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All Journal Jurnal Akuakultur Indonesia Bioma : Berkala Ilmiah Biologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biota Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Perikanan Indonesia Biota Jurnal Biomedika dan Kesehatan Borneo Journal of Medical Laboratory Technology Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Rohmah, Zuliyati
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Modulatory Effects of Fucoidan on Paracetamol-induced Hepatic Damage and Histological Alterations in Rasbora lateristriata Sofyantoro, Fajar; Dafa, Maula Haqul; Primahesa, Alfian; Oktaviana, Shintia; Mayani, Olvita; Simanungkalit, Eben Ezer; Prissandi, Anthera Al Firdaus; Nuriliani, Ardaning; Retnoaji, Bambang; Saragih, Hendry T. S. S. G.; Rohmah, Zuliyati; Widiyanto, Slamet; Wijayanti, Nastiti; Septriani, Nur Indah
Biota Vol 12 No 1 (2026): Jurnal Biota 2026
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/biota.v12i1.27845

Abstract

Paracetamol overdose is a well-documented cause of hepatic injury across vertebrate species, including teleost fish. This study aimed to evaluate the hepatoprotective potential of fucoidan, a sulfated polysaccharide derived from brown algae, against paracetamol-induced liver damage in Rasbora lateristriata. Fish were divided into five experimental groups and exposed to paracetamol (3 mg/L), either alone or in combination with fucoidan at concentrations of 50, 100, or 300 µg/mL, for seven days. Histopathological evaluation of liver tissues was performed using hematoxylin–eosin staining, with semi-quantitative scoring focused on hydropic degeneration, nuclear pyknosis, and necrosis. The results demonstrated that paracetamol exposure induced moderate hepatocellular injury, characterized by cytoplasmic vacuolization, apoptotic nuclear alterations, and necrotic lesions. Co-treatment with fucoidan at 300 µg/mL was associated with reduced severity across all histopathological parameters, indicating partial hepatoprotective effects. In contrast, the 50 µg/mL fucoidan group exhibited paradoxically severe hydropic degeneration despite the absence of pyknosis and necrosis, suggesting a delayed or altered injury profile. Intermediate outcomes were observed at 100 µg/mL. Overall, fucoidan exhibited dose-dependent but inconsistent hepatoprotective effects. The observed histological variability across concentrations suggests that protection may be influenced by factors such as bioavailability, cellular uptake, or interactions with intracellular stress pathways. These findings highlight the need for further mechanistic investigations before fucoidan can be considered a reliable hepatoprotective agent in aquatic toxicology.
Co-Authors Aeniah, Siti Amalia, Ninda Nur Andriyani, Eka Fitri Siti Apriliyani, Tia Apsari, Cintya Nurul Ardaning Nuriliani Ariesti, Wiwin Artania Adnin Tri Suma Bambang Retnoaji Dafa, Maula Haqul Empra, Desi Eka Putri Fajar Sofyantoro Faulana, Arum Fahmi Gusnaniar, Niar Halim, Shuha Ma’muriyah Hendry Tri Sakti Saragih Karlina, Ina Karmilah, Karmilah Maharesi, Chesa Ekani Mayani, Olvita Nastiti Wijayanti Oktaviana, Shintia Perdana, Naufal Ghozi Aditya Prasasti, Filosofia Florista Tesla Aulia Pratiwi, Arini Dian Primahesa, Alfian Prissandi, Anthera Al Firdaus Pusparini, Nur Ainun Oktavia Rahmadian, Desti Rudin, Nur Ahmad Saeed, Faisal Saragih, Hendry Saragih, Hendry T. S. S. G. Saragih, Hendry Tri Sakti SG Sari, Dini Wahyu Kartika Septriani, Nur Indah Septriani, Nur Indah Shalihah, Fianicha Simanungkalit, Eben Ezer Slamet Widiyanto Susilo Hadi, Susilo Ujiantari, Navista Sri Octa Utami, Setyowati Triastuti Woro Anindito Sri Tunjung