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Potensi metabolit sekunder produksi bakteri endofit dari tumbuhan laban (Vitex pubescens Vahl) sebagai antikanker Lenny Anwar; Futra, Dedi
Chempublish Journal Vol. 4 No. 2 (2019): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v4i2.7937

Abstract

Peran mikroba endofit dalam memproduksi metabolit sekunder dengan kualitas yang hampir sama dengan tanaman aslinya sangat potensial untuk dikembangkan. Penelitian ini bertujuan untuk menyelidiki bakteri endofit yang terdapat didalam jaringan kulit batang Laban (Vitex pubescens Vahl) serta kemampuannya untuk memproduksi metabolit bioaktif yang mempunyai aktivitas sitotoksik. Dalam penelitian ini digunakan teknik inokulasi langsung dengan jalan meletakkan sampel tanaman di atas permukaan Nutrient Agar (NA). Metoda Micro tetrazolium (MTT) digunakan untuk menetapkan aktivitas sitotoksik dari ekstrak etilasetat. Bakteri endofit yang berhasil diisolasi sebanyak 3 isolat yaitu Bakteri-2A, Bakteri -3B dan Bakteri-6C. Berdasarkan hasil penapisan dari 3 isolat tersebut didapatkan dua bakteri yang memiliki aktivitas potensial yang baik terhadap sel serviks (HeLa) yaitu isolat Bakteri – 6C (IC50 = 82.54 µg/mL) dan Bakteri-2A (IC50 = 297.09 µg/mL). Isolat yang menunjukkan aktivitas sitotoksik terbesar adalah isolat Bakteri-6C sehingga dapat disimpulkan bahwa isolat tersebut merupakan isolat yang paling potensial sebagai penghasil senyawa antikanker.
Identification of Grade XI Students' Misconceptions on Thermochemistry Using a Five-Tier Diagnostic Test at SMAN 2 Siak Hulu Novia Cristi Br Pasaribu; Sri Haryati; Dedi Futra
Journal of Multidisciplinary Science: MIKAILALSYS Vol 4 No 3 (2026): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v4i3.11780

Abstract

Misconceptions in thermochemistry remain a persistent challenge in chemistry education because they can impede conceptual understanding and adversely affect learning outcomes. This study aimed to identify Grade XI students’ misconceptions about thermochemistry and determine their underlying sources using a five-tier diagnostic test at SMAN 2 Siak Hulu. A descriptive quantitative design was employed, involving 100 students from Classes XI-4, XI-5, and XI-6 who had studied thermochemistry. Data were collected using a 15-item five-tier diagnostic test covering seven thermochemistry concepts and supplemented with structured interviews. The findings revealed misconceptions across all seven concepts, with an average prevalence of 18%, categorized as low. The highest prevalence was identified for thermochemical equations (23%), whereas the lowest was found for heat and energy (9%). Students’ own reasoning was the predominant source of misconceptions (82.13%), followed by textbooks, teachers, peers, and the internet. These findings demonstrate the utility of the five-tier diagnostic test in identifying misconceptions and tracing their underlying sources. The study provides an empirical basis for teachers to develop targeted instructional strategies that prevent and remediate misconceptions, thereby strengthening students’ conceptual understanding of thermochemistry.
Implementation of the POE2WE (Prediction, Observation, Explanation, Elaboration, Write, and Evaluation) Learning Model to Improve Understanding of Chemical Concepts Regarding Buffer Solutions among Grade XI Students at SMAN 2 Siak Hulu Ezra Yulyta Hasibuan; Rasmiwetti; Dedi Futra
Journal of Multidisciplinary Science: MIKAILALSYS Vol 4 No 3 (2026): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v4i3.11796

Abstract

Students’ limited conceptual understanding of buffer solutions presents a substantial learning challenge because the topic integrates acid–base concepts, chemical equilibrium, and pH calculations. This study examined the effectiveness of the Prediction, Observation, Explanation, Elaboration, Write, and Evaluation (POE2WE) learning model in improving Grade XI students’ conceptual understanding of buffer solutions at SMAN 2 Siak Hulu. A quasi-experimental method with a nonequivalent control-group pretest–posttest design was employed. Class XI.4 served as the experimental group, while Class XI.5 served as the control group; both classes were selected through purposive sampling. Data were collected using an essay-based conceptual-understanding test and analyzed through normality and homogeneity tests, a t test, and normalized gain analysis. The findings demonstrated a significant difference in the improvement of conceptual understanding between the two groups, with the calculated t value (2.34) exceeding the critical value (1.998) at the 5% significance level. The experimental group achieved a normalized gain of 0.72, categorized as high, whereas the control group obtained a normalized gain of 0.56, categorized as moderate. Improvements across all indicators of conceptual understanding were also greater in the experimental group. These findings demonstrate that the POE2WE learning model effectively improves students’ conceptual understanding of buffer solutions. The model therefore offers an alternative instructional approach that actively engages students in constructing, explaining, applying, and evaluating their understanding of chemistry concepts.
Efforts to Enhance Learning Activity and Conceptual Understanding among Grade XI Students at SMA IT Al Fityah Using the ICARE Model on the Topic of Salt Hydrolysis Nurul Khafizah; Lenny Anwar; Dedi Futra
Journal of Multidisciplinary Science: MIKAILALSYS Vol 4 No 3 (2026): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v4i3.11853

