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Journal : Indonesian Journal of Cancer

 1 
Toksisitas Hematologi Regimen TAC (Docetaxel-Doksorubisin-Siklofosfamid) dan FAC (Fluorourasil-Doksorubisin-Siklofosfamid) pada Pasien Kanker Payudara di Rumah Sakit Kanker “Dharmais” Jakarta: Analisis Data Rekam Medik 2007-2008 Regimen, Toksisitas Hematologi; ANDRAJATI, RETNOSARI; ANDALUSIA, RIZKA
Indonesian Journal of Cancer Vol 4, No 1 (2010): Jan - Mar 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Breast cancer in Indonesia the second most common cancer in women after cervical cancer in 2008. FAC and TAC are chemotherapy regiments for breast cancer that give good therapy response but affect patient haematology. Study about hematologic toxicity of TAC and FAC in breast cancer patient has not been conducted in “Dharmais” Cancer Hospital. The purpose of this study was to determine hematologic toxicity of 6 cycles TAC (docetaxel 75 mg/m2, doxorubicin 50 mg/m2 and cyclophosphamide 500 mg/m2, day 1, 21) and FAC (fluorouracil 500 mg/m2, doxorubicin 50 mg/m2 and cyclophosphamide 500 mg/m2, day 1, 21) in breast cancer patients in “Dharmais” Cancer Hospital. This study used cross sectional design in 11 and 179 patient medical records that were indentified treated with TAC and FAC. Patients received first cycles both regiments in 2007-2008. All stages of breast cancer were included in this study. Differences between TAC and FAC in proportion of haematology count after chemotherapy and average decrease of hematology count were analyzed by chi square and t test statistic methods. From 66 hematology data in patients treated with 6 cycles TAC grade 1-4 of hematologic toxicity occurred 84,8% in haemoglobin with average decrease 0,71 g/dl; 97% in leucocyte with average decrease 7,51 x 103 cell/?l; 22,7% in trombocyte with average decrease 147,77 x 103 cell/mm3. From 1079 hematology data in patients treated with 6 cycles FAC grade 1-4 of hematologic toxicity occurred 72,6% in haemoglobin with average decrease 0,66 g/dl; 85% in leucocyte with average decrease 2,73 x 103 cell/?l; and 10,9% in thrombocyte with average decrease 104,25 x 103 cell/mm3.
Co-Authors . Widiarti Abdul Munim Adil khan, Muhammad Anton Bahtiar Ardiansyah Kahuripan Ardiansyah Kahuripan, Ardiansyah Arry Yanuar Bambang Wispriyono Berna Elya Dewi Sartika, Ratu Ayu Diah Handayani Djuria, Rachmawati Felani Dumiarsih, Suci Rizki Dwiputra, Anggara Gilang Eliza, Delila Farmasita Budiastuti, Rizky Fuad Zainuddin Harahap, Daimah Wirdatus Sanaun Harianto Harianto Hasanah, Kurniatul Heni Susilowati Heni Susilowati Husnawati Husnawati Ika Puspitasari Imaniar, Rania Indriani, Lusi Iwan Wahyudin Jiři Vlček Juheini Amin Juheini Amin Mahdi Jufri Mahmuda, Nur Amalia Maifitrianti Maifitrianti, Maifitrianti Maifitrianti, Maifitrianti Makhdalena Makhdalena, Makhdalena Margareth Christina Halim, Margareth Christina Masyrifah, Mas Merry Christianie Merry Christianie, Merry Mun‘im, Abdul Nadia Farhanah Syafhan Nasution, Izza Aulia Rizqika Noor, Sidra Noorwati Sutandyo Nur Fauziah Nurhikmah, Rizky Purnasari, Santi Puspitasari, Atika Wahyu Putra, M. Arza Putri, Risani Andalusia Rahmawati, Ni Made Ayu Rais, Yulia Rais, Yulia Rizka Andalusia Rizka Andalusia Safyanty, Rahmi Santi Purna Sari Sinabutar, Reniati Siti Setiati Sri Wahyuni Dewanti Sri Wulandah Fitriani, Sri Wulandah Sudibyo Supardi Sutandyo, Noorwati Tetty Syafridani Tetty Syafridani, Tetty Toksisitas Hematologi Regimen, Toksisitas Hematologi Vernissa, Venni Wardani, Tita Kusuma Widiarti Widiarti Widya Kardela Wulandari, Nora Yeni, Ai Yeni Herlinawati Yona Harianti Putri Yudhorini, Linda Triana Yulia Trisna Yulia Trisna, Yulia Yulian Rahmadini Yulian Rahmadini, Yulian Zainudin, Fuad