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Journal : JURNAL FARMASIMED (JFM)

Test of 25% Ethanol Extract of Betel Nut as a Burn Wound Healing Agent in Male White Mice Farhan, Muhammad; Kasmadi, Fathnur Sani; Humaryanto, Humaryanto; Kusdiyah, Erni; Harahap, Huntari
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/adcwgh75

Abstract

Burns are a serious injury that requires effective therapy to accelerate the healing process. This study aims to evaluate the effectiveness of 25% ethanol extract of areca nut (Areca catechu L.) on healing second-degree burns in male white rats (Rattus norvegicus). The extract was obtained through a maceration method and characterized for its secondary metabolite content. A total of 25 rats were divided into five groups: a negative control (Vaseline flavum), a positive control (Bioplacenton®), and three treatment groups with extract concentrations of 2%, 4%, and 6%. The topical preparation was applied daily for 21 days, then clinical observations were carried out in the form of wound diameter measurements and histopathological analysis (re-epithelialization, collagenization, angiogenesis, and the number of fibroblasts). Phytochemical results showed that the extract contained flavonoids, alkaloids, tannins, phenols, and steroids. Clinically, the treatment group with a concentration of 6% showed the greatest reduction in wound diameter (56.6%) compared to the low concentration extract group and the negative control, although not exceeding the positive control. Histological analysis showed more even re-epithelialization, increased fibroblasts, and a more organized collagen fiber arrangement in the 6% group. These findings indicate that a 25% ethanol extract of areca nut has the potential to accelerate burn wound healing through antioxidant, antimicrobial, astringent, and anti-inflammatory mechanisms, although its effectiveness is still below standard therapy. Further research is needed to optimize the dosage and formulation for its development as an affordable, natural-based alternative phytotherapy.
Co-Authors Ahmad Syauqy Ahmad Syauqy Amalya Nasution, Riska Amelia Dwi Fitri Anati Purwakanthi, Anati Andini Agustina Andini Agustina Anggelia Puspasari Annissa Delfira Anton Trihartanto Armaidi Darmawan Asro Hayani Harahap Asro Hayani Harahap Asro Hayani Harahap Asty, Zahra Frizki Attiya Istarini Betty Marlina Budi Aswin Citra Maharani Denok Tri Hardiningsih Devy Afriyanti Dia, Esa Indah Ayu Dwi Puspita, Puspa Eka Putra, Nofrans Ekaputri, Tia Wida Elfiani Elfiani Elfiani Elfiani Erina Shinta Anggraini Erni Kusdiyah Erny Kusdiyah Esa Indah Ayu, Esa Indah Esa Indah Ayudia Fadil Pramudya Firmansyah Firmansyah Firmansyah Fitriyanti Galih Saputra, Ikmal Hafizah Haifa Nida Firdausa Hanina Hanina, Hanina Hanina, Hanina Hasibuan, Mhd Usni Zamzami Herlambang Herlambang Herlambang HERLAMBANG HERLAMBANG Humaryanto, Humaryanto Humaryanto, Humaryanto Husnun Nisa Iksan, Pahrul Ilham Pratama Putra Imam, Mara indah ayu dia, Esa Indah Ayudia, Esa Indri Okta Sapitri Indrianti Irfannuddin Irfannuddin Irfanuddin Iskandar, Mirna Marhami JMJ, Jurnal Juniarti, Ariska Kurnia Justitia, Budi Krisna Murti Kusdiyah, Erni Lisa Susanti Maharini, Indri Mara Imam Taufiq Siregar Maria Estela Karolina Maria, Ima Martha Yosephine Renata Malau Meylani Mhd Usni Zamzami Hasibuan Miftahurrahmah Miftahurrahmah Miftahurrahmah, Miftahurrahmah Muhammad Anharuddin Muhammad Farhan Muhammad Yusri Nada Zahra, Risa Naufal Adli Marvi Nur, Amrizal Muhammad Nuriyah, Nuriyah Nyimas Natasha Ayu Shafira Nyndya Ariyanty Patrick William Gading Putra Agung, Rhonaz Putri Sari Wulandari Rina Nofri Enis Rion Nofrianda Rita Halim Sani K, Fathnur Subhan, Rahmatika Suzan, Raihanah Tarawifa, Susan Tengku Arief Buana Perkasa Tia Wida Ekaputri Ummi Kalsum Wahyu Indah Dewi Aurora Wida, Tia Willy Hardy Marpaung Zami, Muh. Husni Zam Zamzami , Mhd Usni Zulkhair Ali