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All Journal JURNAL PENELITIAN SAINTIKA AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Chemical Science and Technology Jurnal Buana Farma Jurnal EduHealth Bulletin of Community Engagement Journal of Health and Medical Science International Journal of Health and Pharmaceutical (IJHP) FARMASAINKES PCJN Pharmaceutical and Clinical Journal of Nusantara Usada Nusantara: Jurnal Kesehatan Tradisional Journal of Pharmaceutical and Sciences. JK Jurnal Kesehatan Medic Nutricia : Jurnal Ilmu Kesehatan Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Jurnal Sains dan Kesehatan
Rafita Yuniarti
Program Studi Farmasi, Universitas Muslim Nusantara Al Washliyah
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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The Antibacterial Activity Test Of Leaf Extract Nanoparticles Of Senggani (Melastoma Candidum D.Don) Against Cutibacterium Acnes And Staphylococcus Epidermidis Bacteria Tia Nazilla; Muhammad Amin Nasution; Minda Sari Lubis; Rafita Yuniarti
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Abstract

The aim of this research is to explore and delve deeper into the reasons families request passive euthanasia, the illnesses and conditions that lead individuals to consider such actions, and how the principle of patient autonomy is applied in euthanasia practices at KH. Daud Arif Regional General Hospital, Kuala Tungkal. The research employs a qualitative approach through literature review studies. Data were collected from journals, books, and previous studies, focusing on the withdrawal of life-support measures and the ethical principle of autonomy. The collected information was analyzed to support the research. Based on the findings, decisions regarding euthanasia, particularly passive euthanasia, should ideally be made by patients when they are mentally capable. However, in critical conditions where the patient is incapacitated, the responsibility is transferred to the patient's family, who can make decisions on their behalf, including opting for passive euthanasia. While active euthanasia remains illegal in Indonesia, passive euthanasia, such as the cessation of life-support interventions, is permitted under certain legal frameworks, such as Ministry of Health Regulation No. 37 of 2014. This regulation also emphasizes the importance of therapeutic contracts between patients and healthcare providers. The reasons families or patients choose passive euthanasia at KH. Daud Arif Regional General Hospital, Kuala Tungkal, include prolonged physical suffering and a significant decline in quality of life. The illnesses or conditions considered for passive euthanasia include chronic, incurable diseases that cause ongoing suffering, such as heart disease, kidney failure, or illnesses with poor prognoses.
Formulation And Evaluation Of Anti-Aging Face Spray Preparation With Ethanol Extract Of Shoe Flower (Hibiscus Rosa-Sinensis L.) And DPPH Method Antioxidant Activity Test Syafa Nadira Ashiilah; Rafita Yuniarti; Minda Sari Lubis; Zulmai Rani
Jurnal EduHealth Vol. 16 No. 01 (2025): Jurnal EduHealt, Edition January - March, 2025
Publisher : Sean Institute

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Abstract

Beauty is one of the aspects pursued by women, particularly in terms of skin care. Among the skincare products commonly used by Indonesians is face spray, which offers various benefits, such as protecting against free radicals from ultraviolet rays, preventing premature aging, and addressing dry skin. Antioxidant effects are more effective when formulated in topical preparations, such as cosmetics, compared to oral administration. Hibiscus flower is a plant that contains flavonoids, which function as antioxidants capable of protecting the skin from free radical damage, moisturizing, and enhancing skin circulation. This research is experimental in nature. In this study, ethanol extract face sprays from hibiscus flowers were prepared with concentrations of 0.1%, 0.3%, 0.5%, and 0.7%. The face sprays underwent evaluations for physical quality, preference tests, irritation tests, antioxidant activity tests, and anti-aging effectiveness tests. The anti-aging effectiveness data were analyzed using SPSS with a parametric ANOVA test. Based on the physical quality evaluation, the best formulation was the face spray with a 0.5% extract concentration. It exhibited stable organoleptic characteristics, a pH within the skin’s range of 5–7.26, good spreadability, no coarse particles or clumps, and stability during a 28-day stability test at room temperature (25°C) and a cycling test over 6 cycles. Moreover, it did not irritate the skin. The antioxidant activity test revealed that face sprays with 0.1% and 0.3% extract concentrations showed moderate antioxidant activity, while those with 0.5% and 0.7% concentrations demonstrated strong antioxidant activity. In the anti-aging effectiveness test, all formulations exhibited anti-aging effects.
Penentuan Kadar Hidrokuinon dan Asam Retinoat Pada Krim Malam Yang Dijual Dikota Medan Secara Spektrofotometri Ultraviolet Metode Dual Wavelenght Fauziah Zain; Nia Novranda Pertiwi; Minda Sari Lubis; Rafita Yuniarti
Bulletin of Community Engagement Vol. 4 No. 3 (2024): Bulletin of Community Engagement
Publisher : CV. Creative Tugu Pena

