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All Journal Journal of Nutrition and Health JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Nutrition College Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) GIZI INDONESIA AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia Amerta Nutrition IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Journal Of Sustainability Perspectives Sports Medicine Curiosity Journal Journal of Sustainability Perspectives

MARTHA ARDIARIA

Department Of Nutrition Science, Faculty Of Medicine, Universitas Diponegoro, Jl. Prof. Sudarto No.13, Tembalang, Semarang 50275

Author-ID : 231369

Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Efek integrated nutrition programme terhadap profil lipid dan komposisi tubuh pada remaja obes Martha Ardiaria; Erin Ratna Kustanti; Ria Purnawian Sulistiani; Etika Ratna Noer
Jurnal Gizi Klinik Indonesia Vol 15, No 3 (2019): Januari
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.31594

The effect of integrated nutrition programme on lipid profile and body composition among adolescent obesityBackground: Obesity is a serious public health issue increasingly in the adolescent. Obesity in adolescence will continue into adulthood and lead to later health problems. The adolescent has high food dense calories which high fat and low in fiber that can trigger obesity. Integrated Nutrition Programme (INP) is an intervention model for obesity with an emphasis on a low-calorie diet, low fat, high fiber, moderate physical activity, and nutrition counseling.Objective: This study aimed to evaluate the effect of INP on lipid profile and body composition in obese adolescents.Methods: Quasi-experimental study pre-post trial design with a total of subjects 18 obese adolescents. Duration of intervention in subjects for four weeks with a hypocaloric diet, low fat, high fiber, and prepared by a dietician. Moderate exercise and dietary counseling were conducted on the subject regularly. Bodyweight (BW) and waist circumference (WC) were monitored once a week. Food record intake is done before and during the intervention.Results: The mean weight loss of 1.55 kg. There is a difference in mean BW, WC, and BMI (p<0.01), whereas there were no significant differences in lipid profiles and body composition between before and after the intervention.Conclusions: INP can significantly affect weight loss, BMI, and WC as well as a significant increase in physical activity.

Irregular menstrual cycles as a risk factor of type 2 diabetes mellitus in women of childbearing age Dhea Aghestya; Nurmasari Widyastuti; Martha Ardiaria; Fillah Fithra Dieny
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 1, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss1.art5

Background: Irregular menstrual cycles are a risk factor for developing type 2 diabetes mellitus (DM) in women. Objective: This study aimed to evaluate irregular menstrual cycles as a risk factor of type 2 DM in women of childbearing age with body fat percentage, waist-hip ratio, diet quality, and physical activity as confounding factors.Methods: This was a case-control study. Its subjects were subjects with type 2 diabetes mellitus (n=31) and subjects without any clinical evidence of abnormal glucose regulation (n=31) who attended Puskesmas (Community Health Centre) Rowosari, Tembalang, Semarang with over 30 years of age. Based on their menstrual cycles, they were divided into two groups: women with irregular menstrual cycles, and those with regular menstrual cycles. Cochran Mantel-Haenszel test was used to control their confounding factors. Results: There was an association between irregular menstrual cycles and type 2 DM (p<0.05) with a 7.2 greater risk on women of childbearing age (OR = 7.2, 95% CI=2.18-23.75). By the Cochran Mantel-Haenszel test, the association was still significant; women with over percentage of body fat and central obese with irregular menstrual cycle had 4,85 times and 4,37 times of sequentially greater risk on type 2 DM (OR = 4.85, 95% CI=0.98-23.95 vs OR = 4.37, 95% CI=0.93-20.51).Conclusion: The irregular menstrual cycles was a risk factor of type 2 DM, especially in obese women of childbearing age.

