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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin MEDISAINS Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Health Sains Indian Journal of Forensic Medicine & Toxicology Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Impresi Indonesia Journal of Social Research Jurnal Locus Penelitian dan Pengabdian JKKI : Jurnal Kedokteran dan Kesehatan Indonesia MEDICINUS Journal of General Procedural Dermatology and Venereology Indonesia Cermin Dunia Kedokteran
Dharmawan, Nugrohoaji
Departemen Ilmu Kesehatan Kulit Dan Kelamin, Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr. Moewardi
Religion Aerospace Engineering Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Physical Stability Evaluation of 5% Curcuma Longa Extract Using the Maceration Extraction Method Arrosyid, Azhar; Mulianto, Nurrachmat; Dharmawan, Nugrohoaji
Journal of Social Research Vol. 4 No. 12 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i12.2879

Abstract

Curcuma longa (turmeric) is a medicinal plant widely used for its anti-inflammatory, antioxidant, and antimicrobial properties. Cream formulations are ideal for topical delivery due to their ease of application, good absorption, and patient acceptability. The maceration method is a simple and cost-effective technique for obtaining plant extracts without compromising bioactive compounds. This study aimed to evaluate the physical stability of a cream formulation containing 5% Curcuma longa extract prepared using the maceration extraction method. The extract was prepared through maceration of dried turmeric rhizome using ethanol, followed by evaporation to obtain the concentrated extract. The cream was formulated with stearic acid, cera alba, vaselin album, triethanolamine, propylene glycol, and distilled water as base components. Physical stability parameters were tested over seven days, including pH, dispersion, and adhesion tests. Statistical analysis was performed using the Friedman test. The pH values ranged from 7.33 to 7.50 (p = 0.006), indicating mild alkalinity but remaining within an acceptable range for topical application. Dispersion remained stable throughout the observation period (p = 0.452), while adhesion increased significantly from 182.71 to 200.04 seconds (p = 0.006), suggesting improved cohesiveness. The 5% Curcuma longa extract cream demonstrated good physical stability, indicating that the maceration method is a viable approach for developing stable topical herbal formulations.
Systematic review of the advantages of trichloroacetic acid and electrocautery therapy in verruca vulgaris Kamilah, Lian; Adjie, Sugih Primas; Dharmawan, Nugrohoaji
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 3, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss3.art8

Abstract

Verruca vulgaris (VV), a cutaneous disorder associated with human papillomavirus (HPV), presents as a benign proliferation of keratinocytes. Verruca vulgaris therapy with destructive methods such as trichloroacetic acid (TCA) and electrocautery is the most commonly used therapeutic modality. The study aims to assess the therapeutic efficacy and clinical benefit of trichloroacetic acid (TCA) and electrosurgery in managing VV by synthesising evidence from clinical studies or case series. Systematic review adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). To ensure the collection of accurate and relevant information, literature searches were conducted across PubMed, Google Scholar and Cochrane Library covering publications from 2014 to 2023. Twelve studies were included, comprising eight articles on TCA and four articles on electrosurgery. Trichloroacetic acid achieved a maximum cure rate of 93.3% while electrosurgery reached 100%. During six-month follow-up period, TCA showed no recurrence (0%), whereas electrosurgery had a recurrence rate of 21,9%. Electrocautery has more advantages than TCA with a higher cure rate. Even though it has a higher cure rate, electrocautery has a higher recurrence rate with more severe side effects than TCA.
Tatalaksana Platelet Rich Plasma Pada Pasien Chronic Venous Leg Ulcer Adjie, Sugih Primas; Kariosentono, Harijono; Mulianto, Nurrachmat; Dharmawan, Nugrohoaji; Primisawitri, Pratiwi Prasetya
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 12 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i12.4872

Abstract

Latar belakang: Ulkus kronis pada ekstremitas bawah salah satunya yaitu ulkus venosum. Ulkus venosum didefinisikan sebagai lesi terbuka antara sendi lutut dan pergelangan kaki yang terjadi karena penyakit vena. Tantangan dalam mengobati VLU adalah kekambuhan yang sering terjadi maka terapi luka tingkat lanjut harus dipertimbangkan. Platelet rich plasma (PRP) sebagai terapi adjuvan pengobatan ulkus venosum dan menunjukkan hasil yang menjanjikan. Kasus: Seorang laki-laki berusia 55 tahun dengan keluhan luka yang sulit sembuh sejak dua tahun yang lalu. Pemeriksaan status dermatovenereologi pada regio ekstremitas inferior desktra nampak ulkus multipel dengan ukuran terbesar 9 cm x 5 cm x 0.5 cm, dengan dasar eritem dan serum tanpa disertai pus, nekrosis, nekrotik dan darah. Pasien memiliki riwayat hipertensi dan obesitas derajat II dengan Indeks Masa Tubuh (IMT) 44,29. Pasien diberikan terapi Platelet Rich Plasma (PRP) setiap tujuh hari, Kompres luka dengan cairan NaCl 0,9% selama 10 menit dilanjutkan dengan mupirosin 2% salep dan ditutup dengan menggunakan plester hidrokoloid yang dilakukan per 24 jam. Evaluasi pada minggu ke-6 terapi PRP, pasien menunjukkan adanya perbaikan klinis pada luka. Diskusi: Kandungan PRP terdiri dari banyak faktor pertumbuhan untuk mempercepat penyembuhan luka dan angiogenesis. Trombosit mengandung faktor pertumbuhan yang memicu efek biologis yang merupakan kunci dalam proses perbaikan dan regenerasi jaringan.
Co-Authors Achmad Satya Negara Adjie, Sugih Primas Adniana Nareswari Adniana Nareswari Ahmad Fiqri Ambar Aliwardani Arie Kusumawardani Arie Kusumawardani Arrosyid, Azhar Aulia Rahman Ayu Kusuma Dewi Bobby Febrianto Brian Wasita Danu Yuliarto Diana, Rina Eka Putra W Ellistasari, Endra Yustin Endra Yustin Ellistasari Endy D, Marsita Etty Farida Mustifah Fiqnasyani, Siti Efrida Fiska Rosita Frieda Yanuar Halim Perdana Kusuma Harahap, Irene Jessica Pinarsinta Harijono Kariosentono Imroatul Ulya Indah Julianto Indah Julianto Indah Julianto, Indah Irawanto, Muhammad Eko Irene Jessica Pinarsinta Harahap Kamilah, Lian Kariosentono, Harijono Kusumawardani, Arie Marsita Endy D Moerbono Mochtar Moerbono Mochtar Muhammad Eko Irawanto Muhammad Risman Murastami, Ammarilis Mustifah, Etty Farida Novan Adi Novan Adi Setyawan Novan Adi Setyawan Novan Adi Setyawan Nur Rachmat Mulianto Nurfaiqoh, Elok Nurrachmat Mulianto Octarica, Stella Gracia Oyong Oyong Prasetyadi Mawardi Prasetyadi Mawardi Primisawitri, Pratiwi Prasetya Purwoko, Agus Putra W, Eka Putti Fatiharani Dewi Putti Fatiharani Dewi Rina Diana Rini Hastuti Rini Hastuti Risman, Muhammad Sesia Pradestine Suci Widhiati Suci Widhiati Synthia Sari Toha Triasari Oktavriana Trya Oktaviani Tutik Rahayu TUTIK RAHAYU Ulya, Imroatul Ummi Rinandari Utama, Rahmat Firdaus Dwi Wibisono Nugraha Widhiati, Suci Widyastuti, Zilpa