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51278/bce.v4i3.1498

Abstract

Night cream is a mixture of chemicals and/or other ingredients with the property of whitening the skin or lightening black spots on the skin that is used at night. Hydroquinone is a compound that is often used as a bleach in cosmetics. Excessive use can have dangerous effects on the skin because it can cause skin disorders and can even cause skin cancer. Retinoic acid is prohibited from being used in whitening creams because it can cause dry skin, burning sensation, carcinogenic and teratogenic. This research aims to determine the presence of hydroquinone and retinoic acid compounds and to determine the levels of hydroquinone and retinoic acid in night cream preparations sold in the city. Medan.  In this study, 4 samples were taken with different trademarks and given the initials A, B, C, D. At the sample testing stage, color reagents were tested qualitatively and quantitative tests were used using UV spectrophotometry with the dual Wavelength method.  Based on the results of research conducted on 4 night cream samples, all night cream samples in the city of Medan contained hydroquinone and retinoic acid compounds and the levels obtained in each sample were that the levels in hydroquinone in night cream A, 2.184%, in night cream B were 2.713%. %, in night cream C 2.543%, and in night cream D 4.402%. Retinoic acid was found in night cream A 0.032%, in night cream B 0.033%, in night cream C 0.039, and in night cream D 0.0023%.
Formulation And Evaluation Of Anti-Aging Face Spray Preparation From Ethanol Extract Of Rosemary Leaf (Salvia Rosmarinus Spenn.) And Antioxidant Activity Test Using The DPPH Method Inna Myesha; Rafita Yuniarti; Minda Sari Lubis; Zulmai Rani
Jurnal EduHealth Vol. 16 No. 01 (2025): Jurnal EduHealt, Edition January - March, 2025
Publisher : Sean Institute

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Abstract

The skin's need to prevent premature aging requires skincare products with antioxidant content. A popular skincare product used today is face spray. Face sprays containing active ingredients as antioxidants are beneficial in preventing premature aging. One of the plants known for its antioxidant properties is rosemary leaf (Salvia rosmarinus Spenn.). The development of face spray with the addition of rosemary leaf extract is a form of utilizing plants in cosmetic products. This study is an experimental research. In this study, rosemary leaf ethanol extract face spray was formulated with concentrations of 0%, 0.5%, 1%, 3%, and 5%. Evaluation included physical quality, hedonic test, irritation test, antioxidant activity test, and anti-aging effectiveness test. Anti-aging data were analyzed using SPSS. Based on physical quality evaluation, the face spray formula with the best physical quality was found at extract concentrations of 1%, 3%, and 5%, with observations indicating stable organoleptic properties, pH within the skin range of 4.5-6.5, good spreading ability, no coarse particles or clumping, and stable formulations after 28 days of room temperature stability testing (25°C) and 6 cycle cycling tests. The formulations also showed no irritation to the skin. In the antioxidant activity test, the 0.5% extract concentration exhibited moderate antioxidant activity, while concentrations of 1%, 3%, and 5% showed strong antioxidant activity. In the anti-aging effectiveness test using a skin analyzer, each formula demonstrated significant differences in skin changes with a p-value of <0.05.
PENENTUAN NILAI SPF (Sun Protection Factor) SEDIAAN LOTION EKSTRAK ETANOL KULIT ALPUKAT (Persea americana Mill.) DENGAN METODE SPEKTROFOTOMETRI UV Sri Murni; Rafita Yuniarti; Minda Sari Lubis; Anny Sartika Daulay
Jurnal Kesehatan Vol. 3 No. 2 (2025): Februari
Publisher : CV. ADIBA AISHA AMIRA

