Claim Missing Document
Check
Articles

Found 27 Documents
Search

The Role of Vitamin D in Immune Balance and Inflammation Handayani, Kurnia Maidarmi; Sari, Widia; Khudri, Ghaniyyatul; Dhuha, Alief
Health and Medical Journal Vol 7, No 2 (2025): HEME May 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i2.1699

Abstract

Vitamin D, traditionally known for its role in bone health, is increasingly recognized as a crucial regulator of immune balance and inflammation. This review explores the mechanisms by which vitamin D influences both innate and adaptive immune responses, with a focus on immune cells like macrophages, dendritic cells, T cells, and B cells. Vitamin D, through its active form, calcitriol, modulates immune cell function by binding to the Vitamin D receptor (VDR), which impacts cytokine production and inflammatory pathways. Notably, vitamin D promotes anti-inflammatory effects by shifting immune responses towards a regulatory phenotype, reducing pro-inflammatory cytokines while enhancing anti-inflammatory signals. This regulatory potential highlight vitamin D’s therapeutic value for inflammatory and autoimmune diseases. Further research is essential to determine optimal vitamin D dosing and its implications across diverse populations.
Effects of Vitamin D Supplementation on Blood Glucose Levels in Streptozotocin-Induced Diabetic Rats Hansah, Rendri Bayu; Dhuha, Alief; Susanti, Melya; Sari, Widia; Khudri, Ghaniyyatul; Handayani, Kurnia Maidarmi
Health and Medical Journal Vol 7, No 2 (2025): HEME May 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i2.1717

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin secretion, insulin resistance, or both. Poor glycemic control in DM leads to complications such as cardiovascular disease and nephropathy. Vitamin D has been suggested to influence glucose metabolism by improving insulin secretion and sensitivity thorugh mechanisms involving pancreatic β-cells and anti-inflammatory pathways. This study evaluates the effect of vitamin D supplementation on blood glucose levels in diabetic rats. An experimental study was conducted using 25 males Sprague Dawley rats, divided into five groups: Group A (negative control), Group B (non-DM + 415 IU/kgBW vitamin D), Group C (DM without vitamin D), Group D (DM + 415 IU/kgBW vitamin D), and Group E (DM + 1100 IU/kgBW vitamin D). Diabetes was induced using streptozotocin (50 mg/kg BW), and rats with random blood glucose levels >200 mg/dL were considered diabetic. Vitamin D supplementation was given via gavage for 30 days. Serum vitamin D and random blood glucose levels were measured 30 days after supplementation. Statistical analyses included ANOVA and Pearson correlation tests. Vitamin D supplementation significantly increased serum vitamin D levels in diabetic rats, especially in Group E (DM + 1100 IU/kgBW vitamin D; (p < 0.05). Random blood glucose levels decreased significantly in diabetic groups and Group E showed the largest glucose reduction (p < 0.001). A moderate negative correlation (r = -0.47, p = 0.017) between vitamin D levels and glucose changes was observed. Vitamin D supplementation reduces blood glucose levels in diabetic rats, with higher doses showing greater efficacy. These findings highlight vitamin D’s potential as an adjunctive therapy for diabetes management. Further research is needed to explore underlying mechanisms.
Pengaruh Aplikasi Puzzlemaker terhadap Hasil Belajar Menyimak Materi Teks Berita Siswa Kelas XI SMA Negeri 1 Belitang III Tahun Pelajaran 2023/2024: The Effect of Puzzlemaker Applications on Results Learn to Listen to Student News Text Material Class XI SMA Negeri 1 Belitang III Academic Year 2023/2024 Fitriani, Herni; Adi Pertiwi , Puji; Sari, Widia
Transformatika: Jurnal Bahasa, Sastra, dan Pengajarannya Vol. 9 No. 1 (2025): TRANSFORMATIKA: JURNAL BAHASA, SASTRA, DAN PENGAJARANNYA
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/transformatika.v9i1.2434

Abstract

This study aims to determine the effect of using the Pır Le Maker application on student learning outcomes in listening to news text material in class XI. This study uses a pre-experimental design method, one group pretest-posttest design. The sampling technique used by the researcher is purposive sampling. The number of samples used is 30 students. Data collection techniques using interviews, tests, documentation, Data analysis techniques for this study: validity test, reliability test, normality test and paired sample t-test. The research instrument is an essay test of 20 questions. Based on the results of the study and data analysis, the ability to listen to news texts of students in class XI before using the puzzle maker media or pretest has an average of 67.86 Then after using the puzzle maker media or posttest there is an increase with an average of 83.23 Based on the paired sample test 1 test shows a sig value level (2-tailed) of 0.000 <0.05 with the results of the hypothesis Ho rejected and H, accepted. The conclusion of this study is that the use of the puzzle maker application has a positive influence on student learning outcomes in listening to news text material. It is hoped that the results of this study can be a reference for teachers and curriculum developers in integrating interactive and interesting learning technology in the learning process.
ANALISIS HUKUM TERHADAP TINDAK PIDANA PEREDARAN MATA UANG PALSU (Studi Putusan Nomor 37/Pid.B/2024/PN/Smn) Sari, Widia; Hatta, Muhammad; Nuribadah, Nuribadah
Jurnal Ilmiah Mahasiswa Fakultas Hukum Universitas Malikussaleh Vol. 8 No. 2 (2025): (April)
Publisher : Fakultas Hukum Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jimfh.v8i2.21264

