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IRON DEFICIENCY IN EARLY LIFE AND LATER BEHAVIORAL OUTCOMES: A SYSTEMATIC REVIEW Latifah, Suci; Septiani , Seala; Kusuma, Refani Alycia; Pratiwi, Dessy
Journal of Indonesian Specialized Nutrition Vol. 3 No. 4 (2025): Journal of Indonesian Specialized Nutrition
Publisher : PT. Varians Statistik Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63953/jisn.v3i4.67

Abstract

Background: Iron deficiency during early life is the most common micronutrient deficiency worldwide and may have lasting effects on neurodevelopment and behavior. This systematic review aimed to explore the relationship between iron deficiency in infancy (0–24 months) and behavioral outcomes beyond two years of age. Methods: This study was a systematic literature review of twenty-three articles. These articles were sourced from scientific journal articles on ScienceDirect, covering studies published between 2005 and 2025. Inclusion criteria were longitudinal cohort or randomized controlled trials assessing behavioral outcomes such as attention, hyperactivity, and socio-emotional regulation. Results: Early-life iron deficiency was consistently associated with increased internalizing and externalizing behaviors, attention deficits, and symptoms of ADHD and Sluggish Cognitive Tempo persisting into adolescence. Timing and severity of deficiency influenced outcomes, with prenatal deficiency affecting recognition memory and executive function, while infant deficiency predicted behavioral dysregulation and academic difficulties. Targeted iron supplementation reduced behavioral problems, whereas excessive or non-individualized supplementation showed limited benefits. Conclusions: Iron deficiency in early life has long-term behavioral consequences. Early detection and individualized interventions are crucial for preventing neurobehavioral impairments and optimizing child development.
DEPRESSION-RELATED FACTORS IN PULMONARY TUBERCULOSIS PATIENTS: SECONDARY ANALYSIS OF THE INDONESIAN HEALTH SURVEY 2023: Faktor Terkait Depresi pada Kasus Tuberkulosis Paru: Analisis Sekunder Survei Kesehatan Indonesia 2023 Regina, Agave; Nasution, Helmi Suryani; Syukri, Muhammad; Halim, Rd.; Putra, Ashar Nuzulul; Pratiwi, Dessy; Yuliana, Roma
Jurnal Berkala Epidemiologi Vol. 14 No. 1 (2026): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V14I12026.62-71

Abstract

Background: Depression is highly prevalent among tuberculosis (TB) patients, with reported rates reaching 31-61%, and it is strongly associated with poor medication adherence and adverse treatment outcomes. Despite this considerable burden, mental health screening for TB patients has not yet been integrated into routine TB care. Purpose: This study aimed to identify factors associated with depression among TB patients. Methods: This secondary data analysis used the Survei Kesehatan Indonesia (SKI) or Indonesian Health Survey 2023 with a cross-sectional design. A total sampling approach was applied, to all TB patients who met the inclusion criteria, resulting in 1,163 respondents. Statistical analyses included the chi-square test and multiple logistic regression, with a significance level of p < 0.05. Results: The prevalence of depression among TB patients was 5.38% (95% CI: 3.26–8.76%). Multivariate analysis showed that being female [aPOR = 15.90, 95% CI (1.99-143.09)], age 15-40 years [aPOR = 5.80, 95% CI (1.17-28.67)], TB treatment duration ≤6 months [aPOR = 5.22, 95% CI (1.67-16.34)], smoking [aPOR = 11.33, 95% CI (2.07-61.97)], and stress [aPOR = 39.04, 95% CI (11.23-135.66)] were significantly associated with depression in TB patients. Stress was identified as the most influential factor. Conclusion: Depression remains a relevant issue among TB patients in Indonesia, with stress emerging as the strongest associated factor. Routine depression screening and integrated mental health support within TB programs are strongly warranted, particularly for high-risk groups such as women, younger adults, patients in the early phase of treatment, smokers, and those experiencing stress.
COEXISTENCE OF STUNTING AND ANEMIA AMONG CHILDREN UNDER FIVE: PREVALENCE AND SHARED RISK FACTORS Pratiwi, Dessy; M. Rajab, Nurfadilah; Aulia, Bianda; Larasati, Adisti Qamahadlina
Journal of Indonesian Specialized Nutrition Vol. 4 No. 1 (2026): Journal of Indonesian Specialized Nutrition
Publisher : PT. Varians Statistik Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63953/jisn.v4i1.75

Abstract

Background: Stunting and anemia frequently co-occur in children under five, exacerbating undernutrition burdens in low- and middle-income countries (LMICs). This narrative review synthesizes evidence on the prevalence and shared risk factors of concurrent stunting and anemia in children under five. Methods: We searched three electronic databases: PubMed, Scopus, and Google Scholar and included studies published from January 2010 to December 2025. Search terms combined keywords related to “stunting”, “anemia”, “coexistence”, and “children under five”. Results: The coexistence of stunting and anemia affects approximately one in five children under five in LMICs with individual country estimates varied widely at 5.6–60.1%. Shared determinants included child age, small birth size, recurrent infections, inadequate dietary diversity and intake of animal‑source foods and legumes, maternal anemia, short stature, low maternal education, household poverty, open defecation, and limited access to quality health and water, sanitation and hygiene services. Conclusion: Evidence supports integrated, multi‑sectoral strategies that target maternal nutrition, infant and young child feeding, infection control, and environmental sanitation to reduce the coexistence of stunting and anemia in early childhood.