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Abstract

Tabir surya merupakan sediaan kosmetika yang digunakan untuk melindungi kulit dari paparan sinar matahari, sehingga mencegah terjadinya gangguan kulit karena terpapar sinar matahari. Tujuan untuk mengetahui mutu simplisia, metabolit sekunder, ekstrak etanol kulit alpukat, karektristis sedian lotion serta aktifitas tabir suraya ekstrak kulit alpukat dan lotion ekstrak etanol kuliat alpukat melalu pemantaun mutu nilai SPF. Metode yang digunakan pada penelitian ini metode eksperimental. Pada ekstrak etanol kulit alpukat dan lotion ekstrak etanol ditentukan nilai SPF dengan spektrofotometri UV. Yang diukur pada panjang gelombang 290-390nm dengan interval 5 nm evaluasi mutu fisik dilakukan terhadap uji organoleptis, homogenitas, pH, viskositas, daya sebar dan daya lekat. Hasil penelitian menunjukkan bahwa simplisia kulit alpukat memiliki kadar air 4,7%kadar sari larut dalam air 25,5% kadar sari larut dalam etanol 22,6 % kadar abu total 3,55%, kadar abu tidak larut asam 0,5 % secara keseluruhan memenuhi standar MMI, dengan kandungan senyawa kimia berupa golongan flavonoid, saponin, dan triterpenoid. Uji SPF sediaan lotion ekstrak etanol kulit alpukat dibuat pada konsentrasi 0,3%; 0,36%; 0,48% dengan hasil berturut-turut 9,974; 9,934; 18,8. Organoleptis sediaan lotion secara keseluruhan memiliki bentuk kental dengan warna kecoklatan serta aroma mawar, pH homogen 6, viskositas lotion 1000ppm: 7740Cp; 3000ppm: 2310Cp; 4000ppm: 5890Cp; 5000ppm: 8770 daya sebar lotion dari konsentrasi 3000ppm: 4cm; 4000ppm: 6cm; 5000ppm: 7cm, daya lekat lotion dari konsentrasi 3000ppm: 4,12 dtk; 4000pm: 4,39 dtk; 5000ppm: 4,48 dtk.
Uji Antibakteri Ekstrak Etanol Daun Mangga Golek (Mangifera indica L.) terhadap Bakteri Staphylococcus aureus: Antibacterial Test of Ethanol Extract of Golek Mango Leaves (Mangifera indica L.) Against Staphylococcus aureus Bacteria Yuniarti, Rafita; Rukmana, Siti; Nasution, Haris Munandar; Rani, Zulmai; Fauzi, Ziza Aisyia Putri
Jurnal Sains dan Kesehatan Vol. 7 No. 2 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i2.2427

Abstract

Mango golek is among the numerous beneficial plants in the Mangifera genus. Mango leaves have antibacterial, antifungal, antiviral, and antiparasitic properties. The purpose of this research was to determine how effective an ethanol extract of mango golek leaves was against Staphylococcus aureus bacteria and what kind of secondary metabolites were present in the extract. This study employed laboratory experimental methods such as the maceration method with 70% ethanol solvent, phytochemical screening test, and Mango golek leaf extract (Mangifera indica L.) Staphylococcus aureus antimicrobial activity test at various concentrations of 100 mg/day. mL, 70, 50, 30, and 10 mg/mL using the agar diffusion method. Mango golek leaves ethanol extract included alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids, according to the screening results. values of 100 mg/mL and 70 mg/mL were considered high, while values of 50 and 30 mg/mL were considered moderate. Keywords:          cMangifera indica L., Staphylococcus aureus   Abstrak Salah satu tanaman dari genus Mangifera adalah mangga golek yang memiliki banyak manfaat. Salah satu keuntungan adalah sifat antiparasit, antijamur, antivirus, dan antibakterinya. Tujuan penelitian ini adalah untuk mengetahui seberapa efektif ekstrak daun mangga golek terhadap Bakteri Staphylococcus aureus dan mengidentifikasi metabolit sekundernya. Dalam penelitian ini, menggunakan metode eksperimental yang meliputi uji fitokimia, pembuatan pelarut etanol 70% dari ekstrak daun mangga golek (Mangifera indica L.), dan uji antibakteri Staphylococcus aureus dengan konsentrasi 100, 70, 50, 30, dan 10 mg/mL menggunakan metode difusi agar. Hasil skrining, ekstrak etanol daun mangga golek mengandung alkaloid, flavonoid, saponin, tanin, dan steroid/triterpenoid. Uji antibakteri, ekstrak daun mangga golek memiliki sifat antimikroba Staphylococcus aureus dengan kategori kuat 100 dan 70 mg/mL dan kategori sedang 50 dan 30 mg/mL. Kata Kunci:         Antibakteri, Mangifera indica L, Staphylococcus aureus
KONSENTRASI HAMBAT MINIMUM (KHM) DAN KONSENTRASI BUNUH MINIMUM (KBM) EKSTRAK DAUN KEDONDONG HUTAN (Spondias pinnata (L.f) Kurz.) TERHADAP BAKTERI Escherichia coli Pertiwi, Rahma; Haris Munandar Nasution; Rafita Yuniarti; Zulmai Rani
JURNAL FARMASI, SAINS, dan KESEHATAN Vol. 5 No. 1 (2025): FARMASAINKES: JURNAL FARMASI, SAINS dan KESEHATAN
Publisher : Fakultas Farmasi Universitas Muslim Nusantara Al Washliyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/farmasainkes.v5i1.5147