PERBEDAAN EFEK SEDUHAN KULIT DAN JUS BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) TERHADAP KADAR KOLESTEROL LDL SERUM TIKUS SPRAGUE DAWLEY DISLIPIDEMIA Rani Puspita; Martha Ardiaria; Ahmad Syauqy
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar Belakang : Dislipidemia adalah keadaan ketidaknormalan kadar lemak dalam darah. Buah naga merah (Hylocereus polyrhizus) mengandung polifenol, antioksidan dan serat dalam jumlah tinggi. Polifenol mempunyai kemampuan dalam menurunkan kadar kolesterol LDL pada manusia dan tikus.Tujuan : Mengetahui perbedaan efek seduhan kulit dan jus buah naga merah terhadap kadar kolesterol LDL serum tikus Sprague dawley dislipidemia.Metode : Penelitian ini merupakan penelitian eksperimental dengan desain pre and posttest control group design. Sampel adalah 24 ekor tikus Sprague dawley dengan kriteria tertentu, dibagi secara acak menjadi 4 kelompok yaitu kelompok kontrol negatif yang hanya diberi pakan standar, kontrol positif diberikan pakan standar dan pakan tinggi kolesterol, dua kelompok perlakuan diberikan pakan standar, pakan tinggi kolesterol, seduhan kulit 9,08g/200gbb tikus dan jus buah naga merah 1,53g/200gbb tikus, pemberian intervensi diberikan selama 14 hari. Kadar LDL diperiksa dengan metode CHOD-PAP dan GPO-PAP. Data dianalisis dengan uji Paired t-test dan AnovaHasil : Tidak terdapat perbedaan bermakna sebelum dan setelah intervensi pada kelompok K(-). Namun terdapat perbedaan bermakna sebelum dan sesudah intervensi pada kelompok K(+), P1, dan P2. Pemberian seduhan kulit dan jus buah naga mera selama 14 hari dapat menurunkan kadar LDL (43,33 ± 3,65) dan (27.56±8,01). Setelah intervensi terdapat perbedaan rerata kadar LDL antar kelompok p=0,000 kecuali K(-) dengan seduhan kulit p=0,640.Simpulan : Pemberian seduhan kulit dengan dosis 9,08g/2000gbb tikus dan jus buah naga merah 1,53g/200gbb tikus selama 14 hari dapat menurunkan kadar LDL pada tikus sprague dawley jantan sebesar 43,33 ± 3,65 dan 27.56±8,01.

PERBEDAAN EFEK SEDUHAN KULIT DAN JUS BUAH NAGA MERAH (Hylocereus polyrhizus) TERHADAP KADAR TRIGLISERIDA SERUM TIKUS Sprague dawley DISLIPIDEMIA I Dewa Gede Angga Pramana; Martha Ardiaria; Ahmad Syauqy
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar Belakang : Dislipidemia merupakan abnormalitas profil lipid dalam serum, salah satunya adalah peningkatan kadar trigliserida serum. Buah naga merah (Hylocereus polyrhizus) terbukti memperbaiki profil lipid karena adanya kandungan fenolat dan flavonoid. Kulit buah naga merah mengandung kandungan gizi seperti karbohidrat, lemak, protein, serat dan senyawa betasianin.Tujuan : Mengetahui perbedaan efek pemberian seduhan kulit dan jus daging buah naga merah terhadap kadar trigliserida serum tikus Sprague dawley dislipidemia.Metode : Jenis penelitian adalah true experimental dengan pre and post test with control group design. Sampel adalah tikus jantan Sprague dawley usia 10 minggu, diinduksi dislipidemia dengan telur puyuh dan asam kolat. Pada kelompok K(-) diberi pakan standar, kelompok K(+) diberi pakan tinggi kolesterol, kelompok P1 diberi seduhan kulit buah naga merah dan kelompok P2 diberi jus buah naga merah. Kadar trigliserida serum diperiksa dengan metode CHOD-PAP dan GPO-PAP. Data kemudian dianalisis menggunakan uji paired t test dan one way ANOVA.Hasil : Terdapat perbedaan bermakna sebelum dan setelah intervensi pada kelompok K(-), K(+), P1 dan P2. Pemberian seduhan kulit selama 14 hari dapat menurunkan kadar trigliserida sebesar 53,61 mg/dl (SD= 4,06) sedangkan jus buah naga merah dapat menurunkan kadar trigliserida sebesar 36,99 mg/dl (SD= 8,14). Setelah intervensi terdapat perbedaan rerata kadar trigliserida antar kelompok p=0,000 kecuali K(-) dengan seduhan kulit p=1,000.Simpulan : Pemberian seduhan kulit buah naga merah dan jus daging buah naga merah selama 14 hari dengan dosis 9,08 g/200 gbb tikus dan 1,53 g/200 gbb tikus dapat menurunkan kadar trigliserida serum masing-masing sebesar 53,61 mg/dl (SD= 4,06) dan 36,99 mg/dl (SD= 8,14) pada tikus Sprague dawley dislipidemia.

