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The Potential of Murraya koenigii as a PfAp4AH Inhibitor for Malaria Drug Development Inda Setyawati; Assifah Eryandini; Nadine Rudiyana; Laksmi Ambarsari; I. Made Artika
JURNAL AGRONOMI TANAMAN TROPIKA (JUATIKA) Vol. 7 No. 2 (2025): Vol. 7 No. 2 Mei (2025): Jurnal Agronomi Tanaman Tropika (JUATIKA)
Publisher : LPPM UNIVERSITAS ISLAM KUANTAN SINGINGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36378/juatika.v7i2.4585

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Murraya koenigii, a medicinal plant from the Rutaceae family, is traditionally used as a flavoring agent and is known for its bioactive carbazole alkaloids. Native to the Indo-Malaysian region, China, Sri Lanka, and New Caledonia, this plant has shown potential for therapeutic applications, including antimalarial activity. Malaria, particularly caused by Plasmodium falciparum, remains a significant global health challenge due to rising drug resistance. PfAp4AH, an enzyme involved in diadenosine tetraphosphate (Ap4A) metabolism, has emerged as a promising target for novel antimalarial drugs. This study employed computational approaches—binding site prediction and virtual screening through molecular docking—to identify potential PfAp4AH inhibitors from 156 carbazole alkaloids derived from M. koenigii. Ten compounds demonstrated stronger binding affinities than ATP, with compound 1 showing the highest inhibitory potential through strong and diverse interactions with key residues Tyr87, His43, Pro133, and Leu136. These findings underscore the importance of specific ligand–residue interactions in determining binding strength. The identified compounds, especially compound 1, present promising leads for further experimental validation. While initial bioactivity and toxicity profiles are favorable, comprehensive bioavailability and toxicological evaluations are needed to advance these compounds as antimalarial drug candidates.
Metabolite Profiling Differences of Single and Physical Mixture of Moringa Leaves (Moringa oleifera) and Red Galangal (Alpinia purpurata (Vieill) K. Schum) Martina Simbolon; Rimbawan Rimbawan; Kartin Roosita; I Made Artika
Journal of Health and Nutrition Research Vol. 5 No. 1 (2026)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v5i1.962

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econdary metabolites are bioactive plant constituents that contribute to antioxidant, anti-inflammatory, and anti-microbial activities, making them valuable for functional food and nutraceuticals applications. This study aimed to characterize the secondary metabolites present in powdered Moringa oleifera leaves, red galangal (Alpinia purpurata (Vieill) K. Schum) rhizomes, and their combination. The 85:15 ratio used in the mixed powder was selected based on preliminary material composition considerations. Metabolite identification was conducted using Ultra High Performance Liquid Chromatography Tandem High Resolution Mass Spectrometry (UHPLC-HRMS). Data processing and compound annotation were performed using ChemSpider and mzCloud. A total of 21 metabolites were identified in moringa leaf powder, 16 compounds in red galangal rhizome, and 17 compounds in the combined preparation. Flavonoid were the dominant class in moringa leaves with quercitrin, 4-aminobenzoid acids, and pheophorbide A as the most abundant constituents. In contrast, phenolic compounds, particularly benzoic derivatives were predominant in red galangal, where menadiol, abietin, and sweroside were the major metabolites. The combined formulation retained key constituents from both plants, including cinnamaldehyde, 4-aminobenzoic acid, and pheophorbide A, and additionally showed an increased level of nictoflorin. These findings provide preliminary compositional evidence demostrating the distinct and complementary phytochemical profiles of moringa leaves and red galangal rhizomes. This information may guide future studies into potential functional food or nutraceutical formulations for further validation through bioactivity, bioavailability, and interaction studies.
Aktivitas Kitinase dan Peroksidase dari Ekstrak Protein Daun, Akar, Kalus dan Tunas In Vitro Trichosanthes tricuspidata Lour. Dewi Sukma; Roedhy Poerwanto; , Sudarsono; Nurul Khumaida; Suryo Wiyono; I Made Artika
Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Vol. 36 No. 1 (2008): Buletin Agronomi
Publisher : Indonesia Society of Agronomy (PERAGI) and Department of Agronomy and Horticulture, Faculty of Agriculture, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.991 KB) | DOI: 10.24831/jai.v36i1.1347

