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All Journal International Journal of Evaluation and Research in Education (IJERE) E-Jurnal Medika Udayana Jurnal Pengabdian Kepada Masyarakat Sakai Sambayan MEDISAINS Biomedika Jurnal Kajian Komunikasi BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan BIOEDUSCIENCE CARADDE: Jurnal Pengabdian Kepada Masyarakat IKRA-ITH ABDIMAS Sarwahita : Jurnal Pengabdian Kepada Masyarakat Health Sciences and Pharmacy Journal INTEGRITAS : Jurnal Pengabdian SCRIPTA SCORE Scientific Medical Journal BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Pendidikan Molucca Medica Jurnal Indonesia Sosial Sains SEGARA : Jurnal Pengabdian Kepada Masyarakat Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Setyaningsih, Yuni
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Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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In Vitro Antifungal Activity of Ethanolic Stem Extract of Tinospora crispa Against Candida albicans and Malassezia furfur Mumtaz, Syifa Afifah; Zulfa, Fajriati; Thadeus, Maria Selvester; Setyaningsih, Yuni
BIOEDUSCIENCE Vol 9 No 3 (2025): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/17984

Abstract

Background: Fungal infections such as candidiasis caused by Candida albicans and pityriasis versicolor caused by Malassezia furfur are highly prevalent in Indonesia. Conventional antifungal treatments often face challenges like resistance and adverse side effects. As an alternative, brotowali stem (Tinospora crispa) extract, rich in alkaloids, flavonoids, and tannins, shows promise as an antifungal agent. This research investigates the in vitro antifungal efficacy of ethanol extract from brotowali stem against C. albicans and M. furfur. Methods: A laboratory experimental design utilizing the well-diffusion method was applied, measuring inhibition zone diameters on Sabouraud Dextrose Agar after 2x24 hours at extract concentrations of 45%, 60%, 75%, and 90%. Results: The ethanol extract of brotowali stem exhibited statistically significant but relatively low antifungal activity based on inhibition zone diameters against C. albicans (0,002) and M. furfur (0,001), with higher concentrations showing greater antifungal. The largest inhibition zones measured 5.93 mm for C. albicans and 3.97 mm for M. furfur. Conclusions: The extract concentrations of 90% concentration exhibited moderate antifungal activity against C. albicans. For M. furfur, all concentrations demonstrated weak antifungal activity.
Anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit in obesity-induced liver injury Susantiningsih, Tiwuk; Thadeus, Maria Selvester; Citrawati, Mila; Setyaningsih, Yuni
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.30081

Abstract

Background: Hepatic metabolic disorders are closely associated with obesity and are characterized by systemic inflammation and liver injury. Moringa oleifera fruit contains various bioactive compounds with potential anti-inflammatory and hepatoprotective properties. However, evidence regarding its effects on obesity-induced liver injury remains limited..   Objective: This study aimed to evaluate the anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit extract in an obesity-induced rat model..   Methods: This experimental study used 30 male Sprague-Dawley rats divided into five groups: normal control (N), obese control (O), obese rats treated with Moringa oleifera fruit extract at 500 mg/kg body weight once daily (OEMO1), twice daily (OEMO2), and obese rats treated with vitamin C (OC). Systemic inflammation was assessed by measuring serum C-reactive protein (CRP) levels using ELISA, while hepatic changes were evaluated through biochemical markers and histopathological analysis. Data were analyzed using one-way ANOVA followed by post hoc testing.   Results: Obese rats exhibited significantly elevated serum CRP levels and marked hepatic alterations compared to normal controls (p < 0.05). Administration of Moringa oleifera fruit extract significantly reduced CRP levels and improved hepatic histoarchitecture in obese rats, with the greatest effect observed in the twice-daily treatment group (OEMO2) (p < 0.05). The effects were comparable to or greater than those observed with vitamin C. Conclusions: Moringa oleifera fruit extract demonstrates significant anti-inflammatory and hepatoprotective effects in an obesity-induced rat model, suggesting its potential as a natural therapeutic agent for obesity-related liver injury.
Pelatihan Pembuatan Teh Daun Kelor Kayu Manis pada Ibu-ibu PKK Desa Pangkalan Jati Depok Setyaningsih, Yuni; Tiwuk Susantiningsih; Maria Selvester Thadeus; Mila Citrawati; Hikmah Muktamiroh; Melly kristanti
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 2 (2026)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v7i2.16121

