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All Journal Jurnal Ilmiah Farmasi MPI (Media Pharmaceutica Indonesiana) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Kreativitas PKM JCPS (Journal of Current Pharmaceutical Sciences) Pharmacoscript Lumbung Farmasi : Jurnal Ilmu Kefarmasian Borneo Journal Of Pharmascientech SPIN: Jurnal Kimia & Pendidikan Kimia Jurnal Mandala Pengabdian Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Indonesian Community Journal Journal Borneo Jurnal Bakti Untuk Negeri Literasi: Jurnal Pengabdian Masyarakat dan Inovasi Sains Medisina Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Parapemikir Jurnal Ilmiah Farmasi Jurnal Farmasi dan Farmakoinformatika Borneo Journal of Pharmacy Jurnal Pharma Bhakta Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal of Pharmascience
Fitriyanti, Fitriyanti
Fakultas Farmasi, Universitas Borneo Lestari, Banjarbaru, Kalimantan Selatan, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Antioxidant Activity of Ethanolic Extract from Tandui Leaves (Mangifera rufocostata Kosterm.) by DPPH Radical Scavenging Method Revita Saputri; Tia Mariati Risma Melati; Fitriyanti Fitriyanti
Borneo Journal of Pharmacy Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i2.1070

Abstract

Tandui (Mangifera rufocostata Kosterm.) is a typical plant from South Kalimantan which belongs to the genus of Mangifera. Several species of Mangifera are known to have antioxidant activity. This study aimed to determine the antioxidant activity of ethanol extract of Tandui leaves. Tandui leaves that were obtained from the maceration method used 70% ethanol. Antioxidant activity was conducted quantitative using the DPPH (2,2-diphenyl-1-picrylhydrazil) method. The result of the antioxidant activity of Ethanol extract of Tandui leaves quantitatively obtained IC50 value was 60.7042 µg/mL. The ethanol extract of Tandui leaves has strong antioxidant activity
Pharmacognostic Study of Sangkareho Root (Callicarpa longifolia Lam.) from Pelaihari, South Kalimantan Fitriyanti Fitriyanti; Yusmalina Yusmalina; Rahmi Muthia
Borneo Journal of Pharmacy Vol. 3 No. 2 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i2.1267

Abstract

Sangkareho (Callicarpa longifolia Lam.) is used traditionally by one of Kalimantan's indigenous tribes, the Dayak Tunjung tribe as a medicine for colds and inflammation, where the plant parts used are the roots. Considering its very potential prospects, research aimed at providing a scientific basis for plant pharmacognostic data needs to be carried out with qualitative methods. The qualitative examination is done by several methods including test identification of organoleptic, macroscopic, microscopic, and chemical compounds. Organoleptic test results showed that the roots have a light brown color, bitter and slightly spicy, and a rather pungent odor. Microscopic test results showed sangkareho root has a length of ± 90 cm; width of ± 1 cm; and for the form of a spear with a ride root system. Microscopic observations are found in the form of epidermal cells, exodermis, cortex, endodermis, bearing files, calcium oxalate crystals, and stone cells. The identification of chemical compounds showed positive results against alkaloids, flavonoids, saponins, and triterpenoids. The thin-layer chromatography profile shows four separate stains with eluent ethyl acetate : methanol : water in a ratio of 8 : 2 : 1, respectively.
Uji Aktivitas Antibakteri Ekstrak Metanol Daun Ramania (Bouea. macrophylla Griffith) Terhadap Bakteri Escherichia coli hairunnisa nisa; Fitriyanti Fitriyanti; Putri Kartika Sari
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.463

