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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis JOPS (Journal Of Pharmacy and Science) Jurnal Pengabdian Magister Pendidikan IPA PREPOTIF : Jurnal Kesehatan Masyarakat Indonesian Journal of Pharmaceutical and Clinical Research Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) JUKESHUM: Jurnal Pengabdian Masyarakat Transformatif: Jurnal Pengabdian Masyarakat PEMA: Jurnal Pendidikan dan Pengabdian Kepada Masyarakat International Journal of Health and Pharmaceutical (IJHP) Mestaka: Jurnal Pengabdian Kepada Masyarakat FARMASAINKES Jurnal Bakti Nusantara Fundamental and Applied Research in Medicine and Allied Sciences Indonesia
Sari, Syilvi Rinda
Faculty Of Pharmacy, Universitas Muslim Nusantara Al-Washliyah, Medan, Indonesia
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Potential Antibiotic-Drug Interactions in Hospitalized Patients : A Retrospective Cross Sectional Study Syilvi Rinda Sari; Kiki Rawitri; Hindri Syahputri; Muhammad Amin Nasution; Nia Novranda Pertiwi
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.6018

Abstract

 Infectious diseases are frequently seen in hospitalized patients, and antibiotics are among the most commonly prescribed drugs. Patients in the hospital frequently experience drug interactions because their severe conditions frequently necessitate the simultaneous administration of many medications. This study aims to determine the frequency of potential drug interactions between antibiotics and other drugs in hospitalized patients at Dr. Pirngadi Hospital, Medan, Indonesia. This study uses an observational method with a retrospective cross-sectional study design on 300 patients who met the inclusion criteria in January-December 2023. Potential antibiotic drug interactions seen from the Medscape application. The results showed that only 20.33% of the total sample experienced potential interactions between antibiotics and other drugs in patients at Dr. Pirngadi Hospital in the period January-December 2023, namely only 61 patients from a total sample of 300 patients with 84 cases of potential interactions between antibiotics and other drugs. The potential drug interactions that occur are pharmaceutically as much as 5.26%, pharmacokinetically as much as 10.53%, and the majority, pharmacodynamically, as much as 84.21%.
Hubungan Tingkat Kepatuhan Terhadap Luaran Klinis Pada Pasien Hipertensi Di Puskesmas Teladan Kota Medan Nurhalilah Hutagalung; Kiki Rawitri; Rafita Yuniarti; Syilvi Rinda Sari
JURNAL FARMASI DAN MAKANAN Vol 9 No 1 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i1.6948

Abstract

Hypertension is a non-communicable disease that remains a major health problem worldwide, especially in Indonesia, as it can cause severe complications such as stroke, kidney failure, and heart disease. The success of hypertension control does not only depend on medication but also on patients’ adherence to taking the medicine regularly. Patients with a good level of adherence are usually able to maintain stable blood pressure, thereby preventing complications. This study aims to analyze the relationship between medication adherence and clinical outcomes among hypertensive patients at Puskesmas Teladan, Medan City. This research used a non-experimental method with a cross-sectional study design involving 135 hypertensive patients who met the inclusion criteria at Puskesmas Teladan Medan during May–June 2025. Adherence data were obtained using the MMAS-8 questionnaire, while clinical outcome data in the form of patients’ blood pressure were collected through direct examination. Data were analyzed using the Spearman Rho test with the SPSS program. The results showed an average adherence score of 6.64±1.437, with systolic and diastolic blood pressure averages of 135.11±16.385 and 72.31±11.303, respectively. There was a significant relationship between medication adherence and clinical outcomes (p=0.000; r=0.463) and between adherence and blood pressure control (p=0.000; r=0.387), indicating a moderate correlation (r=0.40–0.69). It can be concluded that higher medication adherence leads to better blood pressure control and improved clinical outcomes in hypertensive patients.
Optimalisasi Terapi Antidiabetik Oral pada Diabetes Mellitus Tipe 2: Studi Komparatif Monoterapi dan Kombinasi terhadap Outcome Glikemik Optimalisasi Terapi Antidiabetik Oral pada Diabetes Mellitus Tipe 2: Studi Komparatif Monoterapi dan Kombinasi terhadap Outcome Glikemik Kiki Rawitri; Sri Wahyuni; Syilvi Rinda Sari; Ziza Putri Aisyia Fauzi; Ferina Septiani Damanik; Cut Intan Annisa Puteri; Anggitha Ningtias
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7854

