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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Brawijaya Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Jurnal Sains dan Teknologi Farmasi Indonesian Journal of Pharmaceutical Science and Technology EduChemia: Jurnal Kimia dan Pendidikan Acta Pharmaceutica Indonesia Pharmascience Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Ilmiah Manuntung Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Abditani : Jurnal Pengabdian Masyarakat Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Jurnal Peduli Masyarakat Borneo Journal Of Pharmascientech Poltekita: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Pharmacy MEDIC MEdical Dedication SCIENCE : Jurnal Inovasi Pendidikan Matematika dan IPA Indonesian Journal of Pharmaceutical Education Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Pharmaceutical Care and Sciences Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Panthera : Jurnal Ilmiah Pendidikan Sains dan Terapan Jurnal Katalisator Riset Informasi Kesehatan Journal of Pharmaceutical and Sciences. Jurnal Kedokteran Meditek Prosiding Seminar Nasional Unimus Borneo Journal of Pharmacy Bencoolen Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Jurnal Abdimas Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Kesehatan Farmasi Nusantara Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Sani K, Fathnur
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan

 1 
PEMBUATAN VIRGIN COCONUT OIL (VCO) DENGAN METODE PENGASAMAN SEBAGAI KRIM TABIR SURYA BERBAHAN AKTIF TiO2 Agung Giri Samudra; Nurfijrin Ramadhani; Fathnur Sani K; Ulfa Febriyani
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.274

Abstract

Palm trees is one plantation commodities important in development sub the plantation sector, among others to meet the needs of domestic, and as a commodity export foreign exchange producing countries. Cream sunscreen is made with an emulsion phase (VCO, lanolin, stearic acid and cetyl alcohol) and aqueous phase (triethanolamine, glycerin, aquadest). TiO2 was added with various concentrations of F0 (0%), F1 (5%), F2 (10%), and F3 (15%). The research vco oil colorless and odorless typical fresh coconut. Produce the centrifugation does not happen the separation between the oil and the water pH value the range of 6.87-7.63; viscosity and range of cp 12400-21600; SPF value at F0 (0.189); F1 (2.857); F2 (4.252); F3 (6.154). Of the value of the two of them have met the standards according to the SPF concentration F2 and F3.
UJI AKTIVITAS EKSTRAK ETANOL DAUN EKOR NAGA (Rhaphidophora pinnata (L.f.) Schott.) SEBAGAI ANTIHIPERURISEMIA TERHADAP MENCIT PUTIH JANTAN Bella Pascila; Fathnur Sani K; Revis Asra; Agung Giri Samudra
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.389

Abstract

Hyperuricemia is a condition of abnormal health hence increasing urid acid level within blood that is up in normal value spesificaly for man is over 7,0 mg/dL and for woman is over 6,0 mg/dL. Ekor naga leaves (Rhaphidophora pinnata L.f.) have some second metabolic compound namely flavonoid and alkaloid that have a capability to hampering xhantine oxidase enzyme. The objective of this reseach is to know the effectiveness giving ethanol extract of ekor naga leaves for decreasing urid acid level and to know the effectiveness dose ethanol extract of ekor naga leaves for decreasing uric acid level. The sample of this reseach was ethanol extract of ekor naga leaves, allopurinol as positive control, chicken liver juice and potassium oxonate as inductioun of hyperuricemia. The design of this research is complete random design with 5 action where in one action consist of 5 mice. The group of action was K+ Allopurinol 0,26mg/kgBB, P1 extract 125mg/kgBB, P2 extract 250mg/kgBB, and P3 extract 375mg/kgBB. The best dose is dose II (250mg/kgBB) with percentage of decreasing uric acid is 45,22%. Than dose III (375 mg/kgBB) with perfentage of dereasing urid acid is 44,66%, and dose I (125 mg/kgBB) with percentage of the decreasing uric acid is 39,60%. Moreover, it can be concluded that all dose of ethanol extract ekor naga leaves have an activity as antyhiperuricemia.
UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN KAYU MANIS (Cinnamomum burmanni) PADA MENCIT PUTIH JANTAN Astika, Rahmila Yuni; Sani K, Fathnur; Elisma
Jurnal Ilmiah Manuntung Vol 8 No 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.465