Abstract

Ramania (B. macrophylla Griffith) can beused as an antibacterial in the gastrointestinal tractOne of the bacteria in the digestive tract is Escherichia coli. The purpose of this study was to determine the group of compounds contained in ramania leaf methanol extract (B. macrophylla Griffith) and the activity of ramania leaf methanol extract (B. macrophylla Griffith) in inhibiting the growth of E. coli bacteria. Using the maceration method with methanol solvent and extract amendment of 8.6019%. Ramania leaf methanol extract (B. macrophylla Griffith) contains secondary metabolite compounds namely alkaloids, flavonoids, saponins, tannins, and steroids. Antibacterial activity test was carried out by the welling method with a concentration of methanol extract of ramania leaves (B. macrophylla Griffith) which is 1,024 mg / ml; 2,048 mg/ml; 4,096 mg/ml; 8.192 mg/ml; 16,384 mg/ml; 32,760 mg/ml; positive control of ciprofloxacin 5μg/disk, and negative control of Na-CMC 0.5%. The results of the antibacterial activity test of ramania leaf methanol extract (B. macrophylla Griffith) showed that the concentration of 2.048 mg / ml included the inhibition zone of the weak category, namely 3.33 mm;, while the concentration of 32,760 mg / ml included the moderate inhibition zone, namely mm; 8.48 mm and the positive control of ciprofloxacin 5μg / disk was included in the category of very strong inhibition zone, namely 22.8 mm. Based on the spss results using the Man-Whitney test the positive control and control had no difference due to the sig value (<0.05). It can be concluded that ramania leaf methanol extract (B. macrophylla Griffith) has antibacterial activity against E. coli bacteria and has secondary metabolite compounds found in ramania leaves (B. macrophylla Griffith) are Alkaloids, Flavonoids, Tannins, Saponins and Steroids.
Uji Aktivitas Antibakteri “Ekstrak Metanol Daun Sungkai (Peronema canescens Jack) Terhadap Bakteri Propionibacterium acnes. Shelin Shelin; Fitriyanti Fitriyanti; Muhammad Saufi
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.489

Abstract

The Sungkai plant (P. canescens Jack) is known to have medicinal properties in the traditional treatment of skin diseases. The aim of this research is to identify groups of phytochemical compounds contained in the methanol extract from Sungkai leaves, as well as evaluate the ability of the methanol extract to inhibit the growth of P. acnes bacteria. In the first stage, phytochemical screening was carried out from the methanol extract of Sungkai leaves. The results of this screening show that the methanol extract of Sungkai leaves contains alkaloids, flavonoids, phenols, triterpenoids and tannins. In the antibacterial activity test, the diffusion method with the well technique was used at extract concentrations of 1%, 5%, 10%, 15% and 20%. As a comparison, the positive control used clindamycin with a concentration of 2 µg/disk, while the negative control used Na-CMC with a concentration of 0.5%. The results of the antibacterial activity test showed that at a concentration of 1%, the methanol extract of Sungkai leaves had an inhibition zone with moderate intensity. However, at a concentration of 20% as well as in the positive control clindamycin with a concentration of 2 µg/disc, there was a stronger zone of inhibition. Thus, these findings indicate that methanol extract from Sungkai leaves has the potential to inhibit the growth of P. acnes, which is often associated with skin problems. The phytochemical compounds contained in this extract can be the basis for potential development in natural-based skin
Uji Aktivitas Antibakteri Ekstrak Etanol 70% Daun Ginseng Jawa (Talinum paniculatum (Jacq.) Gaertn) Terhadap Bakteri Shigella dysenteriae Riwanda Oktaviani; Fitriyanti Fitriyanti; Putri Kartika Sari
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 1 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i1.502

Abstract

Shigellosis is a digestive tract infection that can be caused by S dysenteriae bacteria. Javanese ginseng (T. paniculatum (Jacq.) Gaertner) is a plant known to have antibacterial potential. This study aims to determine the content of the class of compounds contained in the 76% ethanol extract of Javanese ginseng leaves and to observe the antibacterial activity of the 70% ethanol extract of Javanese ginseng leaves against S. dysenteriae based on the diameter of the inhibition zone. Antibacterial testing using the disc diffusion method with six variations of extract concentrations including 5%, 10%, 20%, 40%, 60% and 80% for positive and negative controls used Azithromycin 15µg/disk and 0.5% Na-CMC. Identification of the content of secondary metabolites was carried out on alkaloids, phenols, flavonoids, quinones, saponins, steroids/triterpenoids and tannins. The results of the screening test for 70% ethanol extract of Javanese ginseng leaves contained flavonoids, phenols, saponins, steroids and tannins. Antibacterial testing at the smallest concentration, namely 5% of the inhibition zone, is considered weak with an average inhibition diameter of 4.01 mm and at the largest concentration, namely 10%, the inhibition zone is considered strong with an average inhibition zone diameter of 11.26 mm.
PENGARUH METODE EKSTRAKSI TERHADAP AKTIVITAS ANTIBAKTERI DAUN RAMANIA (Bouea macrophylla Griffith) TERHADAP Staphylococcus aureus Fitriyanti; Syifa; Ahmad; Revita Saputri; Rahmi Muthia
Pharmacoscript Vol. 7 No. 1 (2024): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v7i1.1462