Abstract

Tindakan meniru mata uang dengan maksud mengedarkan atau menyuruh mengedarkan seolah-olah asli merupakan kejahatan berat yang diancam pidana, dan dalam Putusan Nomor 37/Pid.B/2024/PN/Smn ditemukan disparitas hukuman terhadap pelaku. Penelitian ini menggunakan metode yuridis normatif dengan pendekatan perundang-undangan bersifat deskriptif, serta teknik pengumpulan data melalui studi dokumen. Perlindungan hukum terhadap tindak pidana peredaran mata uang palsu diatur dalam Undang-Undang Nomor 7 Tahun 2011 tentang Mata Uang, yang menetapkan ancaman pidana penjara paling lama 10 tahun dan denda paling banyak Rp10.000.000.000,00. Namun, dalam perkara ini, meskipun jaksa menuntut pidana penjara 1 tahun 6 bulan dan denda Rp100.000.000,00, hakim menjatuhkan hukuman jauh lebih ringan, yaitu 10 bulan penjara dengan denda yang sama, dengan alasan meringankan seperti pengakuan terdakwa, penyesalan, tanggungan keluarga, tidak pernah residivis, serta kondisi ekonomi. Padahal, fakta menunjukkan terdakwa membeli dan menggunakan uang palsu untuk kebutuhan sehari-hari, bahkan melakukannya lebih dari sekali. Disparitas ini menunjukkan ketidaksesuaian antara ketentuan hukum, tuntutan jaksa, dan putusan hakim, yang dapat melemahkan ketegasan hukum terhadap kejahatan yang berdampak besar pada masyarakat dan perekonomian negara. Walaupun pertimbangan non-yuridis penting, bobot kejahatan tidak boleh diabaikan, sehingga diperlukan evaluasi agar penegakan hukum tetap proporsional, adil, dan mencerminkan keseriusan negara dalam memberantas peredaran uang palsu.
Correlation Between Body Mass Index and Cardiovascular Fitness in Medical Student Dhuha, Alief; Rahmadhoni, Berry; Sari, Lovea Ajeng; Puspita, Dian; Akbar, Resti Rahmadika; Sari, Widia
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.254

Abstract

Introduction: Cardiovascular fitness is one of the components that can be used to evaluate health-related physical fitness. Body mass index (BMI) is a factor that can influence cardiovascular fitness. This is due to the strong correlation between BMI and cardiovascular fitness. Aims: To assess the correlation between BMI and cardiovascular fitness among medical students at Universitas Baiturrahmah. Method: The research was conducted at the Physiology Laboratory, Faculty of Medicine, Universitas Baiturrahmah. We assessed each subjects’s BMI and evaluated their cardiovascular fitness using the Harvard Step Test. The data were processed using Spearman rho correlation analysis. Results: Among the 50 subjects who participated in this study the mean BMI was 23.66±0.67 kg/m2, with approximately 68% (34) of subjects categorized in the normal BMI group. Out of the total number of subjects, around 34% (17) subjects had good cardiovascular fitness, with a mean value around 75.48±2.17. The results showed a significant correlation between BMI and cardiovascular fitness (r = -0.436, p<0.05), indicating that a higher BMI is related to lower levels of cardiovascular fitness. Conclusion: The results of this study indicate a significant negative correlation between BMI and cardiovascular fitness among medical students at Universitas Baiturrahmah.
Sistem Pendukung Keputusan Dalam Kelayakan Penerima Bantuan PKH Menggunakan Metode Multi Objective Optimization On The Basic Of Rat Io Analysis (MOORA) Sari, Widia; Sari, Herlina Latipa; Fredricka, Jhoanne
Jurnal Media Infotama Vol 21 No 2 (2025): Oktober
Publisher : UNIVED Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37676/jmi.v21i2.9185

Abstract

The Family Hope Program (PKH) is one of the government's efforts to overcome poverty by providing social assistance to poor families. However, selecting the right and objective recipients of assistance is an important challenge to ensure that the assistance is right on target. This study aims to develop a decision support system (DSS) in determining the eligibility of PKH assistance recipients using the Multi-Objective Optimization on the Basis of Ratio Analysis (MOORA) method. The MOORA method was chosen because of its ability to process several criteria simultaneously, So that it can provide more accurate and objective decisions. The system considers various criteria such as income level, number of family members, and socio-economic status to calculate the eligibility score of aid recipients. The results of this system are expected to provide recommendations for PKH aid recipients that are more efficient, fair, and in line with government priorities. The trials conducted on aid recipient data are expected to demonstrate the accuracy and effectiveness of the system in facilitating more precise and transparent decision-making.
Hate Speech Di Media Sosial Dalam Kerangka Komunikasi Pendidikan: - Rifa'i; Sari, Widia
EDUCATE : Journal of Education and Culture Vol. 2 No. 01: Januari 2024
Publisher : Rumah Riset Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61493/educate.v2i01.104

Abstract

Abstract: The increasing number of internet users has a negative impact, one of which is hate speech, so that from year to year on social media the number of hate speech continues to increase without any signs of disappearing or being resolved. Hate speech is an action that is contrary to the communication function of education as an indicator of intelligence and communication ethics. This research aims to describe forms of hate speech on social media as well as analyze hate speech in educational communication in posts by Twitter social media users. The method used in this research is descriptive qualitative. Research data was obtained through listening, taking notes, and documenting uploads and comments from Twitter account users. The results of this research show that there is hate speech on social media in the form of videos, comments, and tweets. In the form of insulting speech, defamation, incitement, provocation, spreading false news, and blasphemy. So educational communication is needed to minimize acts of hate speech by involving educational communication functions including informative functions, educational functions, persuasive functions, and expressive functions. Keywords: educational communication, hate speech