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A number of Trichosanthes species has been reported as a source of bioactive protein associated with defense mechanisms such as chitinase. Chitinase and peroxidase of crude protein extracted from leaves, roots, in vitro calli and shoots of T. tricuspidata had been analysed. Calli were induced on MS medium containing combinations of 1 µM NAA + 1 µM BA (K1), 2 µM NAA + 2 µM BA (K2), 3 µM NAA + 3 µM BA (K3), or 4 µM NAA + 4 µM BA (K4). Shoots were cultured in MS with 1 mg/l of BA, while leaves and roots were harvested from six-month old plants grown on the field. Results of the experiment suggested that K1-K4 medium could be used to induce calli although weight of calli from all medium composition was not significantly different (0.19-0.31 g/explant/4 weeks). Calli from K1 medium had the highest of total crude protein content (3.24 mg/ml). The highest of chitinase activity was found in in vitro shoots (6.51 mM pNP/hour/mg protein) and the highest peroxidase activity was in the plant roots (0.25 ∆ 420/minute/mg protein). Key words: in vitro calli, shoots, crude protein, chitinase and peroxidase activities
MOLECULAR DOCKING ANALYSIS OF SELECTED CURCUMA XANTHORRHIZA CONSTITUENTS AS POTENTIAL ANTICANCER DRUG Akhmad Endang Zainal Hasan; I Made Artika; Suryani; Dhani Luthfi Ramadhani
BIOTROPIA Vol. 30 No. 1 (2023): BIOTROPIA Vol. 30 No. 1 April 2023
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2023.30.1.1386

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Stress conditions will trigger the histone hyperacetylation process due to histone acetyltransferase p300/CBP (HAT PCAF) constantly transfers acetyl groups from acetyl-CoA to conserved lysine residues on histone proteins to form ε-N-acetyllysine. This can be a cause of cancer. The purpose of this study was to investigate the potential mechanisms and inhibition of PCAF HAT by chemical components of C. xanthorrhiza namely, curcumin, demethoxycurcumin, bisdemethoxycurcumin, and xanthorrizhol using in silico, the molecular docking method.  Results showed that the components of C. xanthorrhiza as ligands have the capability to inhibit the binding of acetyl-CoA to histone. These results can be used to predict the inhibitory mechanisms exhibited by C. xanthorrhiza components, as competitive and noncompetitive substances. We hypothesize that C. xanthorrhiza components resemble a substrate, leading to prevention of the natural substrate (histone) to bind to the enzyme, and hence block the product formation. The smallest free Gibs energy was exhibited by curcumin on chain B and by bismethoxycurcumin on chain A, with values of -8.8 and -8.4 Kcal/mol, respectively.
Genetic diversity analysis of Piper betle from eight accessions of Indonesia based on SRAP markers Sharah Nabilla; Ukhradiya Magharaniq Safira; Puspa Julistia Puspita; Dyah Subositi; Anshary Maruzy; I Made Artika
Biodiversitas Journal of Biological Diversity Vol. 22 No. 8 (2021)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d220837

