni Matsrial Putra Rombetasik Miani, Maria Detriani Misnadin, Indri Wahyuningsih Moeda, Yermia P. T. Muntasir, Muntasir Nayoan, Christin Ndoen, Enjelita Mariance Ndun, Helga Jilvera Nathalia Neolaka, Jefri Arisamsi Niluh Putu Evvy Rossanty Niron, Maissie Ginaninta Charoline Nur syamsi Nur Syamsi Pallawagau, Murni Paudi, Cindy Amalia Octaviani Picauly, Intje Rahma Rahma Rahma Resmi, Ayu Citra Riece Hariyati Romeo, Petrus Rut Rosina Riwu Sabakodi, Dwi Andika Umbu Gauka Sampe, Greyson Efraldi Sarci Magdalena Toy Serlie K.A. Littik Situmorang, Corymela Soleman Landi Sulanto Saleh Danu Suryaningrum, Dina Syamruth, Yendris Krisno Takaeb, Afrona Elisabeth Lelan Tanelaph, Julio Martin Usfunan, Irene Kerin Vera Diana Towidjojo Weraman, Pius White, I Putu Ferry Immanuel White, IPFI Yunita Mayang Sari Zai, Frengki Ananda Zaid Akbar Al Muharram