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Antioxidant Active Substances and Influence on Lipid Profile in White Rat Animal Experiments (Rattus norvegicus) Wistar from Kawista Fruit Extract (Limonia acidissima) Ida Bagus Rai Wiadnya; Iswari Pauzi
Lambda: Jurnal Ilmiah Pendidikan MIPA dan Aplikasinya Vol. 6 No. 2 (2026): Lambda
Publisher : Lembaga Bale Literasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58218/lambda.v6i2.4262

Abstract

Background: Kawista fruit (Limonia acidissima) from Bima Regency, West Nusa Tenggara, is empirically known for its antioxidant, tonic, and digestive properties. Its chemical components, including terpenoids, polyphenols, and flavonoids, are expected to reduce lipid profile levels. Purpose: This study aimed to identify active compounds in kawista fruit extract and evaluate its effects on lipid profile (cholesterol, triglycerides) and fasting blood glucose in white rats (Rattus norvegicus) with NAFLD-induced liver damage. Methods: An experimental approach was used. Kawista fruit extract was prepared by maceration with 70% ethanol. Rats were induced with a high-lipid diet and PTU to trigger hypothyroidism. Parameters measured included body weight, total cholesterol, triglycerides, and fasting blood glucose before and after four weeks of treatment at three dose levels. Results: Phytochemical analysis confirmed the presence of terpenoids, polyphenols, and flavonoids, but no alkaloids or saponins. Kawista extract showed a significant effect on triglyceride levels (p=0.002), while effects on cholesterol (p=0.651) and fasting blood glucose (p=0.656) were not significant. Mann-Whitney post-hoc analysis showed significant differences between all groups except between the positive control and dose 1 (p=0.885). Conclusion: Kawista fruit extract has significant potential in reducing triglyceride levels in rats with NAFLD-induced hyperlipidemia, supporting its use as a natural antioxidant and lipid-lowering agent
Co-Authors Agrijanti, Agrijanti Aini Ananda, Dewa Ayu Putu Wiweka Ari Khusuma BaiqIsti Hijriani Dewi, Lale Budi Kusuma Dr. Ershandi Renshaleksmana Dwi Kurnia Febrianti kurnia Eka Atyi Purwasih Erlin Yustin Tatontos Erlin Yustin Tatontos Erna Kristinawati Ersandhi Resnhaleksmana Ersandhi Resnhaleksmana Fihiruddin, Fihiruddin Getas, I Wayan Helenia Ananda Feriska Felanis Hijjati Sukmana Gading HUSNANINGSIH, ASPARIN I Gusti Ayu Nyoman Danuyanti I Gusti Ayu Ratih Yuliartini Ayu I Made Suardika I Made Wahyu Waisnawa I Wayan Getas I Wayan Getas I Wayan Getas I Wayan Getas I wayan Getas I Wayan Getas Iswari Pauzi Kadek Sinta Cahyani, Ni Diah Khairal Yasmin Khairunnisa Kristinawati, Erna Lale Budi Lalu Sri Gede Lalu Srigede Lalu Srigede, Lalu Lidia Febrianisa lusi selfiana Malia Septiana Maruni Wiwin Diarti Melya Alimatul Sa’adati Minovriyanti, Eka Muhammad Luthfi Ni Diah Kadek Sinta Cahyani Ni Kadek Defyantari Ni Luh Gita Dewi Lestari Ni Luh Putu Pebrita Ni Luh Putu Pebrita Anjar Santi Nurul Inayati Pancawati Ariami Pebrita Anjar Santi, Ni Luh Putu Pebrita Anjar Santi, Ni Luh Putu Rohmi Rohmi, Rohmi Salsabila, Yaumi Tasu’a Sani, Syahrul Septiawan, Dandi Siti Zaetun Siti Zaetun Siti zaetun Siti zaetun Siti Zaetun, Siti Sri Hartuti Suaryana, I Made Chandra Thomas Tandi Manu Urip Urip Urip Urip, Urip Waisnawa, I Made Wahyu Wayan Getas Widiasih, Ni Kadek Yaumi Tasu’a Salsabila Yudha Anggit Yudha Anggit Jiwantoro Yunan Jiwintarum Zaenal Fikri Zainal Fikri Zainal Fikri Zainal Fikri, Zainal Ziana Dia Ningsih