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Abstract. Nabilla S, Safira UM, Puspita PJ, Subositi D, Maruzy A, Artika IM. 2021. Genetic diversity analysis of Piper betle from eight accessions of Indonesia based on SRAP markers. Biodiversitas 22: 3401-3408. Leaves of betel vine (Piper betle Linn.) have been used as a traditional medicine in various regions in Indonesia. However, the genetic diversity of this plant has not been well recorded. Considering its diverse usage in traditional and folk medicine, it is essential to analyze and document the genetic diversity of Piper betle L. with the aim to collect the scientific data of betel vine genetics in Indonesia. This study aims at analyzing the population structure and genetic diversity of betel vine from the Singkil, Gayo Serbajadi, Baduy, Bandung, Hutan, Kalisusu, Kaledupa, and Mekongga accession groups of Indonesia using the sequence-related-amplified polymorphism (SRAP) marker technique. Genomic DNA was isolated from each accession and then used as a template for DNA amplification using PCR. As many as 16 SRAP primer combinations were screened for the genetic diversity analysis. Optimization of primer combinations resulted in 7 selected combinations based on their ability to generate clear amplification patterns and polymorphic bands. These were then employed for genetic diversity analysis. The genetic distance dendrogram showed the lowest similarity coefficient was 0.62 and that the betel vine grouping pattern was not based on genotype. The Singkil population had the highest genetic diversity and the Hutan population had the lowest. The mean value of Nei's genetic diversity index was 0.0985, while Shannon's information index was 0.01459 and the percentage of polymorphic loci was 25.81. This study concluded that the level of betel vine diversity is low.
Variability total phenolic content and antioxidant activity of Curcuma zanthorrhiza and C. aeruginosa cultivated in three different locations in West Java, Indonesia SURYANI SURYANI; ASMAUL CHUSNA AL ANSHORY; MARLIN MARLIN; I MADE ARTIKA; LAKSMI AMBARSARI; Waras Nurcholis
Biodiversitas Journal of Biological Diversity Vol. 23 No. 4 (2022)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d230434

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Abstract. Suryani, Al Anshory AC, Marlin, Artika IM, Ambarsari L, Nurcholis W. 2022. Variability total phenolic content and antioxidant activity of Curcuma zanthorrhiza and C. aeruginosa cultivated in three different locations in West Java, Indonesia. Biodiversitas 23: 1998-2003. Curcuma zanthorrhiza Roxb. and C. aeruginosa Roxb. are medicinal plants belonging to the Zingiberaceae family, which contained phenolic compounds. Phenolic is one of the antioxidant compounds. This study aimed to investigate variation on the total phenolic and antioxidant activity of three C. zanthorrhiza varieties and twenty C. aeruginosa genotypes cultivated in three different locations in West Java, Indonesia. Total phenolic content was determined using the Folin-Ciocalteu reagent, whereas antioxidant activity was used spectrophotometry using DPPH method. The total phenolic content ranged from 2.403 to 7.539 mg GAE/ g DW) differed significantly among the C. zanthorrhiza and C. aeruginosa varieties/genotypes, with the highest concentration found in the Cursina 3 variety of C. zanthorrhiza in Cianjur. The antioxidant activity ranged from 2.443 to 14.960 µmol TE/g DW, with the maximum activity identified in the Cursina 2 variety of C. zanthorrhiza in the Bogor location. G1, G6, G13, and G16 were identified as stable genotypes for phenolic antioxidant production. Three C. zanthorrhiza cultivars demonstrated higher total phenolic content and antioxidant activity than all C. aeruginosa genotypes in all planting areas. C. zanthorrhiza cultivars are the most promising source of phenolic content and antioxidant activity and are thus recommended for mass plantation at suitable locations in West Java, Indonesia to maximize potential.
Phenolic and flavonoid content with agro morphological characters of 12 accessions of Justica gendarussa grew in Indonesia NELLY MARLIANI; I MADE ARTIKA; MOHAMAD RAFI; MUHAMAD SYUKUR; RONNY YUNIAR GALINGGING; WARAS NURCHOLIS
Biodiversitas Journal of Biological Diversity Vol. 23 No. 10 (2022)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d231017