Abstract

Cinnamon (Cinnamomum burmannii) leaves extract contains secondary metabolites such as flavonoids, saponins, tannins, alakloids, steroids/terpenoids and phenols. The aims of this study was to examine the anti-inflammatory activity of the ethanolic extract of cinnamon leaves topically and to determine the best concentration for the treatment of inflammation. This research is an experimental research with a post test only control group design approach. The treatment group was devided into 5 groups where each treatment consisted of 7 test animals The treatments included positive control (hydrocortisone acetate 2.5%), negative control (vaselin flavum), ethanol extract of cinnamon leaves with concentrations of 5%, 10% and 20%. The results showed that the ethanolic extract of cinnamon leaves had an anti-inflammatory effect statistically had a significant difference between the treatment groups (p<0.05). The best concentration is 20% then followed by 10% and 5%.
PENGARUH EKSTRAK DAUN EKOR NAGA (Rhaphidophora pinnata (L.f) Schott) TERHADAP KADAR MALONDIALDEHID DARAH PADA TIKUS DIABETES YANG INDUKSI ALOKSAN Sani K, Fathnur; Rahman, Havizur; Yuliawati, Yuliawati; Samudra, Agung Giri
Jurnal Ilmiah Manuntung Vol 8 No 2 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i2.623

Abstract

Ekor Naga (Rhaphidophora pinnata (L.f) Schott) leaves is a traditional medicinal plant that contains secondary metabolites of alkaloids, flavonoids, saponins, and tannins, which have antioxidant effects. Uncontrolled diabetes mellitus will be one of the triggers for high free radicals in the body. This study aims to determine the effect of the effect of ekor naga leaves extract which has potentian as an antioxidant on malondialdehyde levels as a prooxidant marker in alloxan-induced diabetes mellitus rats. The reseaech method used a post test only control group design. The test animals used were 20 animals, each group of 5 test animals. Group 1: Positive Control (Glibenclamide 10 mg/Kg BW), Group 2: Negative Control (Na CMC 0,5%), Group 3: Ekor Naga Leaf Extract 250 mg/Kg BW, and Group 4: Ekor Naga Leaves Extract 500 mg/Kg BW. The data taken is the level of malondialdehyde in the blood. The results were analyzed using One-way ANOVA with a 95% confidence level. The results showed that the ethanolic extract of the ekor naga leaves had a role in reducing Malondialdehyde or lipid peroxide in the blood in diabetic rats where the best dose is 500 mg/Kg with malondialdehyde yield of 0,569 nmol/mL. Followed by a dose of 250 mg/Kg BW with malondialdehyde value of 2,144 nmol/mL.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL 50% BIJI PINANG (Areca catechu) DENGAN METODE DPPH (2,2-diphenyl-1-picryhydrazyl) Humaryanto; Sani K, Fathnur; Yuliawati, Yuliawati; Rahman, Ave Olivia; Muhaimin, Muhaimin
Jurnal Ilmiah Manuntung Vol 9 No 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.659

Abstract

Areca nut is a plant that contains secondary chemical metabolites of flavonoids, alkaloids, tannins, terpenoids, and steroids. Where content has activity as an antioxidant. The aim of this study were to determine the antioxidant activity of 50% ethanol extract of areca nut against DPPH free redicals based on the IC50 value. Extraction method using 50% ethanol with maceration method. The antioxidant activity test was made with 5 concentration series, namely 10 ppm, 50 ppm, 100 ppm, 150 ppm, and 200 ppm. The extract was tested for free radical scavenging against DPPH (2,2-diphenyl-1-picrylhydrazyl) with a wavelength of 517 nm using a UV-Vis spectrophotometer. The comparator used is Vitamin C. The results showed that the 50% ethanol extract of areca nut has a very strong category of antioxidant activity with an IC50 value of 27,565 ppm, while a positive control of Vitamin C has an IC50 value of 28,546 ppm. The conclusion obtained from the above results is that 50% ethanol extract has very strong antioxidant activity.
UJI EFEKTIVITAS ANTIHIPERGLIKEMIA INFUSA ALGA LAUT COKLAT (Sargassum hystrix) PADA MENCIT JANTAN DENGAN METODE TOLERANSI GLUKOSA Samudra, Agung Giri; Ramadhani, Nurfijrin; Utami, Cyntia Dwi; Wirahmi, Nori; Sani K, Fathnur
Jurnal Ilmiah Manuntung Vol 7 No 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.510

