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All Journal Journal of Nutrition and Health JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Nutrition College Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) GIZI INDONESIA AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia Amerta Nutrition IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Journal Of Sustainability Perspectives Sports Medicine Curiosity Journal Journal of Sustainability Perspectives
MARTHA ARDIARIA
Department Of Nutrition Science, Faculty Of Medicine, Universitas Diponegoro, Jl. Prof. Sudarto No.13, Tembalang, Semarang 50275
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Effectiveness of synbiotic red dragon fruit yogurt on glucose and oxidative stress in metabolic syndrome rats Rustanti, Ninik; Armelinda, Nyoman Putri Ari; Febriandina, Kharisma Dwi; Ardiaria, Martha; Rahadiyanti, Ayu; Susilo, Mursid Tri; Pramono, Adriyan
AcTion: Aceh Nutrition Journal Vol 10, No 1 (2025): March
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i1.2231

Abstract

Metabolic syndrome is still a global health problem, especially in Indonesia. Oxidative stress is related to metabolic syndrome because it is triggered by hyperglycemia. Synbiotic yogurt containing the whole red dragon fruit has antioxidant and synbiotic potential. This study aimed to determine the effect of synbiotic yogurt with whole red dragon fruit on fasting blood glucose (FBG) and malondialdehyde (MDA) levels in rats with metabolic syndrome. The design of this study was true-experimental, with a pre-post test and randomized control group design. A total of 24 male Sprague Dawley rats were divided into four groups (K-, K+, P1, P2). Groups K+, P1, and P2 were fed a high-fat, high-fructose diet (HFHFD) for 2 weeks. Groups P1 and P2 were administered synbiotic yogurt intervention of 0,009 mL/gBB/day and 0,018 mL/gBB/day, respectively, for 4 weeks. GOD-PAP method for FBG analysis and TBARS method for MDA analysis.  Data were analyzed using the paired t-test and One-Way ANOVA test. The P1 and P2 groups experienced a significant decrease in FBG levels by 63,45% and 76,07%, respectively (p<0,001), and a significant decrease in MDA by 26,1% and 37,2%, respectively (p<0,001). In conclusion, the administration of synbiotic yogurt at 0,018 mL/gBB/day (200 mL/day for humans) for four weeks was effective in reducing FBG and MDA levels.
Pengaruh Kefir Susu Kambing Terfortifikasi Vitamin D3 terhadap Kadar hs-CRP Tikus Rattus Norvegicus DM Tipe 2: Studi Eksperimental: The Effect of Vitamin D3-Fortified Goat Milk Kefir on hs-CRP Levels of Type 2 Diabetic Rattus Norvegicus Rats: An Experimental Study Zulfa, Fairuz; Utomo, Astika Widy; Ardiaria, Martha; Syauqy, Ahmad; Purwanti, Rachma; Ernalia, Yanti; Masha, Tania; Maharani, Mutiara Irma; Faradina, Amelia; Panunggal, Binar
Amerta Nutrition Vol. 9 No. 4 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i4.2025.667-678