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease with a high prevalence in primary healthcare settings; however, real-world evidence regarding the effectiveness of oral antidiabetic therapies remains limited. This study aimed to compare the effectiveness of oral antidiabetic monotherapy and combination therapy in patients with T2DM at the Teladan Community Health Center (Puskesmas) in Medan. A non-experimental observational study with a cross-sectional design was conducted on 78 patients selected via systematic random sampling, utilizing medical records and data from the "referral-back" program covering the period from September to November 2025. Effectiveness was assessed using random blood glucose (RBG) levels and analyzed with the Kruskal–Wallis test. The results indicated that the combination of glimepiride and metformin was the most frequently used regimen (64.10%), followed by metformin monotherapy (26.92%) and glimepiride monotherapy (8.97%). The lowest mean RBG level was observed in the metformin monotherapy group (147.80±47.27 mg/dl), followed by the metformin-glimepiride combination group (168.72 ± 60.56 mg/dl) and the glimepiride monotherapy group (178±61.31 mg/dL); however, no statistically significant difference was found among the treatment groups (p=0.322). The study concludes that there is no significant difference in effectiveness between monotherapy and combination therapy regarding glycemic control, although metformin showed a trend toward better outcomes. These findings underscore the importance of an individualized approach to therapy for T2DM patients in primary healthcare facilities.
Analysis Of Potential Drug Interactions In Prescribing Type 2 Diabetes Mellitus Patients At A Pharmacy In Medan City Kiki Rawitri Kiki; Sri Wahyuni; Syilvi Rinda Sari
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 1 (2022): February 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.704 KB) | DOI: 10.51601/ijhp.v3i1.142

Abstract

Multiple drugs or polypharmacy received by patients with diabetes mellitus (DM) during therapy can trigger drugrelated problems, one of which is drug interactions. The occurrence of drug interactions causes uncontrolled blood sugar levels which can affect the patient's morbidity, mortality, and quality of life. This study aims to look at the description of potential drug interactions in prescribing type 2 DM patients at a Pharmacy in Medan City for the period January-April 2022. This study is a descriptive study and data were taken retrospectively on 126 prescription sheets for type 2 DM patients who met the inclusion criteria. Identification of potential drug interactions using online literature such as Medscape Drug Interaction Checker, Drugs.com, and Drug Interaction Fact 2009 e-book. Data analysis was carried out univariately to describe the percentage of drug interactions. The results showed that from 126 prescription sheets for type 2 DM patients there were 108 patients (85.71%) who had the incidence potential drug interactions with a total of 238 potential drug interactions. The number of potential drug interactions based on the mechanism of action, namely pharmacodynamic interactions were 117 events (49.15%), pharmacokinetic interactions were 22 events (9.24%), and unknown were 99 events (41.61%) with The severity level was severe (major) with 1 event (0.42%), moderate (moderate) with 223 events (93.69%) and mild (minor) with 14 events (5.89%). Based on the results of the study, it was concluded that an analysis of 126 patients with type 2 diabetes mellitus, there were found 108 (85.71%) prescriptions to potential antidiabetic interactions.
Enhancing Community Knowledge on Prudent Medication Use Based on Symptoms Syilvi Rinda Sari; Hindri Syahputri; Kiki Rawitri; Cut Intan Annisa Puteri; Ferina Septiani Damanik; Muhammad Amin Nasution; Nia Novranda Pertiwi
Transformatif: Jurnal Pengabdian Masyarakat Vol. 7 No. 1 (2026)
Publisher : Universitas Islam Negeri Raden Mas Said Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22515/tranformatif.v7i1.14548

