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liana, nana
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Asupan Magnesium, Kalsium dan Vitamin D dengan Premenstrual Syndrome Jelmila, Sri Nani; Hasni, Dita; Liana, Nana
JURNAL KESEHATAN PERINTIS Vol. 10 No. 2 (2023): Jurnal Kesehatan Perintis
Publisher : LPPM UNIVERSITAS PERINTIS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33653/jkp.v10i2.1031

Abstract

Premenstrual sindrom (PMS) sering terjadi pada fase luteal siklus menstruasi pada wanita usia subur. PMS memberikan dampak terhadap produktivitas, kesehatan mental dan kualitas hidup penderitanya. PMS dapat mempengaruhi prestasi belajar pada mahasiswi. Tujuan penelitian ini adalah untuk melihat hubungan asupan magnesium, kalsium dan vitamin D dengan premenstrual sindroma. Penelitian ini merupakan penelitian analitik observasional dengan design cross sectional. Sampel penelitian ini berjumlah 100 orang yang merupakan mahasiswi Fakultas Kedokteran Universitas Baiturrahmah. Sampel diambil secara consecutive sampling. Analisis data menggunakan uji Mann Whitney. Hasil penelitian ini didapatkan 62% responden dengan asupan magnesium kurang, 93% responden dengan asupan kalsium kurang, 94% responden dengan asupan vitamin D kurang dan 69% responden mengalami PMS ringan. Hubungan asupan magnesium dengan PMS didapatkan nilai p=0,48, hubungan asupan kalsium dengan PMS didapatkan nilai p=0,86 dan hubungan asupan vitamin D dengan PMS didapatkan nilai p=0,72. Kesimpulan dari penelitian ini adalah sebagian besar responden dengan asupan magnesium, kalsium dan vitamin D kurang. Responden terbanyak mengalami PMS ringan. Tidak terdapat hubungan asupan magnesium, kalsium dan vitamin D dengan PMS.
The Profile of Gastrointestinal Stromal Tumors (GISTs) at Dr. M. Djamil General Hospital Padang, Indonesia: A Descriptive Study on 28 Patients Aliska, Gestina; Novianti, Hera; Angraini, Desti; Liana, Nana; Nova, Riki; Rustam, Erlina
Frontiers on Healthcare Research Vol. 1 No. 1 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n1.p19-23.2024

Abstract

Background: Gastrointestinal stromal tumors (GISTs) are the most frequently seen mesenchymal neoplasm in the digestive system. GISTs was originally described as smooth muscle tumor in the 1980s but advances in molecular diagnostic methods and immunohistochemistry moved GISTs into a different category from smooth muscle tumors. The study aims to report on epidemiological, clinical, immunochemical, and therapeutic characteristics of GISTs. Methods: We performed a retrospective descriptive study of 28 cases of GIST in the gastroenterology and general surgery departments of M. Djamil General Hospital Padang, Indonesia was conducted from January 2019 to December 2021. Data collection using medical records of patients in M. Djamil General Hospital Padang, Indonesia. We reported different data: Age, sex, symptoms, site, and immunohistochemistry of the tumor.  Results: Our study included 28 patients 18 males (64,3%) and 10 females (35.7%), with a median age range of 51-60 years. The presenting symptoms were abdominal mass (53.6%), abdominal pain (14.3%), bloody or dark-colored stools (14.3%), constipation (7.1%), fatigue (7.1%), and nausea and vomiting in 1 case (3.6%). Sixteen patients (57.1%) had a primary tumor and twelve patients (42.9%) had further metastatic lesions. The tumors were found in the stomach (21.4%), small intestine (14.3%), rectum (14.3%), and in other sites such as the retroperitoneal, liver, and distal pancreas. The immunohistochemical study was performed in seven cases (expression of  CD117 and DOG1), in four cases  CD117 was positive, while in three cases CD117 was negative. In two cases, the expression of DOG1 was positive, while in one case, it was negative. Eighteen patients with GIST (64.3%) underwent surgical procedures. A combination of surgical and chemotherapy was prescribed in 9 patients (32.1%). The chemotherapy regimen prescribed is imatinib. One patient is inoperable and has received symptomatic treatment. Conclusion : In conclusion, our result showed that GISTs are highest in the male population with an age range of 51-60 years. The most common symptom of GISTs is abdominal mass. Patients who have been diagnosed with GIST by histopathological examination do not always show positive expression in the immunohistochemical study. Surgical resection was indicated in the majority of patients, and a combination of surgery and chemotherapy is also prescribed as a treatment for patients with GIST.
Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Adenokarsinoma Kolorektal Liana, Nana; Hilbertina, Noza; Devianti, Loli; Yetti, Husna
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.490