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Abstract. Marliani N, Artika IM, Rafi M, Syukur M, Galingging RY, Nurcholis W. 2022. Phenolic and flavonoid content with agro morphological characters of 12 accessions of Justica gendarussa grew in Indonesia. Biodiversitas 23: 5101-5107. Justicia gendarussa Burm. f is a medicinal plant used in traditional and modern medicine. This study was conducted to determine the agro morphological characters, phenolic and flavonoid content of 12 accessions of J. gendarussa plants obtained from various locations in Indonesia and then grown in the same conditions and places. The agro morphological characteristics include plant height, number of leaves, number of branches, wet weight, and dry weight of leaves and stems. Total phenolic content (TPC) and total flavonoid content (TFC) were analyzed by spectrophotometric method. The results showed significant differences in the characters of 12 accessions of J. gendarussa (p<0.05). Accessions of BK4 (Bekasi 4) and KP (Kejayan Pasuruan) had the best agro morphological characteristics. Accessions of BK4 (Bekasi 4) and BG (Bogor) had the best growth rates. The highest TPC value was obtained from TG (Trenggalek) accession (0.752 mg GAE/g DW) and the highest TFC (1.899 mg QE/g DW from LK (Langkat) accession. The best accessions based on agro morphological characters were BK4 (Bekasi 4) and KP (Kejayan Pasuruan), and based on the content of polyphenols were TG (Trenggalek) and LK (Langkat). The accessions of BK4, BG, TG, and LK could be further developed into superior varieties of J. gendarussa.
Effect of varieties of Curcuma xanthorrhiza and extraction solvent on total phenolic, total flavonoid content, and antioxidant capacity GARDA YODI; I MADE ARTIKA; WARAS NURCHOLIS
Biodiversitas Journal of Biological Diversity Vol. 24 No. 12 (2023)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d241203

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Abstract. Yodi G, Artika IM, Nurcholis W. 2023. Effect of varieties of Curcuma xanthorrhiza and extraction solvent on total phenolic, total flavonoid content, and antioxidant capacity. Biodiversitas 24: 6425-6431. Temulawak (Curcuma xanthorrhiza Roxb.) is widely recognized for its high phytochemical content and antioxidant capacity. Therefore, this study aimed to measure yields, total phenols, total flavonoids, and antioxidant capacity of acetone and ethyl acetate extracts from three varieties of Temulawak, namely Cursina 1, Cursina 2, and Cursina 3. The samples were extracted using the maceration method and evaporated with a rotary vacuum evaporator. In this study, total phenolic and flavonoid contents were analyzed using a colorimetric method, while antioxidant capacity was assessed through DPPH, ABTS, and FRAP assays. The highest acetone and ethyl acetate extract yields were obtained from Cursina 2, i.e., 5.8% and 4.3%, respectively. The highest phenol in the acetone and ethyl acetate extract was from  Cursina 2, consisting of 9.55±0.37 mg GAE/g DW and 4.60±0.12 GAE/g DW. The highest flavonoid content in the acetone and ethyl acetate extract was from Cursina 2, i.e., 20.48±0.45 QE/g and 8.59±0.14 mg QE/g DW, respectively. The DPPH method showed that acetone and ethyl acetate extracts of Cursina 2 had the highest antioxidant activities, i.e., 3.28±0.03 ?mol TE/g DW and 2.11±0.04 ?mol TE/g DW, respectively. The highest antioxidant capacity based on the ABTS method was found in the acetone extract of Cursina 2 (148.91±6.10 ?mol TE/g DW) and ethyl acetate extract of Cursina 3 (84.30±5.10 ?mol TE/g DW). The FRAP method showed the highest antioxidant capacity was Cursina 2 acetone extract (115.23±2.30 ?mol TE/g DW) and ethyl acetate extract of Cursina 3 (71.88±1.48 ?mol TE/g DW). These results suggested that acetone is a more suitable solvent for the Cursina 2 variety, while ethyl acetate is more suitable for the Cursina 3 variety.
Molecular Docking Study of Bioactive Compounds from Curcuma aeruginosa Roxb. as Antioxidant and Anticancer Activities Laksmi Ambarsari; Siti Nurjanah; I Made Artika; Rizka Fatriani
Jurnal Jamu Indonesia Vol. 8 No. 2 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i2.327