Abstract

Daun kedondong hutan diketahui memiliki kandungan metabolit sekunder salah satunya yaitu flavonoid. Senyawa flavonoid memiliki aktivitas sebagai antibakteri dengan mekanisme menghambat sintesis asam nukleat dan fungsi membran sel. Escherichia coli merupakan bakteri yang sering menyebabkan penyakit infeksi pada saluran pencernaan. Penelitian ini bertujuan menguji kadar hambat minimum dan kadar bunuh minimum ekstrak etanol daun kedondong hutan terhadap bakteri Escherichia coli. Kadar hambat minimum ditentukan menggunakan metode dilusi dilanjutkan dengan uji spektrofotometri UV-Vis dan kadar bunuh minimun ditentukan menggunakan metode dilusi yang disebar merata diatas media MHA dengan konsentrasi ekstrak bervariasi. Hasil penelitian menunjukkan pada konsentrasi 5% dan 7,5% merupakan kadar minimum ekstrak etanol daun kedondong hutan dalam menghambat aktivitas pertumbuhan bakteri Escherichia coli. Penelitian ini menunjukkan ekstrak etanol daun kedondong hutan dapat digunakan sebagai alternatif antibakteri dan dapat dikembangkan lebih lanjut pada bidang kesehatan.
PHENOLIC, FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY WITH SUN PROTECTION FACTOR VALUE OF RED BETEL LEAF ETHANOL EXTRACT (Piper ornatum N. E. Br) Yuniarti, Rafita; Rani, Zulmai; Ridwanto, Ridwanto; Lubis, Minda Sari
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 2 (2025): September
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i2.3149

Abstract

Red betel leaf is a plant that is rich in benefits, one of which is as an antioxidant. The benefits as an antioxidant in plants are due to the content of phenolic and flavonoid compounds. Phenolic compounds also function as protection against UV-B rays, this ability can be seen from the SPF value. The purpose of this study was to determine the amount of phenolic and flavonoid compounds and the antioxidant and sunscreen activity of ethanol extract from red betel leaves. Phenolic content was determined using 10% Follin Ciocalteu reagent and 20% Na2CO3. In contrast, flavonoid content used AlCl3 and CH3COONa solutions, and the determination of antioxidant activity was carried out using DPPH. In contrast, the ability a protect against sunlight (sunscreen) was carried out by determining the sun protection factor (SPF) value. After measurements were carried out using a UV-visible spectrophotometer, the results obtained were a phenolic content of 257.56 mg GAE/g and flavonoids of 46.8008 mg QE/g. They had a very strong antioxidant activity with an IC50 value of 38.9338 ppm and had sunscreen activity with an SPF value of 5, 17, 28, 36, and 38 at concentrations of 100, 300, 500, 700, and 1000 ppm respectively.
Co-Authors A'dilah, Nur Adela Octi Dwiyani Adelia Ramadani Afrida Yeti Ani Sutiani Anny Sartika Daulay Ariandi Asmarani, Asmarani Chairina Milda Cindy Marlina Tambunan Cut Erika Maulydya D. Elysa Putri Mambang D. Elysa Putri Mambang Debi Meilani Dewa, Fasca Dewi Firmayani Dikki Miswanda Dina Veranika Eva Fransiska Farida Yani Fauziah Zain Fitri Febriani Gabena Indrayani Dalimunthe Haris Munandar Nasution Hendraputra, Hardy Handoko Heru Adha Prayogo Ika Fitriani Indah Nasution Indri Juliarni Inna Myesha Jurida, Wike Juwita, Sukma Karlina Butar Butar Khairina Kiki Rawitri Lubis, Minda Sari M Pandapotan Nasution M. Naufal Rifqi M. Pandapotan Nasution Meylisa Pratami Br Sinaga Milwani Harahap Minda Sar Lubis Misna Rosalinda Hutabarat Mohd. Bilal Muhammad Amin Nasution Muhammad Ari Mukhtizar Muhammad Pandapotan Nasution Muhammad Tegar Tri Rizky Nia Novranda Pertiwi Novi Yuliandari Novita Sari, Helsa Pasaribu, Mesi Wilia Afrima Pasaribu, Mesi Willia Afrima Pertiwi, Rahma Purba, Juvantri Fablo Putri Theresia Harianja Rahma Maulidia Fitri Reza Irma Riani, Nur Aslin Ricky Andi Syahputra Ridwan Taher Lubis Ridwanto Ridwanto Risma Fauziah Pasaribu Rukmana, Siti Sagita Marina Simatupang Shinta Mida Ariani Harahap Siregar, Hikmatussabaria Siti Anisa Sri Mulia Ningsih Siregar Sri Murni Sri Natalia Saragih Sri Ria Ranti Syafa Nadira Ashiilah Syahputra, Ricky Andi Syarifah Aulia Tasya Ardana Tia Nazilla Tri Damaiyanti Ummi Khairani Rambe Ummu Safura Sirait Wilda Septia Winda Aulia Yayuk Putri Rahayu Yayuk Putri Rahayu Yuni Sartika Ziza Putri Aisyia Fauzi Zulmai Rani