Abstract

Ekstrak metanol dari daun Ramania (Bouea macrophylla Griffith) telah teruji dengan dosis kecil memiliki efek antibakteri terhadap bakteri Staphylococcus aureus, namun belum pernah dilakukan pengujian pada dosis yang lebih tinggi dan membandingkan pada metode ekstraksi yang berbeda seperti maserasi dan soxhletasi. Pada penelitian bermaksud untuk mengetahui golongan senyawa yang terdapat pada ekstrak metanol dari daun ramania dengan metode yang berbeda dan untuk mengetahui pengaruh peningkatan konsentrasi ekstrak terhadap penghambatan bakteri S.aureus dengan penyarian secara maserasi dan soxhletasi. Uji antibakteri dilakukan menggunakan metode difusi sumuran. Penapisan fitokimia terhadap ektrak metanol daun remania menunjukkan keberadaan senyawa yaitu mengandung senyawa saponin, flavonoid, fenol, tanin, steroid. Hasil ují antibakteri terhadap ekstrak daun ramania yang diperoleh dengan metode maserasi lebih baik dibandingkan dengan ekstrak yang diperoleh dengan metode Soxlet, yaitu pada konsentrasi 50, 40, 30, 20 dan 10%, memberikan zona hambat berturut-turut sebesar 19,28;13,28; 12,93; 12,25; dan 10,98 mm, dengan kategori kuat. Sedangkan hasil pada pengujian dengan esktraksi menggunakan alat soxhlet pada konsentrasi 50, 40, 30, 20 dan 10%, memberikan zona hambat berturut-turut sebesar 10,7; 10,3; 8,9; 8,6; dan  8,3 mm dengan kategori sedang sampai kuat.
Skrining Fitokimia Dan Efektivitas Antibakteri Ekstrak Etanol 70% Daun Jeruk Purut (Citrus hystrix D.C) Terhadap Staphylococcus aureus Fitriyanti, Fitriyanti; Zannah, Meryatul; Nazarudin, Muhammad
Sains Medisina Vol 2 No 3 (2024): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v2i3.356

Abstract

Daun jeruk purut memiliki kandungan flavonoid, saponin, triterpenoid   dan tanin yang dapat berkhasiat sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui uji daya hambat ekstrak daun Jeruk Purut (Citrus hystrix  D.C)   terhadap Staphylococcus aureus . Ekstrak daun Jeruk Purut  (Citrus  hystrix  D.C)  diperoleh  dari  proses  maserasi  dengan  etanol  70%  selanjutnya divariasi konsentrasinya, 10%, 20%, 40%, 60%, 80%, dan 100%. Uji aktivitas  metode pengujian secara difusi sumuran menggunakan media Mueller Hinton Agar (MHA). Hasil menunjukkan ekstrak etanol 70% daun Jeruk Purut dengan konsentrasi 80% dan 100% memiliki aktivitas antibakteri paling baik dengan kategori sangat kuat yaitu dengan rata-rata zona hambat sebesar 19,827 mm dan 20,831 mm terhadap Stapylococcus aureus, sedangkan pada konsentrasi 10% 20%, 40%, dan 60% diperoleh zona hambat dalam kategori kuat. Konsentrasi efektiv ekstrak etanol 70% daun Jeruk Purut jika dibandingkan dengan kontrol positif yaitu Tetrasiklin untuk menghambat pertumbuhan bakteri S.aureus adalah pada konsentrasi 80% dan 100% yang tergolong sangat kuat.
ANTIDIABETIC ACTIVITY OF THE COMBINATION OF SEPAT RAWA FISH FLOUR (Trichopodus thricopterus) AND ETHANOL EXTRACT OF RAMANIA LEAVES (Bouea Macrophylla Griffith): AKTIVITAS ANTIDIABETES KOMBINASI TEPUNG IKAN SEPAT RAWA (Trichopodus thricopterus) DAN EKSTRAK ETANOL DAUN RAMANIA (Bouea Macrophylla Griffith) Fitriyanti; Ika Astuti, Karunita
SPIN JURNAL KIMIA & PENDIDIKAN KIMIA Vol. 6 No. 1 (2024): Januari - Juni 2024
Publisher : UIN Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/spin.v6i1.9505

