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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Cancer Chemoprevention Jurnal Teknologi Informasi dan Ilmu Komputer Indonesian Journal of Tropical and Infectious Disease Majalah Kesehatan FKUB JURNAL WACANA KESEHATAN Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Medica Hospitalia Malang Respiratory Journal Jurnal Klinik dan Riset Kesehatan Indonesian Journal of Cancer Journal of Community Health and Preventive Medicine (JOCHAPM)
Djajalaksana, Susanthy
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Indonesian Journal of Cancer Chemoprevention

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The Role of Serum IL-23 and Volatile Organic Compound Levels to RECIST 1.1 in The Evaluation of Therapeutic Response in Lung Cancer Tjahyadi, Rizal Muldani; Setyawan, Ungky Agus; Astuti, Tri Wahju; Djajalaksana, Susanthy; Wardoyo, Arinto Yudi Ponco
Indonesian Journal of Cancer Chemoprevention Vol 14, No 3 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss3pp171-180

Abstract

The Response Evaluation Criteria in Solid Tumors (RECIST 1.1) is the gold standard for the assessment of lung cancer progression. However, the assessment and diagnosis of early treatment failure is challenging due to the limitations of current tools, as well as the long intervals and unavoidable side effects.This study aims to correlate volatile organic compound (VOC) patterns, serum level of interleukin-23 (IL-23), and RECIST 1.1 to assess chemotherapy response in lung cancer patients at Saiful Anwar Hospital. A prospective observational study was performed to 47 lung cancer patients who received three cycles of platinum-based chemotherapy. Using the Breath Analyzer to measure certain volatile organic compounds (VOCs), the study observed that three of the seven VOCs examined, formaldehyde (CH2O), toluene (C7H8), and hexane (C6H14), showed lower levels after three cycles of chemotherapy. Furthermore, there was a negative correlation between RECIST1.1 and acetone (C3H6O) (p=0.023), while RECIST1.1 and methane (CH4) had a positive correlation (p=0.011). Moreover, a significant positive correlation was observed between IL-23 after-chemotherapy and RECIST 1.1 (p=0.000). According to this study, a correlation exists between methane, IL-23, and RECIST 1.1 after three cycles of chemotherapy. The increase in methane and IL-23 aligns with the disease progression determined by RECIST 1.1. Furthermore, The decrease in acetone after chemotherapy showed a negative correlation with RECIST1.1, consistent with disease progression.Keywords: Volatile Organic Compound, Interleukin-23, RECIST 1.1.
Co-Authors Afif, Zamroni Arinto Wardoyo Arinto Yudi Ponco Wardoyo Bayuadi, Imam Cendani, Wulan Chen, Chung-Yu Chozin, Iin Chozin, Iin Nur Christanto, Anthony Dini, Zata Djajalakasana, Susanthy Edwin Widodo Eka Pratiwi Eka Pratiwi Eko Sakti Pramukantoro, Eko Sakti Erawati, Dini Erawati, Dini Rachma Fahmi, Kristia Falyani , Silvy Falyani, Silvy Falyani, Silvy Amalia Febriawati, Juwita Fitri Sari, Fitri Harun Al Rasyid Indah Sari, Fitri Indrastuti Normahayu, Indrastuti Iqbal Muhammad Irfan, Ferdy Syah Isharanto, Artono Kevin Wahyudy Prasetyo Kristiani, Maria Kusuma Wardhana, Koernia Listyoko, Aditya Listyoko, Aditya Sri Lyono, Albert Mafisah, Saidah Mahendra, Reza Aditya Matabei, Shannon Conversia Pdabo Michaela, Cleine Muarif, Husnul Nanik Setijowati Okta, Shinta Permana, Deden Permatasari, Adinda Pramitra Prasetya, Fahmi Adhi Prasetyo, Kevin Pratiwi, Suryanti Pratiwi, Suryanti Dwi Putra, Ngakan Putra, Ngakan Putu Parsama Rachma Erawati, Dini Rahman, Perdana Rakhma , Sastia Rakhma, Sastia Ramadhan, Fitratul Retnani, Diah Prabawati Safrina Dewi Ratnaningrum, Safrina Dewi santony, Santony Santosa, Andrew Santosa, I Setyawan, Ungky Setyawan, Ungky Agus Setyo Yudhanto, Hendy Sugiri, Yani Jane Sugiri, Yani Jane Rosihaningsih Suprapta, Aloysius Suryaman, Rachmat Susanti, Lia Suwandi, Gede Sasmika Tantular, Rezki Tanuwijaya, Hendra Timuda, Caesar Ensang Tjahyadi, Rizal Muldani Tri Wahju Astuti, Tri Wahju triandani, Ni Komang Revina Triwahju Astuti Wahyu Tejakusuma, Wahyu Wardhana, Koernia Yaman, Muli Yudhanto, Hendy Yudhanto, Hendy Setyo Yusdianto, Adrian