Abstract

Irrational medication use remains a significant public health concern, often stemming from inadequate knowledge of symptom-based drug selection and self-medication practices. This community service activity aimed to enhance public knowledge on rational medication use, specifically focusing on drug classification, reading medication labels, and appropriate dosage instructions. Employing a community-based participatory approach, the activity was conducted at the UPT Puskesmas Teladan and involved 17 purposively selected visitors. The intervention, delivered through interactive lectures, two-way discussions, and medication label simulations supported by educational leaflets, was evaluated using pre-test and post-test instruments. The results demonstrated a notable improvement in participants' understanding, with average scores increasing from 4.94 (low category) to 7.94 (good category) on a 10-point scale. This improvement suggests that a targeted, interactive educational approach is feasible and holds promise for strengthening public knowledge on prudent medication use. This initiative highlights the potential for integrating similar community-based education programs into primary health services to promote safer self-medication behaviors.
Edukasi Bahaya Minuman Manis Kemasan terhadap Kerusakan Ginjal pada Siswa Sekolah Dasar Kiki Rawitri; Sri Wahyuni; Syilvi Rinda Sari; Ferina Septiani Damanik; Cut Intan Annisa Puteri; Ziza Putri Aisyia Fauzi; Lilik Septiana; Hindri Syahputri
Mestaka: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 3 (2026): JUNI 2026
Publisher : Pakis Journal Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58184/mestaka.v5i3.987

Abstract

Consumption of sugar-sweetened packaged beverages among elementary school children continues to increase and may contribute to various health problems, including kidney damage. Limited knowledge regarding the health risks of sugary beverages is one of the factors contributing to high consumption among children. This community service program aimed to improve students’ knowledge about the dangers of packaged sugary drinks on kidney health through health education activities conducted at SD Ar-Ridha, Biru-Biru District, Deli Serdang Regency. The activity was carried out on November 23, 2024, involving 30 elementary school students. The methods used included interactive lectures, discussions, question-and-answer sessions, and evaluation through pre-test and post-test questionnaires. Educational materials covered types of sugary packaged beverages, added sugar content, kidney function, the effects of excessive sugar intake, and kidney disease prevention efforts. The results demonstrated an increase in participants’ knowledge levels after the educational intervention. The percentage of students categorized as having good knowledge increased from 20.0% during the pre-test to 80.0% during the post-test, while the poor knowledge category decreased from 46.7% to 3.3%. These findings indicate that interactive health education methods are effective in improving students’ understanding of the importance of limiting sugary packaged beverage consumption to maintain kidney health from an early age.
Co-Authors Afifah, Puan Ibni Aminah Dalimunthe Anggitha Ningtias Aqmal Ramadhan Pasaribu Chairunnisa Rkt Choiriah, Anida Dikki Miswanda Dinda Sari Utami Elandri Ilmi Guci, Silvi Fendy Prasetyawan Ferina Septiani Damanik Gabena Indrayani Dalimunthe Haris Munandar Nasution Hartini, Putri Tri Hindri Syahputri Hindri Syahputri Istiana Hasibuan, Aninda Lutfhi Karismawati Khairunnisa Kiki Rawitri Lilik Septiana Lubis, Minda Sari Lusi Grasia Situmorang Melia Sari, Melia Minda Sari Lubis Muhammad Amin Nasution Muhammad Amin Nasution Muhammad Andry Muhammad Andry Muhammad Yunus Nasution, Melvi Ariati Nia Novranda Pertiwi Nia Novranda Pertiwi Nia Novranda Pertiwi Ningtias, Anggitha Nomi Noviani Nurhalilah Hutagalung Puteri, Cut Intan Annisa Rafita Yuniarti Restu Anisa Putri sahrianti, Hikmah Simanjuntak, Monica Nelly Sirait, Cici Cahyani Sri Wahyuni Sri Wahyuni Sri Wahyuni Sri Wahyuni Sri Wahyuni Sri Wahyuni Sri Wahyuni Vionica Nasution, Mutiara Dwi Yolanda Nasution, Nurul Widya Yuniarti, Rafita Zhafirah, Rana Ziza Putri Aisyia Fauzi Zulmai Rani