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Journal : MAHESA : Malahayati Health Student Journal

 1 
Efektivitas Pemberian Madu Hutan (Apis Dorsata) dalam Mengatasi Infeksi Klebsiella Pneumoniae pada Mencit ( Mus Musculus) Musa, Muh. Muflih Usman; Wiriansya, Edward Pandu; Dwimartyono, Fendy; Mangarengi, Yusriani; Khalid, Nurfadhillah; Ahmad, Izhar Fitrah; Adrian, Adrian; Faisal, Fathir; Fazdlurrahman, Fazdlurrahman; Ilham, Muhammad
MAHESA : Malahayati Health Student Journal Vol 5, No 11 (2025): Volume 5 Nomor 11 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i11.19657

Abstract

ABSTRACT Nosocomial infections, especially those caused by Klebsiella pneumoniae bacteria, are a significant global health problem. The increasing antibiotic resistance encourages the search for alternative therapies, one of which is through the use of natural ingredients such as honey. Honey, especially Apis dorsata wild honey, is known to have antibacterial properties that can inhibit bacterial growth. To evaluate the effectiveness of giving forest honey (Apis dorsata) based on preventive, curative and supportive groups in treating Klebsiella pneumoniae infections in mice. This research uses a quasi experimental post-test method. A total of 30 mice were divided into 5 treatment groups. The test carried out was the Colony Number Distribution Test, then the Normality Test, after finding that the samples were not normally distributed, we chose the Kruskal Wallis Non-Parametric Test and the Mann-Whitney Test.Of the five groups studied, the intervention in the group given forest honey (Apis dorsata) combined with the antibiotic ceftriaxone as well as in the group given first forest honey (Apis dorsata) showed effective results (P<0.05) while the other groups did not show results. effective (P>0.05). Based on research, it was explained that giving forest honey (Apis dorsata) was effective as a preventive and supportive group, but was not effective as a curative group in treating Klebsiella pneumoniae infections in mice. Keywords: Forest Honey (Apis Dorsata), Klebsiella Pneumoniae Infection, Mice (Mus Musculus).  ABSTRAK Infeksi nosokomial, terutama yang disebabkan oleh bakteri Klebsiella pneumoniae, merupakan masalah kesehatan global yang signifikan. Meningkatnya resistensi antibiotik mendorong pencarian alternatif terapi, salah satunya melalui penggunaan bahan alami seperti madu. Madu, khususnya madu hutan Apis dorsata, diketahui memiliki sifat antibakteri yang dapat menghambat pertumbuhan bakteri. Untuk mengevaluasi efektivitas pemberian madu hutan (Apis dorsata) berdasarkan kelompok upaya preventif, kuratif serta supportif dalam mengatasi infeksi Klebsiella pneumoniae pada mencit. Penelitian ini menggunakan metode quasi experimental post-test. Sebanyak 30 ekor mencit dibagi menjadi 5 kelompok perlakuan. Pengujian yang dilakukan adalah Uji Distribusi Jumlah Koloni, lalu kemudian Uji Normalitas, setelah didapatkan sampel tidak terdistribusi normal sehingga kami memilih Uji Non Parametrik Kruskal Wallis serta Uji  Mann-Whitney. Dari lima kelompok yang diteliti, intervensi pada kelompok pemberian madu hutan (Apis dorsata) yang dikombinasi dengan antibiotik ceftriaxone juga pada kelompok yang diberikan terlebih dahulu madu hutan (Apis dorsata) menunjukkan hasil yang efektif (P<0.05) sedangkan kelompok yang lain tidak menunjukkan hasil yang efektif (P>0.05). Berdasarkan penelitian, dijelaskan bahwa pemberian madu hutan (Apis dorsata) efektif sebagai kelompok preventif dan  supportif, namun tidak efektif sebagai kelompok kuratif dalam mengatasi infeksi Klebsiella pneumoniae pada mencit. Kata Kunci: Madu Hutan (Apis Dorsata), Infeksi Klebsiella Pneumoniae, Mencit (Mus Musculus).
Co-Authors Adi Nugroho, Dwi Ahmad, Izhar Fitrah Algifari, Arif Amrizal Muchtar Anawati, Sri Andika Gunawan Andriani, Rina Anshary, Suci Noviyanah Aprilia, Natasya ARDIANSYAH ARDIANSYAH Asdar Asdar Asmuni Asmuni Aswanto Muhammad Takwi Hede Audry Prana Fadhillah Ayuningtyas, Nirmala Chandra, Dicky Joman Chiuman, Linda Dahlia Ervina Dameria, Rina Defisa, Tomi Dewi Anggraini Diah Aryani, Diah El-Adzkiyaa, Awhan Ibaad Faisal, Fathir Faisal, M. Fathir Fazdlurrahman, Fazdlurrahman Fendy Dwimartyono Fikry Fahrurrizal Firdaus, Jey Fitriana Fitriana Frederick, Henry Waidan Gavrila, Natasha Ginting, Chrismis Novalinda Girsang, Ermi Harimukti Wandebori Hendra Iskandar Herwanto, Agus Ihsan, Adela Elsyaqinah Ika Sartika Ikhwan Abduh Ikram, Dzul Ismail Ismail Jamaluddin Jamaluddin Junanah Junanah, Junanah Karim, Marzelina Karimuna, Siti Rabbani Khalid, Nurfadhillah Labib Muttaqin Liambo, Putri Yuliyanti Lina - Mariana, Lina - Lismawati, A. Lismawati Loveri, Tomi Maharani, Keisya Amalia Mahendra, Arista Mangarengi, Yusriani Mardewi, Mardewi Marpaung, Oktavia May Dwi Tyo Asdi, Putri Michael Michael Muhamad Julfitra Dinata Muhammad Ilham Muhammad, Hasman Muharam, La Ode Musa, Muh. Muflih Usman Mustakim Mustakim Mutia Zahara Nabiilah, Rifdah Nathan, Wilbert Nizar, Zahwa Noor, Moh. Yasin Novi Andriani, Novi Novianti Novianti Novita Eka Putri, Yosephine Nur Ain Nur Hidayat Nurfadilla, Nurfadilla Olivia Yolanda Devari Pasha, Aprilia Mulia Permata, Irma Sari Pramono, Anang Pranoto, Claresta Priscillia, Audrey Puspitasari, Hijriyah Putri Ariasih, Made Putri, Farahayu Galuh Rahmin, Ririn Ali Rayyan, Muh Safira, Safira Samiruddin T, Samiruddin T Samuel Horas Sarjana SAPUTRI, DIAN Sariwating, Beactris Aprilia Selfia, Siti Sianipar, Anton Zulkarnain Siti Hardianti, Siti Soleha Soleha Steven Steven Sukmawati Sukmawati Supriyanto Supriyanto Syahrir P, Andi syaifuddin, muhammad irfan Syair, Wika Purnama Tempo, Jesika Irena Gabela Ulfiana , Umaya Umi Nurhayati, Umi Usman, Muh. Muflih Wibowo, Kuncoro Widia, Widia Wijanarko, Winston Wiriansya, Edward Pandu Wiselee, Ekin Wujarso, Riyanto Yasin, Verdi Yulhendri Yulhendri