the Relationship between A Skinfold Thicknesses with Level of High Sensitivity C-Reactive Protein in Elderly Woman Aini, Chanifatunnisa Nurul; Ardiaria, Martha
Sports Medicine Curiosity Journal Vol 1 No 1 (2022): May 2022
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/smcj.v1i1.58509

Aging causes changes in body composition such as a decrease in muscle mass and an increase in adiposity associated with inflammation. High sensitivity C-reactive protein is the marker of inflammation. This study aimed to analyze the relationship between Skinfold Thicknesses with the Level of High Sensitivity C-Reactive Protein in Elderly women. This observational study used a cross-sectional design. Subjects were determined using consecutive sampling and adjusted for inclusion criteria with minimal sample were 53 subjects. Data collected were skinfold thicknesses measured with skinfold caliper and serum HsCRP analyzed by Enzyme-linked Immunosorbent Assay (ELISA), physical activity level measured by International Physical Activity Questionnaire, and dietary intake measured by food recall 3 x 24 hours. Data analysis using Ranks Spearman correlation test. The median value thickness of the biceps is 17.94 ± 10.60 mm, the thickness of the triceps skinfold thickness is 23.40 ± 8.06 mm, the subscapular skinfold thickness is 14.95 ± 7.48 mm, the suprailiac skinfold thickness is 17.00 ± 8.85 mm while the median HsCRP serum 2.09 ± 2.11 mg/L is classified as moderate. There was a relationship between suprailiac skinfold thickness (r = 0.45 p = 0.001) and subscapular (r =0.40 p =0.003). However, there was no relationship between biceps skinfold thickness (r =0.29 p =0.34) and triceps (r=0.75 p =0.47) with HsCRP levels. There was a significant relationship between suprailiac and subscapular skinfold thickness. However, there was no significant relationship between biceps and triceps skinfold thickness.

The Effect of Edamame milk on Triglyceride Levels in Diabetes Wistar Rats Ajeng, Dhea; Ardiaria, Martha; Kurniawati, Dewi Marfu’ah; Ayustaningwarno, Fitriyono
Sports Medicine Curiosity Journal Vol 1 No 2 (2022): October 2022
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/smcj.v1i2.61645

Type 2 diabetes is a hyperglycemic disease caused by cell insensitivity due to increasing blood glucose levels due to reduced insulin secretion. Hyperglycemia conditions have the risk to increase triglyceride levels in type 2 diabetes. Edamame milk contained isoflavones that had potential to reduce triglyceride level. To find out the effect of given edamame milk on triglyceride levels in type 2 diabetes wistar rats. A true experimental with pre-post randomized control group design towards 24 type 2 diabetes wistar rats in 4 groups. Groups K(+), P1 and P2 were induced Streptozotocin 45 mg/kgBW and Nicotinamide 110 mg/kgBW. P1 and P2 groups were given edamame milk at a dose of 1,8 ml/200grBW and 3,6 ml/200grBW for 28 days. Blood samples were taken through a retro-orbitalis plexus. Triglyceride levels were tested pre and post intervention using the GPO-PAP method. Data analysis had used Paired T test and One Way ANOVA test with Post hoc follow-up test. Triglyceride levels in P1 and P2 groups had significant differences (p<0,05) against the control groups. Edamame milk could reduce triglyceride levels of groups P1 and P2 at dose 1,8 ml/200grBW and 3,6 ml/200grBW. P2 was the highest group reduced in triglyceride levels up to 29,41±3,55 mg/dL. Edamame milk could reduced triglycerides levels in 28 days. Given an edamame milk at a dose 3,6 ml/200grBW more efficient to reduce triglyceride levels in type 2 diabestes rats significantly

Sorghum-Soybean Flour Enteral Formula Reduces Blood Glucose, Cholesterol, Triglycerides, LDL, and Increases HDL and Albumin in Hyperglycemic Rats Probosari, Enny; Dewi, Suci Noviya; Alfadila, Tsania Izza; Handayani, Endah Nur; Rizkita, Maura Sania; Candra, Aryu; Ardiaria, Martha; Puruhita, Niken; Murbawani, Etisa Adi
Molecular and Cellular Biomedical Sciences Vol 9, No 1 (2025)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v9i1.507