Abstract

Cancer is one type of dangerous disease that is increasing every year. Free radicals are the cause of gene mutations (cancer). Cancer will develop uncontrollably due to the occurrence of the cell cycle and the presence of compounds that trigger cell proliferation and inhibit the process of apoptosis. This cancer treatment is carried out by giving cyclin-dependent kinase2 (CDK2) and cyclooxygenase-2 (COX-2) inhibitor drugs to inhibit cancer development, as well as lipoxygenase (LOX) inhibitor drugs for the formation of free radicals. Curcuma aeruginosa RoxB., the plant, is known to have the potential for antioxidant and anticancer properties. This study aims to determine the molecular interaction between the dominant compound in the ethanol extract of C. aeruginosa with CDK2, COX-2, and LOX receptors. The type of ligand interaction with the receptor was determined through the parameters of affinity energy (∆G), inhibition constant (Ki), type of interaction, and percentage of binding site similarity (%BSS). The results showed that the gajutsulacton A had the best potential in inhibiting CDK2. The cucumenol may be a COX-2 inhibitor, and there are no compounds that can inhibit LOX as well as an antioxidant. Thus, our findings demonstrate the potential for C. aeruginosa bioactive to serve as anticancer candidate molecules against CDK2 and COX-2 receptors.
Potential of Sunda Porcupine (Hystrix javanica) Quills Extract as a Wound Healing Medicine: A Review of the Bioactive Components and Mechanisms Yulianto; Waras Nurcholis; I Made Artika
Jurnal Jamu Indonesia Vol. 8 No. 2 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i2.329