Abstract

Background: Insulin resistance and chronic hyperglycemia in diabetes are linked to the synthesis of the inflammatory biomarker hs-CRP. Goat milk kefir and vitamin D have anti-diabetic and anti-inflammatory properties. Objectives: Aimed to evaluate the impact of goat milk kefir fortified with vitamin D3 on hs-CRP levels of diabetic rats. Methods: Twenty-one male Rattus norvegicus rats were randomly divided into four groups for a 35-day study: Control (C), Diabetes Mellitus (DM), unfortified goat milk kefir treatment (P1), and vitamin D3-enriched goat milk kefir treatment (P2). Diabetes was induced via intraperitoneal injection of streptozotocin (STZ) at 65 mg/kg BW and nicotinamide (NA) at 230 mg/kg BW. Goat milk kefir was administered orally at 2 mL/200 g BW/day, with the fortified version containing 600 IU of vitamin D3 per 100 mL. Fasting blood glucose levels and serum hs-CRP were measured pre- and post-intervention using the GOD-PAP and ELISA methods, respectively. Data were analyzed using bivariate and multivariate methods in GraphPad Prism 8. Results: There was a statistically insignificant decrease in hs-CRP levels in the P2 group (p-value=0.21) and in the P1 group (p-value=0.63), suggesting limited impact on inflammation. However, there was a statistically significant drop in blood glucose levels in the P2 group (∆FBG -65.50±35.44 mg/dL, p-value=0.03) and in the P1 group (∆FBG -81.63±50.07 mg/dL, p-value=0.05). Conclusions: The reduction in hs-CRP levels indicates that vitamin D3-fortified kefir may help modulate low-grade inflammation and shows promise in managing diabetes. Future research should examine dose, duration, and sample size for better efficacy assessment.
Co-Authors A. Fahmi Arif Tsani Adriyan Pramono Ahmad Syauqy Ahmad Syauqy Aida Fitri Nazillah Aini, Chanifatunnisa Nurul Ajeng, Dhea Alfadila, Tsania Izza Amelia, Annisa Eka Andini, Arie Nisfu Annisa, Wahyu Ilmi Arini, Prettika Juhan Armelinda, Nyoman Putri Ari Aryu Candra Astika Widy Utomo, Astika Widy Ayu Alfitasari Ayu Rahadiyanti Azalia, Fawnia Binar Panunggal Denny Nugroho Sugianto Deny Yudi Fitranti Deny Yudi Fitranti Dewi, Luthfia Dewi, Suci Noviya Dhea Aghestya Diana Nur Afifah, Diana Nur Ebigail Daeli Elvina R, Devi Enny Probosari Erin Ratna Kustanti Etika Ratna Noer Etisa Adi Murbawani Faadlilah, Nourah Faradina, Amelia Fathin, Annisa Nur Fauzia Purnamasari Fauziyah, Syifa Nala Febriandina, Kharisma Dwi Ferry Sandra Fillah Fithra Dieny Fillah Fithra Dieny Fitriyono Ayustaningwarno Galuh Hardaningsih, Galuh Hagnyonowati Hagnyonowati Handayani, Endah Nur Hartanti Sandi Wijayanti Hastuti, Vivilia Niken Helena Ayatasya Kusuma Cantika Henny, Via Anugrah Hertanto Wahyu Subagio I Dewa Gede Angga Pramana Irmayanti, Lusi Khikmaturrohman, Sya’bani Isnaen Kurniawati, Dewi Marfu’ah Lone, Vicka Frantya Luthfiatul Khusna Maharani, Mutiara Irma Mardiana, Zahra Aulia Marisa, Agnia Marsa, Firdaus Shadiqa Masha, Tania Meisyahputri, Bike Meita Hendrianingtyas Mohammad Sulchan Monikasari, Monikasari Muhammad Ryan Radifan Gustisiya Muhammad Sulchan Mursid Tri Susilo Nadya Diena Rahmah Niken Puruhita Ninik Rustanti Nissa, Choirun Noviasti Rahma Utami Nurmasari Widyastuti Nuryanto Nuryanto Nyoman Suci Widiastiti Prabu Giusta Nugraha Putri, Radhesia Iriani Rachma Purwanti Rachmawati, Rizki Khoirur Rahadiayanti, Ayu Rahma, Fadilla Rahmah, Nadya Diena Rani Puspita Resti, Nina Retno Tri Wulandari Ria Purnawian Sulistiani Ria Purnawian Sulistiani, Ria Purnawian Rizkita, Maura Sania Rosmalinda, Yusie Septiana, Wayan Chitra Setyarsih, Liani SIGIT ADIANTO Sitanggang, Golda Sharon Syafira Noor Pratiwi Tjahjono, Kusmiyati DK Widyanti, Alfreda Sabrina Yanti Ernalia Yuliana, Amanda Rambu Zsa-Zsa Ayu Laksmi Zulfa, Fairuz