Background: Diabetes mellitus prevalence is rising. Liquid feeding in the form of enteral formulas is needed to meet the nutritional needs of patients who cannot consume orally. The development of enteral formulas based on sorghum-soybean flour for diabetes mellitus patients, which has been nutritionally analyzed and adjusted to the requirements of enteral manufacturing, was selected for further in vivo research. This study evaluated the effect of the sorghum-soybean flour formula on fasting blood glucose (FBG), lipid profile levels, and albumin in hyperglycemic rats.Materials and methods: This was a true experimental study with pre–post-test randomized control design. Wistar rats were divided into four groups: negative control group was normal rats and given standard feed only; positive control group was hyperglycemic rats and given standard feed only; treatment (T)1 and T2 groups were hyperglycemic rats given standard feed along with enteral formula at a dose of 4,41 g/day and 5,51 g/day for 28 days. Blood samples were collected to analyze FBG, albumin, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, and total cholesterol.Results: There were differences in the levels of FBG, albumin, LDL, HDL, triglycerides, and total cholesterol before and after the intervention in groups T1 and T2. Group T1 showed an 8.12% decrease in FBG, while T2 showed a 29.89% decrease. Triglycerides decreased by 29.22% in T1 and 31.85% in T2; cholesterol decreased by 11.41% in T1 and 13.94% in T2. LDL levels decreased by 29.97% in T1 and 38.44% in T2. Albumin levels increased by 47.90% in T1 and 56.67% in T2. HDL levels increased by 23.94% in T1 and in 35.04% in T2.Conclusion: Administration of an enteral formula based on sorghum-soybean flour can reduce FBG, triglycerides, total cholesterol, and LDL levels, and increase albumin and HDL levels in hyperglycemic rats.Keywords: hyperglycemia, enteral formula, albumin levels, fasting blood glucose, HDL, LDL, total cholesterol, triglycerides

Exploring rice varietal effects on triglyceride/high density lipoprotein ratio in hyperlipidemia-induced wistar rats Rosmalinda, Yusie; Noer, Etika Ratna; Sulchan, Mohammad; Khikmaturrohman, Sya’bani Isnaen; Ardiaria, Martha; Marsa, Firdaus Shadiqa; Henny, Via Anugrah; Wijayanti, Hartanti Sandi; Panunggal, Binar
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 13, No 2 (2025): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.13.2.170-181

Background: Excessive intake of white rice has been associated with elevated triglyceride (TG) levels and decreased high density lipoprotein (HDL) cholesterol concentrations. Conversely, black and red rice varieties have demonstrated favorable impacts on lipid metabolism. However, despite these benefits, their palatability and texture are often met with aversion by consumers. Consequently, it is imperative to investigate rice blends that are both well-received by individuals and exhibit pronounced efficacy in reducing the TG/HDL ratio.Objective: To investigate the differential effects on the TG/HDL ratio in rats administered different combinations of white, red, and black rice.Methods: This research follows a true experimental design incorporating pre- and post-tests with a control group. Thirty rats were initially fed a hyperlipidemic diet for 14 days. Subsequently, the rats were subjected to interventions involving different rice combinations for a duration of 28 days. These combinations included K(+) (positive control), P1 (100% white rice), P2 (21 g red and 4 g white rice), P3 (16 g black and 4 g white rice), and P4 (8 g black, 8 g red, and 4 g white rice). Triglyceride and HDL levels were quantified using the GPO-PAP and CHOD-PAP methods, respectively. Statistical analysis was performed utilizing ANOVA tests followed by LSD post-hoc tests for comparison.Results: Triglycerides decrease in P4 (-51.04±0.72) was the highest, followed by P3 (47.18±0.51), P2 (-34.60±1.07), P1 (-17.03±1, 06). Cholesterol HDL increase in P4 (49.36±1.68) was the highest, followed by P3 (42.71±0.41), P2 (38.09±0.76), P1 (30.64±0.90). The TG/HDL ratio in P1, P2, P3, and P4 were 0.21±0.092, -2.12±0.164, -2.45±0.123, -2.82±0.148, -3.18±0.371, respectively. The rice combination intervention had a significant decreased on the TG/HDL ratio (p=0.000).Conclusion: The intervention involving rice combinations resulted in a greater reduction in the TG/HDL ratio compared to the consumption of white rice alone. Among the various combinations tested, the combination of white, red, and black rice demonstrated the most significant reduction in the triglyceride to HDL-cholesterol (TG/HDL) ratio.