Abstract

Diabetes mellitus is a metabolic disease with impaired insulin secretion. Sepat Rawa fish has been proven to contain alpha-amino acids, which can increase insulin action by increasing energy in the cell metabolic cycle. Ramania leaves contain compounds for antidiabetic treatment, such as saponins and flavonoids. This study aims to find the best dose to increase the antidiabetic activity of the combination of sepat rawa fish meal and ethanol extract of ramania leaves. This research activity uses pre- and post-tests with a control group design. The 25 mice used were divided into 5 groups, namely group I: negative control (CMC Na 0.5%), group II: positive control (glibenclamide 3 mg/kgBW), group III: sepat Rawa fish meal dose of 300 mg/kg. KgBW, group IV: ramania leaf extract at a dose of 300 mg/kg BW, group V: a combination of fish meal 300 mg/KgBW and ethanol extract of ramania leaf 300mg/kg BW. Mice were induced by alloxan to experience hyperglycemia. Observations on the decrease in blood sugar levels of each test group were carried out on the 7th day after alloxan induction by taking sufficient blood from the tails of mice and measuring using glucose. Data was analyzed for variance (ANOVA) (p=0.05). The result is that a single group of Ramania extract with a dose of 300 mg/KgBB shows the best activity with a percent decrease in blood sugar levels by 28.438,  a combination dose of 25.107 %, and a Sepat Rawa dose of 21,675%. The Third of them was not significantly different with positive control.
Efektivitas Antibakteri Ekstrak Etanol 70% Daun Sirsak (Annona muricata L.) Terhadap Bakteri Penyebab Jerawat Cutibacterium acne Fitriyanti, Fitriyanti; Ayunda, Feradella; Susiani, Eka Fitri
Jurnal Farmasi dan Farmakoinformatika Vol 2, No 2 (2024)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2024.v2i2.10729

Abstract

Penelitian ini dilakukan untuk menguji efektivitas antibakteri ekstrak etanol 70% daun sirsak (Annona muricata L.). Daun sirsak telah lama dimanfaatkan sebagai obat tradisional di Indonesia dan di berbagai negara. Daun sirsak mempunyai manfaat sebagai antibakteri penyebab jerawat. Jerawat merupakan gangguan kulit yang disebabkan adanya sekresi kelenjar sebum yang menyumbat pori-pori kulit sehingga terjadinya pembengkakan pada kulit. Bakteri yang sering menyebabkan infeksi jerawat adalah bakteri Cutibacterium acne. C. acne merupakan jenis bakteri gram positif dan digolongkan sebagai anaerob. Penelitian ini juga melakukan uji skrinning terhadap ekstrak daun sirsak yang menghasilkan senyawa flavonoid, saponin, dan tanin. Uji zona hambat dilakukan dengan metode sumuran dengan berbagai macam konsentrasi dari 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, dan 40%, kontrol positif yaitu klindamisin 2µg, dan kontrol negatif yaitu Na-cmc. Hasil dari uji uji antibakteri menunjukkan bahwa ekstrak etanol 70% daun sirsak memiliki efektivitas antibakteri C. acne pada konsentrasi 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, dan 40% dengan diameter zona hambat senilai 2,3 mm; 2,3 mm; 5 mm; 7 mm; 8,167mm; 9,3 mm; 12 mm; 8,3 mm; dan 12 mm.
Uji Aktivitas Face Mist Ekstrak Etanol Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) sebagai Antibakteri terhadap Staphylococcus aureus, Staphylococcus epidermis, Propionibacterium acnes Hayati, Noor; Chandra, M. Andi; Fitriyanti
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 1 (2024): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i1.6342