Abstract

One type of metabolic disease that is always experiencing an increase in sufferers every year in countries around the world is diabetes mellitus. Sargassum hystrix marine algae are the types that are found and quite abundant in Indonesia. This study aims to prove the hypoglycemic effect of Sargassum hystrix infusion in male white mice. The study was conducted using the oral glucose test method in the positive control group (I) given glibenclamide 0.52mg / 20gramBB; group (II) is a negative control given CMC Na 0.5%; group (III) infusion of Sargassum hystrix with a concentration of 2.5% with a volume of 0.2 mL / 20gram BW; group (IV) infusion of Sargassum hystrix with a concentration of 5% by volume of 0.2 mL / 20gram BW. The results were analyzed using One Way Anova which was then followed by Duncan's test. The results showed that Sargassum hystrix infusion had an antihyperglycemic effect (p <0.05) when compared with negative controls. Sargassum hystrix 5% infusion is the best dose with the antihyperglycemic effect statistically the same as the antihyperglycemic effect of glibenclamide.
FORMULASI NANOPARTIKEL KITOSAN EKSTRAK METANOL ALGA LAUT COKLAT (Sargassum hystrix) DENGAN METODE GELASI IONIK Samudra, Agung Giri; Ramadhani, Nurfijrin; Sani K, Fathnur; Lestari, Gina; Nugroho, Bambang Hernawan
Jurnal Ilmiah Manuntung Vol 7 No 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.428

Abstract

The content of marine algae Sargassum hystrix includes polysaccharides (alginates), polyphenols, proteins, peptides, amino acids, lipids, minerals, and several vitamins. However, the use of natural ingredients has limitations, namely that it often fails in the clinical phase due to low bioavailability. One effort that can be done to overcome this problem is to formulate nanoparticles using chitosan polymer and sodium tri-polyphosphate. This study aims to formulate nanoparticles from the methanol extract of Sargassum hystrix with various chitosan concentration ratios. The methanol extract of Sargassum hystrix was obtained by extraction using the maceration method with 50% methanol as a solvent. The results of the extract were made colloidal nanoparticles using ionic gelation techniques using a variation of the methanol extract of Sargassum hystrix: chitosan: NaTPP: Tween 80, Formulation 1 (0.75 gram: 0.1% 18 mL: 0.1% 9 mL: 0.5% 3 mL); Formulation 2 (0.75 gram: 0.2% 18 mL: 0.2% 9 mL: 0.5% 3 mL); Formulation 3 (0.75 gram: 0.1% 18 mL: 0.2% 9 mL: 0.5% 3 mL); Formulation 4 (0.75 gram: 0.2% 18 mL: 0.1% 9 mL: 0.5% 3 mL). The nanoparticle colloids formed were characterized by particle size (nm), and the zeta potential (mV), Formula 1 (212.65 ± 45.32; -11.4 ± 5.65), Formula 2 (514.55 ± 56.35; -8.85 ± 1.34), Formula 3 (219.35 ± 43.76; -14.5 ± 1.83), Formula 4 (326.5 ± 3.39; -1.25 ± 17.88). All formulas show that they can form nanoparticle formulas between 1-1000 nm., But the preparation that will be more stable is formula 3 because it has a zeta potential that is close to +/- 30 mV.
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN EKOR NAGA (Rhaphidophora pinnata (L.f) Schott) SEBAGAI ANTIHIPERGLIKEMIA TERHADAP MENCIT PUTIH JANTAN YANG DIINDUKSI SUKROSA Lestari, Dian; Lestari, Intan; Sani K, Fathnur
Jurnal Ilmiah Manuntung Vol 7 No 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.433