The Association of Food Insecurity and Chronic Diarrhea on the Prevalence of Stunting in Children under 2-5 Years of Age Marisa, Agnia; Hastuti, Vivilia Niken; Resti, Nina; Hardaningsih, Galuh; Ardiaria, Martha; Sugianto, Denny Nugroho; Afifah, Diana Nur
Journal of Sustainability Perspectives Vol 5, No 1: June 2025
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jsp.2025.28638

Stunting is associated with food insecurity and diarrheal infections. Age under five years is a golden age, which is very important for optimizing growth and development in the future. This study aimed to investigate the association between food insecurity and diarrhea and the prevalence of stunting in toddlers aged 2-5 years. Analytical observations using cross-sectional design. The study sample comprised 140 children aged 2-5 years. The sample was selected by simple random sampling. Data analysis was performed using univariate, chi-squared, Kruskal-Wallis, and multivariate tests. A total of 18.6% of the toddlers were stunted, 66 families were food insecure, and 31 toddlers had diarrhea. There was a relationship between chronic diarrhea and short nutritional status (p<0.001), and there was a significant relationship between food insecurity and the incidence of stunting (p=0.001). Results of the multivariate analysis using logistic regression. The final modal formula was log p (stunting) = -2.549 + 1.808 (parental income < minimum wage) + 6.098 (history of diarrhea) + 1.396 (food insecurity). Diarrhea is the dominant factor that most influences the incidence of stunting.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jsp.2025.28638

Co-Authors A. Fahmi Arif Tsani Adriyan Pramono Ahmad Syauqy Ahmad Syauqy Aida Fitri Nazillah Aini, Chanifatunnisa Nurul Ajeng, Dhea Alfadila, Tsania Izza Amelia, Annisa Eka Andini, Arie Nisfu Annisa, Wahyu Ilmi Arini, Prettika Juhan Armelinda, Nyoman Putri Ari Aryu Candra Astika Widy Utomo, Astika Widy Ayu Alfitasari Ayu Rahadiyanti Azalia, Fawnia Binar Panunggal Denny Nugroho Sugianto Deny Yudi Fitranti Deny Yudi Fitranti Dewi, Luthfia Dewi, Suci Noviya Dhea Aghestya Diana Nur Afifah, Diana Nur Ebigail Daeli Elvina R, Devi Enny Probosari Erin Ratna Kustanti Etika Ratna Noer Etisa Adi Murbawani Faadlilah, Nourah Faradina, Amelia Fathin, Annisa Nur Fauzia Purnamasari Fauziyah, Syifa Nala Febriandina, Kharisma Dwi Ferry Sandra Fillah Fithra Dieny Fillah Fithra Dieny Fitriyono Ayustaningwarno Galuh Hardaningsih, Galuh Hagnyonowati Hagnyonowati Handayani, Endah Nur Hartanti Sandi Wijayanti Hastuti, Vivilia Niken Helena Ayatasya Kusuma Cantika Henny, Via Anugrah Hertanto Wahyu Subagio I Dewa Gede Angga Pramana Irmayanti, Lusi Khikmaturrohman, Sya’bani Isnaen Kurniawati, Dewi Marfu’ah Lone, Vicka Frantya Luthfiatul Khusna Maharani, Mutiara Irma Mardiana, Zahra Aulia Marisa, Agnia Marsa, Firdaus Shadiqa Masha, Tania Meisyahputri, Bike Meita Hendrianingtyas Mohammad Sulchan Monikasari, Monikasari Muhammad Ryan Radifan Gustisiya Muhammad Sulchan Mursid Tri Susilo Nadya Diena Rahmah Niken Puruhita Ninik Rustanti Nissa, Choirun Noviasti Rahma Utami Nurmasari Widyastuti Nuryanto Nuryanto Nyoman Suci Widiastiti Prabu Giusta Nugraha Putri, Radhesia Iriani Rachma Purwanti Rachmawati, Rizki Khoirur Rahadiayanti, Ayu Rahma, Fadilla Rahmah, Nadya Diena Rani Puspita Resti, Nina Retno Tri Wulandari Ria Purnawian Sulistiani Ria Purnawian Sulistiani, Ria Purnawian Rizkita, Maura Sania Rosmalinda, Yusie Septiana, Wayan Chitra Setyarsih, Liani SIGIT ADIANTO Sitanggang, Golda Sharon Syafira Noor Pratiwi Tjahjono, Kusmiyati DK Widyanti, Alfreda Sabrina Yanti Ernalia Yuliana, Amanda Rambu Zsa-Zsa Ayu Laksmi Zulfa, Fairuz

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