Abstract

Ekstrak umbi Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) memiliki aktivitas antibakteri pada S. aureus, S. epidermidis serta P. acnes dan dapat dikembangkan dalam bentuk sediaan yang kemudian dapat diuji aktivitas antibakterinya. Tujuan penelitian ini yaitu mengetahui aktivitas antibakteri dari variasi konsentrasi zat aktif pada formula face mist ekstrak etanol 96% bawang dayak (Eleutherine bulbosa (Mill.) Urb.). Metode pengujian aktivitas antibakteri dilakukan menggunakan metode difusi agar. Adapun variasi konsentrasi ekstrak 2%, 4%, 6% dan 8%. Hasil penelitian ini menunjukkan bahwa aktivitas antibakteri Face mist ekstrak etanol 96% bawang dayak (Eleutherine bulbosa (Mill.) Urb.) terhadap bakteri S. aureus konsentrasi 8% (6,51 mm) tergolong kategori sedang. Pada bakteri S. epidermidis (12,33 mm) aktivitasnya termasuk kategori kuat. Sementara pada bakteri P. acnes (7,15 mm) kategori sedang. Kesimpulannya pada F4 face mist menghasilkan zona hambat lebih tinggi dibandingkan F1(2%), F2(4%) dan F3 (6%) terhadap bakteri S. aureus, S. epidermidis dan P. acnes. Pada analisis data diuji dengan Mann Whitney, didapatkan hasil pada formula F1, F2, F3 dan F4 memiliki nilai signifikansi p≤0,05 terhadap kontrol positif yang berarti terdapat perbedaan antar keempat formula dengan kontrol positif. Dayak Onion Bulb extract (Eleutherine bulbosa (Mill.) Urb.) has antibacterial activity on S. aureus, S. epidermidis and P. acnes, can be developed as a dosage form, and further tested as antibacterial agent. The aim of this research was determine the antibacterial activity of variations in the concentration of active substances in the face mist formula containing 96% ethanol extract of Dayak onion (Eleutherine bulbosa (Mill.) Urb.). The antibacterial activity testing method was carried out using the disc method with varying extract concentrations of 2%, 4%, 6% and 8%. The results of this study showed that the antibacterial activity of face mist 96% ethanol extract of Dayak onion (Eleutherine bulbosa (Mill.) Urb.) against S. aureus bacteria was at a concentration of 8% (6.51 mm) in medium category. In S. epidermidis bacteria (12.33 mm) was strong category. In P. acnes bacteria (7.15 mm) was medium category. In conclusion, F4 face mist produced a higher zone of inhibition than F1 (2%), F2 (4%) and F3 (6%) against S. aureus, S. epidermidis and P. acnes bacteria. In data analysis tested with Mann Whitney, the results obtained for F1, F2, F3 and F4 had a significance value of p≤0,05 against the positive control, which means there was a difference between the four formulas and the positive control.
Co-Authors Abdurrazaq Abdurrazaq Abdurrazaq Abdurrazaq, Abdurrazaq Ahmad Ahmad Ahmad Ridha Akbar, Depy Oktavian Alista, Siti Ari Surya Pratama Aristha Novyra Putri Astuti, Karunita Ika Ayunda, Feradella Azmi Yunarti Azwarina Nuke Azzahra, Tania Nasyawa Bella Rosalina Endah Chandra, M. Andi Depy Oktavian Akbar Dian Handayani Didik Rio Pambudi Eka Sandra Era Habibah Gunawan Gunawan Gusti Khairunnisa Hadirvika Tjuthiyanda Hafiz Ramadhan hairunnisa nisa Helmina Wati Hidayati Rahmi Iedliany, Faradilla Jamaludin, Wahyudin Bin Karunika Ika Astuti Khairunnisa, Gusti Khairunnisa, Gustii Liana Fitriani Hasyim Liana Fitriani Hasymi M. Andi Chandra M. Fahrul Ricky NorHavid Malik Yustika Marlia Fatwa Muammaroh Muhammad Fadhil Kamil Muhammad Hafizudin Muhammad Hidayattullah Muhammad Nazarudin Muhammad Nazarudin, Muhammad Muhammad Nur Rahman Hendrawan Muhammad Reza Fahlevi Muhammad Saufi Murniati . Nashrul Wathan Noor Hayati, Noor Nopita Norazizah, Ufairah Norhasanah Norhasanah Novita Sari Nur Huda Nur Laili Nurbidayah Nurul Hikmah Nurul Mardiati Pasaribu, Cindy Putri Indah Sayakti Putri Kartika Sari Putri Kartika Sari Rahmadina, Aprillia Rahmayanti Fitriah Rahmi Muthia Ratna Restapaty Riwanda Oktaviani Rizaldi, Gusti Rizka D.A. Widianti Rusida, Esty Restiana Saputri, Revita Sari Wahyunita Sauqi, Muhammad Setyo Yogi Shelin Shelin Siti Kholilah Siti Kholilah Susiani, Eka Fitri Syaid Nofal Assegaf Syamratul Qalbiyah Syifa Syifa Tia Mariati Risma Melati Vebruati Vebruati Vebruati Vebruati Wahyudin Bin Jamalludin Yusmalina Yusmalina Yusrina Conitaty Zannah, Meryatul