Abstract

Hyperglycemia is a condition where blood glucose levels increase above normal. Hyperglycemia is a manifestation of diabetes mellitus (DM). Chronic hyperglycemia in diabetes mellitus has an important role in the damage to various organism, including the heart, gynecological eye, nervous and vascular system, which in turn causes complications of diabetes mellitus. Dragon tail leaf extract (Rhaphidophora pinnata (L.f) Schott) contains several compounds that function to reduce glucose in the blood including flavonoids, alkaloids, saponins, steroids and tanins which can inhibit the action of the enzyme α- glucosidase. The purpose of this study was to determine the effect of giving ethanol extract of dragon tail leaves in blood glucose levels and determine the best dose of ethanol extract of dragon tail leaves in reducing blood glucose levels. The samples used were ethanol extract of dragon tail leaves, acarbose as positive control. The study design used was a completely randomized design (CRD) with 5 treatments in which each treatment consisted of 7 mice. The treatment groups are K + acarbose solution at a dose of 50 mg / kgBB, P1 extract dose 125 mg / kgBB, P2 extract dose 250 mg / kgBB, and P3 extract dose 375 mg / kgBB. The testing method used is the Oral Glucose Tolerance Test (OGTT), which is a standard method in the testing antihiperglycemic effect. Observations were carried out for 120 minutes in the time span of 10; 30; 60; 100 and 120 minutes. The research data were analyzed descriptively and One Way ANOVA test. Based on the analysis of the One Way ANOVA test it was found that there were significant differences for each study treatment (p <0.05). Based on Duncan's further tests it was found that the results of the dragon tail leaf extract had antihiperglycemic effect. The best dose of ethanol extract of dragon tail leaves in percent reduction is dose III 375 mg / KgBB with a percent decrease (38,79%). Then followed by dose II 250 mg/KgBB with a percent decrease (17,01%) anf dose I 125 mg/KgBB with percent decrease (5,325%). So it can be concluded that the ethanol extract of dragon tail leaves has effectiveness as an antihiperglycemia.
Co-Authors Adisty, Aura Rasyanda Agung Giri Samudra Agung Giri Samudra Agung Giri Samudra Agung Giri Samudra Aina Fatkhil Haque Alfi Khatib Anggia, Sonia Anggraini, Dewi Febrina Annisa Luthfiyyah Apriza Hongko Putra Asima Widyawaty Sinurat Astika, Rahmila Yuni Ave Olivia Rahman Ave Olivia Rahman Ave Olivia Rahman Bambang Hernawan Nugroho Bambang Hernawan Nugroho, Bambang Hernawan Bella Pascila Bernike Anatasya Cassa de Floris Cathelya, Bunga Daffa Akrama Yuda Danuartha, Dhimas Dara Permata Sari Diah Riski Gusti Diah Tri Utami Diah Tri Utami DIAN LESTARI Dian Magfirah Dinofitri, Hanifah Dominica, Dwi Dwikanti Prindani Putri Dyah Fitriani Efendi, M. Rifki Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Enda Oktri Mayora Eva Melisa Evi Maryanti Febriyani, Ulfa Fitrianingsih Fitrianingsih Fitrianingsih Fitrianingsih Gatot Prasetya Gina Lestari, Gina Haque, Aina Fatkhil Havizur Rahman Havizur Rahman Havizur Rahman Herlina Herlina herlina herlina Humaryanto Humaryanto Humaryanto Humaryanto Humaryanto Humaryanto, Humaryanto Huntari Harahap Idamanda, Rahma Intan Lestari Iskandar, Mirna Marhami Jannah, Miptakul Jannah, Zahratul Joevanda, Salsabila Kristin Simamora Kusdiyah, Erni M. Rifqi Efendi Maharini, Indri Maimum Maulida, Dafa Riska Mayora, Enda Oktri Mesa Sukmadani Rusdi Monic Sri Cahnia Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhammad Farhan Muhammad Syukri Nada Afrilia Naurah Nazifah Nazar, Armenia Neldi, Vina Novia Tri Astuti Nurfijrin Ramadhani Nurfijrin Ramadhani, Nurfijrin nurwani purnama aji Oktarina, Widiawati Pondawinata, Marizki Puspa Dwi Pertiwi Puspa Dwi Pratiwi Putri Aulia, Bilqis Putri, Andinni Putri, Fadilla Aliyah Qiftiah, Mariatul Rahayu, Stepania Dwimulia Rahman , Ave Olivia Rahman, Havizur Rahman, Havizur Raudhatul Jannah Revis Asra Revis Asra Reza Pertiwi Reza Pertiwi Reza Yolandini Rizamevia, Fhidila Sadli, Nurul Kamilah Salsabilla, Navira Santi Perawati, Santi Sari, Dara Permata Sari, Indah Syamsul Arifin Syamsurizal Syamsurizal - - Syamsurizal Syamsurizal Tia Wida Eka Putri Uce Lestari Uce Lestari Uce Lestari Uce Lestari Uce Lestari 1 Ulfa Febriyani Usna, Rozatul Utami, Cyntia Dwi Vanika, Niken Widiawati Oktarina Wirahmi, Nori Yesi Nursofia Yolandini, Reza Yudha Putra, Diky Okta Yuliana Yuliana Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati, Yuliwati