Abstract

Kelor memiliki berbagai manfaat bagi kesehatan seperti sebagai antibakteri, antiinflamasi, antioksidan dan lain-lain. Kelor dapat dikonsumsi sebagai sayuran, bubuk, jus atau teh. Kayu manis merupakan rempah yang memiliki manfaat sebagai antioksidan dan antidiabetes. Pemanfaatan daun kelor kayu manis belum pernah dilakukan di Desa Pangkalan Jati, Cinere, Depok, yang merupakan daerah perbatasan dengan ibu kota. Tujuan pengabdian kepada masyarakat ini adalah untuk meningkatkan pengetahuan dan keterampilan kader PKK dalam membuat teh daun kelor kayu manis. Metode yang dilakukan dengan melakukan penyuluhan tentang manfaat daun kelor bagi kesehatan dan pelatihan pembuatan teh daun kelor kayu manis dari seduhan langsung dan merebus daun kelor. Hasil pengabdian ini menunjukkan terdapat peningkatan pengetahuan yang bermakna tentang manfaat daun kelor dengan uji Wilcoxon p 0,001. Kader PKK juga dapat melakukan pembuatan teh daun kelor kayu manis dengan baik. Pengabdian yang dilakukan berhasil meningkatkan pengetahuan kader tentang manfaat daun kelor dan meningkatkan keterampilan membuat teh daun kelor kayu manis. Diharapkan kader dapat mengaplikasikan pengetahuan yang sudah didapatkan dalam kehidupan sehari-hari dan memberikan informasi pengetahuan ini kepada masyarakat sehingga dapat meningkatkan kesehatan masyarakat.
Peningkatan Literasi Kesehatan Remaja melalui Edukasi Pencegahan Pernikahan Dini dan Stunting Thadeus, Maria Selevster; Citrawati, Mila; Susantiningsih, Tiwuk; Setyaningsih, Yuni; Rahajeng, Herera
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 9 No. 1 (2026): Agustus
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v9i1.3516

Abstract

Abstract. Early marriage is a social and public helath issue that affects reproductive health, education, psychological well-being, and socioeconomic status. From a public helath perspective, early marriage is associated with an increased risk of adolescent pregnancy and may contribute to various complications during pregnancy and childbirth, as well as impaired child growth. Therefore, educating adolescents about these risks is an imprtant promotive and preventive strategy. This community service activity aimed to improved adolescent’s knowledge of stunting prevention efforts before entering marriage and pregnancy. The activity was conducted in Pangkalan Jati Village, Depok, targeting adolescents involved in youth organizations and mosque-based youth groups. The activities included problem identification, a pretest, health counseling and education, the distribution booklets and leaflets, interactive discussion, and a posttest. In addition to the educational intervention, hemoglobin level screening was conducted to provide an initial assessment of the adolescent’s health status. The activity was attendedd by 20 male and female adolescents. The results demonstrated an 20% improvement in participants understanding of the risks associated with early marriage. Community-based education that actively enggages adolescents can serve as a promotive and preventive approach to strengthening adolescent health literacy and supporting sustainable stunting prevention efforts.
Co-Authors Agneta Irmarahayu Akbar, Rafi Thoriq Andri Pramesyanti Pramono Angelica, Tracy Astari, Riezky Valentina Bintang Bayu Aryandi Cantika, Yara Cut Fauziah Fachri Razi Faizah, Shafa Alya Nur Fajriati Zulfa Fardani, Nabil Radif Hikmah Muktamiroh Hutasoit, Chintya Mei Desia Joanne, Anastasia Makkiyah, Feda Anisah Marcella Marhaditya, Muhammad Faiz Maria Selvester Thadeus Maria, Ima Meiskha Bahar Melly Kristanti Mila Citrawati Mumtaz, Syifa Afifah Nela Azalina Aziz Ni Gusti Made Rai, Ni Gusti Made Nisrina, Rumaysha Gikha Prasetyo, Banu Pratama, Muhammad Rafli Pritha Maya Savitri Rahadiantino, Lienggar Rahajeng, Herera Rahmawati, Deti Ratu, Aurelius Savitri, Eka Dian Simanjuntak, Kristina Sungkar, Mustofa Lukman Thadeus, Maria Selevster Tiwuk Susantiningsih Tri Faranita Ubaidillah Ubaidillah Yanti Harjono Hadiwiardjo