Abstract

Salt hydrolysis instruction presents persistent challenges in promoting active participation and conceptual understanding among chemistry students. This study aimed to improve the learning activity and conceptual understanding of 26 Grade XI science students at SMA IT Al Fityah Pekanbaru through the ICARE learning model. A collaborative classroom action research design was implemented across two cycles, each comprising two meetings and the stages of planning, action, observation, and reflection. Data were collected through observation sheets assessing teacher and student activities, documentation, evaluations conducted after each meeting, and conceptual understanding tests administered at the end of each cycle. The data were analyzed descriptively using activity percentages, individual scores, class mastery rates, and achievement across seven indicators of conceptual understanding. The numbers of students who did not meet the mastery criterion and the lowest scores in each cycle were also examined to assess the distribution of learning outcomes. Instructional improvements emphasized participation, group discussion, reflection, and independent application of concepts. Student learning activity increased from 64.47% in Cycle I to 76.68% in Cycle II, representing an increase of 12.21 percentage points. The mean conceptual understanding score rose from 76.35 to 88.08, while the mean class score increased from 76.34 to 88.27. Class mastery improved from 69.22% to 88.46%. By Cycle II, all seven conceptual understanding indicators had reached at least 84.62%, with the ability to restate concepts reaching 100%. These findings demonstrate that ICARE can improve students’ engagement and conceptual understanding of salt hydrolysis. The model therefore offers a viable student-centered approach to chemistry instruction, provided that teachers ensure effective time management, reinforce prerequisite concepts, and distribute participation equitably.
Co-Authors Abdullah Abdullah Abdullah Abdullah Abdullah Adisman, Rendika Afsari, Leni Aisyah Aisyah Alimin, Masnaini Anggi Desviana Siregar Desviana Siregar, Anggi Desviana Siregar Desviana Annisa Al Fatihah Annisa Artanti Apen Sintia Asmat Ahmad Azizahwati Azizahwati Daviq Chairilsyah Dodi Dahnuss Edres, Bunga Elfis Suanto Elmiwarti Indriani Erna Yupeni ERWINA JULIANTARI, ERWINA Eva Refita Ezra Yulyta Hasibuan Fadly Azhar Fadly Azhar Febriarti, Bernadeta Leni Fikriyah, Miftahul Hadriana Hadriana Herdini Indra Primahardani Indra Primahardani Indra Primahardi Isjoni Isjoni Isnawati Lujeng Lestari Jimmi Copriady Kristina Murti, Meri Lee Yook Heng Lenny Anwar Lenny Anwar S Linda*, Roza M. Yogi Riyantama Isjoni Mahdum Maria Erna Maria Erna Maria Erna Kustyawati Mensupriantos Mensupriantos, Mensupriantos Monita Olivia Murti, Meri Kristina Novia Cristi Br Pasaribu Nurbaiti Nurdiansyah Nurdiansyah Nurul Khafizah Pani Pransiska Putri Prayunli, Ranny Putra, Riki Apriyandi Qurratun Mardhatillah Rahmani, Syauqi Susana Rasmiwetti Rasmiwetti Rasmiwetti Rehamita. S, Rehamita. S Rendika Adisman Riki Apriyandi Putra Riki Apriyandi Putra Riki Apriyandi Putra Riki Apriyandi Putra Riki Apriyandi Putra Riki Apriyandi Putra Riri Aisyah Riri Aisyah, Riri Rita Kurnia Riyantama, Muhammad Yogi Rosiana, Yuni Roza Linda Sri Haryati Sri Haryati Sri Haryati Sri Haryati Sri Wilda Albeta Sri Wilda Albeta Sukrisno, Sukrisno Susilawati Susilawati Susilawati, S. Tetty Marta Linda Tissa Indah Tri Padila Rahmasari Wan Syafii Wan Syafii Wansyafii Wansyafii Wati, Andini Saras Widianita Widianita Yennita Y Yuni Rosiana Yuni Rosiana Yuwapi, Mukholladun Hamdan