Abstract

BackgroundColorectal carcinoma is the third most common malignancy in the world. Colorectal carcinoma is a heterogeneous tumor withdifferent clinical pathologic features and prognostic values. For the same tumor-stage, patients could have difference prognosis andit has been suggested that the angiogenesis might be correlated with the prognosis, especially expression of vascular endothelialgrowth factor (VEGF) as the main pro-angiogenic factor. High VEGF expression in colorectal adenocarcinoma is associated withincreased blood vessels in invasive tumor area, cell proliferation and metastases. However, relation VEGF expression with thedegree of differentiation and lymphovascular invasion is not known.MethodsThis was a retrospective observational study with cross sectional approach. Samples were obtained from 39 paraffin blocks withdiagnosis adenocarcinoma not otherwise specific (NOS) in four Anatomical Pathology Laboratory in West Sumatera 2018 andevaluated for degree of differentiation and lymphovascular invasion. VEGF expressions in tumor cell were analyzed usingimmunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant.ResultsColorectal adenocarcinoma with high grade differentiation entirely had high VEGF expression (100%), while low gradedifferantiation with high VEGF expression was 60.7%. Lymphovascular invasion positive was mostly found with high VEGFexpression (80.6%). Statistical analysis showed significant association between VEGF expression with degree of differentiation(p=0.017) and lymphovascular invasion (p=0.028).ConclusionThe conclusion was VEGF expression had significant association with degree of differentiation and lymphovascular invasion ofcolorectal adenocarcinoma.
COMMUNITY-ACQUIRED PNEUMONIA OLEH KLEBSIELLA PNEUMONIAE DI RSUP DR. M. DJAMIL PADANG TAHUN 2024: GAMBARAN MORTALITAS TINGGI DAN TANTANGAN KLINIS Ruhsyahadati, Ruhsyahadati; Liana, Nana; Triyana, Rahma; Puspita, Dian; Rizki Saputra, Muhammad; Helmizar, Roland; Malik, Rifkind; Akbar, Aulia
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1859

Abstract

Community-acquired pneumonia (CAP) caused by Klebsiella pneumoniae is frequently associated with severe clinical courses and high mortality, particularly among elderly patients and those with comorbidities. The increasing rate of antimicrobial resistance has further limited the effectiveness of standard empirical therapy. This was a retrospective descriptive observational study using secondary data from medical records of hospitalized CAP patients at Dr. M. Djamil General Hospital, Padang, from January 2022 to December 2023. Subjects were adults (≥18 years) diagnosed with CAP and with positive cultures for K. pneumoniae. Variables included demographic characteristics, length of hospital stay, clinical outcomes, and antibiotic susceptibility patterns. Data were analyzed using univariate descriptive analysis. A total of 50 patients were included, predominantly male (58%) and aged over 65 years (40%). The most frequent comorbidities were hypertension (60%) and diabetes mellitus (36%). The mean length of hospital stay was 14 days. Mortality was high, reaching 56%. Antibiotic susceptibility testing showed the highest sensitivity to meropenem (96%) and amikacin (92%), while commonly used first-line agents such as ceftriaxone, ampicillin–sulbactam, and ciprofloxacin demonstrated low sensitivity (<15%). CAP due to Klebsiella pneumoniae at Dr. M. Djamil General Hospital is associated with very high mortality and widespread resistance to first-line antibiotics. Empirical therapy should be guided by local antibiogram data and supported by strong antimicrobial stewardship programs.
Status Vitamin D dan Hubungannya dengan Kadar Kolesterol Total Mahasiswa Fakultas Kedokteran Universitas Baiturrahmah Jelmila, Sri Nani; Mutiya Rahmi, Rafiqa; Suharni; Helmizar, Roland; Liana, Nana
Scientific Journal Vol. 5 No. 1 (2026): SCIENA Volume V No 1, January 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i1.321

Abstract

Pendahuluan: Defisiensi vitamin D dilaporkan tinggi pada populasi dewasa muda termasuk mahasiswa kedokteran, meskipun berada di negara tropis. Vitamin D diduga berperan dalam metabolisme lipid melalui modulasi inflamasi dan regulasi metabolik.Tujuan penelitian: menganalisis status vitamin D dan hubungannya dengan kadar kolesterol total pada mahasiswa Fakultas Kedokteran Universitas Baiturrahmah. Metode: Penelitian analitik observasional dengan desain cross-sectional dilakukan pada 61 sampel. Kadar 25-hidroksivitamin D diperiksa dengan ELISA dan diklasifikasikan menjadi defisiensi, insufisiensi, dan sufisiensi, sedangkan kolesterol total diperiksa dengan metode enzimatik kolorimetrik. Hasil: Hasil menunjukkan status vitamin D terbanyak adalah defisiensi (36,1%), rerata kadar kolesterol total adalah 174,16±28,81 mg/dL. Analisis menunjukkan tidak terdapat hubungan bermakna antara status vitamin D dan kadar kolesterol total (p=0,14). Kesimpulan: defisiensi vitamin D merupakan kondisi yang dominan pada mahasiswa kedokteran, namun tidak berhubungan signifikan dengan kadar kolesterol total.
Co-Authors A, Meridha Mutiara Adelin, Prima Aditia Permana, Yudhi Ajisman, Ruhsyahadati Aliefia, Desi Amanah Fauziah, Suci Andi Friadi Anggraini, Debie Angraini, Desti Arifa, Nurwahidatul Aswiyanti Asri Aulia Akbar Devianti, Loli Dhuha, Alief Dian Puspita Eldrian, Febiane Erlina Rustam Ferdian, Arif Gestina Aliska Haiga, Yuri Hasni, Dita Helmizar, Roland Husna Yetti Jelmila, Sri Nani Lismawati Lismawati, Lismawati Malik, Rifkind Melya Susanti Miming Andika Muhammad Rizki Saputra, Muhammad Rizki Mutiya Rahmi, Rafiqa Nani Jelmila, Sri Nizar, RZ Nova, Riki Novianti, Hera Noza Hilbertina, Noza Nurwiyeni Oktora, Meta Zulyanti Oktora, Meta Zulyati Oktora, MetaZulyati Putriyuni, Anandia Rasyid, Lismawati Reza, Tia Riyada, Fauziatul Rizki Saputra, Muhammad Ruhsyahadati Ruhsyahadati, Ruhsyahadati Setiawati, Erdanela Suharni Suharni Suharni Tasya, Cerint Iralloza Tri Septiana, Vina Tri Yana, Rahma Triyana, Rahma Yahdian Rasyadi Yenita . Yesika, Relin Yurizali, Bun Zulyati Oktora, Meta