Abstract

Sunda porcupine (Hystrix javanica), a native species of Indonesia, is renowned for its distinctive sharp quills enveloping its body. Despite its reputation as a spiky creature, the use of porcupine quills in traditional medicine in Indonesian society, especially for toothache and stomach ulcers, shows that there are benefits as an alternative to herbal medicine that has yet to be fully explored. Even outside Indonesia, North American porcupine quills are reported to have antibiotic properties related to the free fatty acids that coat the spines. Extracts of Sunda porcupine quills have also shown interesting antibacterial activity. Several bioactive compounds have been found in Sunda porcupine quills extract, including alkaloids, flavonoids, saponins, steroids, triterpenoids, and peptides. These compounds have various health benefits, such as analgesic, anti-inflammatory, and antimicrobial. In addition, the antibacterial activity test on the extract showed strong potential against the growth of gram-positive bacteria. The activities of secondary metabolites that play a role in helping wound healing are anti-inflammatory, antioxidant, and antibacterial/antimicrobial activities. Wound healing mechanisms involve several complex interactions of various cellular and molecular processes. Recent research has revealed the great potential of extracts from Sunda porcupine quills as a wound healing medicine. Although the potential of Sunda porcupine quills extract as a wound healing medicine has attracted attention, this research still has limitations. Critical measures, such as in vivo and in vitro testing, still need to be improved, leaving gaps in information that require further research. The challenge of an in-depth understanding of the activity and mechanisms of bioactive compounds is the focus on optimizing the utilization of Indonesia's natural potential. This article reviews the bioactive components of Sunda porcupine quills extract and their mechanism as a wound healing agent.
Co-Authors . SURYANI A. E. Zainal Hasan AA Sudharmawan, AA Abdillah, Ramadhani Malik Abdul Choliq ABIYYU, NAUFAL ADINDA VIRGINIA DWI SETYO Agung Eru Wibowo AHMAD ENDANG ZAINAL HASAN AHMAD ENDANG ZAINAL HASAN Ahmad Sulaeman Akhmad Endang Zainal Hasan Akhmad Endang Zainal Hasan Amanda, Nisa Widya AMIN FATONI Andani, Gita Putri Andita Fitri Mutiara Rizki, Andita Fitri Mutiara Anshary Maruzy Antonius Padua Ratu Apipah Aprianti Apon Zaenal Mustopa APON ZAENAL MUSTOPA Arya Arendra ASMAUL CHUSNA AL ANSHORY Asri Sulfianti Assifah Eryandini Azmi Azhari Azmi Azhari, Azmi Azmi, Wihda Aisarul BUGI RATNO BUDIARTO Canggih Setya Budi Cok Istri Agung T Apriliyanti DEDI JUSADI Denny Irawati Desi Purwaningsih Dewi Sukma Dhani Luthfi Ramadhani DIMAS ANDRIANTO Djarot Sasongko Hami Seno Dodi Safari Dodi Safari Dodi Safari Dodi Safari Dwi N. Susilowati Dyah Subositi Dzihan Dinar Rabani Eliza Halim Erismar Amri Erlank Bagjavicenna Erna Puspasari Evi Nur Qolbaini Fatriani, Rizka Fina Febrianti Firda DIMAWARNITA Firdausy, Iman Akhyar Firmansyah, Ridwan Putra Fitrianita, Alfia Fri Rahmawati GARDA YODI Gholam, Gusnia Meilin Gita Putri Andani Gusnia Meilin Gholam H. A. E. Zainal Hasan Hani 'Athiyya Rafi Hardinsyah Harsana, Ngurah HARTUTIK EKA SUSANTI HARYANTO SUSILO Hasim - HASIM DANURI Hayatul Rahmi Herti Sugiarti Herti Sugiarti, Herti Hyakansa HANIF I Nyoman Rai Widiartha Kesuma Ifa Manzila Iman Rusmana Inawati Inawati Inda Setyawati, Inda Irsal, Riyan Alifbi Putera Jajang Suhyana K, Popi A Kartin Roosita Kurnia Agustini Laita Nurjanah Laita Nurjanah, Laita LAKSMI AMBARSARI Lasmiyanti, Metty Lusiana Kresnawati Hartono Luzicoiij, Michael Edison M. Zairin Junior M.Pd Prof. Dr. I Nyoman Sudiana . Mala Nurilmala MARIA BINTANG MARLIN MARLIN Martina Simbolon Meilisza, Nina Melva Louisa Mirza Dikari Kusrini Mohamad Rafi MS, Yulia Atika Muhaimin Muhaimin Muhamad Syukur MUHAMMAD AGUS SUPRAYUDI Muhammad Dailami, Muhammad Muhammad Nafiz Muhammad Zairin Jr. Mutmainnah A. Umar Nadine Rudiyana NELLY MARLIANI Ni Kadek Sintya Anggreni Ni Putu Asri Ratna Suhita Ni Putu Peggy Liliyani Nina Meilisza Nisa Widya Amanda Noorwati Sutandyo Norman Razief Azwar Norman Razief Azwar Novik Nurhidayat Novik Nurhidayat Nuke Annisa Nasution NUNUK WIDHYASTUTI Nur Bambang Priyo Utomo Nur Hasanah Nurmala Sari Nurul Khumaida Nurul Khumaida Perkasa Arian Popi Asri Kurniatin Puji Lestari Purwanto, Ukhradiya Magharaniq Safira Puspa Julistia Puspita Rahadian Pratama Rahmawati, Fri Rava Raisha Putra Resti Rahmawati Putri Ridwan Putra Firmansyah Rimbawan Rimbawan Rini Kurniasih, Rini Rizka Fatriani Roedhy Poerwanto RONNY YUNIAR GALINGGING Sang Ayu Made Sri Tandewi Sang Ayu Putu Didi K Agustini Septiany C. Palilingan Sharah Nabilla Sheryn Sunni Albani Shobiroh Nuur Alimah Siagian, Putri Junita Siregar, Josephine Elizabeth Siti Nurjanah Siti Nurjanah Soekarno Mismana Putra Soekarno Mismana Putra, Soekarno Mismana Sogandi Sogandi Sogandi Sogandi Sudarsono Suharyanto Suharyanto Sulistiani sulistiani Suryani SURYANI SURYANI Suryani Suryani Suryani Suryani Suryo Wiyono Sutoro Sutoro Syaeful Abidin Syamsul Falah Tatik Khusniati Tetty Chaidamsari Tetty Chaidamsari, Tetty Tri Panji Tri Rini Nuringtyas Trini Suryani Kadir Vita Rosaline Fahri Waras Nurcholis Wardhani, Bantari Wisynu Kusuma Wasrin Syafii Wibowo, Syahputra Wijiastuti Wijiastuti Yadi Suryadi Yahdiana Harahap Yulianto YUNITA ARIAN SANI ANWAR Zahra, Hafizh